Gene Symbol | lin-18 |
Entrez Gene ID | 180679 |
Full Name | Inactive tyrosine-protein kinase RYK |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » lin-18 cDNA ORF clone
Gene Symbol | lin-18 |
Entrez Gene ID | 180679 |
Full Name | Inactive tyrosine-protein kinase RYK |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_076283.5 | NP_508684.4 | Inactive tyrosine-protein kinase RYK |
NM_076283.4 | NP_508684.4 | Inactive tyrosine-protein kinase RYK |
Mus musculus (house mouse) | Ryk | NP_038677.3 |
Bos taurus (cattle) | RYK | XP_002685146.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006405 | XP_316438.5 |
Pan troglodytes (chimpanzee) | RYK | XP_003310084.1 |
Homo sapiens (human) | RYK | NP_001005861.1 |
Gallus gallus (chicken) | RYK | XP_422674.4 |
Caenorhabditis elegans (roundworm) | lin-18 | NP_508684.4 |
Xenopus tropicalis (tropical clawed frog) | ryk | NP_001017272.1 |
Canis lupus familiaris (dog) | RYK | XP_005634509.1 |
Rattus norvegicus (Norway rat) | Ryk | NP_536327.1 |
Danio rerio (zebrafish) | ryk | NP_001077295.1 |
Drosophila melanogaster (fruit fly) | Drl-2 | NP_610835.2 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Release of LIN-18ICD by cleavage at the membrane is not the main mechanism of LIN-18 signaling in vulval cells. results suggest LIN-18 intracellular domain interacts with Wnt pathway and a 14-3-3 protein and likely plays a minor role in LIN-18 signaling
Title: Function of the Ryk intracellular domain in C. elegans vulval development.
Ryk-intracellular domain fragment suppressed neuroprotection by lin-18/Ryk loss-of-function in expanded-polyQ nematodes, repressed FOXO transcriptional activity, and abolished beta-catenin protection of mutant htt striatal cells against cell death
Title: The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
In a Frizzled-dependent manner, PLR-1 reduces surface levels of the Wnt receptors CAM-1/Ror and LIN-18/Ryk.
Title: The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.
ceMIB (Caenorhabditis elegans Mindbomb/Y47D3A.22) plays a role in the regulation of C. elegans Wnt/RYK (lin-18) /TCF signaling.
Title: Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/?-catenin signaling.
lin-17 (Frizzled type Wnt receptor) and lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva.
Title: lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development.
The following lin-18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the lin-18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa349371 | |
Clone ID Related Accession (Same CDS sequence) | NM_076283.5 , NM_076283.4 | |
Accession Version | NM_076283.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1752bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Inactive tyrosine-protein kinase RYK | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Sep 4, 2019 this sequence version replaced NM_076283.4. |
1 | ATGATTCTTC GCTACCTGAT TTTTTTCGCG CAGTTATGGG CACTCTGCCT GGCCAATGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_508684.4 |
CDS | 9..1760 |
Translation |
Target ORF information:
Target ORF information:
|
NM_076283.5 |
1 | ATGATTCTTC GCTACCTGAT TTTTTTCGCG CAGTTATGGG CACTCTGCCT GGCCAATGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349371 | |
Clone ID Related Accession (Same CDS sequence) | NM_076283.5 , NM_076283.4 | |
Accession Version | NM_076283.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1752bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Inactive tyrosine-protein kinase RYK | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_076283.3. COMPLETENESS: incomplete on both ends. |
1 | ATGATTCTTC GCTACCTGAT TTTTTTCGCG CAGTTATGGG CACTCTGCCT GGCCAATGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_508684.4 |
CDS | 1..1752 |
Translation |
Target ORF information:
Target ORF information:
|
NM_076283.4 |
1 | ATGATTCTTC GCTACCTGAT TTTTTTCGCG CAGTTATGGG CACTCTGCCT GGCCAATGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |