Gene Symbol | sel-12 |
Entrez Gene ID | 180441 |
Full Name | Presenilin sel-12 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » sel-12 cDNA ORF clone
Gene Symbol | sel-12 |
Entrez Gene ID | 180441 |
Full Name | Presenilin sel-12 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_075774.5 | NP_508175.1 | Presenilin sel-12 |
NM_075774.7 | NP_508175.1 | Presenilin sel-12 |
Pan troglodytes (chimpanzee) | PSEN1 | XP_001150037.1 |
Canis lupus familiaris (dog) | PSEN1 | NP_001002943.1 |
PSEN1 | XP_001088635.1 | |
Rattus norvegicus (Norway rat) | Psen1 | NP_062036.2 |
Arabidopsis thaliana (thale cress) | PS1 | NP_172346.1 |
Homo sapiens (human) | PSEN1 | NP_000012.1 |
Bos taurus (cattle) | PSEN1 | NP_777146.1 |
Gallus gallus (chicken) | PSEN1 | NP_989494.1 |
Arabidopsis thaliana (thale cress) | PS2 | NP_180551.1 |
Mus musculus (house mouse) | Psen1 | NP_032969.1 |
Danio rerio (zebrafish) | psen1 | NP_571099.1 |
Caenorhabditis elegans (roundworm) | sel-12 | NP_508175.1 |
Oryza sativa (rice) | Os03g0603700 | NP_001173529.1 |
Xenopus tropicalis (tropical clawed frog) | psen1 | NP_001027027.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
mutations in sel-12 result in defects in calcium homeostasis, leading to mitochondrial dysfunction
Title: A ?-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans.
spr-2 mutations do not suppress sel-12 by affecting nonsense mediated decay, and increase the levels of sel-12 transcripts with premature translation termination codons.
Title: Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegans.
Data report the cloning and characterization of spr-3 and spr-4, which encode large basic zinc-finger proteins which act as transcriptional repressors for sel-12 [spr-3 and spr-4].
Title: Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.
A genetic null allele mutant, sel-12(ar171), showed resistance to oxidative stress and prevented mitochondrial dysfunction-induced apoptosis.
Title: The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities.
The following sel-12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the sel-12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa349812 | |
Clone ID Related Accession (Same CDS sequence) | NM_075774.5 , NM_075774.7 | |
Accession Version | NM_075774.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Presenilin sel-12 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Jun 26, 2012 this sequence version replaced NM_075774.4. COMPLETENESS: incomplete on both ends. |
1 | ATGCCTTCCA CAAGGAGACA ACAGGAGGGC GGAGGTGCAG ATGCGGAAAC ACATACCGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_508175.1 |
CDS | 1..1335 |
Translation |
Target ORF information:
Target ORF information:
|
NM_075774.5 |
1 | ATGCCTTCCA CAAGGAGACA ACAGGAGGGC GGAGGTGCAG ATGCGGAAAC ACATACCGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa349812 | |
Clone ID Related Accession (Same CDS sequence) | NM_075774.5 , NM_075774.7 | |
Accession Version | NM_075774.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Presenilin sel-12 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003284). On Oct 18, 2019 this sequence version replaced NM_075774.6. |
1 | ATGCCTTCCA CAAGGAGACA ACAGGAGGGC GGAGGTGCAG ATGCGGAAAC ACATACCGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_508175.1 |
CDS | 8..1342 |
Translation |
Target ORF information:
Target ORF information:
|
NM_075774.7 |
1 | ATGCCTTCCA CAAGGAGACA ACAGGAGGGC GGAGGTGCAG ATGCGGAAAC ACATACCGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |