| Gene Symbol | unc-116 |
| Entrez Gene ID | 176179 |
| Full Name | Kinesin heavy chain |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » unc-116 cDNA ORF clone
| Gene Symbol | unc-116 |
| Entrez Gene ID | 176179 |
| Full Name | Kinesin heavy chain |
| Gene Type | protein-coding |
| Organism | Caenorhabditis elegans |
| mRNA | Protein | Name |
|---|---|---|
| NM_066441.6 | NP_498842.1 | Kinesin heavy chain |
| NM_066441.7 | NP_498842.1 | Kinesin heavy chain |
| Homo sapiens (human) | KIF5B | NP_004512.1 |
| Bos taurus (cattle) | KIF5B | NP_001179294.1 |
| Canis lupus familiaris (dog) | KIF5B | XP_003638926.1 |
| Danio rerio (zebrafish) | kif5ba | XP_005171465.1 |
| Caenorhabditis elegans (roundworm) | unc-116 | NP_498842.1 |
| Neurospora crassa | NCU09730 | XP_964432.2 |
| KIF5B | XP_002805653.1 | |
| Drosophila melanogaster (fruit fly) | Khc | NP_476590.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000561 | XP_310522.2 |
| Pan troglodytes (chimpanzee) | KIF5B | XP_507730.2 |
| Mus musculus (house mouse) | Kif5b | NP_032474.2 |
| Rattus norvegicus (Norway rat) | Kif5b | NP_476550.1 |
| Gallus gallus (chicken) | KIF5B | XP_004939228.1 |
| Danio rerio (zebrafish) | kif5bb | XP_002664065.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_01757 | XP_003714755.1 |
| Xenopus tropicalis (tropical clawed frog) | kif5b | NP_001122126.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
dendritic branch distribution depends on the balance between the molecular motors UNC-116 and dynein, and we propose that RAB-10 regulates dendrite morphology by balancing the activity of these motors to the transmembrane receptor DMA-1.
Title: RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport.
data support a model in which ongoing motor-driven delivery and removal of AMPARs controls not only the number but also the composition of synaptic AMPARs, and thus the strength of synaptic transmission.
Title: Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors.
Kinesin-1 regulates dendrite microtubule polarity through directly gliding the plus-end-out MTs out of the dendrite using both the motor domain and the C-terminal MT-binding domain.
Title: Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans.
results support a model in which the MIG-15 kinase and the UNC-116-WVE-1 complex act on opposite sides of the growth cone to promote robust directional migration
Title: MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1.
Data present evidence that bicd-1 operates in a conserved pathway with dhc-1 and unc-116.
Title: C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites.
The following unc-116 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the unc-116 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OCa341620 | |
| Clone ID Related Accession (Same CDS sequence) | NM_066441.6 , NM_066441.7 | |
| Accession Version | NM_066441.6 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2448bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Caenorhabditis elegans | |
| Product | Kinesin heavy chain | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_066441.5. COMPLETENESS: incomplete on both ends. | |
1 | ATGGAGCCGC GGACAGACGG AGCAGAATGC GGTGTCCAGG TATTTTGTCG TATTCGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_498842.1 |
| CDS | 1..2448 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_066441.6 |
1 | ATGGAGCCGC GGACAGACGG AGCAGAATGC GGTGTCCAGG TATTTTGTCG TATTCGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OCa341620 | |
| Clone ID Related Accession (Same CDS sequence) | NM_066441.6 , NM_066441.7 | |
| Accession Version | NM_066441.7 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2448bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Caenorhabditis elegans | |
| Product | Kinesin heavy chain | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_066441.6. | |
1 | ATGGAGCCGC GGACAGACGG AGCAGAATGC GGTGTCCAGG TATTTTGTCG TATTCGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_498842.1 |
| CDS | 80..2527 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_066441.7 |
1 | ATGGAGCCGC GGACAGACGG AGCAGAATGC GGTGTCCAGG TATTTTGTCG TATTCGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |