dlc-1 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	dlc-1
Entrez Gene ID	175922
Full Name	Dynein light chain 1, cytoplasmic
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_066021.4	NP_498422.1	Dynein light chain 1, cytoplasmic
NM_066021.5	NP_498422.1	Dynein light chain 1, cytoplasmic

Pathways from BioSystems

Homologies

Homo sapiens (human)	DYNLL2	NP_542408.1
Mus musculus (house mouse)	Dynll2	NP_080832.1
Rattus norvegicus (Norway rat)	Dynll2	NP_542428.1
Drosophila melanogaster (fruit fly)	ctp	NP_001245530.1
Drosophila melanogaster (fruit fly)	Cdlc2	NP_001245836.1
Magnaporthe oryzae (rice blast fungus)	MGG_15645	XP_003714113.1
Danio rerio (zebrafish)	dynll2a	NP_956393.1
Xenopus tropicalis (tropical clawed frog)	dynll2	NP_001165079.1
Pan troglodytes (chimpanzee)	DYNLL2	NP_001229550.1
Canis lupus familiaris (dog)	DYNLL2	XP_005624774.1
Bos taurus (cattle)	DYNLL2	NP_001106774.1
Gallus gallus (chicken)	DYNLL2	XP_004946822.1
Danio rerio (zebrafish)	dynll2b	NP_001025171.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001335	XP_321810.4
Caenorhabditis elegans (roundworm)	dlc-1	NP_498422.1
Schizosaccharomyces pombe (fission yeast)	dlc2	NP_594368.1
Oryza sativa (rice)	Os01g0256400	NP_001042625.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DLC-1 directly binds to FBF-2 outside of the RNA-binding domain and promotes FBF-2 localization and function. This result identifies a new role for DLC-1 in post-transcriptional regulation of gene expression.
Title: Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells.

DLC-1 is functioning cell nonautonomously through the same pathway as kri-1 in response to ionizing radiation-induced apoptosis.
Title: Cell-nonautonomous inhibition of radiation-induced apoptosis by dynein light chain 1 in Caenorhabditis elegans.

Dynein light chain 1 (DLC-1) and its partner, dynein heavy chain 1, inhibit the proliferative cell fate, in part through regulation of METT-10, a conserved putative methyltransferase.
Title: A role for dynein in the inhibition of germ cell proliferative fate.

The following dlc-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the dlc-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa340933	NM_066021.5 Latest version!	Caenorhabditis elegans Dynein light chain 1, cytoplasmic (dlc-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OCa340933	NM_066021.4	Caenorhabditis elegans Dynein light chain 1, cytoplasmic (dlc-1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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1 Clone	30% OFF
2-4 Clone	40% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

dlc-1 ( NM_066021.4 ) cDNA ORF clone, Caenorhabditis elegans -> NP_498422.1 Caenorhabditis elegans Dynein light chain 1, cytoplasmic (dlc-1), partial mRNA.

Price & Availability↑

CloneID	OCa340933
Clone ID Related Accession (Same CDS sequence)	NM_066021.4 , NM_066021.5
Accession Version	NM_066021.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_066021.3. COMPLETENESS: incomplete on both ends.

ATGGTTGACC GCAAGGCTGT GATCAAGAAT GCCGACATGT CCGATGACAT GCAACAGGAC 
GCCATCGACT GCGCCACCCA GGCCCTCGAG AAATACAACA TCGAGAAGGA TATTGCCGCT 
TACATCAAGA AGGAGTTCGA CAAGAAATAC AACCCAACCT GGCATTGCAT CGTCGGAAGA 
AACTTTGGAA GCTACGTGAC CCACGAGACT AAGCACTTTA TCTACTTCTA CCTTGGACAG 
GTCGCCATCC TGCTATTCAA GTCTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_498422.1
CDS	1..270
Translation	MVDRKAVIKNADMSDDMQQDAIDCATQALEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_066021.4
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Dynein light chain 1, cytoplasmic (dlc-1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_066021.4

ORF Insert Sequence:

ATGGTTGACC GCAAGGCTGT GATCAAGAAT GCCGACATGT CCGATGACAT GCAACAGGAC 
GCCATCGACT GCGCCACCCA GGCCCTCGAG AAATACAACA TCGAGAAGGA TATTGCCGCT 
TACATCAAGA AGGAGTTCGA CAAGAAATAC AACCCAACCT GGCATTGCAT CGTCGGAAGA 
AACTTTGGAA GCTACGTGAC CCACGAGACT AAGCACTTTA TCTACTTCTA CCTTGGACAG 
GTCGCCATCC TGCTATTCAA GTCTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

dlc-1 ( NM_066021.5 ) cDNA ORF clone, Caenorhabditis elegans -> NP_498422.1 Caenorhabditis elegans Dynein light chain 1, cytoplasmic (dlc-1), mRNA.

Price & Availability↑

CloneID	OCa340933
Clone ID Related Accession (Same CDS sequence)	NM_066021.4 , NM_066021.5
Accession Version	NM_066021.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Dynein light chain 1, cytoplasmic
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_066021.4.

ATGGTTGACC GCAAGGCTGT GATCAAGAAT GCCGACATGT CCGATGACAT GCAACAGGAC 
GCCATCGACT GCGCCACCCA GGCCCTCGAG AAATACAACA TCGAGAAGGA TATTGCCGCT 
TACATCAAGA AGGAGTTCGA CAAGAAATAC AACCCAACCT GGCATTGCAT CGTCGGAAGA 
AACTTTGGAA GCTACGTGAC CCACGAGACT AAGCACTTTA TCTACTTCTA CCTTGGACAG 
GTCGCCATCC TGCTATTCAA GTCTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_498422.1
CDS	16..285
Translation	MVDRKAVIKNADMSDDMQQDAIDCATQALEKYNIEKDIAAYIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_066021.5
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Dynein light chain 1, cytoplasmic (dlc-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_066021.5

ORF Insert Sequence:

ATGGTTGACC GCAAGGCTGT GATCAAGAAT GCCGACATGT CCGATGACAT GCAACAGGAC 
GCCATCGACT GCGCCACCCA GGCCCTCGAG AAATACAACA TCGAGAAGGA TATTGCCGCT 
TACATCAAGA AGGAGTTCGA CAAGAAATAC AACCCAACCT GGCATTGCAT CGTCGGAAGA 
AACTTTGGAA GCTACGTGAC CCACGAGACT AAGCACTTTA TCTACTTCTA CCTTGGACAG 
GTCGCCATCC TGCTATTCAA GTCTGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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dlc-1 cDNA ORF clone, Caenorhabditis elegans

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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