Gene Symbol | efk-1 |
Entrez Gene ID | 175871 |
Full Name | Eukaryotic elongation factor 2 kinase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » efk-1 cDNA ORF clone
Gene Symbol | efk-1 |
Entrez Gene ID | 175871 |
Full Name | Eukaryotic elongation factor 2 kinase |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001027401.2 | NP_001022572.1 | Eukaryotic elongation factor 2 kinase |
NM_001027402.3 | NP_001022573.1 | Eukaryotic elongation factor 2 kinase |
NM_001027401.3 | NP_001022572.1 | Eukaryotic elongation factor 2 kinase |
NM_001027402.4 | NP_001022573.1 | Eukaryotic elongation factor 2 kinase |
Homo sapiens (human) | EEF2K | NP_037434.1 |
Bos taurus (cattle) | EEF2K | NP_001179471.1 |
EEF2K | XP_001092565.1 | |
Canis lupus familiaris (dog) | EEF2K | XP_005621491.1 |
Pan troglodytes (chimpanzee) | EEF2K | XP_001161085.2 |
Rattus norvegicus (Norway rat) | Eef2k | NP_037079.1 |
Danio rerio (zebrafish) | eef2k | NP_001002740.1 |
Caenorhabditis elegans (roundworm) | efk-1 | NP_001022572.1 |
Xenopus tropicalis (tropical clawed frog) | eef2k | NP_001120146.1 |
Mus musculus (house mouse) | Eef2k | NP_001254640.1 |
Gallus gallus (chicken) | EEF2K | XP_004945358.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Genetic deletion of the eEF2K ortholog efk-1 reduced oxidative stress, and improved chemotaxis and serotonin sensitivity in C. elegans expressing human Abeta42 in neurons. Study highlights the potential utility of eEF2K inhibition to reduce Abeta-mediated oxidative stress in Alzheimer's disease.
Title: eEF2K inhibition blocks A?42 neurotoxicity by promoting an NRF2 antioxidant response.
C. elegans strains deficient in efk-1, the eEF2K ortholog, were severely compromised in their response to nutrient depletion.
Title: The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
The following efk-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the efk-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa341088 | |
Clone ID Related Accession (Same CDS sequence) | NM_001027401.2 , NM_001027401.3 | |
Accession Version | NM_001027401.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2307bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Eukaryotic elongation factor 2 kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_001027401.1. COMPLETENESS: incomplete on both ends. |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001022572.1 |
CDS | 1..2307 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001027401.2 |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341088 | |
Clone ID Related Accession (Same CDS sequence) | NM_001027401.2 , NM_001027401.3 | |
Accession Version | NM_001027401.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2307bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Eukaryotic elongation factor 2 kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001027401.2. |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001022572.1 |
CDS | 18..2324 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001027401.3 |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341089 | |
Clone ID Related Accession (Same CDS sequence) | NM_001027402.3 , NM_001027402.4 | |
Accession Version | NM_001027402.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Eukaryotic elongation factor 2 kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_001027402.2. COMPLETENESS: incomplete on both ends. |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001022573.1 |
CDS | 1..2283 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001027402.3 |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341089 | |
Clone ID Related Accession (Same CDS sequence) | NM_001027402.3 , NM_001027402.4 | |
Accession Version | NM_001027402.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2283bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Eukaryotic elongation factor 2 kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001027402.3. |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001022573.1 |
CDS | 18..2300 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001027402.4 |
1 | ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |