Gene Symbol | daf-2 |
Entrez Gene ID | 175410 |
Full Name | Insulin-like receptor subunit beta |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » daf-2 cDNA ORF clone
Gene Symbol | daf-2 |
Entrez Gene ID | 175410 |
Full Name | Insulin-like receptor subunit beta |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_001312990.1 | NP_001299919.1 | hypothetical protein |
NM_001312991.1 | NP_001299920.1 | hypothetical protein |
NM_001312987.2 | NP_001299916.1 | Receptor protein-tyrosine kinase |
NM_001312989.2 | NP_001299918.1 | Receptor protein-tyrosine kinase |
NM_001312991.2 | NP_001299920.1 | Protein kinase domain-containing protein |
NM_001312990.2 | NP_001299919.1 | hypothetical protein |
NM_001312988.2 | NP_001299917.1 | Receptor protein-tyrosine kinase |
NM_065249.4 | NP_497650.4 | Insulin-like receptor subunit beta |
NM_001312988.1 | NP_001299917.1 | Receptor protein-tyrosine kinase |
NM_001312989.1 | NP_001299918.1 | Receptor protein-tyrosine kinase |
NM_065249.5 | NP_497650.4 | Insulin-like receptor subunit beta |
NM_001312987.1 | NP_001299916.1 | Receptor protein-tyrosine kinase |
Pan troglodytes (chimpanzee) | IGF1R | XP_510613.2 |
Canis lupus familiaris (dog) | IGF1R | XP_545828.2 |
Mus musculus (house mouse) | Igf1r | NP_034643.2 |
Gallus gallus (chicken) | IGF1R | NP_990363.1 |
Bos taurus (cattle) | IGF1R | NP_001231541.1 |
Danio rerio (zebrafish) | igf1ra | NP_694500.1 |
Caenorhabditis elegans (roundworm) | daf-2 | NP_497650.4 |
Homo sapiens (human) | IGF1R | NP_000866.1 |
Rattus norvegicus (Norway rat) | Igf1r | NP_434694.1 |
Danio rerio (zebrafish) | igf1rb | NP_694501.1 |
Anopheles gambiae (African malaria mosquito) | INR | XP_320130.3 |
Xenopus tropicalis (tropical clawed frog) | igf1r | XP_002933351.1 |
IGF1R | XP_001100407.1 | |
Drosophila melanogaster (fruit fly) | InR | NP_001138093.1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
this study shows that daf-2(-) mutants are hyper-immune and exhibit reduced pathological consequences during challenge with Coxiella burnetii
Title: Analysis of the Caenorhabditis elegans innate immune response to Coxiella burnetii.
Cholesterol is required for the fasting-induced upregulation of transcriptional target genes such as the insulin/IGF-1 pathway effector DAF-16, and cholesterol deprivation suppresses the long lifespan of the insulin/IGF-1 receptor daf-2 mutant. Remarkably, we found that cholesterol plays an important role in the fasting-induced nuclear accumulation of DAF-16.
Title: Cholesterol regulates DAF-16 nuclear localization and fasting-induced longevity in C. elegans.
Five MMP alleles proved to be novel dauer-enhancing mutations, including one new allele in the previously uncharacterized C-terminus of DAF-2 CRISPR-Cas9 genome editing was used to confirm the phenotypic consequence of six of these DAF-2 mutations and to replicate an allelic series of known human disease mutations in a highly conserved tyrosine kinase active site residue
Title: Caenorhabditis elegans DAF-2 as a Model for Human Insulin Receptoropathies.
Reduced signaling through the insulin-like receptor daf-2/InsR in the maternal soma causes constitutively large progeny, and its effector daf-16/FoxO is required for this effect. nhr-49/Hnf4, pha-4/FoxA, and skn-1/Nrf also regulate progeny-size plasticity. Genetic analysis suggests that insulin-like signaling controls progeny size in part through regulation of nhr-49/Hnf4, and that pha-4/FoxA and skn-1/Nrf function
Title: Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance.
this study shows that heat shock increases the life span of wild type Caenorhabditis elegans upon pathogenic encounter; similar increase in resistance towards pathogenesis observed in long-lived C. elegans daf-2 mutants
Title: External induction of heat shock stimulates the immune response and longevity of Caenorhabditis elegans towards pathogen exposure.
The following daf-2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the daf-2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa352261 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312991.1 , NM_001312991.2 | |
Accession Version | NM_001312991.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-09 | |
Organism | Caenorhabditis elegans | |
Product | hypothetical protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). COMPLETENESS: incomplete on both ends. |
1 | ATGACGCCAG GCTTCTTCAC TGTGGAAATC ATTCTCGGCA TGCTTCTCGT CTTTTTGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299920.1 |
CDS | 1..2019 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312991.1 |
1 | ATGACGCCAG GCTTCTTCAC TGTGGAAATC ATTCTCGGCA TGCTTCTCGT CTTTTTGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa352261 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312991.1 , NM_001312991.2 | |
Accession Version | NM_001312991.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2019bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Protein kinase domain-containing protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001312991.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGACGCCAG GCTTCTTCAC TGTGGAAATC ATTCTCGGCA TGCTTCTCGT CTTTTTGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299920.1 |
CDS | 1..2019 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312991.2 |
1 | ATGACGCCAG GCTTCTTCAC TGTGGAAATC ATTCTCGGCA TGCTTCTCGT CTTTTTGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa352260 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312990.1 , NM_001312990.2 | |
Accession Version | NM_001312990.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3111bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-09 | |
Organism | Caenorhabditis elegans | |
Product | hypothetical protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). COMPLETENESS: incomplete on both ends. |
1 | ATGTGGCGTG AGAATGAAGT GAGCCCGTAC GAGGAAGCCG AAAAGTTTTG TACAGATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299919.1 |
CDS | 1..3111 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312990.1 |
1 | ATGTGGCGTG AGAATGAAGT GAGCCCGTAC GAGGAAGCCG AAAAGTTTTG TACAGATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa352260 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312990.1 , NM_001312990.2 | |
Accession Version | NM_001312990.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3111bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Caenorhabditis elegans | |
Product | hypothetical protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001312990.1. |
1 | ATGTGGCGTG AGAATGAAGT GAGCCCGTAC GAGGAAGCCG AAAAGTTTTG TACAGATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299919.1 |
CDS | 10..3120 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312990.2 |
1 | ATGTGGCGTG AGAATGAAGT GAGCCCGTAC GAGGAAGCCG AAAAGTTTTG TACAGATGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa339938 | |
Clone ID Related Accession (Same CDS sequence) | NM_065249.4 , NM_065249.5 | |
Accession Version | NM_065249.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5541bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Insulin-like receptor subunit beta | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_065249.3. COMPLETENESS: incomplete on both ends. |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_497650.4 |
CDS | 1..5541 |
Translation |
Target ORF information:
Target ORF information:
|
NM_065249.4 |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa339938 | |
Clone ID Related Accession (Same CDS sequence) | NM_065249.4 , NM_065249.5 | |
Accession Version | NM_065249.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5541bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Insulin-like receptor subunit beta | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_065249.4. |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_497650.4 |
CDS | 99..5639 |
Translation |
Target ORF information:
Target ORF information:
|
NM_065249.5 |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341981 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312987.2 , NM_001312987.1 | |
Accession Version | NM_001312987.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5787bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Receptor protein-tyrosine kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001312987.1. |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299916.1 |
CDS | 99..5885 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312987.2 |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341981 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312987.2 , NM_001312987.1 | |
Accession Version | NM_001312987.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5787bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Receptor protein-tyrosine kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). COMPLETENESS: incomplete on both ends. |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299916.1 |
CDS | 1..5787 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312987.1 |
1 | ATGACGAGAA TGAATATTGT CAGATGTCGG AGACGACACA AAATTTTGGA AAATTTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341982 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312988.2 , NM_001312988.1 | |
Accession Version | NM_001312988.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5400bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Receptor protein-tyrosine kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001312988.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGAGGCTTA AGCAGCAGCG AAGCTCGTCG CGTGCCACGG AGCACGATAT TGTCGACGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299917.1 |
CDS | 1..5400 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312988.2 |
1 | ATGAGGCTTA AGCAGCAGCG AAGCTCGTCG CGTGCCACGG AGCACGATAT TGTCGACGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341982 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312988.2 , NM_001312988.1 | |
Accession Version | NM_001312988.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5400bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Receptor protein-tyrosine kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). COMPLETENESS: incomplete on both ends. |
1 | ATGAGGCTTA AGCAGCAGCG AAGCTCGTCG CGTGCCACGG AGCACGATAT TGTCGACGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299917.1 |
CDS | 1..5400 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312988.1 |
1 | ATGAGGCTTA AGCAGCAGCG AAGCTCGTCG CGTGCCACGG AGCACGATAT TGTCGACGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341983 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312989.2 , NM_001312989.1 | |
Accession Version | NM_001312989.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5313bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Receptor protein-tyrosine kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001312989.1. COMPLETENESS: incomplete on the 5' end. |
1 | ATGAGACGGC TTCGACTTGT CAAAAATTCG CGGACGCGGC GTAGAACGAC GCCCGATTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299918.1 |
CDS | 1..5313 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312989.2 |
1 | ATGAGACGGC TTCGACTTGT CAAAAATTCG CGGACGCGGC GTAGAACGAC GCCCGATTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa341983 | |
Clone ID Related Accession (Same CDS sequence) | NM_001312989.2 , NM_001312989.1 | |
Accession Version | NM_001312989.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5313bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Receptor protein-tyrosine kinase | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). COMPLETENESS: incomplete on both ends. |
1 | ATGAGACGGC TTCGACTTGT CAAAAATTCG CGGACGCGGC GTAGAACGAC GCCCGATTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001299918.1 |
CDS | 1..5313 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001312989.1 |
1 | ATGAGACGGC TTCGACTTGT CAAAAATTCG CGGACGCGGC GTAGAACGAC GCCCGATTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |