cdc-42 cDNA ORF clone, Caenorhabditis elegans

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

Junctional CDC-42 controls actin organization and adherens junction protein levels during epithelial morphogenesis.
Title: Cdc42 regulates junctional actin but not cell polarization in the

PAR-3 exists in a dynamic equilibrium between an unclustered form and a clustered form, in response to cortical tension mainly exerted by actomyosin contractility. Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.
Title: Cortical forces and CDC-42 control clustering of PAR?proteins for Caenorhabditis elegans embryonic?polarization.

we find that vab-1 lies in the same genetic pathway as cdc-42 and is responsible for polarizing CDC-42 activity to the medial tip. Together, these data establish a previously uncharacterized role for polarized CDC-42, in conjunction with PAR-6, PAR-3 and an Eph receptor(vab-1), during epithelial intercalation.
Title: CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis.

MRCK-1 is required for activation of contractile actomyosin dynamics and elevated cortical tension in the apical cell cortex of endoderm precursor cells. MRCK-1 is apically localized by active Cdc42 at the external, cell-cell contact-free surfaces of apically constricting cells, downstream of cell fate determination mechanisms.
Title: MRCK-1 Drives Apical Constriction in C.?elegans by Linking Developmental Patterning to Force Generation.

CDC-42 is required for the invasive membrane localization of WSP-1 (N-WASP), a CDC-42 effector that promotes polymerization of F-actin. Loss of CDC-42 or WSP-1 resulted in fewer invadopodia and delayed BM breaching
Title: A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.