frh-1 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	frh-1
Entrez Gene ID	174002
Full Name	Frataxin, mitochondrial
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_062782.3	NP_495183.1	Frataxin, mitochondrial
NM_062782.4	NP_495183.1	Frataxin, mitochondrial

Pathways from BioSystems

Homologies

Caenorhabditis elegans (roundworm)	frh-1	NP_495183.1
Drosophila melanogaster (fruit fly)	fh	NP_511094.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000813	XP_311351.5

Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Demonstrate a causal connection between induction of autophagy and lifespan extension following reduced frataxin expression.
Title: Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.

Frataxin suppression by RNAi significantly reduces lifespan in C. elegans.
Title: Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia.

Study describes in detail the structure of all of the coding units within the CEOP2232 operon, coding for frataxin; it is composed of eight genes of a diverse nature, organized in a complex structure.
Title: The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation.

The genomic structure of frh-1, the development of an RNA interference model, and the interaction of frh-1 with mev-1 are reported.
Title: Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.

Frataxin suppression by RNAi significantly extends lifespan in C. elegans.
Title: Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans.

The following frh-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the frh-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa339166	NM_062782.4 Latest version!	Caenorhabditis elegans Frataxin, mitochondrial (frh-1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OCa339166	NM_062782.3	Caenorhabditis elegans Frataxin, mitochondrial (frh-1), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

frh-1 ( NM_062782.3 ) cDNA ORF clone, Caenorhabditis elegans -> NP_495183.1 Caenorhabditis elegans Frataxin, mitochondrial (frh-1), partial mRNA.

Price & Availability↑

CloneID	OCa339166
Clone ID Related Accession (Same CDS sequence)	NM_062782.3 , NM_062782.4
Accession Version	NM_062782.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Frataxin, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Jun 26, 2012 this sequence version replaced NM_062782.2. COMPLETENESS: incomplete on both ends.

ATGCTCTCCA CTATTCTACG AAACAATTTT GTACGTCGCT CATTTTCGTC CCGGATTTTC 
AGTCAAAATG AGTACGAAAC AGCAGCTGAT TCAACATTAG AAAGATTATC AGACTATTTC 
GATCAAATTG CCGATTCATT TCCGGTTTCC GAACAATTTG ATGTATCTCA TGCAATGGGA 
GTTTTGACTG TTAATGTATC GAAATCTGTT GGAACGTATG TTATTAACAA ACAATCACCA 
AATAAGCAAA TTTGGTTGTC CAGTCCGATG TCTGGTCCGA AAAGATATGA TTTAGAAGAG 
GAGGGAAAAT GGACTTATGC ACACGATGGT GAACAACTTG ACTCGCTTCT AAACAGAGAA 
TTCCGAAAGA TTCTGGCCGA TGACCGAATC GATTTCTCGC GACATGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_495183.1
CDS	1..411
Translation	MLSTILRNNFVRRSFSSRIFSQNEYETAADSTLERLSDYFDQIADSFPVSEQFDVSHAMGVLTVNVSKSVGTYVINKQSPNKQIWLSSPMSGPKRYDLEEEGKWTYAHDGEQLDSLLNREFRKILADDRIDFSRHV

Target ORF information:

RefSeq Version	NM_062782.3
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Frataxin, mitochondrial (frh-1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_062782.3

ORF Insert Sequence:

ATGCTCTCCA CTATTCTACG AAACAATTTT GTACGTCGCT CATTTTCGTC CCGGATTTTC 
AGTCAAAATG AGTACGAAAC AGCAGCTGAT TCAACATTAG AAAGATTATC AGACTATTTC 
GATCAAATTG CCGATTCATT TCCGGTTTCC GAACAATTTG ATGTATCTCA TGCAATGGGA 
GTTTTGACTG TTAATGTATC GAAATCTGTT GGAACGTATG TTATTAACAA ACAATCACCA 
AATAAGCAAA TTTGGTTGTC CAGTCCGATG TCTGGTCCGA AAAGATATGA TTTAGAAGAG 
GAGGGAAAAT GGACTTATGC ACACGATGGT GAACAACTTG ACTCGCTTCT AAACAGAGAA 
TTCCGAAAGA TTCTGGCCGA TGACCGAATC GATTTCTCGC GACATGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

frh-1 ( NM_062782.4 ) cDNA ORF clone, Caenorhabditis elegans -> NP_495183.1 Caenorhabditis elegans Frataxin, mitochondrial (frh-1), partial mRNA.

Price & Availability↑

CloneID	OCa339166
Clone ID Related Accession (Same CDS sequence)	NM_062782.3 , NM_062782.4
Accession Version	NM_062782.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Frataxin, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003280). On Sep 4, 2019 this sequence version replaced NM_062782.3. COMPLETENESS: incomplete on the 5' end.

ATGCTCTCCA CTATTCTACG AAACAATTTT GTACGTCGCT CATTTTCGTC CCGGATTTTC 
AGTCAAAATG AGTACGAAAC AGCAGCTGAT TCAACATTAG AAAGATTATC AGACTATTTC 
GATCAAATTG CCGATTCATT TCCGGTTTCC GAACAATTTG ATGTATCTCA TGCAATGGGA 
GTTTTGACTG TTAATGTATC GAAATCTGTT GGAACGTATG TTATTAACAA ACAATCACCA 
AATAAGCAAA TTTGGTTGTC CAGTCCGATG TCTGGTCCGA AAAGATATGA TTTAGAAGAG 
GAGGGAAAAT GGACTTATGC ACACGATGGT GAACAACTTG ACTCGCTTCT AAACAGAGAA 
TTCCGAAAGA TTCTGGCCGA TGACCGAATC GATTTCTCGC GACATGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_495183.1
CDS	1..411
Translation	MLSTILRNNFVRRSFSSRIFSQNEYETAADSTLERLSDYFDQIADSFPVSEQFDVSHAMGVLTVNVSKSVGTYVINKQSPNKQIWLSSPMSGPKRYDLEEEGKWTYAHDGEQLDSLLNREFRKILADDRIDFSRHV

Target ORF information:

RefSeq Version	NM_062782.4
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Frataxin, mitochondrial (frh-1), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_062782.4

ORF Insert Sequence:

ATGCTCTCCA CTATTCTACG AAACAATTTT GTACGTCGCT CATTTTCGTC CCGGATTTTC 
AGTCAAAATG AGTACGAAAC AGCAGCTGAT TCAACATTAG AAAGATTATC AGACTATTTC 
GATCAAATTG CCGATTCATT TCCGGTTTCC GAACAATTTG ATGTATCTCA TGCAATGGGA 
GTTTTGACTG TTAATGTATC GAAATCTGTT GGAACGTATG TTATTAACAA ACAATCACCA 
AATAAGCAAA TTTGGTTGTC CAGTCCGATG TCTGGTCCGA AAAGATATGA TTTAGAAGAG 
GAGGGAAAAT GGACTTATGC ACACGATGGT GAACAACTTG ACTCGCTTCT AAACAGAGAA 
TTCCGAAAGA TTCTGGCCGA TGACCGAATC GATTTCTCGC GACATGTCTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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frh-1 cDNA ORF clone, Caenorhabditis elegans

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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