gsk-3 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	gsk-3
Entrez Gene ID	173149
Full Name	Glycogen synthase kinase-3
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_060842.5	NP_493243.1	Glycogen synthase kinase-3
NM_060842.6	NP_493243.1	Glycogen synthase kinase-3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GSK3B	NP_001094780.1
Mus musculus (house mouse)	Gsk3b	NP_062801.1
Rattus norvegicus (Norway rat)	Gsk3b	NP_114469.1
Caenorhabditis elegans (roundworm)	gsk-3	NP_493243.1
Xenopus tropicalis (tropical clawed frog)	gsk3b	XP_002941025.2
Pan troglodytes (chimpanzee)	GSK3B	XP_003339094.1
Canis lupus familiaris (dog)	GSK3B	XP_535751.2
Danio rerio (zebrafish)	gsk3b	NP_571456.1
Homo sapiens (human)	GSK3B	NP_002084.2
Arabidopsis thaliana (thale cress)	SK13	NP_196968.2
Gallus gallus (chicken)	GSK3B	XP_416557.4
Oryza sativa (rice)	Os05g0134000	NP_001054564.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rearrangement of mitotic spindles requires the GSK-3 kinase. Apoptotic cell clearance and migration of the distal tip cell require the GSK-3 kinase.
Title: The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.

GSK3 converts OMA-1 and OMA-2 from being key regulators of oocyte maturation to key regulators of 1-cell embryo development
Title: DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans.

(i) GSK-3 inhibits SKN-1 activity in the intestine, (ii) the phase II response integrates multiple regulatory signals, and (iii), by inhibiting this response, GSK-3 may influence redox conditions.
Title: Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.

The following gsk-3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the gsk-3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa336048	NM_060842.6 Latest version!	Caenorhabditis elegans Glycogen synthase kinase-3 (gsk-3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OCa336048	NM_060842.5	Caenorhabditis elegans Glycogen synthase kinase-3 (gsk-3), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$258.30 $369.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

gsk-3 ( NM_060842.5 ) cDNA ORF clone, Caenorhabditis elegans -> NP_493243.1 Caenorhabditis elegans Glycogen synthase kinase-3 (gsk-3), partial mRNA.

Price & Availability↑

CloneID	OCa336048
Clone ID Related Accession (Same CDS sequence)	NM_060842.5 , NM_060842.6
Accession Version	NM_060842.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Glycogen synthase kinase-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_060842.4. COMPLETENESS: incomplete on both ends.

ATGAATAAGC AGTTACTATC GTGCTCGCTG AAAAGCGGAA AACAAGTGAC GATGGTCGTC 
GCGTCAGTCG CCACGGATGG TGTTGATCAG CAGGTTGAAA TCTCGTACTA CGATCAGAAA 
GTGATTGGAA ATGGATCATT CGGAGTGGTA TTCCTTGCCA AACTCTCTAC AACAAATGAA 
ATGGTTGCAA TCAAGAAAGT TCTTCAGGAC AAACGATTCA AGAATCGTGA ACTACAGATT 
ATGCGAAAAT TGAATCATCC AAATATCGTG AAGCTCAAAT ACTTTTTCTA TTCGAGCGGC 
GAGAAGAAGG ATGAACTCTA CTTGAATTTG ATTCTCGAAT ATGTTCCTGA AACTGTCTAC 
AGAGTTGCCC GGCACTATTC GAAGCAGCGA CAACAAATTC CAATGATTTA TGTCAAATTG 
TACATGTATC AGCTTCTCCG TTCATTGGCC TACATTCATA GCATTGGAAT CTGTCACCGT 
GACATTAAGC CTCAGAATTT GCTCATTGAC CCGGAAAGCG GAGTGCTTAA GCTCTGTGAT 
TTTGGATCTG CCAAATATTT GGTTCGCAAT GAGCCAAACG TCTCGTACAT TTGCTCGCGA 
TATTATCGTG CTCCGGAGCT CATTTTCGGC GCTACAAACT ACACGAACTC GATTGACGTT 
TGGTCGGCTG GAACTGTAAT GGCAGAGCTT CTTCTCGGCC AACCAATTTT CCCTGGTGAC 
TCTGGAGTTG ATCAACTCGT TGAAATTATT AAAGTTCTTG GAACACCGAC TCGTGAACAA 
ATTCAAAGTA TGAATCCGAA CTACAAGGAA TTCAAATTTC CACAGATAAA GGCACATCCA 
TGGAATAAGG TATTCCGTGT ACACACGCCT GCTGAAGCGA TTGATCTCAT TTCGAAGATT 
ATCGAGTATA CGCCGACGTC TCGGCCAACA CCTCAAGCGG CCTGCCAGCA CGCATTCTTT 
GATGAGCTCC GAAACCCGGA TGCACGTCTT CCATCTGGTC GACCTCTTCC AACACTTGAG 
ATGGACGGTC CAATGGGAAC TGGTGAAGTT TCAACGACAA GCGGTGATGT GGCTGGCCCA 
TCGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_493243.1
CDS	1..1089
Translation	MNKQLLSCSLKSGKQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRNPDARLPSGRPLPTLEMDGPMGTGEVSTTSGDVAGPSA

Target ORF information:

RefSeq Version	NM_060842.5
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Glycogen synthase kinase-3 (gsk-3), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_060842.5

ORF Insert Sequence:

ATGAATAAGC AGTTACTATC GTGCTCGCTG AAAAGCGGAA AACAAGTGAC GATGGTCGTC 
GCGTCAGTCG CCACGGATGG TGTTGATCAG CAGGTTGAAA TCTCGTACTA CGATCAGAAA 
GTGATTGGAA ATGGATCATT CGGAGTGGTA TTCCTTGCCA AACTCTCTAC AACAAATGAA 
ATGGTTGCAA TCAAGAAAGT TCTTCAGGAC AAACGATTCA AGAATCGTGA ACTACAGATT 
ATGCGAAAAT TGAATCATCC AAATATCGTG AAGCTCAAAT ACTTTTTCTA TTCGAGCGGC 
GAGAAGAAGG ATGAACTCTA CTTGAATTTG ATTCTCGAAT ATGTTCCTGA AACTGTCTAC 
AGAGTTGCCC GGCACTATTC GAAGCAGCGA CAACAAATTC CAATGATTTA TGTCAAATTG 
TACATGTATC AGCTTCTCCG TTCATTGGCC TACATTCATA GCATTGGAAT CTGTCACCGT 
GACATTAAGC CTCAGAATTT GCTCATTGAC CCGGAAAGCG GAGTGCTTAA GCTCTGTGAT 
TTTGGATCTG CCAAATATTT GGTTCGCAAT GAGCCAAACG TCTCGTACAT TTGCTCGCGA 
TATTATCGTG CTCCGGAGCT CATTTTCGGC GCTACAAACT ACACGAACTC GATTGACGTT 
TGGTCGGCTG GAACTGTAAT GGCAGAGCTT CTTCTCGGCC AACCAATTTT CCCTGGTGAC 
TCTGGAGTTG ATCAACTCGT TGAAATTATT AAAGTTCTTG GAACACCGAC TCGTGAACAA 
ATTCAAAGTA TGAATCCGAA CTACAAGGAA TTCAAATTTC CACAGATAAA GGCACATCCA 
TGGAATAAGG TATTCCGTGT ACACACGCCT GCTGAAGCGA TTGATCTCAT TTCGAAGATT 
ATCGAGTATA CGCCGACGTC TCGGCCAACA CCTCAAGCGG CCTGCCAGCA CGCATTCTTT 
GATGAGCTCC GAAACCCGGA TGCACGTCTT CCATCTGGTC GACCTCTTCC AACACTTGAG 
ATGGACGGTC CAATGGGAAC TGGTGAAGTT TCAACGACAA GCGGTGATGT GGCTGGCCCA 
TCGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

gsk-3 ( NM_060842.6 ) cDNA ORF clone, Caenorhabditis elegans -> NP_493243.1 Caenorhabditis elegans Glycogen synthase kinase-3 (gsk-3), mRNA.

Price & Availability↑

CloneID	OCa336048
Clone ID Related Accession (Same CDS sequence)	NM_060842.5 , NM_060842.6
Accession Version	NM_060842.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Glycogen synthase kinase-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_060842.5.

ATGAATAAGC AGTTACTATC GTGCTCGCTG AAAAGCGGAA AACAAGTGAC GATGGTCGTC 
GCGTCAGTCG CCACGGATGG TGTTGATCAG CAGGTTGAAA TCTCGTACTA CGATCAGAAA 
GTGATTGGAA ATGGATCATT CGGAGTGGTA TTCCTTGCCA AACTCTCTAC AACAAATGAA 
ATGGTTGCAA TCAAGAAAGT TCTTCAGGAC AAACGATTCA AGAATCGTGA ACTACAGATT 
ATGCGAAAAT TGAATCATCC AAATATCGTG AAGCTCAAAT ACTTTTTCTA TTCGAGCGGC 
GAGAAGAAGG ATGAACTCTA CTTGAATTTG ATTCTCGAAT ATGTTCCTGA AACTGTCTAC 
AGAGTTGCCC GGCACTATTC GAAGCAGCGA CAACAAATTC CAATGATTTA TGTCAAATTG 
TACATGTATC AGCTTCTCCG TTCATTGGCC TACATTCATA GCATTGGAAT CTGTCACCGT 
GACATTAAGC CTCAGAATTT GCTCATTGAC CCGGAAAGCG GAGTGCTTAA GCTCTGTGAT 
TTTGGATCTG CCAAATATTT GGTTCGCAAT GAGCCAAACG TCTCGTACAT TTGCTCGCGA 
TATTATCGTG CTCCGGAGCT CATTTTCGGC GCTACAAACT ACACGAACTC GATTGACGTT 
TGGTCGGCTG GAACTGTAAT GGCAGAGCTT CTTCTCGGCC AACCAATTTT CCCTGGTGAC 
TCTGGAGTTG ATCAACTCGT TGAAATTATT AAAGTTCTTG GAACACCGAC TCGTGAACAA 
ATTCAAAGTA TGAATCCGAA CTACAAGGAA TTCAAATTTC CACAGATAAA GGCACATCCA 
TGGAATAAGG TATTCCGTGT ACACACGCCT GCTGAAGCGA TTGATCTCAT TTCGAAGATT 
ATCGAGTATA CGCCGACGTC TCGGCCAACA CCTCAAGCGG CCTGCCAGCA CGCATTCTTT 
GATGAGCTCC GAAACCCGGA TGCACGTCTT CCATCTGGTC GACCTCTTCC AACACTTGAG 
ATGGACGGTC CAATGGGAAC TGGTGAAGTT TCAACGACAA GCGGTGATGT GGCTGGCCCA 
TCGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_493243.1
CDS	147..1235
Translation	MNKQLLSCSLKSGKQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRNPDARLPSGRPLPTLEMDGPMGTGEVSTTSGDVAGPSA

Target ORF information:

RefSeq Version	NM_060842.6
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Glycogen synthase kinase-3 (gsk-3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_060842.6

ORF Insert Sequence:

ATGAATAAGC AGTTACTATC GTGCTCGCTG AAAAGCGGAA AACAAGTGAC GATGGTCGTC 
GCGTCAGTCG CCACGGATGG TGTTGATCAG CAGGTTGAAA TCTCGTACTA CGATCAGAAA 
GTGATTGGAA ATGGATCATT CGGAGTGGTA TTCCTTGCCA AACTCTCTAC AACAAATGAA 
ATGGTTGCAA TCAAGAAAGT TCTTCAGGAC AAACGATTCA AGAATCGTGA ACTACAGATT 
ATGCGAAAAT TGAATCATCC AAATATCGTG AAGCTCAAAT ACTTTTTCTA TTCGAGCGGC 
GAGAAGAAGG ATGAACTCTA CTTGAATTTG ATTCTCGAAT ATGTTCCTGA AACTGTCTAC 
AGAGTTGCCC GGCACTATTC GAAGCAGCGA CAACAAATTC CAATGATTTA TGTCAAATTG 
TACATGTATC AGCTTCTCCG TTCATTGGCC TACATTCATA GCATTGGAAT CTGTCACCGT 
GACATTAAGC CTCAGAATTT GCTCATTGAC CCGGAAAGCG GAGTGCTTAA GCTCTGTGAT 
TTTGGATCTG CCAAATATTT GGTTCGCAAT GAGCCAAACG TCTCGTACAT TTGCTCGCGA 
TATTATCGTG CTCCGGAGCT CATTTTCGGC GCTACAAACT ACACGAACTC GATTGACGTT 
TGGTCGGCTG GAACTGTAAT GGCAGAGCTT CTTCTCGGCC AACCAATTTT CCCTGGTGAC 
TCTGGAGTTG ATCAACTCGT TGAAATTATT AAAGTTCTTG GAACACCGAC TCGTGAACAA 
ATTCAAAGTA TGAATCCGAA CTACAAGGAA TTCAAATTTC CACAGATAAA GGCACATCCA 
TGGAATAAGG TATTCCGTGT ACACACGCCT GCTGAAGCGA TTGATCTCAT TTCGAAGATT 
ATCGAGTATA CGCCGACGTC TCGGCCAACA CCTCAAGCGG CCTGCCAGCA CGCATTCTTT 
GATGAGCTCC GAAACCCGGA TGCACGTCTT CCATCTGGTC GACCTCTTCC AACACTTGAG 
ATGGACGGTC CAATGGGAAC TGGTGAAGTT TCAACGACAA GCGGTGATGT GGCTGGCCCA 
TCGGCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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gsk-3 cDNA ORF clone, Caenorhabditis elegans

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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