Gene Symbol | mtm-1 |
Entrez Gene ID | 172148 |
Full Name | Myotubularin-related protein 1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » mtm-1 cDNA ORF clone
Gene Symbol | mtm-1 |
Entrez Gene ID | 172148 |
Full Name | Myotubularin-related protein 1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_059130.4 | NP_491531.2 | Myotubularin-related protein 1 |
NM_059130.5 | NP_491531.2 | Myotubularin-related protein 1 |
Bos taurus (cattle) | MTM1 | NP_001193354.1 |
Gallus gallus (chicken) | MTM1 | XP_004940916.1 |
Homo sapiens (human) | MTM1 | NP_000243.1 |
Pan troglodytes (chimpanzee) | MTM1 | XP_003317805.1 |
Canis lupus familiaris (dog) | MTM1 | XP_005641991.1 |
Danio rerio (zebrafish) | mtm1 | NP_001032773.1 |
Xenopus tropicalis (tropical clawed frog) | mtm1 | NP_001015828.1 |
Mus musculus (house mouse) | Mtm1 | NP_001157662.1 |
MTM1 | XP_002806476.1 | |
Rattus norvegicus (Norway rat) | Mtm1 | NP_001013065.1 |
Caenorhabditis elegans (roundworm) | mtm-1 | NP_491531.2 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
MTM-1, a PI 3-phosphatase that antagonizes the activities of PIKI-1 and VPS-34 by down-regulating phosphatidylinositol 3-phosphate on phagosomes.
Title: Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells.
Loss of mtm-1 function leads to substantially reduced numbers of persistent cell corpses in engulfment mutants, which is a result of a restoration of engulfment function rather than of impaired or delayed programmed cell death.
Title: The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.
Identified Caenorhabditis elegans myotubularin MTM-1 as a negative regulator of cell corpse engulfment. Show that loss of mtm-1 function accelerates the clearance of cell corpses by promoting their internalization.
Title: Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells.
at least three C. elegans MTMs play essential roles in coelomocyte endocytosis
Title: Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
The following mtm-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mtm-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa336593 | |
Clone ID Related Accession (Same CDS sequence) | NM_059130.4 , NM_059130.5 | |
Accession Version | NM_059130.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1767bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Myotubularin-related protein 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_059130.3. COMPLETENESS: incomplete on both ends. |
1 | ATGGATGACA GAGGGAACAA TAGTGGAGAA GTTGGAGAAT TTGCCAGTTC ATCAATGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_491531.2 |
CDS | 1..1767 |
Translation |
Target ORF information:
Target ORF information:
|
NM_059130.4 |
1 | ATGGATGACA GAGGGAACAA TAGTGGAGAA GTTGGAGAAT TTGCCAGTTC ATCAATGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336593 | |
Clone ID Related Accession (Same CDS sequence) | NM_059130.4 , NM_059130.5 | |
Accession Version | NM_059130.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1767bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Myotubularin-related protein 1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_059130.4. |
1 | ATGGATGACA GAGGGAACAA TAGTGGAGAA GTTGGAGAAT TTGCCAGTTC ATCAATGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_491531.2 |
CDS | 59..1825 |
Translation |
Target ORF information:
Target ORF information:
|
NM_059130.5 |
1 | ATGGATGACA GAGGGAACAA TAGTGGAGAA GTTGGAGAAT TTGCCAGTTC ATCAATGATA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |