Gene Symbol | GSK3B |
Entrez Gene ID | 790875 |
Full Name | glycogen synthase kinase 3 beta |
Synonyms | GSK3beta |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » GSK3B cDNA ORF clone
Gene Symbol | GSK3B |
Entrez Gene ID | 790875 |
Full Name | glycogen synthase kinase 3 beta |
Synonyms | GSK3beta |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_024992904.1 | XP_024848672.1 | glycogen synthase kinase-3 beta isoform X3 |
NM_001101310.1 | NP_001094780.1 | glycogen synthase kinase-3 beta |
XM_024992902.1 | XP_024848670.1 | glycogen synthase kinase-3 beta isoform X1 |
XM_024992903.1 | XP_024848671.1 | glycogen synthase kinase-3 beta isoform X2 |
Bos taurus (cattle) | GSK3B | NP_001094780.1 |
Mus musculus (house mouse) | Gsk3b | NP_062801.1 |
Rattus norvegicus (Norway rat) | Gsk3b | NP_114469.1 |
Caenorhabditis elegans (roundworm) | gsk-3 | NP_493243.1 |
Xenopus tropicalis (tropical clawed frog) | gsk3b | XP_002941025.2 |
Pan troglodytes (chimpanzee) | GSK3B | XP_003339094.1 |
Canis lupus familiaris (dog) | GSK3B | XP_535751.2 |
Danio rerio (zebrafish) | gsk3b | NP_571456.1 |
Homo sapiens (human) | GSK3B | NP_002084.2 |
Arabidopsis thaliana (thale cress) | SK13 | NP_196968.2 |
Gallus gallus (chicken) | GSK3B | XP_416557.4 |
Oryza sativa (rice) | Os05g0134000 | NP_001054564.1 |
Role and regulation of Glycogen synthase kinase-3 beta in bovine spermatozoa.
Belenky M, Breitbart H
Molecular reproduction and development84(1)8-18(2017 Jan)
GSK3? regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway.
Zhang X, Zhao F, Si Y, Huang Y, Yu C, Luo C, Zhang N, Li Q, Gao X
Molecules (Basel, Switzerland)19(7)9435-52(2014 Jul)
Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.
Nemoto T, Miyazaki S, Kanai T, Maruta T, Satoh S, Yoshikawa N, Yanagita T, Wada A
European journal of pharmacology640(1-3)20-8(2010 Aug)
Identification and regulation of glycogen synthase kinase-3 during bovine embryo development.
Aparicio IM, Garcia-Herreros M, Fair T, Lonergan P
Reproduction (Cambridge, England)140(1)83-92(2010 Jul)
Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.
Nemoto T, Satoh S, Maruta T, Kanai T, Yoshikawa N, Miyazaki S, Yanagita T, Wada A
Neuropharmacology58(7)1097-108(2010 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggest that maintenance of sperm motility and acrosome reaction timing are mediated by PKA through the regulation of GSK-3 beta activity.
Title: Role and regulation of Glycogen synthase kinase-3 beta in bovine spermatozoa.
GSK3B and phosphorylated GSK3B regulate milk synthesis and proliferation dairy cow mammary epithelial cells.
Title: GSK3? regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
Title: Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38.
GSK3B serine phosphorylation was positively correlated with embryo development
Title: Identification and regulation of glycogen synthase kinase-3 during bovine embryo development.
IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
Title: Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.
The following GSK3B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSK3B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa01539 | |
Clone ID Related Accession (Same CDS sequence) | NM_001101310.1 | |
Accession Version | NM_001101310.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-13 | |
Organism | Bos taurus(cattle) | |
Product | glycogen synthase kinase-3 beta | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC146176.1. On Aug 14, 2007 this sequence version replaced XM_001257234.1. ##Evidence-Data-START## Transcript exon combination :: BC146176.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001094780.1 |
CDS | 431..1729 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001101310.1 |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa219001 | |
Clone ID Related Accession (Same CDS sequence) | XM_024992902.1 | |
Accession Version | XM_024992902.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | glycogen synthase kinase-3 beta isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037328.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024848670.1 |
CDS | 1143..2402 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024992902.1 |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa219002 | |
Clone ID Related Accession (Same CDS sequence) | XM_024992903.1 | |
Accession Version | XM_024992903.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | glycogen synthase kinase-3 beta isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037328.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024848671.1 |
CDS | 557..1795 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024992903.1 |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa219003 | |
Clone ID Related Accession (Same CDS sequence) | XM_024992904.1 | |
Accession Version | XM_024992904.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | glycogen synthase kinase-3 beta isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037328.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024848672.1 |
CDS | 1024..2223 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024992904.1 |
1 | ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Role and regulation of Glycogen synthase kinase-3 beta in bovine spermatozoa. |
GSK3? regulates milk synthesis in and proliferation of dairy cow mammary epithelial cells via the mTOR/S6K1 signaling pathway. |
Nav1.7-Ca2+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK) and p38 attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK and p38. |
Identification and regulation of glycogen synthase kinase-3 during bovine embryo development. |
Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation. |