SELENOM cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	SELENOM
Entrez Gene ID	787736
Full Name	selenoprotein M
Synonyms	SELM
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001163171.3	NP_001156643.2	selenoprotein M precursor
NM_001163171.2	NP_001156643.1	selenoprotein M precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SELM	NP_536355.1
Mus musculus (house mouse)	Selm	NP_444497.1
Pan troglodytes (chimpanzee)	SELM	NP_001140172.1
Xenopus tropicalis (tropical clawed frog)	selm	NP_001165078.1
	SELM	NP_001152871.1
Canis lupus familiaris (dog)	SELM	NP_001108486.1
Rattus norvegicus (Norway rat)	Selm	NP_001108485.1
Danio rerio (zebrafish)	selm	NP_840071.2
Gallus gallus (chicken)	SELM	NP_001264788.1
Bos taurus (cattle)	SELM	NP_001156643.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

A second generation radiation hybrid map to aid the assembly of the bovine genome sequence.
Jann OC, Aerts J, Jones M, Hastings N, Law A, McKay S, Marques E, Prasad A, Yu J, Moore SS, Floriot S, Mah? MF, Eggen A, Silveri L, Negrini R, Milanesi E, Ajmone-Marsan P, Valentini A, Marchitelli C, Savarese MC, Janitz M, Herwig R, Hennig S, Gorni C, Connor EE, Sonstegard TS, Smith T, Dr?gem?ller C, Williams JL
BMC genomics7283(2006 Nov)

Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ESTs.
Casey OM, Fitzpatrick R, McInerney JO, Morris DG, Powell R, Sreenan JM
Biochimica et biophysica acta1679(1)10-7(2004 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SELENOM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SELENOM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa40895	NM_001163171.2 Latest version!	Bos taurus selenoprotein M (SELENOM), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OBa239167	NM_001163171.3 Latest version!	Bos taurus selenoprotein M (SELENOM), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SELENOM ( NM_001163171.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001156643.1 Bos taurus selenoprotein M (SELENOM), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OBa40895
Clone ID Related Accession (Same CDS sequence)	NM_001163171.2
Accession Version	NM_001163171.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-22
Organism	Bos taurus(cattle)
Product	selenoprotein M precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU917216.1, DN535256.1 and DT811468.1. On Dec 14, 2016 this sequence version replaced NM_001163171.1. Transcript Variant: This variant (1) represents the selenoprotein encoding transcript. ##Evidence-Data-START## Transcript exon combination :: HX924822.1, EE952148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04019720 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACCTCC CGCTGCCTCC GCCGCCGCTG CTGCTCCTCC TCGCGGCAGT CGCGGCCGCC 
ACCACCACCT TCCGGCCCGA CTGGAACCGT CTACAAGGCC TGGCCCGAGC CCGGGTAGAG 
ACATGTGGAG GATGACAGCT TAATCGCCTG AAGGAGGTGA AGGCCTTCGT CACCCAGGAC 
ATCCCACTCT ACCACAACCT GGTGATGAAA CACCTGCCGG GGGCCGACCC AGAGCTCGTG 
TTGCTCGGCC ACCGCTTTGA GGAACTGGAG CGAATTCCAC TCAGCGACAT GACCCGCGAG 
GAGATCAACG CGCTGGTGCA GGAGCTCGGC TTCTACCGCA AGGCGTCGCC CGACGAGCCT 
GTGCCCCCGG AGTACCTTCG GGCGCCCGCT AGGCCCGCCG GAGACGCTCC TGACCACGCA 
GACCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156643.1
CDS	97..525
Translation	MHLPLPPPPLLLLLAAVAAATTTFRPDWNRLQGLARARVETCGG*QLNRLKEVKAFVTQDIPLYHNLVMKHLPGADPELVLLGHRFEELERIPLSDMTREEINALVQELGFYRKASPDEPVPPEYLRAPARPAGDAPDHADL

Target ORF information:

RefSeq Version	NM_001163171.2
Organism	Bos taurus(cattle)
Definition	Bos taurus selenoprotein M (SELENOM), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163171.2

ORF Insert Sequence:

ATGCACCTCC CGCTGCCTCC GCCGCCGCTG CTGCTCCTCC TCGCGGCAGT CGCGGCCGCC 
ACCACCACCT TCCGGCCCGA CTGGAACCGT CTACAAGGCC TGGCCCGAGC CCGGGTAGAG 
ACATGTGGAG GATGACAGCT TAATCGCCTG AAGGAGGTGA AGGCCTTCGT CACCCAGGAC 
ATCCCACTCT ACCACAACCT GGTGATGAAA CACCTGCCGG GGGCCGACCC AGAGCTCGTG 
TTGCTCGGCC ACCGCTTTGA GGAACTGGAG CGAATTCCAC TCAGCGACAT GACCCGCGAG 
GAGATCAACG CGCTGGTGCA GGAGCTCGGC TTCTACCGCA AGGCGTCGCC CGACGAGCCT 
GTGCCCCCGG AGTACCTTCG GGCGCCCGCT AGGCCCGCCG GAGACGCTCC TGACCACGCA 
GACCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SELENOM ( NM_001163171.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001156643.2 Bos taurus selenoprotein M (SELENOM), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OBa239167
Clone ID Related Accession (Same CDS sequence)	NM_001163171.3
Accession Version	NM_001163171.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-11
Organism	Bos taurus(cattle)
Product	selenoprotein M precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU917216.1, DN539864.1 and CO893319.1. On Jun 21, 2018 this sequence version replaced NM_001163171.2. Transcript Variant: This variant (1) represents the selenoprotein encoding transcript. ##Evidence-Data-START## Transcript exon combination :: HX924822.1, SRR5571257.2074.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACCTCC CGCTGCCTCC GCCGCCGCTG CTGCTCCTCC TCGCGGCAGT CGCGGCCGCC 
ACCACCACCT TCCGGCCCGA CTGGAACCGT CTACAAGGCC TGGCCCGAGC CCGGGTAGAG 
ACATGTGGAG GATGACAGCT TAATCGCCTG AAGGAGGTGA AGGCCTTCGT CACCCAGGAC 
ATCCCACTCT ACCACAACCT GGTGATGAAA CACCTGCCGG GGGCCGACCC AGAGCTCGTG 
TTGCTCGGCC ACCGCTTTGA GGAACTGGAG CGAATTCCAC TCAGCGACAT GACCCGCGAG 
GAGATCAACG CGCTGGTGCA GGAGCTCGGC TTCTACCGCA AGGCGTCGCC CGACGAGCCT 
GTGCCCCCGG AGTACCTTCG GGCGCCCGCT AGGCCCGCCG GAGACGCTCC TGACCACTCA 
GACCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156643.2
CDS	97..525
Translation	MHLPLPPPPLLLLLAAVAAATTTFRPDWNRLQGLARARVETCGG*QLNRLKEVKAFVTQDIPLYHNLVMKHLPGADPELVLLGHRFEELERIPLSDMTREEINALVQELGFYRKASPDEPVPPEYLRAPARPAGDAPDHSDL

Target ORF information:

RefSeq Version	NM_001163171.3
Organism	Bos taurus(cattle)
Definition	Bos taurus selenoprotein M (SELENOM), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163171.3

ORF Insert Sequence:

ATGCACCTCC CGCTGCCTCC GCCGCCGCTG CTGCTCCTCC TCGCGGCAGT CGCGGCCGCC 
ACCACCACCT TCCGGCCCGA CTGGAACCGT CTACAAGGCC TGGCCCGAGC CCGGGTAGAG 
ACATGTGGAG GATGACAGCT TAATCGCCTG AAGGAGGTGA AGGCCTTCGT CACCCAGGAC 
ATCCCACTCT ACCACAACCT GGTGATGAAA CACCTGCCGG GGGCCGACCC AGAGCTCGTG 
TTGCTCGGCC ACCGCTTTGA GGAACTGGAG CGAATTCCAC TCAGCGACAT GACCCGCGAG 
GAGATCAACG CGCTGGTGCA GGAGCTCGGC TTCTACCGCA AGGCGTCGCC CGACGAGCCT 
GTGCCCCCGG AGTACCTTCG GGCGCCCGCT AGGCCCGCCG GAGACGCTCC TGACCACTCA 
GACCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

A second generation radiation hybrid map to aid the assembly of the bovine genome sequence.
BMC genomics7283(2006 Nov)
Jann OC,Aerts J,Jones M,Hastings N,Law A,McKay S,Marques E,Prasad A,Yu J,Moore SS,Floriot S,Mah? MF,Eggen A,Silveri L,Negrini R,Milanesi E,Ajmone-Marsan P,Valentini A,Marchitelli C,Savarese MC,Janitz M,Herwig R,Hennig S,Gorni C,Connor EE,Sonstegard TS,Smith T,Dr?gem?ller C,Williams JL

Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ESTs.
Biochimica et biophysica acta1679(1)10-7(2004 Jul)
Casey OM,Fitzpatrick R,McInerney JO,Morris DG,Powell R,Sreenan JM

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SELENOM cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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