ADORA3 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADORA3
Entrez Gene ID	780806
Full Name	adenosine A3 receptor
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors involved in a variety of intracellular signaling pathways and physiological functions. Studies of orthologous proteins suggest that the receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it may have neuroprotective and neurodegenerative effects, and it may also mediate cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:104564307, which encodes a transmembrane and immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302768.1	NP_001289697.1	adenosine receptor A3 isoform 2
NM_001104611.2	NP_001098081.1	adenosine receptor A3 isoform 1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100496142	XP_002932848.2
Xenopus tropicalis (tropical clawed frog)	LOC100496301	XP_002932849.2
Danio rerio (zebrafish)	LOC571410	XP_700086.1
Xenopus tropicalis (tropical clawed frog)	LOC101734629	XP_004910785.1
Pan troglodytes (chimpanzee)	ADORA3	XP_001158919.1
Canis lupus familiaris (dog)	ADORA3	NP_001003178.1
Bos taurus (cattle)	ADORA3	NP_001098081.1
Homo sapiens (human)	ADORA3	NP_000668.1
Gallus gallus (chicken)	ADORA3	NP_989482.1
Mus musculus (house mouse)	Adora3	NP_033761.2

Gene Ontology
Bibliography

Related articles in PubMed

G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.
Eisenstein A, Ravid K
Journal of cellular physiology229(4)414-21(2014 Apr)

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.
Hill SJ, May LT, Kellam B, Woolard J
British journal of pharmacology171(5)1102-13(2014 Mar)

A3 receptor ligands: past, present and future trends.
Taliani S, Pugliesi I, Bellandi M, La Motta C, Da Settimo F
Current topics in medicinal chemistry10(10)942-75(2010)

The A3 adenosine receptor: an enigmatic player in cell biology.
Gessi S, Merighi S, Varani K, Leung E, Mac Lennan S, Borea PA
Pharmacology & therapeutics117(1)123-40(2008 Jan)

A second generation radiation hybrid map to aid the assembly of the bovine genome sequence.
Jann OC, Aerts J, Jones M, Hastings N, Law A, McKay S, Marques E, Prasad A, Yu J, Moore SS, Floriot S, Mah? MF, Eggen A, Silveri L, Negrini R, Milanesi E, Ajmone-Marsan P, Valentini A, Marchitelli C, Savarese MC, Janitz M, Herwig R, Hennig S, Gorni C, Connor EE, Sonstegard TS, Smith T, Dr?gem?ller C, Williams JL
BMC genomics7283(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADORA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADORA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43277	NM_001104611.2 Latest version!	Bos taurus adenosine A3 receptor (ADORA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OBa56976	NM_001302768.1 Latest version!	Bos taurus adenosine A3 receptor (ADORA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADORA3 ( NM_001104611.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001098081.1 Bos taurus adenosine A3 receptor (ADORA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OBa43277
Clone ID Related Accession (Same CDS sequence)	NM_001104611.2
Accession Version	NM_001104611.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Bos taurus(cattle)
Product	adenosine receptor A3 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DY460588.1, BC120305.1 and CO894234.1. On Nov 13, 2014 this sequence version replaced NM_001104611.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: DV831578.1, BC120305.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTGTCA ACAGTACTGC CGTGTCCTTG GCCAGCGTCA CCTACATCTC TGTGGAGATT 
CTCATCGGGC TCTGCGCCAT AGTGGGCAAC GTTCTGGTCA TCTGGGTGGT CAAACTGAAC 
CCCAGCCTAC AGACCACCAC CTTCTATTTC ATTGTCTCCC TAGCTCTGGC TGACATTGCT 
GTTGGGGTGC TGGTTATGCC TTTGGCCATT GTCATCAGCC TGGGTGTCAC AATCCACTTT 
TATAGCTGCC TTCTCATGAC CTGCTTGCTG ATGATCTTCA CCCACGCATC CATCATGTCC 
TTGCTAGCCA TTGCCGTGGA CCGATACCTG CGGGTCAAGC TCACAGTCAG ATACAGGAGA 
GTCACCACGC AAAGAAGAAT ATGGTTGGCT CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGATTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA GCTCAGCAGA CAAAAATCTT 
ACCTTCCTAC CCTGCCAATT CCGTTCGGTC ATGAGGATGG ATTACATGGT CTACTTCAGT 
TTCTTCACGT GGATTCTCAT TCCCCTGGTT GTCATGTGTG CCATCTACTT CGATATCTTC 
TATGTCATCC GGAACCGACT CAGTCAGAAC TTTTCTGGCT CCAAAGAGAC AGGTGCATTC 
TATGGACGGG AGTTCAAGAC AGCCAAGTCT CTGTCACTGG TTCTTTTCTT GTTTGCTTTG 
TCCTGGCTGC CTTTGTCCAT CATCAACTGT ATCATCTACT TTAACGGTGA AGTGCCACAA 
ATTGTGCTGT ACTTGGGCAT CCTGCTCTCC CACGCCAACT CCATGATGAA CCCTATCGTC 
TATGCTTATA AAATAAAGAA GTTCAAGGAA ACCTATCTCT TGATCCTCAA AGCCTGTGTG 
ATCTGCCAGC CCTCTAAGTC CATGGACCCA AGCATTGAGC AGACTTCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001098081.1
CDS	264..1217
Translation	MPVNSTAVSLASVTYISVEILIGLCAIVGNVLVIWVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVISLGVTIHFYSCLLMTCLLMIFTHASIMSLLAIAVDRYLRVKLTVRYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWNMKLSSADKNLTFLPCQFRSVMRMDYMVYFSFFTWILIPLVVMCAIYFDIFYVIRNRLSQNFSGSKETGAFYGREFKTAKSLSLVLFLFALSWLPLSIINCIIYFNGEVPQIVLYLGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVICQPSKSMDPSIEQTSE

Target ORF information:

RefSeq Version	NM_001104611.2
Organism	Bos taurus(cattle)
Definition	Bos taurus adenosine A3 receptor (ADORA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001104611.2

ORF Insert Sequence:

ATGCCTGTCA ACAGTACTGC CGTGTCCTTG GCCAGCGTCA CCTACATCTC TGTGGAGATT 
CTCATCGGGC TCTGCGCCAT AGTGGGCAAC GTTCTGGTCA TCTGGGTGGT CAAACTGAAC 
CCCAGCCTAC AGACCACCAC CTTCTATTTC ATTGTCTCCC TAGCTCTGGC TGACATTGCT 
GTTGGGGTGC TGGTTATGCC TTTGGCCATT GTCATCAGCC TGGGTGTCAC AATCCACTTT 
TATAGCTGCC TTCTCATGAC CTGCTTGCTG ATGATCTTCA CCCACGCATC CATCATGTCC 
TTGCTAGCCA TTGCCGTGGA CCGATACCTG CGGGTCAAGC TCACAGTCAG ATACAGGAGA 
GTCACCACGC AAAGAAGAAT ATGGTTGGCT CTGGGCCTTT GCTGGCTGGT GTCATTCCTG 
GTGGGATTGA CCCCCATGTT TGGCTGGAAC ATGAAACTGA GCTCAGCAGA CAAAAATCTT 
ACCTTCCTAC CCTGCCAATT CCGTTCGGTC ATGAGGATGG ATTACATGGT CTACTTCAGT 
TTCTTCACGT GGATTCTCAT TCCCCTGGTT GTCATGTGTG CCATCTACTT CGATATCTTC 
TATGTCATCC GGAACCGACT CAGTCAGAAC TTTTCTGGCT CCAAAGAGAC AGGTGCATTC 
TATGGACGGG AGTTCAAGAC AGCCAAGTCT CTGTCACTGG TTCTTTTCTT GTTTGCTTTG 
TCCTGGCTGC CTTTGTCCAT CATCAACTGT ATCATCTACT TTAACGGTGA AGTGCCACAA 
ATTGTGCTGT ACTTGGGCAT CCTGCTCTCC CACGCCAACT CCATGATGAA CCCTATCGTC 
TATGCTTATA AAATAAAGAA GTTCAAGGAA ACCTATCTCT TGATCCTCAA AGCCTGTGTG 
ATCTGCCAGC CCTCTAAGTC CATGGACCCA AGCATTGAGC AGACTTCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADORA3 ( NM_001302768.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001289697.1 Bos taurus adenosine A3 receptor (ADORA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OBa56976
Clone ID Related Accession (Same CDS sequence)	NM_001302768.1
Accession Version	NM_001302768.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Bos taurus(cattle)
Product	adenosine receptor A3 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FE014702.1, BC120305.1 and CO894234.1. Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR and 5' coding region, resulting in translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: FE014702.1, EH145095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145415, SAMN03145418 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTGG CTGACATTGC TGTTGGGGTG CTGGTTATGC CTTTGGCCAT TGTCATCAGC 
CTGGGTGTCA CAATCCACTT TTATAGCTGC CTTCTCATGA CCTGCTTGCT GATGATCTTC 
ACCCACGCAT CCATCATGTC CTTGCTAGCC ATTGCCGTGG ACCGATACCT GCGGGTCAAG 
CTCACAGTCA GATACAGGAG AGTCACCACG CAAAGAAGAA TATGGTTGGC TCTGGGCCTT 
TGCTGGCTGG TGTCATTCCT GGTGGGATTG ACCCCCATGT TTGGCTGGAA CATGAAACTG 
AGCTCAGCAG ACAAAAATCT TACCTTCCTA CCCTGCCAAT TCCGTTCGGT CATGAGGATG 
GATTACATGG TCTACTTCAG TTTCTTCACG TGGATTCTCA TTCCCCTGGT TGTCATGTGT 
GCCATCTACT TCGATATCTT CTATGTCATC CGGAACCGAC TCAGTCAGAA CTTTTCTGGC 
TCCAAAGAGA CAGGTGCATT CTATGGACGG GAGTTCAAGA CAGCCAAGTC TCTGTCACTG 
GTTCTTTTCT TGTTTGCTTT GTCCTGGCTG CCTTTGTCCA TCATCAACTG TATCATCTAC 
TTTAACGGTG AAGTGCCACA AATTGTGCTG TACTTGGGCA TCCTGCTCTC CCACGCCAAC 
TCCATGATGA ACCCTATCGT CTATGCTTAT AAAATAAAGA AGTTCAAGGA AACCTATCTC 
TTGATCCTCA AAGCCTGTGT GATCTGCCAG CCCTCTAAGT CCATGGACCC AAGCATTGAG 
CAGACTTCTG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289697.1
CDS	126..920
Translation	MALADIAVGVLVMPLAIVISLGVTIHFYSCLLMTCLLMIFTHASIMSLLAIAVDRYLRVKLTVRYRRVTTQRRIWLALGLCWLVSFLVGLTPMFGWNMKLSSADKNLTFLPCQFRSVMRMDYMVYFSFFTWILIPLVVMCAIYFDIFYVIRNRLSQNFSGSKETGAFYGREFKTAKSLSLVLFLFALSWLPLSIINCIIYFNGEVPQIVLYLGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVICQPSKSMDPSIEQTSE

Target ORF information:

RefSeq Version	NM_001302768.1
Organism	Bos taurus(cattle)
Definition	Bos taurus adenosine A3 receptor (ADORA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302768.1

ORF Insert Sequence:

ATGGCTCTGG CTGACATTGC TGTTGGGGTG CTGGTTATGC CTTTGGCCAT TGTCATCAGC 
CTGGGTGTCA CAATCCACTT TTATAGCTGC CTTCTCATGA CCTGCTTGCT GATGATCTTC 
ACCCACGCAT CCATCATGTC CTTGCTAGCC ATTGCCGTGG ACCGATACCT GCGGGTCAAG 
CTCACAGTCA GATACAGGAG AGTCACCACG CAAAGAAGAA TATGGTTGGC TCTGGGCCTT 
TGCTGGCTGG TGTCATTCCT GGTGGGATTG ACCCCCATGT TTGGCTGGAA CATGAAACTG 
AGCTCAGCAG ACAAAAATCT TACCTTCCTA CCCTGCCAAT TCCGTTCGGT CATGAGGATG 
GATTACATGG TCTACTTCAG TTTCTTCACG TGGATTCTCA TTCCCCTGGT TGTCATGTGT 
GCCATCTACT TCGATATCTT CTATGTCATC CGGAACCGAC TCAGTCAGAA CTTTTCTGGC 
TCCAAAGAGA CAGGTGCATT CTATGGACGG GAGTTCAAGA CAGCCAAGTC TCTGTCACTG 
GTTCTTTTCT TGTTTGCTTT GTCCTGGCTG CCTTTGTCCA TCATCAACTG TATCATCTAC 
TTTAACGGTG AAGTGCCACA AATTGTGCTG TACTTGGGCA TCCTGCTCTC CCACGCCAAC 
TCCATGATGA ACCCTATCGT CTATGCTTAT AAAATAAAGA AGTTCAAGGA AACCTATCTC 
TTGATCCTCA AAGCCTGTGT GATCTGCCAG CCCTCTAAGT CCATGGACCC AAGCATTGAG 
CAGACTTCTG AGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.
Journal of cellular physiology229(4)414-21(2014 Apr)
Eisenstein A,Ravid K

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.
British journal of pharmacology171(5)1102-13(2014 Mar)
Hill SJ,May LT,Kellam B,Woolard J

A3 receptor ligands: past, present and future trends.
Current topics in medicinal chemistry10(10)942-75(2010)
Taliani S,Pugliesi I,Bellandi M,La Motta C,Da Settimo F

The A3 adenosine receptor: an enigmatic player in cell biology.
Pharmacology & therapeutics117(1)123-40(2008 Jan)
Gessi S,Merighi S,Varani K,Leung E,Mac Lennan S,Borea PA

A second generation radiation hybrid map to aid the assembly of the bovine genome sequence.
BMC genomics7283(2006 Nov)
Jann OC,Aerts J,Jones M,Hastings N,Law A,McKay S,Marques E,Prasad A,Yu J,Moore SS,Floriot S,Mah? MF,Eggen A,Silveri L,Negrini R,Milanesi E,Ajmone-Marsan P,Valentini A,Marchitelli C,Savarese MC,Janitz M,Herwig R,Hennig S,Gorni C,Connor EE,Sonstegard TS,Smith T,Dr?gem?ller C,Williams JL

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ADORA3 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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