NR1D1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	NR1D1
Entrez Gene ID	768225
Full Name	nuclear receptor subfamily 1 group D member 1
General protein information	Preferred Names nuclear receptor subfamily 1 group D member 1 Names nuclear receptor subfamily 1 group D member 1 EAR-1 V-erbA-related protein 1 V-erbA-related protein EAR-1 rev-erbA-alpha
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001078100.2	NP_001071568.1	nuclear receptor subfamily 1 group D member 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NR1D1	XP_003435298.1
Rattus norvegicus (Norway rat)	Nr1d1	NP_001106893.1
Danio rerio (zebrafish)	nr1d1	NP_991292.1
Homo sapiens (human)	NR1D1	NP_068370.1
Pan troglodytes (chimpanzee)	NR1D1	XP_511468.2
Bos taurus (cattle)	NR1D1	NP_001071568.1
Mus musculus (house mouse)	Nr1d1	NP_663409.2
Xenopus tropicalis (tropical clawed frog)	nr1d1	NP_001093675.1

Gene Ontology
Bibliography

Related articles in PubMed

REV-ERB? inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids.
Isayama K, Chen H, Yamauchi N, Hattori MA
The Journal of reproduction and development60(5)362-70(2014)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis.
Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S
Arthritis and rheumatism54(11)3513-22(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha) plays an inhibitory role in the expression of prostaglandin G/H synthetase(PTGS2) in both bovine uterine stromal and epithelial cells treated with ovarian steroids
Title: REV-ERB? inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids.

Rev-ErbAalpha is highly expressed in articular chondrocytes
Title: Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis.

The following NR1D1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NR1D1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa44303	NM_001078100.2 Latest version!	Bos taurus nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NR1D1 ( NM_001078100.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001071568.1 Bos taurus nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.

Price & Availability↑

CloneID	OBa44303
Clone ID Related Accession (Same CDS sequence)	NM_001078100.2
Accession Version	NM_001078100.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Bos taurus(cattle)
Product	nuclear receptor subfamily 1 group D member 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from EH179361.1 and BC123488.1. On Feb 7, 2014 this sequence version replaced NM_001078100.1. ##Evidence-Data-START## Transcript exon combination :: BC123488.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGACCC TGGACTCTAA CAACAACACA GGTGGCGTCA TCACCTATAT TGGCTCCAGT 
GGCTCCTCTC CAAACCGCAC CAGCCCTGAA TCCCTATACA GTGACAGCTC GAATGGCAGC 
TTCCAGTCCC TGACCCAAGG TTGCCCCACC TACTTCCCAC CATCACCCAC TGGCTCCCTC 
ACCCAGGACC CAGCTCGCTC TTTTGGGAGC ATTCCGCCCA GCTTGGGTGA TGATGGTTCT 
CCTTCTTCTT CATCTTCCTC CTCGTCATCG TCGTCCTCTT CCTTCTATAA TGGGAGCCCC 
CCAGGGGGTC TACAGGTGGC CCTGGAAGAC AGTAACCGAG TGTCTCCCAG CAAGAGCACC 
AGCAACATCA CCAAGCTGAA TGGCATGGTG TTGCTGTGTA AGGTGTGTGG GGACGTGGCT 
TCGGGCTTCC ACTATGGCGT GCATGCCTGC GAGGGCTGCA AGGGCTTTTT CCGTCGGAGC 
ATCCAGCAGA ACATCCAGTA CAAAAGGTGT CTGAAAAATG AGAACTGCTC CATCGTCCGC 
ATCAATCGTA ACCGCTGCCA GCAATGCCGC TTCAAGAAGT GTCTCTCCGT GGGCATGTCT 
CGAGATGCTG TGCGTTTTGG GCGCATCCCC AAACGGGAGA AGCAGCGGAT GCTGGCCGAG 
ATGCAGAGTG CCATGAACCT GGCCAACAAC CAGCTGAGCA GCCAGTGCCC ACTGGAGACC 
CCACCCACCC AGCACCCCAC CCCGGGCCCC ATGGGCCCCT CACCGCCCCC AGCCCCTGCC 
CCCTCACCCC TGGTGGGCTT CTCCCAGTTC CCACAGCAGC TGACGCCTCC TCGATCCCCA 
AGTCCCGAGC CCACAGTGGA GGATGTGATA TCCCAGGTAG CCCGGGCCCA CCGCGAGATC 
TTCACCTACG CCCATGACAA ACTGGGCACC TCACCTGGCA ACTTCAATGC CAACCATGCC 
TCGGGCAACC GTCCGGCCAC CACCCCACAT CGCTGGGAAA GTCAGGGCTG CCCGCCTGCC 
AATGACAACA TCATGGCCGC CCAGCGTCAC AACGAGGCCC TGAACAGTTT ACGCCAGGCT 
TCCTCCTCCT ACCCTCCTCC TTGGCCCCCC GGCGCTGCCC ACCACAGCTG CCACCAGCCC 
AACAGCAATG GGCACCGTCT GTGCCCCACC CACGTGTACC CAGCCCCCGA AGGCGAAGCC 
CCTGTCAACA GTCCGCGGCA GGGCAACTCC AAGAACATTC TGCTGGCATG TCCCATGAAC 
ATGTACCCGC ATGGACGCAG CGGGCGAACT GTGCAGGAGA TCTGGGAGGA CTTCTCCATG 
AGCTTCACAC CCGCTGTGCG GGAGGTGGTA GAGTTTGCCA AGCACATCCC CGGTTTCCGT 
GATCTTTCTC AGCACGACCA GGTCACCCTG CTTAAGGCTG GCACCTTTGA GGTGCTGATG 
GTGCGCTTTG CGTCGCTGTT CAACGTGAAG GACCAGACGG TGATGTTCCT GAGCCGCACC 
ACCTACAGCC TGCAGGAGCT CGGCGCCATG GGCATGGGGG ACCTGCTCAA TGCCATGTTC 
GACTTCAGCG AGAAGCTCAA CTCCCTGGCG CTTACCGAGG AGGAGCTGGG CCTCTTCACC 
GCGGTGGTGC TCGTCTCTGC AGACCGCTCG GGAATGGAGA ATTCCGCTTC GGTGGAGCAG 
CTCCAGGAGA CGCTGCTGCG GGCTCTTCGG GCTCTGGTGC TGAAGAACCG GCCCTCGGAG 
ACTTCCCGCT TCACCAAGCT GCTGCTCAAG CTGCCGGACC TGCGGACCCT GAACAACATG 
CACTCCGAGA AGCTGCTGTC CTTCCGGGTG GACGCCCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071568.1
CDS	535..2376
Translation	MTTLDSNNNTGGVITYIGSSGSSPNRTSPESLYSDSSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLGDDGSPSSSSSSSSSSSSSFYNGSPPGGLQVALEDSNRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETPPTQHPTPGPMGPSPPPAPAPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASGNRPATTPHRWESQGCPPANDNIMAAQRHNEALNSLRQASSSYPPPWPPGAAHHSCHQPNSNGHRLCPTHVYPAPEGEAPVNSPRQGNSKNILLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPSETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ

Target ORF information:

RefSeq Version	NM_001078100.2
Organism	Bos taurus(cattle)
Definition	Bos taurus nuclear receptor subfamily 1 group D member 1 (NR1D1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001078100.2

ORF Insert Sequence:

ATGACGACCC TGGACTCTAA CAACAACACA GGTGGCGTCA TCACCTATAT TGGCTCCAGT 
GGCTCCTCTC CAAACCGCAC CAGCCCTGAA TCCCTATACA GTGACAGCTC GAATGGCAGC 
TTCCAGTCCC TGACCCAAGG TTGCCCCACC TACTTCCCAC CATCACCCAC TGGCTCCCTC 
ACCCAGGACC CAGCTCGCTC TTTTGGGAGC ATTCCGCCCA GCTTGGGTGA TGATGGTTCT 
CCTTCTTCTT CATCTTCCTC CTCGTCATCG TCGTCCTCTT CCTTCTATAA TGGGAGCCCC 
CCAGGGGGTC TACAGGTGGC CCTGGAAGAC AGTAACCGAG TGTCTCCCAG CAAGAGCACC 
AGCAACATCA CCAAGCTGAA TGGCATGGTG TTGCTGTGTA AGGTGTGTGG GGACGTGGCT 
TCGGGCTTCC ACTATGGCGT GCATGCCTGC GAGGGCTGCA AGGGCTTTTT CCGTCGGAGC 
ATCCAGCAGA ACATCCAGTA CAAAAGGTGT CTGAAAAATG AGAACTGCTC CATCGTCCGC 
ATCAATCGTA ACCGCTGCCA GCAATGCCGC TTCAAGAAGT GTCTCTCCGT GGGCATGTCT 
CGAGATGCTG TGCGTTTTGG GCGCATCCCC AAACGGGAGA AGCAGCGGAT GCTGGCCGAG 
ATGCAGAGTG CCATGAACCT GGCCAACAAC CAGCTGAGCA GCCAGTGCCC ACTGGAGACC 
CCACCCACCC AGCACCCCAC CCCGGGCCCC ATGGGCCCCT CACCGCCCCC AGCCCCTGCC 
CCCTCACCCC TGGTGGGCTT CTCCCAGTTC CCACAGCAGC TGACGCCTCC TCGATCCCCA 
AGTCCCGAGC CCACAGTGGA GGATGTGATA TCCCAGGTAG CCCGGGCCCA CCGCGAGATC 
TTCACCTACG CCCATGACAA ACTGGGCACC TCACCTGGCA ACTTCAATGC CAACCATGCC 
TCGGGCAACC GTCCGGCCAC CACCCCACAT CGCTGGGAAA GTCAGGGCTG CCCGCCTGCC 
AATGACAACA TCATGGCCGC CCAGCGTCAC AACGAGGCCC TGAACAGTTT ACGCCAGGCT 
TCCTCCTCCT ACCCTCCTCC TTGGCCCCCC GGCGCTGCCC ACCACAGCTG CCACCAGCCC 
AACAGCAATG GGCACCGTCT GTGCCCCACC CACGTGTACC CAGCCCCCGA AGGCGAAGCC 
CCTGTCAACA GTCCGCGGCA GGGCAACTCC AAGAACATTC TGCTGGCATG TCCCATGAAC 
ATGTACCCGC ATGGACGCAG CGGGCGAACT GTGCAGGAGA TCTGGGAGGA CTTCTCCATG 
AGCTTCACAC CCGCTGTGCG GGAGGTGGTA GAGTTTGCCA AGCACATCCC CGGTTTCCGT 
GATCTTTCTC AGCACGACCA GGTCACCCTG CTTAAGGCTG GCACCTTTGA GGTGCTGATG 
GTGCGCTTTG CGTCGCTGTT CAACGTGAAG GACCAGACGG TGATGTTCCT GAGCCGCACC 
ACCTACAGCC TGCAGGAGCT CGGCGCCATG GGCATGGGGG ACCTGCTCAA TGCCATGTTC 
GACTTCAGCG AGAAGCTCAA CTCCCTGGCG CTTACCGAGG AGGAGCTGGG CCTCTTCACC 
GCGGTGGTGC TCGTCTCTGC AGACCGCTCG GGAATGGAGA ATTCCGCTTC GGTGGAGCAG 
CTCCAGGAGA CGCTGCTGCG GGCTCTTCGG GCTCTGGTGC TGAAGAACCG GCCCTCGGAG 
ACTTCCCGCT TCACCAAGCT GCTGCTCAAG CTGCCGGACC TGCGGACCCT GAACAACATG 
CACTCCGAGA AGCTGCTGTC CTTCCGGGTG GACGCCCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

REV-ERB? inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids.
The Journal of reproduction and development60(5)362-70(2014)
Isayama K,Chen H,Yamauchi N,Hattori MA

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis.
Arthritis and rheumatism54(11)3513-22(2006 Nov)
Chaturvedi P,Pratta M,Steplewski K,Connor J,Kumar S

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NR1D1 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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