HSP90AB1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSP90AB1
Entrez Gene ID	767874
Full Name	heat shock protein 90 alpha family class B member 1
Synonyms	HSPCB
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001079637.1	NP_001073105.1	heat shock protein HSP 90-beta

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Hsp83	NP_001261362.1
Arabidopsis thaliana (thale cress)	HSP90.1	NP_200076.1
Mus musculus (house mouse)	Hsp90ab1	NP_032328.2
Gallus gallus (chicken)	HSP90AB1	NP_996842.1
Saccharomyces cerevisiae (baker's yeast)	HSP82	NP_015084.1
Kluyveromyces lactis	KLLA0D12958g	XP_453640.1
Schizosaccharomyces pombe (fission yeast)	hsp90	NP_594365.1
Canis lupus familiaris (dog)	HSP90AB1	XP_532154.4
Bos taurus (cattle)	HSP90AB1	NP_001073105.1
Danio rerio (zebrafish)	hsp90ab1	NP_571385.2
Caenorhabditis elegans (roundworm)	daf-21	NP_506626.1
Neurospora crassa	NCU04142	XP_961298.1
Oryza sativa (rice)	Os08g0500700	NP_001062159.1
Homo sapiens (human)	HSP90AB1	NP_001258898.1
Pan troglodytes (chimpanzee)	HSP90AB1	XP_003311385.1
	HSP90AB1	XP_001099135.2
Rattus norvegicus (Norway rat)	Hsp90ab1	NP_001004082.3
Anopheles gambiae (African malaria mosquito)	HSP83_ANOGA	XP_308800.3
Eremothecium gossypii	AGOS_AFL148C	NP_985402.1
Magnaporthe oryzae (rice blast fungus)	MGG_06759	XP_003709473.1
Xenopus tropicalis (tropical clawed frog)	hsp90ab1	NP_001025655.1
Saccharomyces cerevisiae (baker's yeast)	HSC82	NP_013911.1

Gene Ontology
Bibliography

Related articles in PubMed

Thermotolerance, health profile and cellular expression of HSP90AB1 in Nguni and Boran cows raised on natural pastures under tropical conditions.
Katiyatiya CLF, Bradley G, Muchenje V
Journal of thermal biology6985-94(2017 Oct)

Identification of SNP in HSP90AB1 and its association with the relative thermotolerance and milk production traits in Indian dairy cattle.
Sajjanar B, Deb R, Singh U, Kumar S, Brahmane M, Nirmale A, Bal SK, Minhas PS
Animal biotechnology26(1)45-50(2015)

Polymorphisms in the bovine HSP90AB1 gene are associated with heat tolerance in Thai indigenous cattle.
Charoensook R, Gatphayak K, Sharifi AR, Chaisongkram C, Brenig B, Knorr C
Tropical animal health and production44(4)921-8(2012 Apr)

Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.
Antonov AS, Antonova GN, Fujii M, ten Dijke P, Handa V, Catravas JD, Verin AD
Journal of cellular physiology227(2)759-71(2012 Feb)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studied the nucleotide polymorphism within the HSP90AB1 gene (SNP g.4338T>C) in Indian breeds of dairy cattle.
Title: Identification of SNP in HSP90AB1 and its association with the relative thermotolerance and milk production traits in Indian dairy cattle.

Association analysis revealed that the T allele at SNP g.4338T>C of the HSP90AB1 gene improved heat tolerance in cattle. Allele T was 100% in White Lamphun animals, 84% in Mountain cattle, and 18% in Holstein Friesian heifers.
Title: Polymorphisms in the bovine HSP90AB1 gene are associated with heat tolerance in Thai indigenous cattle.

This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 and ALK5 interact with heat shock protein 90(HSP90).
Title: Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.

the protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase
Title: Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells.

The following HSP90AB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSP90AB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42495	NM_001079637.1 Latest version!	Bos taurus heat shock protein 90 alpha family class B member 1 (HSP90AB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSP90AB1 ( NM_001079637.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001073105.1 Bos taurus heat shock protein 90 alpha family class B member 1 (HSP90AB1), mRNA.

Price & Availability↑

CloneID	OBa42495
Clone ID Related Accession (Same CDS sequence)	NM_001079637.1
Accession Version	NM_001079637.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2175bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Bos taurus(cattle)
Product	heat shock protein HSP 90-beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BT025368.1. On or before Jan 14, 2007 this sequence version replaced XM_001253264.1, XM_001253285.1. ##Evidence-Data-START## Transcript exon combination :: BT025368.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGAGG AAGTGCACCA TGGAGAGGAG GAGGTGGAGA CATTTGCCTT CCAGGCAGAA 
ATTGCCCAAC TCATGTCTCT TATTATCAAC ACCTTCTATT CCAACAAGGA AATTTTTCTT 
CGGGAGTTGA TCAGTAATGC TTCTGATGCC TTAGACAAGA TTCGCTATGA GAGCCTGACA 
GACCCTTCCA AATTGGACAG TGGTAAAGAG CTGAAAATTG ACATCATCCC AAACCCCCAG 
GAGCGTACTC TGACTCTGGT AGACACAGGC ATTGGCATGA CCAAAGCTGA TCTTGTAAAT 
AATTTGGGAA CCATTGCCAA GTCTGGCACT AAAGCGTTTA TGGAGGCTCT TCAGGCTGGT 
GCAGACATCT CCATGATTGG GCAATTTGGT GTGGGCTTCT ACTCTGCCTA CCTAGTGGCA 
GAGAAAGTGG TTGTGATCAC AAAGCATAAC GATGATGAAC AGTATGCTTG GGAGTCTTCT 
GCTGGAGGTT CCTTCACTGT CCGTGCTGAC CATGGTGAGC CTATTGGCCG CGGTACCAAA 
GTGATTCTCC ACCTGAAGGA AGACCAGACA GAGTACTTGG AAGAGAGGCG GGTCAAAGAA 
GTGGTGAAGA AGCACTCTCA GTTCATAGGC TATCCCATCA CACTTTATCT GGAGAAAGAA 
CGTGAGAAGG AAATCAGTGA TGATGAGGCT GAAGAAGAGA AAGGTGAGAA AGAAGAGGAA 
GATAAAGATG ATGAAGAGAA GCCTAAGATT GAAGATGTGG GCTCAGACGA GGAGGATGAT 
AGTGGCAAAG ATAAGAAAAA GAAGACAAAG AAGATAAAGG AGAAGTACAT TGATCAGGAA 
GAACTGAACA AGACCAAGCC CATTTGGACC AGGAACCCTG ATGACATCAC CCAGGAGGAA 
TATGGAGAGT TCTACAAGAG TCTTACCAAT GACTGGGAAG ATCACTTGGC AGTGAAGCAC 
TTCTCTGTAG AAGGTCAACT GGAATTCAGA GCACTGCTGT TCATCCCCCG TCGGGCTCCT 
TTTGACCTCT TCGAGAACAA AAAGAAAAAG AACAACATCA AACTGTATGT CCGCCGTGTG 
TTCATCATGG ACAGCTGTGA TGAGTTGATT CCGGAATATC TCAACTTCAT CCGTGGGGTG 
GTTGACTCTG AAGACCTCCC CCTGAACATC TCCCGAGAAA TGCTCCAGCA GAGCAAAATT 
TTGAAGGTTA TTCGTAAGAA CATTGTTAAG AAGTGCCTTG AGCTCTTCTC TGAGCTAGCA 
GAAGACAAGG AGAACTATAA GAAATTCTAT GAGGCGTTCT CTAAAAACCT GAAGCTTGGA 
ATCCATGAGG ACTCCACTAA CCGGCGACGC CTTTCTGAGC TGCTGCGCTA TCACACGTCC 
CAGTCTGGAG ACGAGATGAC TTCTCTCTCA GAATATGTGT CTCGCATGAA GGAGACGCAG 
AAGTCCATCT ATTACATCAC TGGTGAGAGC AAAGAGCAGG TTGCCAACTC TGCATTTGTG 
GAGCGCGTGC GGAAGCGGGG CTTTGAGGTG GTGTACATGA CAGAGCCCAT CGATGAGTAC 
TGTGTACAGC AGCTCAAGGA GTTTGATGGG AAGAGTCTAG TCTCTGTGAC CAAGGAGGGC 
CTGGAGCTGC CCGAGGATGA GGAGGAGAAG AAGAAGATGG AGGAGAGCAA GGCAAAGTTT 
GAGAACCTCT GCAAACTCAT GAAGGAGATC CTGGATAAGA AGGTGGAGAA GGTGACGATC 
TCCAACAGGC TTGTGTCGTC ACCCTGCTGC ATCGTGACCA GCACCTACGG CTGGACCGCC 
AACATGGAGC GCATCATGAA AGCCCAGGCG CTTCGGGACA ACTCGACCAT GGGCTACATG 
ATGGCCAAAA AGCATCTGGA GATCAACCCT GACCACCCCA TCGTGGAGAC CCTGCGGCAG 
AAGGCAGAGG CGGACAAAAA CGACAAGGCC GTCAAGGACC TGGTGGTGCT GCTGTTCGAA 
ACTGCACTGC TCTCCTCTGG CTTCTCGCTT GAGGATCCCC AGACCCACTC CAACCGCATC 
TACCGCATGA TAAAGCTCGG CCTGGGCATT GATGAAGATG AGGTGACGGC AGAGGAGCCC 
AGTGCTGCTG TTCCTGATGA GATTCCCCCC CTTGAGGGTG ACGAGGACGC CTCTCGCATG 
GAAGAAGTAG ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073105.1
CDS	88..2262
Translation	MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVTAEEPSAAVPDEIPPLEGDEDASRMEEVD

Target ORF information:

RefSeq Version	NM_001079637.1
Organism	Bos taurus(cattle)
Definition	Bos taurus heat shock protein 90 alpha family class B member 1 (HSP90AB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079637.1

ORF Insert Sequence:

ATGCCTGAGG AAGTGCACCA TGGAGAGGAG GAGGTGGAGA CATTTGCCTT CCAGGCAGAA 
ATTGCCCAAC TCATGTCTCT TATTATCAAC ACCTTCTATT CCAACAAGGA AATTTTTCTT 
CGGGAGTTGA TCAGTAATGC TTCTGATGCC TTAGACAAGA TTCGCTATGA GAGCCTGACA 
GACCCTTCCA AATTGGACAG TGGTAAAGAG CTGAAAATTG ACATCATCCC AAACCCCCAG 
GAGCGTACTC TGACTCTGGT AGACACAGGC ATTGGCATGA CCAAAGCTGA TCTTGTAAAT 
AATTTGGGAA CCATTGCCAA GTCTGGCACT AAAGCGTTTA TGGAGGCTCT TCAGGCTGGT 
GCAGACATCT CCATGATTGG GCAATTTGGT GTGGGCTTCT ACTCTGCCTA CCTAGTGGCA 
GAGAAAGTGG TTGTGATCAC AAAGCATAAC GATGATGAAC AGTATGCTTG GGAGTCTTCT 
GCTGGAGGTT CCTTCACTGT CCGTGCTGAC CATGGTGAGC CTATTGGCCG CGGTACCAAA 
GTGATTCTCC ACCTGAAGGA AGACCAGACA GAGTACTTGG AAGAGAGGCG GGTCAAAGAA 
GTGGTGAAGA AGCACTCTCA GTTCATAGGC TATCCCATCA CACTTTATCT GGAGAAAGAA 
CGTGAGAAGG AAATCAGTGA TGATGAGGCT GAAGAAGAGA AAGGTGAGAA AGAAGAGGAA 
GATAAAGATG ATGAAGAGAA GCCTAAGATT GAAGATGTGG GCTCAGACGA GGAGGATGAT 
AGTGGCAAAG ATAAGAAAAA GAAGACAAAG AAGATAAAGG AGAAGTACAT TGATCAGGAA 
GAACTGAACA AGACCAAGCC CATTTGGACC AGGAACCCTG ATGACATCAC CCAGGAGGAA 
TATGGAGAGT TCTACAAGAG TCTTACCAAT GACTGGGAAG ATCACTTGGC AGTGAAGCAC 
TTCTCTGTAG AAGGTCAACT GGAATTCAGA GCACTGCTGT TCATCCCCCG TCGGGCTCCT 
TTTGACCTCT TCGAGAACAA AAAGAAAAAG AACAACATCA AACTGTATGT CCGCCGTGTG 
TTCATCATGG ACAGCTGTGA TGAGTTGATT CCGGAATATC TCAACTTCAT CCGTGGGGTG 
GTTGACTCTG AAGACCTCCC CCTGAACATC TCCCGAGAAA TGCTCCAGCA GAGCAAAATT 
TTGAAGGTTA TTCGTAAGAA CATTGTTAAG AAGTGCCTTG AGCTCTTCTC TGAGCTAGCA 
GAAGACAAGG AGAACTATAA GAAATTCTAT GAGGCGTTCT CTAAAAACCT GAAGCTTGGA 
ATCCATGAGG ACTCCACTAA CCGGCGACGC CTTTCTGAGC TGCTGCGCTA TCACACGTCC 
CAGTCTGGAG ACGAGATGAC TTCTCTCTCA GAATATGTGT CTCGCATGAA GGAGACGCAG 
AAGTCCATCT ATTACATCAC TGGTGAGAGC AAAGAGCAGG TTGCCAACTC TGCATTTGTG 
GAGCGCGTGC GGAAGCGGGG CTTTGAGGTG GTGTACATGA CAGAGCCCAT CGATGAGTAC 
TGTGTACAGC AGCTCAAGGA GTTTGATGGG AAGAGTCTAG TCTCTGTGAC CAAGGAGGGC 
CTGGAGCTGC CCGAGGATGA GGAGGAGAAG AAGAAGATGG AGGAGAGCAA GGCAAAGTTT 
GAGAACCTCT GCAAACTCAT GAAGGAGATC CTGGATAAGA AGGTGGAGAA GGTGACGATC 
TCCAACAGGC TTGTGTCGTC ACCCTGCTGC ATCGTGACCA GCACCTACGG CTGGACCGCC 
AACATGGAGC GCATCATGAA AGCCCAGGCG CTTCGGGACA ACTCGACCAT GGGCTACATG 
ATGGCCAAAA AGCATCTGGA GATCAACCCT GACCACCCCA TCGTGGAGAC CCTGCGGCAG 
AAGGCAGAGG CGGACAAAAA CGACAAGGCC GTCAAGGACC TGGTGGTGCT GCTGTTCGAA 
ACTGCACTGC TCTCCTCTGG CTTCTCGCTT GAGGATCCCC AGACCCACTC CAACCGCATC 
TACCGCATGA TAAAGCTCGG CCTGGGCATT GATGAAGATG AGGTGACGGC AGAGGAGCCC 
AGTGCTGCTG TTCCTGATGA GATTCCCCCC CTTGAGGGTG ACGAGGACGC CTCTCGCATG 
GAAGAAGTAG ATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Thermotolerance, health profile and cellular expression of HSP90AB1 in Nguni and Boran cows raised on natural pastures under tropical conditions.
Journal of thermal biology6985-94(2017 Oct)
Katiyatiya CLF,Bradley G,Muchenje V

Identification of SNP in HSP90AB1 and its association with the relative thermotolerance and milk production traits in Indian dairy cattle.
Animal biotechnology26(1)45-50(2015)
Sajjanar B,Deb R,Singh U,Kumar S,Brahmane M,Nirmale A,Bal SK,Minhas PS

Polymorphisms in the bovine HSP90AB1 gene are associated with heat tolerance in Thai indigenous cattle.
Tropical animal health and production44(4)921-8(2012 Apr)
Charoensook R,Gatphayak K,Sharifi AR,Chaisongkram C,Brenig B,Knorr C

Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.
Journal of cellular physiology227(2)759-71(2012 Feb)
Antonov AS,Antonova GN,Fujii M,ten Dijke P,Handa V,Catravas JD,Verin AD

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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HSP90AB1 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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