GPX2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX2
Entrez Gene ID	533088
Full Name	glutathione peroxidase 2
General protein information	Preferred Names glutathione peroxidase 2 Names glutathione peroxidase 2 glutathione peroxidase 2 (gastrointestinal)
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001163139.2	NP_001156611.1	glutathione peroxidase 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Gpx2	NP_899653.2
Homo sapiens (human)	GPX2	NP_002074.2
Gallus gallus (chicken)	GPX2	NP_001264783.1
Bos taurus (cattle)	GPX2	NP_001156611.1
Xenopus tropicalis (tropical clawed frog)	gpx2	NP_001243244.1
Mus musculus (house mouse)	Gpx2	NP_109602.2
Pan troglodytes (chimpanzee)	GPX2	NP_001108606.1
	GPX2	NP_001108609.1
Canis lupus familiaris (dog)	GPX2	NP_001108607.1

Gene Ontology
Bibliography

Related articles in PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Characterization of mammalian selenoproteomes.
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guig? R, Gladyshev VN
Science (New York, N.Y.)300(5624)1439-43(2003 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa39989	NM_001163139.2 Latest version!	Bos taurus glutathione peroxidase 2 (GPX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX2 ( NM_001163139.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001156611.1 Bos taurus glutathione peroxidase 2 (GPX2), mRNA.

Price & Availability↑

CloneID	OBa39989
Clone ID Related Accession (Same CDS sequence)	NM_001163139.2
Accession Version	NM_001163139.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-22
Organism	Bos taurus(cattle)
Product	glutathione peroxidase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from NKLS02000010.1, DY220788.1, CK971967.1, CK951005.1 and FE006529.1. On Jul 22, 2016 this sequence version replaced NM_001163139.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR5571259.65.1, CK948294.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTTACA TTGCCAAGTC CTTCTACGAC CTCAGTGCTA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACATTCCG AGGCAGGGCA GTGCTGATTG AGAACGTGGC CTCGCTTTGA 
GGCACAACCA CCCGGGACTT CACCCAACTC AACGAGCTGC AATGCCGCTT CCCCAGGCGT 
CTGGTGGTTC TTGGCTTCCC TTGCAATCAA TTTGGACATC AGGAGAACTG TCAGAATGAA 
GAGATCTTGA ACAGCCTCAA GTACGTCCGC CCCGGGGGTG GGTTCCAGCC CACCTTCACC 
CTTGTCCAGA AGTGTGATGT GAATGGTCAG AATGAGCATC CTGTCTTTGC CTACCTGAAG 
GATAAGCTCC CCTACCCTTA TGATGACCCG TTTTCCCTCA TGACCGATCC CAAGTTCATC 
ATTTGGAGCC CCGTGCGCCG CTCAGATGTG TCCTGGAACT TTGAGAAGTT CCTCATTGGG 
CCGGAAGGGG AGCCCTTCCG CCGCTACAGC CGCACCTTCC AAACCATCAA CATCGAGCCT 
GACATCAAGC GCCTCCTCAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156611.1
CDS	167..739
Translation	MAYIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASL*GTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGFQPTFTLVQKCDVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKFIIWSPVRRSDVSWNFEKFLIGPEGEPFRRYSRTFQTINIEPDIKRLLKVAI

Target ORF information:

RefSeq Version	NM_001163139.2
Organism	Bos taurus(cattle)
Definition	Bos taurus glutathione peroxidase 2 (GPX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163139.2

ORF Insert Sequence:

ATGGCTTACA TTGCCAAGTC CTTCTACGAC CTCAGTGCTA TCAGCCTGGA TGGGGAGAAG 
GTAGATTTCA ATACATTCCG AGGCAGGGCA GTGCTGATTG AGAACGTGGC CTCGCTTTGA 
GGCACAACCA CCCGGGACTT CACCCAACTC AACGAGCTGC AATGCCGCTT CCCCAGGCGT 
CTGGTGGTTC TTGGCTTCCC TTGCAATCAA TTTGGACATC AGGAGAACTG TCAGAATGAA 
GAGATCTTGA ACAGCCTCAA GTACGTCCGC CCCGGGGGTG GGTTCCAGCC CACCTTCACC 
CTTGTCCAGA AGTGTGATGT GAATGGTCAG AATGAGCATC CTGTCTTTGC CTACCTGAAG 
GATAAGCTCC CCTACCCTTA TGATGACCCG TTTTCCCTCA TGACCGATCC CAAGTTCATC 
ATTTGGAGCC CCGTGCGCCG CTCAGATGTG TCCTGGAACT TTGAGAAGTT CCTCATTGGG 
CCGGAAGGGG AGCCCTTCCG CCGCTACAGC CGCACCTTCC AAACCATCAA CATCGAGCCT 
GACATCAAGC GCCTCCTCAA AGTTGCCATA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Characterization of mammalian selenoproteomes.
Science (New York, N.Y.)300(5624)1439-43(2003 May)
Kryukov GV,Castellano S,Novoselov SV,Lobanov AV,Zehtab O,Guig? R,Gladyshev VN

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GPX2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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