Gene Symbol | AGT |
Entrez Gene ID | 527114 |
Full Name | angiotensinogen |
Synonyms | SERPINA8 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » AGT cDNA ORF clone
Gene Symbol | AGT |
Entrez Gene ID | 527114 |
Full Name | angiotensinogen |
Synonyms | SERPINA8 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_001114082.2 | NP_001107554.1 | angiotensinogen precursor |
Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell-Mediated Relaxations of Bovine Adrenal Cortical Arteries.
Kopf PG, Park SK, Herrnreiter A, Krause C, Roques BP, Campbell WB
Endocrinology159(1)238-247(2018 Jan)
Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation.
Chowdhury A, Sarkar J, Pramanik PK, Chakraborti T, Chakraborti S
Archives of biochemistry and biophysics60391-101(2016 Aug)
Endothelial metabolism of angiotensin II to angiotensin III, not angiotensin (1-7), augments the vasorelaxation response in adrenal cortical arteries.
Kopf PG, Campbell WB
Endocrinology154(12)4768-76(2013 Dec)
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL
Molecular and cellular biology33(16)3227-41(2013 Aug)
Preovulatory changes in the angiotensin II system in bovine follicles.
Siqueira LC, dos Santos JT, Ferreira R, Souza dos Santos R, dos Reis AM, Oliveira JF, Fortune JE, Gon?alves PB
Reproduction, fertility, and development25(3)539-46(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
NADPH oxidase plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC proliferation occurs through the involvement of Spm-Cer-S1P signaling axis under ANG II stimulation of PASMCs
Title: Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation.
The metabolism of angiotensin II (Ang II) to angiotensin III (Ang III) and its role in the vasorelaxation response in adrenal arteries are reported.
Title: Endothelial metabolism of angiotensin II to angiotensin III, not angiotensin (1-7), augments the vasorelaxation response in adrenal cortical arteries.
The study identified the serine phosphorylation (p-Ser) sites induced by PKC-Beta activation or AGT, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells.
Title: Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.
Data suggest up-regulation of AGT in granulosa cells and of Ang II in follicular fluid during preovulatory period; Ang II appears to amplify stimulatory effects of luteinizing hormone on secretion of progesterone/prostaglandins by granulosa cells.
Title: Preovulatory changes in the angiotensin II system in bovine follicles.
Data suggest that angiotensin II promotes uptake/accumulation of iron (non-transferrin bound iron) into vascular endothelial cells; such iron accumulation appears to depend on activation of angiotensin type 1 receptor and promotes oxidative stress.
Title: Angiotensin II promotes iron accumulation and depresses PGI? and NO synthesis in endothelial cells: effects of losartan and propranolol analogs.
The following AGT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AGT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa44956 | |
Clone ID Related Accession (Same CDS sequence) | NM_001114082.2 | |
Accession Version | NM_001114082.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-23 | |
Organism | Bos taurus(cattle) | |
Product | angiotensinogen precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC102854.1. On Aug 30, 2012 this sequence version replaced NM_001114082.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC102854.1, DV885766.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTCCTG CTGGCCTGAG CCTAGGGGCT GCCATCCTTT GCCTCTTGGC CTGGGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001107554.1 |
CDS | 136..1410 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001114082.2 |
1 | ATGGCTCCTG CTGGCCTGAG CCTAGGGGCT GCCATCCTTT GCCTCTTGGC CTGGGCTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell-Mediated Relaxations of Bovine Adrenal Cortical Arteries. |
Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation. |
Endothelial metabolism of angiotensin II to angiotensin III, not angiotensin (1-7), augments the vasorelaxation response in adrenal cortical arteries. |
Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. |
Preovulatory changes in the angiotensin II system in bovine follicles. |