OPA3 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPA3
Entrez Gene ID	523579
Full Name	OPA3, outer mitochondrial membrane lipid metabolism regulator
General protein information	Preferred Names OPA3, outer mitochondrial membrane lipid metabolism regulator Names optic atrophy 3 protein homolog mitochondrial optic atrophy 3 protein optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001245934.1	NP_001232863.1	optic atrophy 3 protein homolog isoform 2
NM_001079605.1	NP_001073073.1	optic atrophy 3 protein homolog isoform 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OPA3	NP_001232863.1
Danio rerio (zebrafish)	opa3	NP_001073635.1
Homo sapiens (human)	OPA3	NP_001017989.2
Mus musculus (house mouse)	Opa3	NP_997408.2
Xenopus tropicalis (tropical clawed frog)	opa3	XP_002932648.1
Canis lupus familiaris (dog)	OPA3	XP_855096.1
Drosophila melanogaster (fruit fly)	CG13601	NP_001262890.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001401	XP_321733.4

Gene Ontology
Bibliography

Related articles in PubMed

Detection of the nonsense mutation of OPA3 gene in Holstein Friesian cattle with dilated cardiomyopathy in Japan.
Horiuchi N, Kumagai D, Matsumoto K, Inokuma H, Furuoka H, Kobayashi Y
The Journal of veterinary medical science77(10)1281-3(2015 Oct)

A nonsense mutation in the optic atrophy 3 gene (OPA3) causes dilated cardiomyopathy in Red Holstein cattle.
Owczarek-Lipska M, Plattet P, Zipperle L, Dr?gem?ller C, Posthaus H, Dolf G, Braunschweig MH
Genomics97(1)51-7(2011 Jan)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present study is the first report of the OPA3 mutation in dilated cardiomyopathy affected cows outside Switzerland.
Title: Detection of the nonsense mutation of OPA3 gene in Holstein Friesian cattle with dilated cardiomyopathy in Japan.

the nonsense mutation c.343C>T in the bovine OPA3 gene causes the late-onset dilated cardiomyopathy in Red Holstein cattle.
Title: A nonsense mutation in the optic atrophy 3 gene (OPA3) causes dilated cardiomyopathy in Red Holstein cattle.

The following OPA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43771	NM_001079605.1 Latest version!	Bos taurus outer mitochondrial membrane lipid metabolism regulator OPA3 (OPA3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OBa44259	NM_001245934.1 Latest version!	Bos taurus outer mitochondrial membrane lipid metabolism regulator OPA3 (OPA3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPA3 ( NM_001079605.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001073073.1 Bos taurus outer mitochondrial membrane lipid metabolism regulator OPA3 (OPA3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OBa43771
Clone ID Related Accession (Same CDS sequence)	NM_001079605.1
Accession Version	NM_001079605.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	optic atrophy 3 protein homolog isoform 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC122701.1. On Dec 5, 2006 this sequence version replaced XM_609313.2. ##Evidence-Data-START## Transcript exon combination :: BC122701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145420, SAMN03145428 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 18614015, 12865426 ##RefSeq-Attributes-END##

ATGGTGGTGG GCGCGTTCCC TATGGCGAAG CTGCTATACT TGGGCATCCG GCAGGTCAGC 
AAGCCGCTTG CCAACCGCAT TAAGGAGGCC GCCCGCCGAA GCGAGTTCTT CAAGACCTAT 
ATCTGCCTCC CGCCGGCTCA GCTGTACCAC TGGGTCGAGA TGCGGGCCAA GATGCGCCTC 
ATGGGCTTCA ATGCGGAAAC CATCAAGCCG TTGAACGAGG AGGCAGCTGC GGAGCTGGGC 
GCCGAGCTGC TGGGCGAGGC CACCATCTTC TTGGTGGCCT GCGGCTGCCT GGTGCTGGAG 
TACTCGCGAC AAAAGACGCA ACAGCGTCGC AAGGAGGGAG AGCAGCTCGC CGCCTGGGAC 
GCGATGCGGG ACGAGGTGGA CCACCTGGCG CTGGTGCTGG AGGCCCTGCA GGCGCAGGTG 
CAGGCGGCGC CGCCGCCGGG CGCCCTGGAG GAGCTGCAGG CGCAGATGCG AGAGGTGCGC 
GCCCAGCTCT GCGTCCAGGA CCTGCCGCCG GCGCCCCAGG AAGAGCCCAC ACCAAGGGAT 
GAGGGGCCGC CAGACCCAGG TCTCGGACAG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073073.1
CDS	33..608
Translation	MVVGAFPMAKLLYLGIRQVSKPLANRIKEAARRSEFFKTYICLPPAQLYHWVEMRAKMRLMGFNAETIKPLNEEAAAELGAELLGEATIFLVACGCLVLEYSRQKTQQRRKEGEQLAAWDAMRDEVDHLALVLEALQAQVQAAPPPGALEELQAQMREVRAQLCVQDLPPAPQEEPTPRDEGPPDPGLGQD

Target ORF information:

RefSeq Version	NM_001079605.1
Organism	Bos taurus(cattle)
Definition	Bos taurus outer mitochondrial membrane lipid metabolism regulator OPA3 (OPA3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079605.1

ORF Insert Sequence:

ATGGTGGTGG GCGCGTTCCC TATGGCGAAG CTGCTATACT TGGGCATCCG GCAGGTCAGC 
AAGCCGCTTG CCAACCGCAT TAAGGAGGCC GCCCGCCGAA GCGAGTTCTT CAAGACCTAT 
ATCTGCCTCC CGCCGGCTCA GCTGTACCAC TGGGTCGAGA TGCGGGCCAA GATGCGCCTC 
ATGGGCTTCA ATGCGGAAAC CATCAAGCCG TTGAACGAGG AGGCAGCTGC GGAGCTGGGC 
GCCGAGCTGC TGGGCGAGGC CACCATCTTC TTGGTGGCCT GCGGCTGCCT GGTGCTGGAG 
TACTCGCGAC AAAAGACGCA ACAGCGTCGC AAGGAGGGAG AGCAGCTCGC CGCCTGGGAC 
GCGATGCGGG ACGAGGTGGA CCACCTGGCG CTGGTGCTGG AGGCCCTGCA GGCGCAGGTG 
CAGGCGGCGC CGCCGCCGGG CGCCCTGGAG GAGCTGCAGG CGCAGATGCG AGAGGTGCGC 
GCCCAGCTCT GCGTCCAGGA CCTGCCGCCG GCGCCCCAGG AAGAGCCCAC ACCAAGGGAT 
GAGGGGCCGC CAGACCCAGG TCTCGGACAG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OPA3 ( NM_001245934.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001232863.1 Bos taurus outer mitochondrial membrane lipid metabolism regulator OPA3 (OPA3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OBa44259
Clone ID Related Accession (Same CDS sequence)	NM_001245934.1
Accession Version	NM_001245934.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	optic atrophy 3 protein homolog isoform 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from HM136903.1. On Oct 10, 2011 this sequence version replaced XM_601880.3. ##Evidence-Data-START## Transcript exon combination :: HM136903.1, DV876220.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05861795, SAMN05861880 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 18614015, 12865426 ##RefSeq-Attributes-END##

ATGGTGGTGG GCGCGTTCCC TATGGCGAAG CTGCTATACT TGGGCATCCG GCAGGTCAGC 
AAGCCGCTTG CCAACCGCAT TAAGGAGGCC GCCCGCCGAA GCGAGTTCTT CAAGACCTAT 
ATCTGCCTCC CGCCGGCTCA GCTGTACCAC TGGGTGGAGA TGCGGACCAA GATGCGCATC 
ATGGGCTTCC GGGGCACGGT CATTAAGCCG CTGAACGAGG AGGCGGCCGC CGAGCTGGGT 
GCCGAGCTGC TGGGCGAGGC CACCATCTTC ATCGTGGGCG GCGGTTGCCT GGTGCTGGAG 
TACTGGCGCC ACCAGGCGCA GCAGCGGCGC AAGGAGGAGG AGCAGCGCGC CGCCTGGGAC 
GCGATGCGAG ACGAGGTGGG CCACCTGGCG CTGGCGCTCG AGGCCCTGCA GACGCAGGTG 
CAGGCAGCGC CGCCAAAGGG TGACCTGGAG GAGCTGCAGG CGCAGATGCG AGAGGTGCGC 
GCCCAGCTGC GCGCCGGGGA CCCGCCGTCC ACCCCCGGGG CCGCGTCCAC GTCCCAGGCA 
GCATCCTCAC CCAAGAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001232863.1
CDS	1..561
Translation	MVVGAFPMAKLLYLGIRQVSKPLANRIKEAARRSEFFKTYICLPPAQLYHWVEMRTKMRIMGFRGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQAQQRRKEEEQRAAWDAMRDEVGHLALALEALQTQVQAAPPKGDLEELQAQMREVRAQLRAGDPPSTPGAASTSQAASSPKK

Target ORF information:

RefSeq Version	NM_001245934.1
Organism	Bos taurus(cattle)
Definition	Bos taurus outer mitochondrial membrane lipid metabolism regulator OPA3 (OPA3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001245934.1

ORF Insert Sequence:

ATGGTGGTGG GCGCGTTCCC TATGGCGAAG CTGCTATACT TGGGCATCCG GCAGGTCAGC 
AAGCCGCTTG CCAACCGCAT TAAGGAGGCC GCCCGCCGAA GCGAGTTCTT CAAGACCTAT 
ATCTGCCTCC CGCCGGCTCA GCTGTACCAC TGGGTGGAGA TGCGGACCAA GATGCGCATC 
ATGGGCTTCC GGGGCACGGT CATTAAGCCG CTGAACGAGG AGGCGGCCGC CGAGCTGGGT 
GCCGAGCTGC TGGGCGAGGC CACCATCTTC ATCGTGGGCG GCGGTTGCCT GGTGCTGGAG 
TACTGGCGCC ACCAGGCGCA GCAGCGGCGC AAGGAGGAGG AGCAGCGCGC CGCCTGGGAC 
GCGATGCGAG ACGAGGTGGG CCACCTGGCG CTGGCGCTCG AGGCCCTGCA GACGCAGGTG 
CAGGCAGCGC CGCCAAAGGG TGACCTGGAG GAGCTGCAGG CGCAGATGCG AGAGGTGCGC 
GCCCAGCTGC GCGCCGGGGA CCCGCCGTCC ACCCCCGGGG CCGCGTCCAC GTCCCAGGCA 
GCATCCTCAC CCAAGAAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Detection of the nonsense mutation of OPA3 gene in Holstein Friesian cattle with dilated cardiomyopathy in Japan.
The Journal of veterinary medical science77(10)1281-3(2015 Oct)
Horiuchi N,Kumagai D,Matsumoto K,Inokuma H,Furuoka H,Kobayashi Y

A nonsense mutation in the optic atrophy 3 gene (OPA3) causes dilated cardiomyopathy in Red Holstein cattle.
Genomics97(1)51-7(2011 Jan)
Owczarek-Lipska M,Plattet P,Zipperle L,Dr?gem?ller C,Posthaus H,Dolf G,Braunschweig MH

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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OPA3 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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