Gene Symbol | BOLA |
Entrez Gene ID | 515712 |
Full Name | MHC class I heavy chain |
Synonyms | 3349.1,BoLA-N,Bota,D18.5,LA-A11 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » BOLA cDNA ORF clone
Gene Symbol | BOLA |
Entrez Gene ID | 515712 |
Full Name | MHC class I heavy chain |
Synonyms | 3349.1,BoLA-N,Bota,D18.5,LA-A11 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_010818341.2 | XP_010816643.1 | MHC class I heavy chain isoform X1 |
NM_001038518.2 | NP_001033607.1 | MHC class I heavy chain isoform 1 precursor |
NM_001040532.1 | NP_001035622.1 | MHC class I heavy chain isoform 2 precursor |
XM_010818341.3 | XP_010816643.1 | MHC class I heavy chain isoform X1 |
Canis lupus familiaris (dog) | DLA-64 | NP_001014400.1 |
Bos taurus (cattle) | BOLA-NC1 | NP_001099086.1 |
Danio rerio (zebrafish) | mhc1uka | XP_005159527.1 |
Danio rerio (zebrafish) | LOC101883648 | XP_005161941.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100127707 | NP_001265363.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100493954 | XP_002940102.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100495225 | XP_002940109.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100497446 | XP_004918996.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494770 | XP_002940106.1 |
Xenopus tropicalis (tropical clawed frog) | mhc1b2 | NP_001234924.1 |
Bos taurus (cattle) | BOLA-A | NP_001035644.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100490553 | XP_002938999.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100497122 | XP_004918998.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100496024 | XP_002940114.2 |
Xenopus tropicalis (tropical clawed frog) | LOC101734387 | XP_004918994.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100495382 | XP_002940110.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494618 | XP_002940105.1 |
Canis lupus familiaris (dog) | DLA-12 | NP_001014401.1 |
Bos taurus (cattle) | BOLA | NP_001033607.1 |
Bos taurus (cattle) | JSP.1 | NP_001035588.1 |
Danio rerio (zebrafish) | mhc1uba | NP_571546.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100217322 | XP_004919447.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100490896 | XP_002939001.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100496639 | XP_002940118.2 |
Xenopus tropicalis (tropical clawed frog) | mr1 | XP_002940116.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100496176 | XP_002940115.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100494130 | XP_004918993.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494930 | XP_004918997.1 |
Xenopus tropicalis (tropical clawed frog) | LOC101730341 | XP_004919000.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100490378 | XP_002938998.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100487860 | XP_002944047.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494293 | XP_002940103.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100495081 | XP_002940108.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494456 | XP_002940104.2 |
Homo sapiens (human) | HLA-B | NP_005505.2 |
Pan troglodytes (chimpanzee) | PATR-B | NP_001009081.1 |
MAMU-B18 | NP_001108436.1 | |
Canis lupus familiaris (dog) | DLA88 | NP_001014767.1 |
Danio rerio (zebrafish) | LOC796419 | XP_001336749.4 |
Xenopus tropicalis (tropical clawed frog) | hla-a | NP_001106536.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100495868 | XP_002940113.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100490728 | XP_002939000.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100495703 | XP_002940112.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100496488 | XP_002940117.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100170421 | NP_001123671.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100170569 | XP_004918999.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100495542 | XP_002940111.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100485167 | XP_002935389.2 |
BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva.
Svitek N, Awino E, Nene V, Steinaa L
Veterinary immunology and immunopathology167(1-2)80-5(2015 Sep)
BoLA class I allele diversity and polymorphism in a herd of cattle.
Babiuk S, Horseman B, Zhang C, Bickis M, Kusalik A, Schook LB, Abrahamsen MS, Pontarollo R
Immunogenetics59(2)167-76(2007 Feb)
Evidence for expression of both classical and non-classical major histocompatibility complex class I genes in bovine trophoblast cells.
Davies CJ, Eldridge JA, Fisher PJ, Schlafer DH
American journal of reproductive immunology (New York, N.Y. : 1989)55(3)188-200(2006 Mar)
Variation in the number of expressed MHC genes in different cattle class I haplotypes.
Ellis SA, Holmes EC, Staines KA, Smith KB, Stear MJ, McKeever DJ, MacHugh ND, Morrison WI
Immunogenetics50(5-6)319-28(1999 Dec)
Transmembrane and cytoplasmic domain sequences demonstrate at least two expressed bovine MHC class I loci.
Ellis SA, Braem KA, Morrison WI
Immunogenetics37(1)49-56(1992)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Crystal structure data indicates that Glu97 in the MHC molecule plays a role in epitope binding through electro-static interaction with a lysine residue in position 5 of the epitope, which also functions as an additional anchor residue.
Title: BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva.
The following BOLA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BOLA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa40978 | |
Clone ID Related Accession (Same CDS sequence) | NM_001038518.2 | |
Accession Version | NM_001038518.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-13 | |
Organism | Bos taurus(cattle) | |
Product | MHC class I heavy chain isoform 1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC109586.1. On Aug 18, 2015 this sequence version replaced NM_001038518.1. ##Evidence-Data-START## Transcript exon combination :: BC109586.1, M21043.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145420, SAMN03145425 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCGAGTTA TGAGGCCGCG AACCCTCCTC CTGCTGCTCT CGGGGGTCCT GGTCCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001033607.1 |
CDS | 22..1107 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001038518.2 |
1 | ATGCGAGTTA TGAGGCCGCG AACCCTCCTC CTGCTGCTCT CGGGGGTCCT GGTCCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa40979 | |
Clone ID Related Accession (Same CDS sequence) | NM_001040532.1 | |
Accession Version | NM_001040532.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-13 | |
Organism | Bos taurus(cattle) | |
Product | MHC class I heavy chain isoform 2 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ010867.1. On May 10, 2006 this sequence version replaced XM_593785.2. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03145420, SAMN03145425 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGGCCGC GAACCCTCCT CCTGCTGCTC TCGGGGGTCC TGGTCCTGAC CGAGACCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001035622.1 |
CDS | 1..1077 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001040532.1 |
1 | ATGGGGCCGC GAACCCTCCT CCTGCTGCTC TCGGGGGTCC TGGTCCTGAC CGAGACCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa49392 | |
Clone ID Related Accession (Same CDS sequence) | XM_010818341.2 , XM_010818341.3 | |
Accession Version | XM_010818341.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | MHC class I heavy chain isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104557.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_010818341.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGAGTTA TGAGGCCGCG AACCCTCCTC CTGCTGCTCT CGGGGGTCCT GGTCCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_010816643.1 |
CDS | 59..1096 |
Translation |
Target ORF information:
Target ORF information:
|
XM_010818341.2 |
1 | ATGCGAGTTA TGAGGCCGCG AACCCTCCTC CTGCTGCTCT CGGGGGTCCT GGTCCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa49392 | |
Clone ID Related Accession (Same CDS sequence) | XM_010818341.2 , XM_010818341.3 | |
Accession Version | XM_010818341.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | MHC class I heavy chain isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037350.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_010818341.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGAGTTA TGAGGCCGCG AACCCTCCTC CTGCTGCTCT CGGGGGTCCT GGTCCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_010816643.1 |
CDS | 81..1118 |
Translation |
Target ORF information:
Target ORF information:
|
XM_010818341.3 |
1 | ATGCGAGTTA TGAGGCCGCG AACCCTCCTC CTGCTGCTCT CGGGGGTCCT GGTCCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva. |
BoLA class I allele diversity and polymorphism in a herd of cattle. |
Evidence for expression of both classical and non-classical major histocompatibility complex class I genes in bovine trophoblast cells. |
Variation in the number of expressed MHC genes in different cattle class I haplotypes. |
Transmembrane and cytoplasmic domain sequences demonstrate at least two expressed bovine MHC class I loci. |