| Gene Symbol | A2M |
| Entrez Gene ID | 513856 |
| Full Name | alpha-2-macroglobulin |
| Gene Type | protein-coding |
| Organism | Bos taurus(cattle) |
gRNAs
The following A2M gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the A2M cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OBa44140 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001109795.1 | |
| Accession Version | NM_001109795.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4533bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-25 | |
| Organism | Bos taurus(cattle) | |
| Product | alpha-2-macroglobulin precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC153840.1. On Oct 9, 2007 this sequence version replaced XM_591612.3. ##Evidence-Data-START## Transcript exon combination :: BC153840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGGAAGA ACAAACTCCT TTATCCAAGT CTTACTCTTC TTCTTCTGCT CTTGCTGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001103265.1 |
| CDS | 72..4604 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001109795.1 |
1 | ATGGGGAAGA ACAAACTCCT TTATCCAAGT CTTACTCTTC TTCTTCTGCT CTTGCTGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OBa19732 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005207056.3 , XM_005207056.4 | |
| Accession Version | XM_005207056.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4533bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-01-25 | |
| Organism | Bos taurus(cattle) | |
| Product | alpha-2-macroglobulin isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003103939.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005207056.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGGGAAG GCAGACTTCT TCACTCATGT CTCCTGCTAC TTCTCGTCAT TCGGTTTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005207113.1 |
| CDS | 64..4596 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005207056.3 |
1 | ATGGGGGAAG GCAGACTTCT TCACTCATGT CTCCTGCTAC TTCTCGTCAT TCGGTTTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OBa19732 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005207056.3 , XM_005207056.4 | |
| Accession Version | XM_005207056.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4533bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-05-06 | |
| Organism | Bos taurus(cattle) | |
| Product | alpha-2-macroglobulin isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037332.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005207056.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGGGAAG GCAGACTTCT TCACTCATGT CTCCTGCTAC TTCTCGTCAT TCGGTTTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005207113.1 |
| CDS | 211..4743 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005207056.4 |
1 | ATGGGGGAAG GCAGACTTCT TCACTCATGT CTCCTGCTAC TTCTCGTCAT TCGGTTTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Regulatory mutations in the A2M gene are involved in the mastitis susceptibility in dairy cows. |
Secreted phosphoprotein-24?kDa (Spp24) attenuates BMP-2-stimulated Smad 1/5 phosphorylation and alkaline phosphatase induction and was purified in a protective complex with alpha2 -Macroglobulins From Serum. |
The exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis in dairy cattle. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Evidence for autocrine or paracrine roles of alpha2-macroglobulin in regulation of estradiol production by granulosa cells and development of dominant follicles. |
