CASP8 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CASP8
Entrez Gene ID	507481
Full Name	caspase 8
General protein information	Preferred Names caspase 8 Names caspase-8 caspase 8, apoptosis-related cysteine peptidase
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001045970.2	NP_001039435.1	caspase-8
XM_005202615.4	XP_005202672.1	caspase-8 isoform X1
XM_005202615.3	XP_005202672.1	caspase-8 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Casp8	NP_071613.1
Xenopus tropicalis (tropical clawed frog)	casp8	XP_002936586.2
Homo sapiens (human)	CASP8	NP_001073594.1
Bos taurus (cattle)	CASP8	NP_001039435.1
Danio rerio (zebrafish)	casp8	NP_571585.2
Danio rerio (zebrafish)	casp8l1	NP_001092089.1
Pan troglodytes (chimpanzee)	CASP8	XP_001172193.1
Canis lupus familiaris (dog)	CASP8	NP_001041494.1
Gallus gallus (chicken)	CASP8	NP_989923.1
	CASP8	XP_001091080.2
Mus musculus (house mouse)	Casp8	NP_001264855.1

Gene Ontology
Bibliography

Related articles in PubMed

Staphylococcus aureus induces apoptosis in primary bovine mammary epithelial cells through Fas-FADD death receptor-linked caspase-8 signaling.
Hu Q, Cui X, Tao L, Xiu L, Wang T, Wang X
DNA and cell biology33(6)388-97(2014 Jun)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species.
Kuckleburg CJ, Tiwari R, Czuprynski CJ
Thrombosis and haemostasis99(2)363-72(2008 Feb)

Cloning and radiation hybrid mapping of bovine toll-like receptor-4 (TLR-4) signaling molecules.
Connor EE, Cates EA, Williams JL, Bannerman DD
Veterinary immunology and immunopathology112(3-4)302-8(2006 Aug)

Characterization of 954 bovine full-CDS cDNA sequences.
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP
BMC genomics6166(2005 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.
Title: Staphylococcus aureus induces apoptosis in primary bovine mammary epithelial cells through Fas-FADD death receptor-linked caspase-8 signaling.

Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9.
Title: Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species.

The following CASP8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASP8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa16546	NM_001045970.2 Latest version!	Bos taurus caspase 8 (CASP8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa16546	XM_005202615.4 Latest version!	Bos taurus caspase 8 (CASP8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
View Old Accession Versions >>
OBa16546	XM_005202615.3	Bos taurus caspase 8 (CASP8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CASP8 ( NM_001045970.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001039435.1 Bos taurus caspase 8 (CASP8), mRNA.

Price & Availability↑

CloneID	OBa16546
Clone ID Related Accession (Same CDS sequence)	NM_001045970.2 , XM_005202615.4 , XM_005202615.3
Accession Version	NM_001045970.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-13
Organism	Bos taurus(cattle)
Product	caspase-8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC134534.1. On Apr 1, 2007 this sequence version replaced NM_001045970.1. ##Evidence-Data-START## Transcript exon combination :: BC134534.1, BT030512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCTCA CCCAATGTCT CTATAATATT GGGGAGCAGC TGGGCAGTGA CGACCTGGCT 
GCCCTCAAGT TCCTAAGCCG GGACCACATC CCATATAGGA AGCAGGAACC CATCAAGGAT 
GCCTTGATGC TATTCCAGAG GCTCCAAGAA AAGAGAATGT TGGAGGAAAA CAATCTGTCC 
TTCTTGAAGG AGCTGCTTTT CCGAGTGAAT AGACTGGATC TGCTGCTTAA CTACTTGTAT 
ACCAGCGAGG AGGAGATGAA GAGGGAGCTT CAGATACCCG GCAGGGCCCA GATCTCTGCC 
TACAGGATTC TGCTTTTCCA GATTTCAGAA GATGTGAACA AAGTAGAATT GAAGGACTTT 
AAGTTTTTTT TGAGCCAGGA GATTGCCAAA TGTAAGCTGG ATGATGACAT GACTTTGCTT 
GATATTTTCG TGGAGATGGA GAAGAGGACC ATCCTAGGGG AAGAGAACTT GGACACCCTG 
AAAAGAATCT GTGAGCAGGT CAACAAGAGC TTGCTGAAGA AAATCTATGA TTATGAAGAA 
TTAAGAAAAG AGAGAAGAAT GAGCCTTGAA AGAGATCCAT ATGCATTTTC AAATGACATG 
TCACAATCGC TTCCAGAGGA GGGCTACTCT AAGATGCCGG CCATGTCAGA CTCTCCAGAA 
CAGGACAGTG AGTTGCAGAC ATCTGACACA GTTTACCGAA TGACAAGCAA ACCTCGGGGA 
TACTGTTTGA TCTTTAACAA TTATGATTTT AGCATAGCAC GGAAGCAGGT GCCTGAACTT 
CACGACCTTA AGGATAGGAC TGGAACAGAC TTTGATGCAG ACGCTTTGGA TAAGACCTTT 
CGTGAACTTC ATTTTGAGAT AGTGCACTAC AAAGACCTAA CAGCAAAGGG AATCTGTGAG 
GTTCTAGAAT CCTACCAGAA GAAGGACCAC AAAAACAAAG ACTGCTTCAT CTGCTGCATC 
CTCACCCACG GAAACAAGGG CATCATCTAT GGCTCCGATG GGCAAGAAGC CTCCATCTAT 
GAGCTGACCT CTTACTTCAC TGGCTTAAAG TGCCCTTCCC TTATTGGCAA ACCCAAAATC 
TTTTTTATTC AGGCTTGCCA AGGGGACAAG TACCAGAAAG GTGTAGCCGT TGAGACCGAC 
TCAGAACAGA TGGAAGCCTA TTTAGAGGTG GACTCATCAC CTCAGAAGAG ATATATCCCA 
GATGAGGCTG ACTTTCTGCT GGGGATGGCC ACTGTGAAAA ACTATGTTTC CTACCGAAAC 
ATCTGGAATG GGGCCTGGTA TATCCAGTCA CTTTGCCAGA ATCTGAGAGA AAGATGTCCT 
AGGGGTGAAG ACATTCTGAC CATCCTAACC AAGGTGAACT TCGAAGTAAG CAAACTGGAT 
GACAAGCAAC GTATGGCCAA ACAGATGCCA CAACCTACTT TCACACTGCG AAAAAAACTC 
TTCTTTCCTC TTAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001039435.1
CDS	282..1739
Translation	MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSFLKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAYRILLFQISEDVNKVELKDFKFFLSQEIAKCKLDDDMTLLDIFVEMEKRTILGEENLDTLKRICEQVNKSLLKKIYDYEELRKERRMSLERDPYAFSNDMSQSLPEEGYSKMPAMSDSPEQDSELQTSDTVYRMTSKPRGYCLIFNNYDFSIARKQVPELHDLKDRTGTDFDADALDKTFRELHFEIVHYKDLTAKGICEVLESYQKKDHKNKDCFICCILTHGNKGIIYGSDGQEASIYELTSYFTGLKCPSLIGKPKIFFIQACQGDKYQKGVAVETDSEQMEAYLEVDSSPQKRYIPDEADFLLGMATVKNYVSYRNIWNGAWYIQSLCQNLRERCPRGEDILTILTKVNFEVSKLDDKQRMAKQMPQPTFTLRKKLFFPLN

Target ORF information:

RefSeq Version	NM_001045970.2
Organism	Bos taurus(cattle)
Definition	Bos taurus caspase 8 (CASP8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001045970.2

ORF Insert Sequence:

ATGGCGCTCA CCCAATGTCT CTATAATATT GGGGAGCAGC TGGGCAGTGA CGACCTGGCT 
GCCCTCAAGT TCCTAAGCCG GGACCACATC CCATATAGGA AGCAGGAACC CATCAAGGAT 
GCCTTGATGC TATTCCAGAG GCTCCAAGAA AAGAGAATGT TGGAGGAAAA CAATCTGTCC 
TTCTTGAAGG AGCTGCTTTT CCGAGTGAAT AGACTGGATC TGCTGCTTAA CTACTTGTAT 
ACCAGCGAGG AGGAGATGAA GAGGGAGCTT CAGATACCCG GCAGGGCCCA GATCTCTGCC 
TACAGGATTC TGCTTTTCCA GATTTCAGAA GATGTGAACA AAGTAGAATT GAAGGACTTT 
AAGTTTTTTT TGAGCCAGGA GATTGCCAAA TGTAAGCTGG ATGATGACAT GACTTTGCTT 
GATATTTTCG TGGAGATGGA GAAGAGGACC ATCCTAGGGG AAGAGAACTT GGACACCCTG 
AAAAGAATCT GTGAGCAGGT CAACAAGAGC TTGCTGAAGA AAATCTATGA TTATGAAGAA 
TTAAGAAAAG AGAGAAGAAT GAGCCTTGAA AGAGATCCAT ATGCATTTTC AAATGACATG 
TCACAATCGC TTCCAGAGGA GGGCTACTCT AAGATGCCGG CCATGTCAGA CTCTCCAGAA 
CAGGACAGTG AGTTGCAGAC ATCTGACACA GTTTACCGAA TGACAAGCAA ACCTCGGGGA 
TACTGTTTGA TCTTTAACAA TTATGATTTT AGCATAGCAC GGAAGCAGGT GCCTGAACTT 
CACGACCTTA AGGATAGGAC TGGAACAGAC TTTGATGCAG ACGCTTTGGA TAAGACCTTT 
CGTGAACTTC ATTTTGAGAT AGTGCACTAC AAAGACCTAA CAGCAAAGGG AATCTGTGAG 
GTTCTAGAAT CCTACCAGAA GAAGGACCAC AAAAACAAAG ACTGCTTCAT CTGCTGCATC 
CTCACCCACG GAAACAAGGG CATCATCTAT GGCTCCGATG GGCAAGAAGC CTCCATCTAT 
GAGCTGACCT CTTACTTCAC TGGCTTAAAG TGCCCTTCCC TTATTGGCAA ACCCAAAATC 
TTTTTTATTC AGGCTTGCCA AGGGGACAAG TACCAGAAAG GTGTAGCCGT TGAGACCGAC 
TCAGAACAGA TGGAAGCCTA TTTAGAGGTG GACTCATCAC CTCAGAAGAG ATATATCCCA 
GATGAGGCTG ACTTTCTGCT GGGGATGGCC ACTGTGAAAA ACTATGTTTC CTACCGAAAC 
ATCTGGAATG GGGCCTGGTA TATCCAGTCA CTTTGCCAGA ATCTGAGAGA AAGATGTCCT 
AGGGGTGAAG ACATTCTGAC CATCCTAACC AAGGTGAACT TCGAAGTAAG CAAACTGGAT 
GACAAGCAAC GTATGGCCAA ACAGATGCCA CAACCTACTT TCACACTGCG AAAAAAACTC 
TTCTTTCCTC TTAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP8 ( XM_005202615.4 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005202672.1 Bos taurus caspase 8 (CASP8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa16546
Clone ID Related Accession (Same CDS sequence)	NM_001045970.2 , XM_005202615.4 , XM_005202615.3
Accession Version	XM_005202615.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	caspase-8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037329.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005202615.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCTCA CCCAATGTCT CTATAATATT GGGGAGCAGC TGGGCAGTGA CGACCTGGCT 
GCCCTCAAGT TCCTAAGCCG GGACCACATC CCATATAGGA AGCAGGAACC CATCAAGGAT 
GCCTTGATGC TATTCCAGAG GCTCCAAGAA AAGAGAATGT TGGAGGAAAA CAATCTGTCC 
TTCTTGAAGG AGCTGCTTTT CCGAGTGAAT AGACTGGATC TGCTGCTTAA CTACTTGTAT 
ACCAGCGAGG AGGAGATGAA GAGGGAGCTT CAGATACCCG GCAGGGCCCA GATCTCTGCC 
TACAGGATTC TGCTTTTCCA GATTTCAGAA GATGTGAACA AAGTAGAATT GAAGGACTTT 
AAGTTTTTTT TGAGCCAGGA GATTGCCAAA TGTAAGCTGG ATGATGACAT GACTTTGCTT 
GATATTTTCG TGGAGATGGA GAAGAGGACC ATCCTAGGGG AAGAGAACTT GGACACCCTG 
AAAAGAATCT GTGAGCAGGT CAACAAGAGC TTGCTGAAGA AAATCTATGA TTATGAAGAA 
TTAAGAAAAG AGAGAAGAAT GAGCCTTGAA AGAGATCCAT ATGCATTTTC AAATGACATG 
TCACAATCGC TTCCAGAGGA GGGCTACTCT AAGATGCCGG CCATGTCAGA CTCTCCAGAA 
CAGGACAGTG AGTTGCAGAC ATCTGACACA GTTTACCGAA TGACAAGCAA ACCTCGGGGA 
TACTGTTTGA TCTTTAACAA TTATGATTTT AGCATAGCAC GGAAGCAGGT GCCTGAACTT 
CACGACCTTA AGGATAGGAC TGGAACAGAC TTTGATGCAG ACGCTTTGGA TAAGACCTTT 
CGTGAACTTC ATTTTGAGAT AGTGCACTAC AAAGACCTAA CAGCAAAGGG AATCTGTGAG 
GTTCTAGAAT CCTACCAGAA GAAGGACCAC AAAAACAAAG ACTGCTTCAT CTGCTGCATC 
CTCACCCACG GAAACAAGGG CATCATCTAT GGCTCCGATG GGCAAGAAGC CTCCATCTAT 
GAGCTGACCT CTTACTTCAC TGGCTTAAAG TGCCCTTCCC TTATTGGCAA ACCCAAAATC 
TTTTTTATTC AGGCTTGCCA AGGGGACAAG TACCAGAAAG GTGTAGCCGT TGAGACCGAC 
TCAGAACAGA TGGAAGCCTA TTTAGAGGTG GACTCATCAC CTCAGAAGAG ATATATCCCA 
GATGAGGCTG ACTTTCTGCT GGGGATGGCC ACTGTGAAAA ACTATGTTTC CTACCGAAAC 
ATCTGGAATG GGGCCTGGTA TATCCAGTCA CTTTGCCAGA ATCTGAGAGA AAGATGTCCT 
AGGGGTGAAG ACATTCTGAC CATCCTAACC AAGGTGAACT TCGAAGTAAG CAAACTGGAT 
GACAAGCAAC GTATGGCCAA ACAGATGCCA CAACCTACTT TCACACTGCG AAAAAAACTC 
TTCTTTCCTC TTAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005202672.1
CDS	293..1750
Translation	MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSFLKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAYRILLFQISEDVNKVELKDFKFFLSQEIAKCKLDDDMTLLDIFVEMEKRTILGEENLDTLKRICEQVNKSLLKKIYDYEELRKERRMSLERDPYAFSNDMSQSLPEEGYSKMPAMSDSPEQDSELQTSDTVYRMTSKPRGYCLIFNNYDFSIARKQVPELHDLKDRTGTDFDADALDKTFRELHFEIVHYKDLTAKGICEVLESYQKKDHKNKDCFICCILTHGNKGIIYGSDGQEASIYELTSYFTGLKCPSLIGKPKIFFIQACQGDKYQKGVAVETDSEQMEAYLEVDSSPQKRYIPDEADFLLGMATVKNYVSYRNIWNGAWYIQSLCQNLRERCPRGEDILTILTKVNFEVSKLDDKQRMAKQMPQPTFTLRKKLFFPLN

Target ORF information:

RefSeq Version	XM_005202615.4
Organism	Bos taurus(cattle)
Definition	Bos taurus caspase 8 (CASP8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005202615.4

ORF Insert Sequence:

ATGGCGCTCA CCCAATGTCT CTATAATATT GGGGAGCAGC TGGGCAGTGA CGACCTGGCT 
GCCCTCAAGT TCCTAAGCCG GGACCACATC CCATATAGGA AGCAGGAACC CATCAAGGAT 
GCCTTGATGC TATTCCAGAG GCTCCAAGAA AAGAGAATGT TGGAGGAAAA CAATCTGTCC 
TTCTTGAAGG AGCTGCTTTT CCGAGTGAAT AGACTGGATC TGCTGCTTAA CTACTTGTAT 
ACCAGCGAGG AGGAGATGAA GAGGGAGCTT CAGATACCCG GCAGGGCCCA GATCTCTGCC 
TACAGGATTC TGCTTTTCCA GATTTCAGAA GATGTGAACA AAGTAGAATT GAAGGACTTT 
AAGTTTTTTT TGAGCCAGGA GATTGCCAAA TGTAAGCTGG ATGATGACAT GACTTTGCTT 
GATATTTTCG TGGAGATGGA GAAGAGGACC ATCCTAGGGG AAGAGAACTT GGACACCCTG 
AAAAGAATCT GTGAGCAGGT CAACAAGAGC TTGCTGAAGA AAATCTATGA TTATGAAGAA 
TTAAGAAAAG AGAGAAGAAT GAGCCTTGAA AGAGATCCAT ATGCATTTTC AAATGACATG 
TCACAATCGC TTCCAGAGGA GGGCTACTCT AAGATGCCGG CCATGTCAGA CTCTCCAGAA 
CAGGACAGTG AGTTGCAGAC ATCTGACACA GTTTACCGAA TGACAAGCAA ACCTCGGGGA 
TACTGTTTGA TCTTTAACAA TTATGATTTT AGCATAGCAC GGAAGCAGGT GCCTGAACTT 
CACGACCTTA AGGATAGGAC TGGAACAGAC TTTGATGCAG ACGCTTTGGA TAAGACCTTT 
CGTGAACTTC ATTTTGAGAT AGTGCACTAC AAAGACCTAA CAGCAAAGGG AATCTGTGAG 
GTTCTAGAAT CCTACCAGAA GAAGGACCAC AAAAACAAAG ACTGCTTCAT CTGCTGCATC 
CTCACCCACG GAAACAAGGG CATCATCTAT GGCTCCGATG GGCAAGAAGC CTCCATCTAT 
GAGCTGACCT CTTACTTCAC TGGCTTAAAG TGCCCTTCCC TTATTGGCAA ACCCAAAATC 
TTTTTTATTC AGGCTTGCCA AGGGGACAAG TACCAGAAAG GTGTAGCCGT TGAGACCGAC 
TCAGAACAGA TGGAAGCCTA TTTAGAGGTG GACTCATCAC CTCAGAAGAG ATATATCCCA 
GATGAGGCTG ACTTTCTGCT GGGGATGGCC ACTGTGAAAA ACTATGTTTC CTACCGAAAC 
ATCTGGAATG GGGCCTGGTA TATCCAGTCA CTTTGCCAGA ATCTGAGAGA AAGATGTCCT 
AGGGGTGAAG ACATTCTGAC CATCCTAACC AAGGTGAACT TCGAAGTAAG CAAACTGGAT 
GACAAGCAAC GTATGGCCAA ACAGATGCCA CAACCTACTT TCACACTGCG AAAAAAACTC 
TTCTTTCCTC TTAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CASP8 ( XM_005202615.3 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005202672.1 Bos taurus caspase 8 (CASP8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa16546
Clone ID Related Accession (Same CDS sequence)	NM_001045970.2 , XM_005202615.4 , XM_005202615.3
Accession Version	XM_005202615.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	caspase-8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003103845.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005202615.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCTCA CCCAATGTCT CTATAATATT GGGGAGCAGC TGGGCAGTGA CGACCTGGCT 
GCCCTCAAGT TCCTAAGCCG GGACCACATC CCATATAGGA AGCAGGAACC CATCAAGGAT 
GCCTTGATGC TATTCCAGAG GCTCCAAGAA AAGAGAATGT TGGAGGAAAA CAATCTGTCC 
TTCTTGAAGG AGCTGCTTTT CCGAGTGAAT AGACTGGATC TGCTGCTTAA CTACTTGTAT 
ACCAGCGAGG AGGAGATGAA GAGGGAGCTT CAGATACCCG GCAGGGCCCA GATCTCTGCC 
TACAGGATTC TGCTTTTCCA GATTTCAGAA GATGTGAACA AAGTAGAATT GAAGGACTTT 
AAGTTTTTTT TGAGCCAGGA GATTGCCAAA TGTAAGCTGG ATGATGACAT GACTTTGCTT 
GATATTTTCG TGGAGATGGA GAAGAGGACC ATCCTAGGGG AAGAGAACTT GGACACCCTG 
AAAAGAATCT GTGAGCAGGT CAACAAGAGC TTGCTGAAGA AAATCTATGA TTATGAAGAA 
TTAAGAAAAG AGAGAAGAAT GAGCCTTGAA AGAGATCCAT ATGCATTTTC AAATGACATG 
TCACAATCGC TTCCAGAGGA GGGCTACTCT AAGATGCCGG CCATGTCAGA CTCTCCAGAA 
CAGGACAGTG AGTTGCAGAC ATCTGACACA GTTTACCGAA TGACAAGCAA ACCTCGGGGA 
TACTGTTTGA TCTTTAACAA TTATGATTTT AGCATAGCAC GGAAGCAGGT GCCTGAACTT 
CACGACCTTA AGGATAGGAC TGGAACAGAC TTTGATGCAG ACGCTTTGGA TAAGACCTTT 
CGTGAACTTC ATTTTGAGAT AGTGCACTAC AAAGACCTAA CAGCAAAGGG AATCTGTGAG 
GTTCTAGAAT CCTACCAGAA GAAGGACCAC AAAAACAAAG ACTGCTTCAT CTGCTGCATC 
CTCACCCACG GAAACAAGGG CATCATCTAT GGCTCCGATG GGCAAGAAGC CTCCATCTAT 
GAGCTGACCT CTTACTTCAC TGGCTTAAAG TGCCCTTCCC TTATTGGCAA ACCCAAAATC 
TTTTTTATTC AGGCTTGCCA AGGGGACAAG TACCAGAAAG GTGTAGCCGT TGAGACCGAC 
TCAGAACAGA TGGAAGCCTA TTTAGAGGTG GACTCATCAC CTCAGAAGAG ATATATCCCA 
GATGAGGCTG ACTTTCTGCT GGGGATGGCC ACTGTGAAAA ACTATGTTTC CTACCGAAAC 
ATCTGGAATG GGGCCTGGTA TATCCAGTCA CTTTGCCAGA ATCTGAGAGA AAGATGTCCT 
AGGGGTGAAG ACATTCTGAC CATCCTAACC AAGGTGAACT TCGAAGTAAG CAAACTGGAT 
GACAAGCAAC GTATGGCCAA ACAGATGCCA CAACCTACTT TCACACTGCG AAAAAAACTC 
TTCTTTCCTC TTAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005202672.1
CDS	512..1969
Translation	MALTQCLYNIGEQLGSDDLAALKFLSRDHIPYRKQEPIKDALMLFQRLQEKRMLEENNLSFLKELLFRVNRLDLLLNYLYTSEEEMKRELQIPGRAQISAYRILLFQISEDVNKVELKDFKFFLSQEIAKCKLDDDMTLLDIFVEMEKRTILGEENLDTLKRICEQVNKSLLKKIYDYEELRKERRMSLERDPYAFSNDMSQSLPEEGYSKMPAMSDSPEQDSELQTSDTVYRMTSKPRGYCLIFNNYDFSIARKQVPELHDLKDRTGTDFDADALDKTFRELHFEIVHYKDLTAKGICEVLESYQKKDHKNKDCFICCILTHGNKGIIYGSDGQEASIYELTSYFTGLKCPSLIGKPKIFFIQACQGDKYQKGVAVETDSEQMEAYLEVDSSPQKRYIPDEADFLLGMATVKNYVSYRNIWNGAWYIQSLCQNLRERCPRGEDILTILTKVNFEVSKLDDKQRMAKQMPQPTFTLRKKLFFPLN

Target ORF information:

RefSeq Version	XM_005202615.3
Organism	Bos taurus(cattle)
Definition	Bos taurus caspase 8 (CASP8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005202615.3

ORF Insert Sequence:

ATGGCGCTCA CCCAATGTCT CTATAATATT GGGGAGCAGC TGGGCAGTGA CGACCTGGCT 
GCCCTCAAGT TCCTAAGCCG GGACCACATC CCATATAGGA AGCAGGAACC CATCAAGGAT 
GCCTTGATGC TATTCCAGAG GCTCCAAGAA AAGAGAATGT TGGAGGAAAA CAATCTGTCC 
TTCTTGAAGG AGCTGCTTTT CCGAGTGAAT AGACTGGATC TGCTGCTTAA CTACTTGTAT 
ACCAGCGAGG AGGAGATGAA GAGGGAGCTT CAGATACCCG GCAGGGCCCA GATCTCTGCC 
TACAGGATTC TGCTTTTCCA GATTTCAGAA GATGTGAACA AAGTAGAATT GAAGGACTTT 
AAGTTTTTTT TGAGCCAGGA GATTGCCAAA TGTAAGCTGG ATGATGACAT GACTTTGCTT 
GATATTTTCG TGGAGATGGA GAAGAGGACC ATCCTAGGGG AAGAGAACTT GGACACCCTG 
AAAAGAATCT GTGAGCAGGT CAACAAGAGC TTGCTGAAGA AAATCTATGA TTATGAAGAA 
TTAAGAAAAG AGAGAAGAAT GAGCCTTGAA AGAGATCCAT ATGCATTTTC AAATGACATG 
TCACAATCGC TTCCAGAGGA GGGCTACTCT AAGATGCCGG CCATGTCAGA CTCTCCAGAA 
CAGGACAGTG AGTTGCAGAC ATCTGACACA GTTTACCGAA TGACAAGCAA ACCTCGGGGA 
TACTGTTTGA TCTTTAACAA TTATGATTTT AGCATAGCAC GGAAGCAGGT GCCTGAACTT 
CACGACCTTA AGGATAGGAC TGGAACAGAC TTTGATGCAG ACGCTTTGGA TAAGACCTTT 
CGTGAACTTC ATTTTGAGAT AGTGCACTAC AAAGACCTAA CAGCAAAGGG AATCTGTGAG 
GTTCTAGAAT CCTACCAGAA GAAGGACCAC AAAAACAAAG ACTGCTTCAT CTGCTGCATC 
CTCACCCACG GAAACAAGGG CATCATCTAT GGCTCCGATG GGCAAGAAGC CTCCATCTAT 
GAGCTGACCT CTTACTTCAC TGGCTTAAAG TGCCCTTCCC TTATTGGCAA ACCCAAAATC 
TTTTTTATTC AGGCTTGCCA AGGGGACAAG TACCAGAAAG GTGTAGCCGT TGAGACCGAC 
TCAGAACAGA TGGAAGCCTA TTTAGAGGTG GACTCATCAC CTCAGAAGAG ATATATCCCA 
GATGAGGCTG ACTTTCTGCT GGGGATGGCC ACTGTGAAAA ACTATGTTTC CTACCGAAAC 
ATCTGGAATG GGGCCTGGTA TATCCAGTCA CTTTGCCAGA ATCTGAGAGA AAGATGTCCT 
AGGGGTGAAG ACATTCTGAC CATCCTAACC AAGGTGAACT TCGAAGTAAG CAAACTGGAT 
GACAAGCAAC GTATGGCCAA ACAGATGCCA CAACCTACTT TCACACTGCG AAAAAAACTC 
TTCTTTCCTC TTAATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Staphylococcus aureus induces apoptosis in primary bovine mammary epithelial cells through Fas-FADD death receptor-linked caspase-8 signaling.
DNA and cell biology33(6)388-97(2014 Jun)
Hu Q,Cui X,Tao L,Xiu L,Wang T,Wang X

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species.
Thrombosis and haemostasis99(2)363-72(2008 Feb)
Kuckleburg CJ,Tiwari R,Czuprynski CJ

Cloning and radiation hybrid mapping of bovine toll-like receptor-4 (TLR-4) signaling molecules.
Veterinary immunology and immunopathology112(3-4)302-8(2006 Aug)
Connor EE,Cates EA,Williams JL,Bannerman DD

Characterization of 954 bovine full-CDS cDNA sequences.
BMC genomics6166(2005 Nov)
Harhay GP,Sonstegard TS,Keele JW,Heaton MP,Clawson ML,Snelling WM,Wiedmann RT,Van Tassell CP,Smith TP

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CASP8 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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