Gene Symbol | CYP46A1 |
Entrez Gene ID | 506438 |
Full Name | cytochrome P450, family 46, subfamily A, polypeptide 1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » CYP46A1 cDNA ORF clone
Gene Symbol | CYP46A1 |
Entrez Gene ID | 506438 |
Full Name | cytochrome P450, family 46, subfamily A, polypeptide 1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_001076810.1 | NP_001070278.1 | cholesterol 24-hydroxylase |
LOC705843 | XP_001103455.2 | |
Gallus gallus (chicken) | CYP46A1 | NP_001238956.1 |
Arabidopsis thaliana (thale cress) | CYP97A3 | NP_564384.1 |
Canis lupus familiaris (dog) | CYP46A1 | XP_005623990.1 |
Rattus norvegicus (Norway rat) | Cyp46a1 | NP_001102193.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_04469 | XP_003710992.1 |
Xenopus tropicalis (tropical clawed frog) | mgc108213 | NP_001027517.1 |
Xenopus tropicalis (tropical clawed frog) | mgc108077 | NP_001027519.1 |
Mus musculus (house mouse) | Cyp46a1 | NP_034140.1 |
Xenopus tropicalis (tropical clawed frog) | cyp46a1 | NP_001072550.1 |
Homo sapiens (human) | CYP46A1 | NP_006659.1 |
Pan troglodytes (chimpanzee) | CYP46A1 | XP_510158.3 |
Bos taurus (cattle) | CYP46A1 | NP_001070278.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_14217 | XP_003720504.1 |
Oryza sativa (rice) | Os02g0817900 | NP_001048526.1 |
Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice.
Mast N, Li Y, Linger M, Clark M, Wiseman J, Pikuleva IA
The Journal of biological chemistry289(6)3529-38(2014 Feb)
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
Mast N, Zheng W, Stout CD, Pikuleva IA
The Journal of biological chemistry288(7)4613-24(2013 Feb)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina.
Bretillon L, Diczfalusy U, Bj?rkhem I, Maire MA, Martine L, Joffre C, Acar N, Bron A, Creuzot-Garcher C
Current eye research32(4)361-6(2007 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
EFV enhanced CYP46A1 activity and cerebral cholesterol turnover in animals with no effect on the levels of brain cholesterol.
Title: Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice.
analysis of binding of the cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1
Title: Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
Neural retina specifically expresses cholesterol-24S-hydroxylase, a metabolizing enzyme responsible for the removal of cholesterol in neurons. May be valuable gene candidate for retinal pathologies.
Title: Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina.
The following CYP46A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP46A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa01394 | |
Clone ID Related Accession (Same CDS sequence) | NM_001076810.1 | |
Accession Version | NM_001076810.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1506bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-13 | |
Organism | Bos taurus(cattle) | |
Product | cholesterol 24-hydroxylase | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC123817.1. On Oct 11, 2006 this sequence version replaced XM_582887.2. ##Evidence-Data-START## Transcript exon combination :: BC123817.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145415, SAMN03145419 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGCCCCG GGCTGCTGAT GCTGCTTGGC AGCGCCGTCC TGGTCGTCTT CGGCCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001070278.1 |
CDS | 99..1604 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001076810.1 |
1 | ATGAGCCCCG GGCTGCTGAT GCTGCTTGGC AGCGCCGTCC TGGTCGTCTT CGGCCTCTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice. |
Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina. |