IDO1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	IDO1
Entrez Gene ID	506281
Full Name	indoleamine 2,3-dioxygenase 1
Synonyms	INDO
General protein information	Preferred Names indoleamine 2,3-dioxygenase 1 Names indoleamine 2,3-dioxygenase 1 indoleamine-pyrrole 2,3 dioxygenase
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001101866.2	NP_001095336.1	indoleamine 2,3-dioxygenase 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	IDO1	XP_532793.1
Bos taurus (cattle)	IDO1	NP_001095336.1
Neurospora crassa	NCU05752	XP_959727.1
Homo sapiens (human)	IDO1	NP_002155.1
Magnaporthe oryzae (rice blast fungus)	MGG_13773	XP_003710825.1
Saccharomyces cerevisiae (baker's yeast)	BNA2	NP_012612.3
Pan troglodytes (chimpanzee)	IDO1	XP_001137531.1
	IDO1	NP_001070951.1
Mus musculus (house mouse)	Ido1	NP_032350.1
Rattus norvegicus (Norway rat)	Ido1	NP_076463.1
Eremothecium gossypii	AGOS_ACR188C	NP_983590.1

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Palomares RA, Hurley DJ, Woolums AR, Parrish JE, Brock KV
Comparative immunology, microbiology and infectious diseases37(5-6)331-8(2014 Dec)

Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.
Plain KM, de Silva K, Earl J, Begg DJ, Purdie AC, Whittington RJ
Infection and immunity79(9)3821-32(2011 Sep)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Indoleamine 2,3-dioxygenase participates in the interferon-gamma-induced cell death process in cultured bovine luteal cells.
Cannon MJ, Pate JL
Biology of reproduction74(3)552-9(2006 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Differential expression of CD25 and IDO mRNA with high and low virulence bovine viral diarrhea virus might reflect temporal differences in transcription during the immune response elicited by these viral strains.
Title: Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.

IDO may be involved in downregulating immune responses to M. avium subsp. paratuberculosis and other virulent mycobacteria, which may be an example of the pathogen harnessing host immunoregulatory pathways to aid survival.
Title: Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.

INDO participates in IFN-gama-induced death of bovine luteal cells, through a mechanism that involves degradation of tryptophan, thereby reducing tryptophan concentrations to a point insufficient to meet luteal cells needs
Title: Indoleamine 2,3-dioxygenase participates in the interferon-gamma-induced cell death process in cultured bovine luteal cells.

The following IDO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IDO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa37351	NM_001101866.2 Latest version!	Bos taurus indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IDO1 ( NM_001101866.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001095336.1 Bos taurus indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.

Price & Availability↑

CloneID	OBa37351
Clone ID Related Accession (Same CDS sequence)	NM_001101866.2
Accession Version	NM_001101866.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-13
Organism	Bos taurus(cattle)
Product	indoleamine 2,3-dioxygenase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC151535.1. On Aug 31, 2012 this sequence version replaced NM_001101866.1. ##Evidence-Data-START## Transcript exon combination :: BC151535.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145415 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGGTG ACATGTCATC TCCTGTGGAA AATTCATGGA CCATCTTTAA GGAATACCAC 
ATTGATGAAG ACGTAGGCTT TGCTCTTCCA TATCCACTGG AGGACCTACC TCATCCTTAT 
GATGCCTGGA TCTCTATTGC TAGAAATCTG CCTGAACTGA TCAAGAACAA CCAACTACGT 
GTGGAAGTTG AGAAGTTAGC AACGCTCAAC ATTAATGGCC TCCGAGGCCA CAGGGCACAG 
CGCCTGGCAC ACTTGGTTCT GGGATACATC ACGATGGCGT ATGTGTGGGG TCAAGGCGAT 
GGAGACATCC GAAAGGTCTT GCCAAGCAAT ATCGCTGTTC CTTACTGCAA ACTGTCTGAG 
AAGCTGGGAC TGCCTCCTAT TCTACTTTAT GCAGATTGTG TCTTGGCAAA CTGGAAGAAA 
AAGGATCTCA ATGGGCCCAT GACTTATGAG AACATGGACA TTCTGTTCTC ATTTCCTGGT 
GGGGACTGCG GCAAAGGCTT CTTTCTGGTT TCTCTGTTGG TGGAAATAGC AGCTGCCTCT 
GCAATCAAAG TGATCCCCAG TATATTTGAT GCAGTACAAC GTAAAGACTC AGATACTTTG 
CAGAAAGCGC TGCTTGAAAT ATCTTCCAGC CTGCACAAAG CCCTGGAAGT GTTTTCCCAA 
ATTCATAAAT ATGTGGACCC AAACCTATTT TTCAATGTTC TTCGAATATA CTTGTCTGGT 
TGGAAAGGCA ACCCCTTGCT GTCAGAGGGT CTGCTGTATG AAGGCATCTG GGACACCCCA 
AAGAAGTTTG CCGGAGGCAG CGCAGCCCAA AGCAGCATCT TTCAGTGCTT TGATGTTCTC 
CTGGGCATTC AGCACAGTAT TGGTGGAGTC CCTGCAGACT CTGCTGCTGA ATTTCTCCAG 
GAGATGAGAA CATACATGCC ACCAGCTCAC CACAGCTTTC TCCTCTCATT AAAGTCAAAG 
CCCTCGGTCC GTGAGTTTGT TCTTTCAGAA GGCAATGCTA CCCTGCAGGA AATTTACAAT 
AAGTGTGTGC AAGCTATGGT CTCCTTGAGA AACTACCATT TGCAAATAGT AGCTAAATAC 
ATCGTGATTC CTGCAAGGCA GCAACCCCAG GTGGAAGAAA ACTTGGAAGA AGAAAATAGA 
GGAACTGGAG GCACCAATGT CATGGACTTT CTGAAGACTG TAAGAAGTAA AACTAAGAAT 
TCCCTGTTGA AGGAAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001095336.1
CDS	27..1247
Translation	MAGDMSSPVENSWTIFKEYHIDEDVGFALPYPLEDLPHPYDAWISIARNLPELIKNNQLRVEVEKLATLNINGLRGHRAQRLAHLVLGYITMAYVWGQGDGDIRKVLPSNIAVPYCKLSEKLGLPPILLYADCVLANWKKKDLNGPMTYENMDILFSFPGGDCGKGFFLVSLLVEIAAASAIKVIPSIFDAVQRKDSDTLQKALLEISSSLHKALEVFSQIHKYVDPNLFFNVLRIYLSGWKGNPLLSEGLLYEGIWDTPKKFAGGSAAQSSIFQCFDVLLGIQHSIGGVPADSAAEFLQEMRTYMPPAHHSFLLSLKSKPSVREFVLSEGNATLQEIYNKCVQAMVSLRNYHLQIVAKYIVIPARQQPQVEENLEEENRGTGGTNVMDFLKTVRSKTKNSLLKEE

Target ORF information:

RefSeq Version	NM_001101866.2
Organism	Bos taurus(cattle)
Definition	Bos taurus indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001101866.2

ORF Insert Sequence:

ATGGCAGGTG ACATGTCATC TCCTGTGGAA AATTCATGGA CCATCTTTAA GGAATACCAC 
ATTGATGAAG ACGTAGGCTT TGCTCTTCCA TATCCACTGG AGGACCTACC TCATCCTTAT 
GATGCCTGGA TCTCTATTGC TAGAAATCTG CCTGAACTGA TCAAGAACAA CCAACTACGT 
GTGGAAGTTG AGAAGTTAGC AACGCTCAAC ATTAATGGCC TCCGAGGCCA CAGGGCACAG 
CGCCTGGCAC ACTTGGTTCT GGGATACATC ACGATGGCGT ATGTGTGGGG TCAAGGCGAT 
GGAGACATCC GAAAGGTCTT GCCAAGCAAT ATCGCTGTTC CTTACTGCAA ACTGTCTGAG 
AAGCTGGGAC TGCCTCCTAT TCTACTTTAT GCAGATTGTG TCTTGGCAAA CTGGAAGAAA 
AAGGATCTCA ATGGGCCCAT GACTTATGAG AACATGGACA TTCTGTTCTC ATTTCCTGGT 
GGGGACTGCG GCAAAGGCTT CTTTCTGGTT TCTCTGTTGG TGGAAATAGC AGCTGCCTCT 
GCAATCAAAG TGATCCCCAG TATATTTGAT GCAGTACAAC GTAAAGACTC AGATACTTTG 
CAGAAAGCGC TGCTTGAAAT ATCTTCCAGC CTGCACAAAG CCCTGGAAGT GTTTTCCCAA 
ATTCATAAAT ATGTGGACCC AAACCTATTT TTCAATGTTC TTCGAATATA CTTGTCTGGT 
TGGAAAGGCA ACCCCTTGCT GTCAGAGGGT CTGCTGTATG AAGGCATCTG GGACACCCCA 
AAGAAGTTTG CCGGAGGCAG CGCAGCCCAA AGCAGCATCT TTCAGTGCTT TGATGTTCTC 
CTGGGCATTC AGCACAGTAT TGGTGGAGTC CCTGCAGACT CTGCTGCTGA ATTTCTCCAG 
GAGATGAGAA CATACATGCC ACCAGCTCAC CACAGCTTTC TCCTCTCATT AAAGTCAAAG 
CCCTCGGTCC GTGAGTTTGT TCTTTCAGAA GGCAATGCTA CCCTGCAGGA AATTTACAAT 
AAGTGTGTGC AAGCTATGGT CTCCTTGAGA AACTACCATT TGCAAATAGT AGCTAAATAC 
ATCGTGATTC CTGCAAGGCA GCAACCCCAG GTGGAAGAAA ACTTGGAAGA AGAAAATAGA 
GGAACTGGAG GCACCAATGT CATGGACTTT CTGAAGACTG TAAGAAGTAA AACTAAGAAT 
TCCCTGTTGA AGGAAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.
Comparative immunology, microbiology and infectious diseases37(5-6)331-8(2014 Dec)
Palomares RA,Hurley DJ,Woolums AR,Parrish JE,Brock KV

Indoleamine 2,3-dioxygenase, tryptophan catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for chronic mycobacterial infections.
Infection and immunity79(9)3821-32(2011 Sep)
Plain KM,de Silva K,Earl J,Begg DJ,Purdie AC,Whittington RJ

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Indoleamine 2,3-dioxygenase participates in the interferon-gamma-induced cell death process in cultured bovine luteal cells.
Biology of reproduction74(3)552-9(2006 Mar)
Cannon MJ,Pate JL

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IDO1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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