F11 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	F11
Entrez Gene ID	407998
Full Name	coagulation factor XI
Synonyms	FXI
General protein information	Preferred Names coagulation factor XI Names coagulation factor XI PTA blood coagulation factor XI plasma thromboplastin antecedent truncated coagulation factor XI
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008665.1	NP_001008665.1	coagulation factor XI precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	klkb1	XP_004911242.1
Canis lupus familiaris (dog)	F11	NP_001128595.1
Bos taurus (cattle)	F11	NP_001008665.1
Mus musculus (house mouse)	F11	NP_082342.1
Homo sapiens (human)	F11	NP_000119.1
Pan troglodytes (chimpanzee)	F11	XP_001165847.1
Rattus norvegicus (Norway rat)	F11	NP_001041313.1
	F11	XP_001090398.2
Gallus gallus (chicken)	F11	XP_420678.3

Gene Ontology
Bibliography

Related articles in PubMed

A genetic predisposition for bovine neonatal pancytopenia is not due to mutations in coagulation factor XI.
Krappmann K, Weikard R, Gerst S, Wolf C, K?hn Ch
Veterinary journal (London, England : 1997)190(2)225-9(2011 Nov)

Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle.
Gurgul A, Rubis D, Slota E
Journal of applied genetics50(2)149-52(2009)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

DNA extraction from bovine mummified fetuses and detection of factor XI gene deficiency in the mummies.
Ghanem ME, Nishibori M, Nakao T, Moriyoshi M
The Journal of reproduction and development51(3)347-52(2005 Jun)

An insertion mutation of the bovine Fii gene is responsible for factor XI deficiency in Japanese black cattle.
Kunieda M, Tsuji T, Abbasi AR, Khalaj M, Ikeda M, Miyadera K, Ogawa H, Kunieda T
Mammalian genome : official journal of the International Mammalian Genome Society16(5)383-9(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.
Title: A genetic predisposition for bovine neonatal pancytopenia is not due to mutations in coagulation factor XI.

The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene
Title: Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle.

DNA was extracted and amplified from the bovine mummified fetuses, and the samples were successfully tested for Factor XI gene deficiency in the mummies.
Title: DNA extraction from bovine mummified fetuses and detection of factor XI gene deficiency in the mummies.

Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.
Title: An insertion mutation of the bovine Fii gene is responsible for factor XI deficiency in Japanese black cattle.

The following F11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41445	NM_001008665.1 Latest version!	Bos taurus coagulation factor XI (F11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F11 ( NM_001008665.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001008665.1 Bos taurus coagulation factor XI (F11), mRNA.

Price & Availability↑

CloneID	OBa41445
Clone ID Related Accession (Same CDS sequence)	NM_001008665.1
Accession Version	NM_001008665.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	coagulation factor XI precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB196307.1. ##Evidence-Data-START## Transcript exon combination :: AB196307.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145419, SAMN03145420 [ECO:0000348] ##Evidence-Data-END##

ATGACTTTAT TATATCAAAT GGTACATTTC GCTTTATTTG CCTCCGTTGC TGGTGAGTGT 
GTGACCACGC TGTTCCAAGA TGCCTGCTTT AAAGGAGGAG ACATCACTGT GGCTTTCGCG 
CCAAATGCCA AGCACTGCCA AATCATCTGC ACCCACCACC CAAGGTGCTT GCTCTTCACT 
TTTATGACTG AATCATCATC AGAAGATCCT ACCAAGTGGT ATACTTGCAT CCTGAAAGAC 
AGTGTTACAG AAACACTGCC AATGGTGAAT ATGACAGGAG CAATTTCTGG ATATTCTTCC 
AAGCAATGCT TGCACCACAT AAGTGCTTGC AGCAAAGACA TGTATGTGGA CCTAAACATG 
AAGGGGATGA ACTATAACAG CTCCCTTGCC CAGAGCGCTC GGGAATGCCA ACAGAGGTGT 
ACAGACGACA CGCACTGCCA TTTTTTTACA TTCGCCACAA GGCACTTTCC AAGCATAAAG 
GATCGTAACA CTTGTCTGTT GAAGAACACC CAAACAGGGA CACCAACCAG CATAACGAAG 
CTCCACGAAG TGGTATCTGG ATTTTCTTTG AAGTCCTGTG GCCTTTCTAA CCTGGCTTGT 
ATTAGGGACA TTTTCCCCAG AACCGCGTTT GTGGACATCA CCATTGACAC TGTCATGGCC 
CCAGATCCCT TTGTCTGTCG CAGCATCTGT ACTCACCATC CCAGTTGTCT GTTTTTTACC 
TTCTTGTCTG AAGAATGGCC AACAGCATCT GAAAGAAATC TGTGTCTCCT TAAAACATCT 
TCAAGTGGAT TGCCAAGCGC ACGCTTTAGA AAGAACAGAG CTTTTTCTGG TTTTAGTCTA 
CAACACTGCC AGCACAGTGT CCCAGTGTTC TGCCATTCTT CATTCTATCG CAACACTGAT 
TTCTTGGGAG AAGAACTGGA CATCGTAGAC GCGGACAGCC ACGAAGCCTG CCAGAAAACA 
TGTACCAACA GCATCCGCTG CCAGTTCTTT ACCTATTCTC CATCTCAAGA ATCGTGCAAC 
GGAGGGAAGG GTAAATGCTA CTTAAAACTT TCTGCAAATG GATCTCCAAC TAAAATACTT 
CATGGGACAG GAAGCATCTC TGGATACACG TTAAGGTTAT GTAAAATGGA TAATGTGTGT 
ACAACCAAAA TCAAGACCAG AATTGTAGGA GGAACCCAGT CTGTTCACGG AGAGTGGCCG 
TGGCAGATAA CTCTGCACGT GACATCACCC ACCCAGAGAC ACCTGTGTGG AGGCGCCATC 
ATCGGAAACC AGTGGATATT AACAGCTGCT CACTGTTTCA ACGAGGTCAA GTCACCTAAT 
GTGTTGCGTG TCTATAGCGG CATTTTGAAT CAATCAGAAA TAAAAGAGGA TACATCTTTC 
TTTGGGGTTC AAGAAATAAT AATTCATGAT CAATATGAAA AGGCAGAAAG TGGATATGAC 
ATTGCCTTGT TGAAACTAGA AACGGCAATG AATTATACAG ACTCTCAATG GCCCATATGC 
CTACCTTCCA AAGGAGATAG AAATGTAATG TATACTGAAT GCTGGGTGAC CGGATGGGGA 
TACAGAAAAT TAAGAGACAA AATACAGAAT ACTCTCCAGA AAGCCAAGGT ACCCTTGATG 
ACCAATGAAG AATGCCAGGC AGGTTACAGA GAGCACAGAA TAACCAGCAA GATGGTCTGT 
GCAGGCTACA GAGAAGGAGG GAAGGACGCC TGTAAGGGGG ATTCAGGGGG GCCCCTGTCC 
TGTAAGCACA ACGAGGTGTG GCACCTGGTA GGCATCACGA GCTGGGGTGA AGGCTGCGGC 
CAAAGGGAGC GGCCAGGTGT TTACAGCAAC GTGGTCGAGT ATGTGGACTG GATTCTGGAG 
AAAACGCAAG GCCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008665.1
CDS	356..2233
Translation	MTLLYQMVHFALFASVAGECVTTLFQDACFKGGDITVAFAPNAKHCQIICTHHPRCLLFTFMTESSSEDPTKWYTCILKDSVTETLPMVNMTGAISGYSSKQCLHHISACSKDMYVDLNMKGMNYNSSLAQSARECQQRCTDDTHCHFFTFATRHFPSIKDRNTCLLKNTQTGTPTSITKLHEVVSGFSLKSCGLSNLACIRDIFPRTAFVDITIDTVMAPDPFVCRSICTHHPSCLFFTFLSEEWPTASERNLCLLKTSSSGLPSARFRKNRAFSGFSLQHCQHSVPVFCHSSFYRNTDFLGEELDIVDADSHEACQKTCTNSIRCQFFTYSPSQESCNGGKGKCYLKLSANGSPTKILHGTGSISGYTLRLCKMDNVCTTKIKTRIVGGTQSVHGEWPWQITLHVTSPTQRHLCGGAIIGNQWILTAAHCFNEVKSPNVLRVYSGILNQSEIKEDTSFFGVQEIIIHDQYEKAESGYDIALLKLETAMNYTDSQWPICLPSKGDRNVMYTECWVTGWGYRKLRDKIQNTLQKAKVPLMTNEECQAGYREHRITSKMVCAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCGQRERPGVYSNVVEYVDWILEKTQGP

Target ORF information:

RefSeq Version	NM_001008665.1
Organism	Bos taurus(cattle)
Definition	Bos taurus coagulation factor XI (F11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008665.1

ORF Insert Sequence:

ATGACTTTAT TATATCAAAT GGTACATTTC GCTTTATTTG CCTCCGTTGC TGGTGAGTGT 
GTGACCACGC TGTTCCAAGA TGCCTGCTTT AAAGGAGGAG ACATCACTGT GGCTTTCGCG 
CCAAATGCCA AGCACTGCCA AATCATCTGC ACCCACCACC CAAGGTGCTT GCTCTTCACT 
TTTATGACTG AATCATCATC AGAAGATCCT ACCAAGTGGT ATACTTGCAT CCTGAAAGAC 
AGTGTTACAG AAACACTGCC AATGGTGAAT ATGACAGGAG CAATTTCTGG ATATTCTTCC 
AAGCAATGCT TGCACCACAT AAGTGCTTGC AGCAAAGACA TGTATGTGGA CCTAAACATG 
AAGGGGATGA ACTATAACAG CTCCCTTGCC CAGAGCGCTC GGGAATGCCA ACAGAGGTGT 
ACAGACGACA CGCACTGCCA TTTTTTTACA TTCGCCACAA GGCACTTTCC AAGCATAAAG 
GATCGTAACA CTTGTCTGTT GAAGAACACC CAAACAGGGA CACCAACCAG CATAACGAAG 
CTCCACGAAG TGGTATCTGG ATTTTCTTTG AAGTCCTGTG GCCTTTCTAA CCTGGCTTGT 
ATTAGGGACA TTTTCCCCAG AACCGCGTTT GTGGACATCA CCATTGACAC TGTCATGGCC 
CCAGATCCCT TTGTCTGTCG CAGCATCTGT ACTCACCATC CCAGTTGTCT GTTTTTTACC 
TTCTTGTCTG AAGAATGGCC AACAGCATCT GAAAGAAATC TGTGTCTCCT TAAAACATCT 
TCAAGTGGAT TGCCAAGCGC ACGCTTTAGA AAGAACAGAG CTTTTTCTGG TTTTAGTCTA 
CAACACTGCC AGCACAGTGT CCCAGTGTTC TGCCATTCTT CATTCTATCG CAACACTGAT 
TTCTTGGGAG AAGAACTGGA CATCGTAGAC GCGGACAGCC ACGAAGCCTG CCAGAAAACA 
TGTACCAACA GCATCCGCTG CCAGTTCTTT ACCTATTCTC CATCTCAAGA ATCGTGCAAC 
GGAGGGAAGG GTAAATGCTA CTTAAAACTT TCTGCAAATG GATCTCCAAC TAAAATACTT 
CATGGGACAG GAAGCATCTC TGGATACACG TTAAGGTTAT GTAAAATGGA TAATGTGTGT 
ACAACCAAAA TCAAGACCAG AATTGTAGGA GGAACCCAGT CTGTTCACGG AGAGTGGCCG 
TGGCAGATAA CTCTGCACGT GACATCACCC ACCCAGAGAC ACCTGTGTGG AGGCGCCATC 
ATCGGAAACC AGTGGATATT AACAGCTGCT CACTGTTTCA ACGAGGTCAA GTCACCTAAT 
GTGTTGCGTG TCTATAGCGG CATTTTGAAT CAATCAGAAA TAAAAGAGGA TACATCTTTC 
TTTGGGGTTC AAGAAATAAT AATTCATGAT CAATATGAAA AGGCAGAAAG TGGATATGAC 
ATTGCCTTGT TGAAACTAGA AACGGCAATG AATTATACAG ACTCTCAATG GCCCATATGC 
CTACCTTCCA AAGGAGATAG AAATGTAATG TATACTGAAT GCTGGGTGAC CGGATGGGGA 
TACAGAAAAT TAAGAGACAA AATACAGAAT ACTCTCCAGA AAGCCAAGGT ACCCTTGATG 
ACCAATGAAG AATGCCAGGC AGGTTACAGA GAGCACAGAA TAACCAGCAA GATGGTCTGT 
GCAGGCTACA GAGAAGGAGG GAAGGACGCC TGTAAGGGGG ATTCAGGGGG GCCCCTGTCC 
TGTAAGCACA ACGAGGTGTG GCACCTGGTA GGCATCACGA GCTGGGGTGA AGGCTGCGGC 
CAAAGGGAGC GGCCAGGTGT TTACAGCAAC GTGGTCGAGT ATGTGGACTG GATTCTGGAG 
AAAACGCAAG GCCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A genetic predisposition for bovine neonatal pancytopenia is not due to mutations in coagulation factor XI.
Veterinary journal (London, England : 1997)190(2)225-9(2011 Nov)
Krappmann K,Weikard R,Gerst S,Wolf C,K?hn Ch

Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle.
Journal of applied genetics50(2)149-52(2009)
Gurgul A,Rubis D,Slota E

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

DNA extraction from bovine mummified fetuses and detection of factor XI gene deficiency in the mummies.
The Journal of reproduction and development51(3)347-52(2005 Jun)
Ghanem ME,Nishibori M,Nakao T,Moriyoshi M

An insertion mutation of the bovine Fii gene is responsible for factor XI deficiency in Japanese black cattle.
Mammalian genome : official journal of the International Mammalian Genome Society16(5)383-9(2005 May)
Kunieda M,Tsuji T,Abbasi AR,Khalaj M,Ikeda M,Miyadera K,Ogawa H,Kunieda T

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F11 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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