Gene Symbol | LAP |
Entrez Gene ID | 403090 |
Full Name | lingual antimicrobial peptide |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » LAP cDNA ORF clone
Gene Symbol | LAP |
Entrez Gene ID | 403090 |
Full Name | lingual antimicrobial peptide |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_203435.4 | NP_982259.3 | lingual antimicrobial peptide precursor |
Expression of antimicrobial peptides by bovine endothelial cells.
Alva-Murillo N, T?llez-P?rez AD, Sagrero-Cisneros E, L?pez-Meza JE, Ochoa-Zarzosa A
Cellular immunology280(1)108-12(2012 Nov)
The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells.
Yang J, Sang Y, Meade KG, Ross C
Immunogenetics63(11)715-25(2011 Nov)
Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-?B p65 and C/EBP? in mammary epithelial cells.
Liu S, Shi X, Bauer I, G?nther J, Seyfert HM
Molecular immunology48(6-7)895-908(2011 Mar)
Existence of functional lingual antimicrobial peptide in bovine milk.
Isobe N, Nakamura J, Nakano H, Yoshimura Y
Journal of dairy science92(6)2691-5(2009 Jun)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Stimulation of umbilical-vein endothelial cells with S. aureus or LPS induced the expression of lingual antimicrobial peptide. This expression was regulated by the autocrine production of tumor necrosis factor-alpha.
Title: Expression of antimicrobial peptides by bovine endothelial cells.
The results from this study clearly demonstrate the involvement of octamer transcription factor-1 in the regulation of tracheal antimicrobial peptide and lingual antimicrobial peptide expression.
Title: The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells.
The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
Title: Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-?B p65 and C/EBP? in mammary epithelial cells.
LAP was detected in the eluate by competitive enzyme immunoassay and had antimicrobial activity against E. coli
Title: Existence of functional lingual antimicrobial peptide in bovine milk.
The following LAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa95425 | |
Clone ID Related Accession (Same CDS sequence) | NM_203435.4 | |
Accession Version | NM_203435.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 195bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Bos taurus(cattle) | |
Product | lingual antimicrobial peptide precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY911374.1. On May 11, 2016 this sequence version replaced NM_203435.3. ##Evidence-Data-START## Transcript exon combination :: AY911374.1, EV690623.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGGCTCC ATCACCTGCT CCTTGCGCTC CTCTTCCTGG TCCTGTCTGC TGGGTCAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_982259.3 |
CDS | 84..278 |
Translation |
Target ORF information:
Target ORF information:
|
NM_203435.4 |
1 | ATGAGGCTCC ATCACCTGCT CCTTGCGCTC CTCTTCCTGG TCCTGTCTGC TGGGTCAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Expression of antimicrobial peptides by bovine endothelial cells. |
The role of oct-1 in the regulation of tracheal antimicrobial peptide (TAP) and lingual antimicrobial peptide (LAP) expression in bovine mammary epithelial cells. |
Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-?B p65 and C/EBP? in mammary epithelial cells. |
Existence of functional lingual antimicrobial peptide in bovine milk. |
A whole-genome assembly of the domestic cow, Bos taurus. |