MAPK1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MAPK1
Entrez Gene ID	327672
Full Name	mitogen-activated protein kinase 1
Synonyms	ERK2
General protein information	Preferred Names mitogen-activated protein kinase 1 Names mitogen-activated protein kinase 1 ERK-2 ERT1 MAP kinase 1 MAP kinase 2 MAPK 1 MAPK 2 extracellular signal-regulated kinase 2 mitogen-activated protein kinase 2 p42-MAPK
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_175793.2	NP_786987.1	mitogen-activated protein kinase 1

Pathways from BioSystems

Homologies

	MAPK1	XP_001089600.2
Bos taurus (cattle)	MAPK1	NP_786987.1
Gallus gallus (chicken)	MAPK1	NP_989481.1
Caenorhabditis elegans (roundworm)	mpk-1	NP_001022583.1
Oryza sativa (rice)	Os06g0154500	NP_001056846.1
Homo sapiens (human)	MAPK1	NP_002736.3
Canis lupus familiaris (dog)	MAPK1	NP_001104270.1
Rattus norvegicus (Norway rat)	Mapk1	NP_446294.1
Danio rerio (zebrafish)	mapk1	NP_878308.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009207	XP_319983.4
Xenopus tropicalis (tropical clawed frog)	mapk1	NP_001017127.1
Mus musculus (house mouse)	Mapk1	NP_001033752.1
Drosophila melanogaster (fruit fly)	rl	NP_001015122.1
Saccharomyces cerevisiae (baker's yeast)	KSS1	NP_011554.3
Eremothecium gossypii	AGOS_ACL191C	NP_983213.1
Arabidopsis thaliana (thale cress)	MPK6	NP_181907.1
Pan troglodytes (chimpanzee)	MAPK1	XP_515005.2
Kluyveromyces lactis	KLLA0A02497g	XP_451110.1

Gene Ontology
Bibliography

Related articles in PubMed

The effects of demecolcine, alone or in combination with sucrose on bovine oocyte protrusion rate, MAPK1 protein level and c-mos gene expression level.
Gao Y, Ren J, Zhang L, Zhang Y, Wu X, Jiang H, Xu F, Yuan B, Yu X, Zhang J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology34(6)1974-82(2014)

Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis.
Lu LM, Li QZ, Huang JG, Gao XJ
Molecules (Basel, Switzerland)18(1)263-75(2012 Dec)

Endoplasmic reticulum Ca2+ release modulates endothelial nitric-oxide synthase via extracellular signal-regulated kinase (ERK) 1/2-mediated serine 635 phosphorylation.
Xiao Z, Wang T, Qin H, Huang C, Feng Y, Xia Y
The Journal of biological chemistry286(22)20100-8(2011 Jun)

Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
Hartney T, Birari R, Venkataraman S, Villegas L, Martinez M, Black SM, Stenmark KR, Nozik-Grayck E
PloS one6(11)e27531(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The present results suggest that demecolcine might contribute to the activation of the Mos/MAPK pathway and affect spindle structure
Title: The effects of demecolcine, alone or in combination with sucrose on bovine oocyte protrusion rate, MAPK1 protein level and c-mos gene expression level.

MAPK1 upregulated milk protein synthesis through the Stat5 and mTOR pathways.
Title: Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis.

ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Title: Endoplasmic reticulum Ca2+ release modulates endothelial nitric-oxide synthase via extracellular signal-regulated kinase (ERK) 1/2-mediated serine 635 phosphorylation.

Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.
Title: Thrombospondin 1, fibronectin, and vitronectin are differentially dependent upon RAS, ERK1/2, and p38 for induction of vascular smooth muscle cell chemotaxis.

Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
Title: Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.

The following MAPK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAPK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41762	NM_175793.2 Latest version!	Bos taurus mitogen-activated protein kinase 1 (MAPK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MAPK1 ( NM_175793.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_786987.1 Bos taurus mitogen-activated protein kinase 1 (MAPK1), mRNA.

Price & Availability↑

CloneID	OBa41762
Clone ID Related Accession (Same CDS sequence)	NM_175793.2
Accession Version	NM_175793.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Bos taurus(cattle)
Product	mitogen-activated protein kinase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z14089.1. On Jun 3, 2003 this sequence version replaced NM_175793.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z14089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCGG CGGCGGCGGC GGGCGCGGGC CCGGAGATGG TCCGCGGGCA GGTGTTCGAC 
GTGGGGCCGC GCTACACCAA TCTCTCGTAC ATCGGCGAGG GCGCCTACGG CATGGTGTGC 
TCTGCTTATG ACAATGTCAA CAAAGTCCGA GTCGCCATCA AGAAAATCAG CCCTTTTGAG 
CACCAGACGT ACTGCCAGAG AACGCTGAGA GAGATAAAGA TCTTACTGCG CTTCAGACAT 
GAGAACATCA TCGGAATCAA TGACATTATT CGAGCACCGA CCATCGAGCA GATGAAAGAT 
GTGTATATAG TACAGGACCT CATGGAAACA GATCTCTACA AGCTCTTGAA GACGCAACAC 
CTCAGCAACG ACCACATCTG CTATTTTCTC TACCAGATCC TCAGAGGGTT AAAGTATATT 
CATTCAGCCA ACGTGCTGCA CCGTGACCTC AAACCTTCCA ACCTGCTGCT CAACACCACC 
TGCGATCTCA AGATCTGTGA CTTTGGCTTG GCCCGTGTTG CAGATCCAGA CCACGACCAC 
ACAGGGTTCT TGACAGAGTA CGTGGCCACT CGCTGGTACC GGGCTCCAGA AATCATGTTG 
AATTCCAAGG GCTACACCAA GTCCATCGAC ATCTGGTCCG TCGGCTGCAT CCTCGCGGAG 
ATGCTCTCCA ACAGGCCCAT CTTCCCCGGG AAGCACTACC TTGACCAGCT GAACCACATT 
CTGGGTATTC TTGGATCCCC GTCGCAGGAA GACCTGAATT GTATAATAAA TTTAAAAGCT 
AGAAACTACC TGCTCTCTCT TCCACACAAA AATAAGGTGC CATGGAACAG GCTGTTCCCG 
AACGCGGACT CCAAAGCTCT GGATCTACTG GACAAAATGT TGACGTTCAA CCCTCACAAG 
AGGATCGAGG TGGAGCAGGC TCTGGCCCAT CCTTACCTGG AGCAGTACTA CGACCCGAGC 
GATGAGCCCG TCGCCGAAGC ACCCTTCAAG TTTGACATGG AATTGGATGA CTTGCCCAAG 
GAAAAGCTCA AAGAACTCAT TTTTGAAGAG ACTGCTCGAT TCCAGCCGGG ATACCGATCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_786987.1
CDS	156..1238
Translation	MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPVAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

Target ORF information:

RefSeq Version	NM_175793.2
Organism	Bos taurus(cattle)
Definition	Bos taurus mitogen-activated protein kinase 1 (MAPK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175793.2

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC GGGCGCGGGC CCGGAGATGG TCCGCGGGCA GGTGTTCGAC 
GTGGGGCCGC GCTACACCAA TCTCTCGTAC ATCGGCGAGG GCGCCTACGG CATGGTGTGC 
TCTGCTTATG ACAATGTCAA CAAAGTCCGA GTCGCCATCA AGAAAATCAG CCCTTTTGAG 
CACCAGACGT ACTGCCAGAG AACGCTGAGA GAGATAAAGA TCTTACTGCG CTTCAGACAT 
GAGAACATCA TCGGAATCAA TGACATTATT CGAGCACCGA CCATCGAGCA GATGAAAGAT 
GTGTATATAG TACAGGACCT CATGGAAACA GATCTCTACA AGCTCTTGAA GACGCAACAC 
CTCAGCAACG ACCACATCTG CTATTTTCTC TACCAGATCC TCAGAGGGTT AAAGTATATT 
CATTCAGCCA ACGTGCTGCA CCGTGACCTC AAACCTTCCA ACCTGCTGCT CAACACCACC 
TGCGATCTCA AGATCTGTGA CTTTGGCTTG GCCCGTGTTG CAGATCCAGA CCACGACCAC 
ACAGGGTTCT TGACAGAGTA CGTGGCCACT CGCTGGTACC GGGCTCCAGA AATCATGTTG 
AATTCCAAGG GCTACACCAA GTCCATCGAC ATCTGGTCCG TCGGCTGCAT CCTCGCGGAG 
ATGCTCTCCA ACAGGCCCAT CTTCCCCGGG AAGCACTACC TTGACCAGCT GAACCACATT 
CTGGGTATTC TTGGATCCCC GTCGCAGGAA GACCTGAATT GTATAATAAA TTTAAAAGCT 
AGAAACTACC TGCTCTCTCT TCCACACAAA AATAAGGTGC CATGGAACAG GCTGTTCCCG 
AACGCGGACT CCAAAGCTCT GGATCTACTG GACAAAATGT TGACGTTCAA CCCTCACAAG 
AGGATCGAGG TGGAGCAGGC TCTGGCCCAT CCTTACCTGG AGCAGTACTA CGACCCGAGC 
GATGAGCCCG TCGCCGAAGC ACCCTTCAAG TTTGACATGG AATTGGATGA CTTGCCCAAG 
GAAAAGCTCA AAGAACTCAT TTTTGAAGAG ACTGCTCGAT TCCAGCCGGG ATACCGATCT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The effects of demecolcine, alone or in combination with sucrose on bovine oocyte protrusion rate, MAPK1 protein level and c-mos gene expression level.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology34(6)1974-82(2014)
Gao Y,Ren J,Zhang L,Zhang Y,Wu X,Jiang H,Xu F,Yuan B,Yu X,Zhang J

Proteomic and functional analyses reveal MAPK1 regulates milk protein synthesis.
Molecules (Basel, Switzerland)18(1)263-75(2012 Dec)
Lu LM,Li QZ,Huang JG,Gao XJ

Endoplasmic reticulum Ca2+ release modulates endothelial nitric-oxide synthase via extracellular signal-regulated kinase (ERK) 1/2-mediated serine 635 phosphorylation.
The Journal of biological chemistry286(22)20100-8(2011 Jun)
Xiao Z,Wang T,Qin H,Huang C,Feng Y,Xia Y

Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
PloS one6(11)e27531(2011)
Hartney T,Birari R,Venkataraman S,Villegas L,Martinez M,Black SM,Stenmark KR,Nozik-Grayck E

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MAPK1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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