ANXA1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANXA1
Entrez Gene ID	327662
Full Name	annexin A1
Synonyms	p35
General protein information	Preferred Names annexin A1 Names annexin A1 annexin I annexin-1 calpactin II calpactin-2 chromobindin-9 lipocortin I phospholipase A2 inhibitory protein
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_175784.3	NP_786978.2	annexin A1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Anxa1	NP_034860.2
Danio rerio (zebrafish)	anxa1a	NP_861423.1
Xenopus tropicalis (tropical clawed frog)	anxa1	NP_001006702.1
Bos taurus (cattle)	ANXA1	NP_786978.2
Rattus norvegicus (Norway rat)	Anxa1	NP_037036.1
Gallus gallus (chicken)	ANXA1	NP_996789.1
Homo sapiens (human)	ANXA1	NP_000691.1
Canis lupus familiaris (dog)	ANXA1	XP_533524.2
Pan troglodytes (chimpanzee)	ANXA1	NP_001092037.1
	ANXA1	XP_001098693.2

Gene Ontology
Bibliography

Related articles in PubMed

Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.
Senthilkumaran C, Hewson J, Ollivett TL, Bienzle D, Lillie BN, Clark M, Caswell JL
Veterinary research466(2015 Feb)

Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.
Senthilkumaran C, Clark ME, Abdelaziz K, Bateman KG, MacKay A, Hewson J, Caswell JL
Veterinary research4424(2013 Apr)

Ubiquitination and SUMOylation of annexin A1 and helicase activity.
Hirata F, Thibodeau LM, Hirata A
Biochimica et biophysica acta1800(9)899-905(2010 Sep)

Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines.
Talbot NC, Powell AM, Caperna TJ, Garrett WM
Animal reproduction science120(1-4)187-202(2010 Jul)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Annexins A1 and A2 are proteins produced by airway epithelial cells that may prevent inflammation in the healthy lung and be relevant to development of pneumonia in stressed cattle.
Title: Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.

Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle.
Title: Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.

Ubiquitination of annexin A1 may play an important role in mutagenesis, an initial step of cell transformation.
Title: Ubiquitination and SUMOylation of annexin A1 and helicase activity.

Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer)trophectoderm may be related to the frequent failures of NT pregnancies.
Title: Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines.

The following ANXA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANXA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42861	NM_175784.3 Latest version!	Bos taurus annexin A1 (ANXA1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANXA1 ( NM_175784.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_786978.2 Bos taurus annexin A1 (ANXA1), mRNA.

Price & Availability↑

CloneID	OBa42861
Clone ID Related Accession (Same CDS sequence)	NM_175784.3
Accession Version	NM_175784.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	annexin A1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC103375.1. On Aug 28, 2005 this sequence version replaced NM_175784.2. ##Evidence-Data-START## Transcript exon combination :: BC103375.1, BT021501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGGCAATGG TATCTGAATT CCTCAAGCAG GCCTGGTTTA TTGAAAATGA AGAGCAGGAA 
TACATTAAAA CGGTGAAAGG ATCCAAAGGT GGTCCTGGGT CAGCAGTGAG CCCCTATCCT 
ACGTTCAATC CATCCTCGGA TGTTGAGGCC TTGCACAAAG CAATCACAGT TAAAGGTGTG 
GATGAAGCAA CCATCATTGA AATTCTGACT AAGAGAAACA ATGCACAGCG TCAGCAGATC 
AAAGCGGCCT ATCTGCAGGA GAAAGGAAAG CCCCTGGATG AAGTTCTGAA GAAAGCCCTC 
CTCGGTCACC TTGAGGAAGT TGTTTTGGCT CTATTGAAAA CTCCAGCCCA GTTTGATGCC 
GAAGAGCTCC GTGCTGCCAT GAAGGGCCTT GGGACTGATG AAGACACTCT GAATGAAATT 
CTGGCATCAA GAACTAACAG AGAGATCAGA GAAATTAACA GAGTCTATAG AGAAGAACTG 
AAGAGAGATC TGGCTAAAGA CATCGCCTCA GACACATCTG GAGATTATGA GAAGGCTTTG 
CTTTCTCTTG CTAAGGGTGA CCGATCCGAG GAGCTTGCTG TAAATGACGA CTTGGCTGAT 
TCAGATGCCA GGGCCTTATA TGAAGCAGGA GAAAGAAGAA AAGGGACAGA TGTGAATGTG 
TTCATTACCA TTCTTACCAC CAGGAGCTAT CCCCATCTCC GCAGAGTGTT TCAGAAATAT 
TCCAAGTATA GCAAGCATGA CATGAACAAA GTTCTGGACC TGGAGTTGAA AGGTGACATC 
GAGAAATGCC TCACAGTTAT TGTGAAGTGT GCTACAAGCC AGCCAATGTT CTTTGCTGAG 
AAGCTCCATC AGGCCATGAA GGGTATTGGA ACTCGTCATA AGACACTGAT CAGGATTATG 
GTTTCCCGCT CTGAAATTGA CATGAATGAC ATCAAAGCAT GCTATCAGAA GTTGTATGGC 
ATCTCTCTCT GTCAAGCCAT CCTGGATGAA ACCAAAGGAG ATTATGAAAA AATCCTGGTG 
GCTCTCTGTG GAAGAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_786978.2
CDS	78..1118
Translation	MAMVSEFLKQAWFIENEEQEYIKTVKGSKGGPGSAVSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKALLGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNREIREINRVYREELKRDLAKDIASDTSGDYEKALLSLAKGDRSEELAVNDDLADSDARALYEAGERRKGTDVNVFITILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIEKCLTVIVKCATSQPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEKILVALCGRD

Target ORF information:

RefSeq Version	NM_175784.3
Organism	Bos taurus(cattle)
Definition	Bos taurus annexin A1 (ANXA1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175784.3

ORF Insert Sequence:

ATGGCAATGG TATCTGAATT CCTCAAGCAG GCCTGGTTTA TTGAAAATGA AGAGCAGGAA 
TACATTAAAA CGGTGAAAGG ATCCAAAGGT GGTCCTGGGT CAGCAGTGAG CCCCTATCCT 
ACGTTCAATC CATCCTCGGA TGTTGAGGCC TTGCACAAAG CAATCACAGT TAAAGGTGTG 
GATGAAGCAA CCATCATTGA AATTCTGACT AAGAGAAACA ATGCACAGCG TCAGCAGATC 
AAAGCGGCCT ATCTGCAGGA GAAAGGAAAG CCCCTGGATG AAGTTCTGAA GAAAGCCCTC 
CTCGGTCACC TTGAGGAAGT TGTTTTGGCT CTATTGAAAA CTCCAGCCCA GTTTGATGCC 
GAAGAGCTCC GTGCTGCCAT GAAGGGCCTT GGGACTGATG AAGACACTCT GAATGAAATT 
CTGGCATCAA GAACTAACAG AGAGATCAGA GAAATTAACA GAGTCTATAG AGAAGAACTG 
AAGAGAGATC TGGCTAAAGA CATCGCCTCA GACACATCTG GAGATTATGA GAAGGCTTTG 
CTTTCTCTTG CTAAGGGTGA CCGATCCGAG GAGCTTGCTG TAAATGACGA CTTGGCTGAT 
TCAGATGCCA GGGCCTTATA TGAAGCAGGA GAAAGAAGAA AAGGGACAGA TGTGAATGTG 
TTCATTACCA TTCTTACCAC CAGGAGCTAT CCCCATCTCC GCAGAGTGTT TCAGAAATAT 
TCCAAGTATA GCAAGCATGA CATGAACAAA GTTCTGGACC TGGAGTTGAA AGGTGACATC 
GAGAAATGCC TCACAGTTAT TGTGAAGTGT GCTACAAGCC AGCCAATGTT CTTTGCTGAG 
AAGCTCCATC AGGCCATGAA GGGTATTGGA ACTCGTCATA AGACACTGAT CAGGATTATG 
GTTTCCCGCT CTGAAATTGA CATGAATGAC ATCAAAGCAT GCTATCAGAA GTTGTATGGC 
ATCTCTCTCT GTCAAGCCAT CCTGGATGAA ACCAAAGGAG ATTATGAAAA AATCCTGGTG 
GCTCTCTGTG GAAGAGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.
Veterinary research466(2015 Feb)
Senthilkumaran C,Hewson J,Ollivett TL,Bienzle D,Lillie BN,Clark M,Caswell JL

Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.
Veterinary research4424(2013 Apr)
Senthilkumaran C,Clark ME,Abdelaziz K,Bateman KG,MacKay A,Hewson J,Caswell JL

Ubiquitination and SUMOylation of annexin A1 and helicase activity.
Biochimica et biophysica acta1800(9)899-905(2010 Sep)
Hirata F,Thibodeau LM,Hirata A

Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines.
Animal reproduction science120(1-4)187-202(2010 Jul)
Talbot NC,Powell AM,Caperna TJ,Garrett WM

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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ANXA1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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