PGRMC1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	PGRMC1
Entrez Gene ID	317706
Full Name	progesterone receptor membrane component 1
Synonyms	mPR
General protein information	Preferred Names progesterone receptor membrane component 1 Names membrane-associated progesterone receptor component 1
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001075133.1	NP_001068601.1	membrane-associated progesterone receptor component 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PGRMC1	NP_006658.1
	PGRMC1	XP_002806413.1
Bos taurus (cattle)	PGRMC1	NP_001068601.1
Mus musculus (house mouse)	Pgrmc1	NP_058063.2
Gallus gallus (chicken)	PGRMC1	NP_001258868.1
Eremothecium gossypii	AGOS_AAL106W	NP_982436.1
Magnaporthe oryzae (rice blast fungus)	MGG_00274	XP_003718823.1
Neurospora crassa	NCU07286	XP_962140.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000767	XP_311303.4
Schizosaccharomyces pombe (fission yeast)	dap1	NP_594461.1
Rattus norvegicus (Norway rat)	Pgrmc1	NP_068534.1
Saccharomyces cerevisiae (baker's yeast)	DAP1	NP_015155.1
Kluyveromyces lactis	KLLA0C09757g	XP_452633.1
Caenorhabditis elegans (roundworm)	vem-1	NP_001024769.1
Xenopus tropicalis (tropical clawed frog)	pgrmc1	NP_001006842.1
Canis lupus familiaris (dog)	PGRMC1	NP_001182077.1
Danio rerio (zebrafish)	pgrmc1	NP_001007393.1
Drosophila melanogaster (fruit fly)	MSBP	NP_001162765.1

Gene Ontology
Bibliography

Related articles in PubMed

PGRMC1 participates in late events of bovine granulosa cells mitosis and oocyte meiosis.
Terzaghi L, Tessaro I, Raucci F, Merico V, Mazzini G, Garagna S, Zuccotti M, Franciosi F, Lodde V
Cell cycle (Georgetown, Tex.)15(15)2019-32(2016 Aug)

Expression and cellular distribution of estrogen and progesterone receptors and the real-time proliferation of porcine cumulus cells.
Kempisty B, Zi??kowska A, Ciesi??ka S, Piotrowska H, Antosik P, Bukowska D, Br?ssow KP, Nowicki M, Zabel M
Zygote (Cambridge, England)23(6)836-45(2015 Dec)

Expression and localization of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 in the bovine corpus luteum during the estrous cycle and the first trimester of pregnancy.
Kowalik MK, Rekawiecki R, Kotwica J
Theriogenology82(8)1086-93(2014 Nov)

Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.
Luciano AM, Franciosi F, Lodde V, Tessaro I, Corbani D, Modina SC, Peluso JJ
Biology of reproduction88(3)58(2013 Mar)

Expression of progesterone receptor membrane component (PGRMC) 1 and 2, serpine mRNA binding protein 1 (SERBP1) and nuclear progesterone receptor (PGR) in the bovine endometrium during the estrous cycle and the first trimester of pregnancy.
Kowalik MK, Slonina D, Rekawiecki R, Kotwica J
Reproductive biology13(1)15-23(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PGRMC1 participates in late events of both mammalian mitosis and oocyte meiosis, consistent with PGRMC1's localization at the mid-zone and mid-body of the mitotic and meiotic spindle.
Title: PGRMC1 participates in late events of bovine granulosa cells mitosis and oocyte meiosis.

PGRMC1 protein expression and cellular distribution in cumulus cells
Title: Expression and cellular distribution of estrogen and progesterone receptors and the real-time proliferation of porcine cumulus cells.

data indicate variable expression of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 mRNA and protein in bovine corpus luteum and suggest that progesterone may regulate corpus luteum function via its membrane receptors
Title: Expression and localization of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 in the bovine corpus luteum during the estrous cycle and the first trimester of pregnancy.

Alterations in PGRMC1 and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
Title: Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.

endometrial mRNA level elevated during pregnancy is unchanged during estrous cycle
Title: Expression of progesterone receptor membrane component (PGRMC) 1 and 2, serpine mRNA binding protein 1 (SERBP1) and nuclear progesterone receptor (PGR) in the bovine endometrium during the estrous cycle and the first trimester of pregnancy.

The following PGRMC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGRMC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41252	NM_001075133.1 Latest version!	Bos taurus progesterone receptor membrane component 1 (PGRMC1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PGRMC1 ( NM_001075133.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001068601.1 Bos taurus progesterone receptor membrane component 1 (PGRMC1), mRNA.

Price & Availability↑

CloneID	OBa41252
Clone ID Related Accession (Same CDS sequence)	NM_001075133.1
Accession Version	NM_001075133.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	membrane-associated progesterone receptor component 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC118444.1. On or before Oct 4, 2006 this sequence version replaced XM_612500.2, XM_874120.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC118444.1, DV883019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCCG AGGATGTGGC GGCGACCGGC GCAGACACGA GCGAGCTCGA GAGCGGCGGG 
CTGCTGCAAG AGATTTTCAC GTCGCCGCTC AACCTGCTGC TCCTTGGCCT TTGCATCTTT 
CTGCTCTACA AGATCGTGCG CGGGGACCAG CCGGCGGCCA GCGATAGCGA CGACGACGAG 
CCGCCCCCGC TGCCCCGCCT TAAGCGGCGC GACTTCACCC CTGCCGAGCT GCGGCGCTTC 
GACGGCGTAC AGGACCCGCG TATACTCATG GCCATCAATG GCAAGGTGTT CGACGTAACC 
AAAGGCCGCA AGTTCTACGG GCCTGAGGGG CCGTATGGAG TCTTTGCTGG AAGAGATGCA 
TCCAGAGGCC TTGCCACCTT TTGCCTGGAT AAGGAAGCGC TGAAGGATGA GTACGATGAC 
CTTTCCGACC TCACTCCTGC CCAGCAGGAG ACCCTGAGTG ACTGGGACTC TCAGTTCACT 
TTCAAGTACC ATCATGTGGG CAAACTGCTG AAGGACGGGG AGGAGCCCAC CGTGTACTCA 
GACAAGGAGG AGCCAAAAGA TGAGAGCACT CGGAAGAATG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001068601.1
CDS	77..661
Translation	MAAEDVAATGADTSELESGGLLQEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLSDWDSQFTFKYHHVGKLLKDGEEPTVYSDKEEPKDESTRKND

Target ORF information:

RefSeq Version	NM_001075133.1
Organism	Bos taurus(cattle)
Definition	Bos taurus progesterone receptor membrane component 1 (PGRMC1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001075133.1

ORF Insert Sequence:

ATGGCTGCCG AGGATGTGGC GGCGACCGGC GCAGACACGA GCGAGCTCGA GAGCGGCGGG 
CTGCTGCAAG AGATTTTCAC GTCGCCGCTC AACCTGCTGC TCCTTGGCCT TTGCATCTTT 
CTGCTCTACA AGATCGTGCG CGGGGACCAG CCGGCGGCCA GCGATAGCGA CGACGACGAG 
CCGCCCCCGC TGCCCCGCCT TAAGCGGCGC GACTTCACCC CTGCCGAGCT GCGGCGCTTC 
GACGGCGTAC AGGACCCGCG TATACTCATG GCCATCAATG GCAAGGTGTT CGACGTAACC 
AAAGGCCGCA AGTTCTACGG GCCTGAGGGG CCGTATGGAG TCTTTGCTGG AAGAGATGCA 
TCCAGAGGCC TTGCCACCTT TTGCCTGGAT AAGGAAGCGC TGAAGGATGA GTACGATGAC 
CTTTCCGACC TCACTCCTGC CCAGCAGGAG ACCCTGAGTG ACTGGGACTC TCAGTTCACT 
TTCAAGTACC ATCATGTGGG CAAACTGCTG AAGGACGGGG AGGAGCCCAC CGTGTACTCA 
GACAAGGAGG AGCCAAAAGA TGAGAGCACT CGGAAGAATG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PGRMC1 participates in late events of bovine granulosa cells mitosis and oocyte meiosis.
Cell cycle (Georgetown, Tex.)15(15)2019-32(2016 Aug)
Terzaghi L,Tessaro I,Raucci F,Merico V,Mazzini G,Garagna S,Zuccotti M,Franciosi F,Lodde V

Expression and cellular distribution of estrogen and progesterone receptors and the real-time proliferation of porcine cumulus cells.
Zygote (Cambridge, England)23(6)836-45(2015 Dec)
Kempisty B,Zi??kowska A,Ciesi??ka S,Piotrowska H,Antosik P,Bukowska D,Br?ssow KP,Nowicki M,Zabel M

Expression and localization of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 in the bovine corpus luteum during the estrous cycle and the first trimester of pregnancy.
Theriogenology82(8)1086-93(2014 Nov)
Kowalik MK,Rekawiecki R,Kotwica J

Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.
Biology of reproduction88(3)58(2013 Mar)
Luciano AM,Franciosi F,Lodde V,Tessaro I,Corbani D,Modina SC,Peluso JJ

Expression of progesterone receptor membrane component (PGRMC) 1 and 2, serpine mRNA binding protein 1 (SERBP1) and nuclear progesterone receptor (PGR) in the bovine endometrium during the estrous cycle and the first trimester of pregnancy.
Reproductive biology13(1)15-23(2013 Mar)
Kowalik MK,Slonina D,Rekawiecki R,Kotwica J

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PGRMC1 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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