Gene Symbol | DEFB4A |
Entrez Gene ID | 286836 |
Full Name | defensin, beta 4A |
Synonyms | BNBD-4,BNBD4,DEFB4 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » DEFB4A cDNA ORF clone
Gene Symbol | DEFB4A |
Entrez Gene ID | 286836 |
Full Name | defensin, beta 4A |
Synonyms | BNBD-4,BNBD4,DEFB4 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_010820225.1 | XP_010818527.1 | beta-defensin 4 isoform X1 |
NM_174775.1 | NP_777200.1 | beta-defensin 4 precursor |
Multiple ?-defensin genes are upregulated by the vitamin D pathway in cattle.
Merriman KE, Kweh MF, Powell JL, Lippolis JD, Nelson CD
The Journal of steroid biochemistry and molecular biology154120-9(2015 Nov)
Antimicrobial activity of recombinant mature bovine neutrophil ?-defensin 4 on mycobacterial infection.
Kang JJ, Lyu Y, Zhao DM, Tian LH, Yin XM, Yang LF, Teng KD, Zhou XM
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease19(6)711-6(2015 Jun)
Expression of antimicrobial peptides by bovine endothelial cells.
Alva-Murillo N, T?llez-P?rez AD, Sagrero-Cisneros E, L?pez-Meza JE, Ochoa-Zarzosa A
Cellular immunology280(1)108-12(2012 Nov)
The polymorphism in the beta4-defensin gene and its association with production and somatic cell count in Holstein-Friesian cows.
Bagnicka E, Strza?kowska N, Flisikowski K, Szreder T, J??wik A, Prusak B, Krzyzewski J, Zwierzchowski L
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie124(3)150-6(2007 Jun)
Cloning and expression of bovine neutrophil beta-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules.
Yount NY, Yuan J, Tarver A, Castro T, Diamond G, Tran PA, Levy JN, McCullough C, Cullor JS, Bevins CL, Selsted ME
The Journal of biological chemistry274(37)26249-58(1999 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Bovine DEFB4 mRNA is upregulated by lipopolysaccharide in bovine neutrophils and mammary epithelial cells and by 1,25-dihydroxyvitamin D3 in bovine monocytes and mammary epithelial cells.
Title: Multiple ?-defensin genes are upregulated by the vitamin D pathway in cattle.
Recombinant mature bovine neutrophil beta-defensin 4 inhibits mycobacterial growth and controls intracellular survival of mycobacteria.
Title: Antimicrobial activity of recombinant mature bovine neutrophil ?-defensin 4 on mycobacterial infection.
Stimulation of umbilical-vein endothelial cells with S. aureus or LPS induced the expression of bovine neutrophil beta-defensin 4. This expression was regulated by the autocrine production of tumor necrosis factor-alpha.
Title: Expression of antimicrobial peptides by bovine endothelial cells.
The isolation of polymorphisms of BNBD-4 and milk production and somatic cell count are reported.
Title: The polymorphism in the beta4-defensin gene and its association with production and somatic cell count in Holstein-Friesian cows.
The following DEFB4A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFB4A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa41594 | |
Clone ID Related Accession (Same CDS sequence) | NM_174775.1 | |
Accession Version | NM_174775.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 192bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Bos taurus(cattle) | |
Product | beta-defensin 4 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U36200.1. ##Evidence-Data-START## Transcript exon combination :: U36200.1, FE017659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145415, SAMN03145424 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGGCTCC ATCACCTGCT CCTCGCAGTC CTCTTCCTGG TCCTGTCTGC TGGGTCAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_777200.1 |
CDS | 136..327 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGGCTCC ATCACCTGCT CCTCGCAGTC CTCTTCCTGG TCCTGTCTGC TGGGTCAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa45520 | |
Clone ID Related Accession (Same CDS sequence) | XM_010820225.1 | |
Accession Version | XM_010820225.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | beta-defensin 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104596.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 9% of CDS bases ##RefSeq-Attributes-END## |
1 | ATGGCTGTCT CTGTGGATGC TGGGAGTCTT GCCCCTGCTT TGTGCTATAA AGGCCACTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_010818527.1 |
CDS | 1..477 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGTCT CTGTGGATGC TGGGAGTCTT GCCCCTGCTT TGTGCTATAA AGGCCACTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Multiple ?-defensin genes are upregulated by the vitamin D pathway in cattle. |
Antimicrobial activity of recombinant mature bovine neutrophil ?-defensin 4 on mycobacterial infection. |
Expression of antimicrobial peptides by bovine endothelial cells. |
The polymorphism in the beta4-defensin gene and its association with production and somatic cell count in Holstein-Friesian cows. |
Cloning and expression of bovine neutrophil beta-defensins. Biosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules. |