SERPINA3-1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	SERPINA3-1
Entrez Gene ID	286804
Full Name	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Synonyms	SERPINA3
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174768.2	NP_777193.2	serpin A3-1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SERPINA3-7	NP_001012283.2
Bos taurus (cattle)	LOC784932	XP_002696874.1
Bos taurus (cattle)	SERPINA3	XP_005222351.1
Mus musculus (house mouse)	Serpina3n	NP_033278.2
Homo sapiens (human)	SERPINA3	NP_001076.2
Bos taurus (cattle)	SERPINA3-1	NP_777193.2
Bos taurus (cattle)	SERPINA3-3	NP_001033293.1
Mus musculus (house mouse)	Serpina3c	NP_032484.1
Pan troglodytes (chimpanzee)	SERPINA3	XP_510145.2
Mus musculus (house mouse)	Serpina3k	NP_035588.2
Mus musculus (house mouse)	Serpina3m	NP_033279.2
Rattus norvegicus (Norway rat)	Serpina3n	NP_113719.1
	SERPINA3	XP_001096947.2
Canis lupus familiaris (dog)	SERPINA3	XP_005623829.1
Bos taurus (cattle)	SERPINA3-8	NP_001075181.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3.
Herrera-Mendez CH, Becila S, Blanchet X, Pelissier P, Delourme D, Coulis G, Sentandreu MA, Boudjellal A, Bremaud L, Ouali A
FEBS letters583(17)2743-8(2009 Sep)

Muscle endopin 1, a muscle intracellular serpin which strongly inhibits elastase: purification, characterization, cellular localization and tissue distribution.
Tassy C, Herrera-Mendez CH, Sentandreu MA, Aubry L, Br?maud L, P?lissier P, Delourme D, Brillard M, Gauthier F, Lev?ziel H, Ouali A
The Biochemical journal388(Pt 1)273-80(2005 May)

Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1.
Hwang SR, Steineckert B, Yasothornsrikul S, Sei CA, Toneff T, Rattan J, Hook VY
The Journal of biological chemistry274(48)34164-73(1999 Nov)

Unique reactive site domains of neuroendocrine isoforms of alpha 1-antichymotrypsin from bovine adrenal medulla and pituitary revealed by molecular cloning.
Hwang SR, Kohn AB, Hook VY
FEBS letters368(3)471-6(1995 Jul)

Molecular cloning reveals isoforms of bovine alpha 1-antichymotrypsin.
Hwang SR, Kohn AB, Hook VY
Proceedings of the National Academy of Sciences of the United States of America91(20)9579-83(1994 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data demonstrate the strong inhibition of human initiator and effector caspases 3 and 8 by bovine SERPINA3-1 and A3-3.
Title: Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3.

The isolation and characterization of muscle endopin 1 are reported.
Title: Muscle endopin 1, a muscle intracellular serpin which strongly inhibits elastase: purification, characterization, cellular localization and tissue distribution.

The following SERPINA3-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINA3-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41313	NM_174768.2 Latest version!	Bos taurus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SERPINA3-1 ( NM_174768.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777193.2 Bos taurus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3-1), mRNA.

Price & Availability↑

CloneID	OBa41313
Clone ID Related Accession (Same CDS sequence)	NM_174768.2
Accession Version	NM_174768.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1236bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Bos taurus(cattle)
Product	serpin A3-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF125526.2. On Jun 3, 2003 this sequence version replaced NM_174768.1. ##Evidence-Data-START## Transcript exon combination :: AF125526.2, DV789391.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145427, SAMN04019641 [ECO:0000348] ##Evidence-Data-END##

ATGAGGGCAG AGAGAACTTC CTTCCTCCTG GCCCTGGGGC TCCTGGTGGC TGGGATCCCG 
AGTGTCCACT GCCTCCCAGA AAATGTGGTG GTGAAGGACC AGCACAGAAG GGTGGATGGC 
CACACGTTAG CCTCCAGCAA CACTGACTTC GCCTTCAGCC TCTACAAGCA GTTGCCTTTG 
AAGAACCCCA ATAAGAATGT CATCTTATCC CCGCTGAGTG TCTCCATAGC CTTGGCCTTC 
CTGTCCCTGG GGGCCCGTGG CTCCACCCTG ACAGAGATCC TCGAAGGTCT GAAGTTCAAC 
CTCACAGAGA TCCAGGAGAA AGAAATACAC CATAGCTTTC AGCACCTCCT GCAGGCGCTC 
AATCAACCCA GCAACCAGCT GCAGCTGAGC GTGGGCAACG CCATGTTCGT GCAGGAGGAG 
CTGAAGCTGC TGGACAAGTT CATAGAAGAT GCCCAGGTGC TGTACTCCTC TGAGGCCTTC 
CCGACCAACT TCAGGGATTC TGAAGCTGCC AGGAGTCTAA TAAATGACTA TGTGAAGAAT 
AAAACCCAGG GGAAAATTGA AGAGCTGTTC AAGTACCTTT CCCCGAGAAC AGAGTTGGTG 
CTAGTGAATT ACATCTACTT TAAAGCCCAA TGGAAGACCC CCTTTGACCC CAAACACACT 
GAGCAGGCAG AGTTCCACGT GAGCGACAAC AAGACGGTGG AGGTGCCCAT GATGACCCTT 
GACCTGGAAA CCCCTTACTT CCGGGACGAG GAGCTGGGCT GCACGCTGGT GGAGCTCACG 
TACACCAGCA ACGACAGCGC CCTCTTCATC CTCCCCGACG AGGGCAAAAT GCGGGACCTG 
GAAGCCAAGC TGACCCCGGA GACGCTGACG AGGTGGCGAA ACTCCCTGCA GCCCAGACGA 
ATACATGAAC TCTACCTGCC AAAATTTTCC ATCAAAAGCA ACTATGAACT GAATGACATC 
CTCTCCCAGC TGGGCATTAG GAAAATATTT GCCAACGCTG ACTTGTCAGG AATCACAGGG 
ACCGCGGACC TGGTAGTCTC CCAGGTGGTC CACGGCGCTG CGCTGGACGT GGACGAGGAG 
GGCACGGAAG GAGCTGCTGC CACGGGAATC AGCATGGAAA GAACGATCTT GAGAATCATT 
GTGCGTGTCA ACAGGCCCTT CCTGATTGCC ATAGTTCTCA AAGACACCCA GAGCATCATC 
TTTTTGGGGA AAGTCACCAA CCCCAGTGAA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777193.2
CDS	25..1260
Translation	MRAERTSFLLALGLLVAGIPSVHCLPENVVVKDQHRRVDGHTLASSNTDFAFSLYKQLPLKNPNKNVILSPLSVSIALAFLSLGARGSTLTEILEGLKFNLTEIQEKEIHHSFQHLLQALNQPSNQLQLSVGNAMFVQEELKLLDKFIEDAQVLYSSEAFPTNFRDSEAARSLINDYVKNKTQGKIEELFKYLSPRTELVLVNYIYFKAQWKTPFDPKHTEQAEFHVSDNKTVEVPMMTLDLETPYFRDEELGCTLVELTYTSNDSALFILPDEGKMRDLEAKLTPETLTRWRNSLQPRRIHELYLPKFSIKSNYELNDILSQLGIRKIFANADLSGITGTADLVVSQVVHGAALDVDEEGTEGAAATGISMERTILRIIVRVNRPFLIAIVLKDTQSIIFLGKVTNPSEA

Target ORF information:

RefSeq Version	NM_174768.2
Organism	Bos taurus(cattle)
Definition	Bos taurus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174768.2

ORF Insert Sequence:

ATGAGGGCAG AGAGAACTTC CTTCCTCCTG GCCCTGGGGC TCCTGGTGGC TGGGATCCCG 
AGTGTCCACT GCCTCCCAGA AAATGTGGTG GTGAAGGACC AGCACAGAAG GGTGGATGGC 
CACACGTTAG CCTCCAGCAA CACTGACTTC GCCTTCAGCC TCTACAAGCA GTTGCCTTTG 
AAGAACCCCA ATAAGAATGT CATCTTATCC CCGCTGAGTG TCTCCATAGC CTTGGCCTTC 
CTGTCCCTGG GGGCCCGTGG CTCCACCCTG ACAGAGATCC TCGAAGGTCT GAAGTTCAAC 
CTCACAGAGA TCCAGGAGAA AGAAATACAC CATAGCTTTC AGCACCTCCT GCAGGCGCTC 
AATCAACCCA GCAACCAGCT GCAGCTGAGC GTGGGCAACG CCATGTTCGT GCAGGAGGAG 
CTGAAGCTGC TGGACAAGTT CATAGAAGAT GCCCAGGTGC TGTACTCCTC TGAGGCCTTC 
CCGACCAACT TCAGGGATTC TGAAGCTGCC AGGAGTCTAA TAAATGACTA TGTGAAGAAT 
AAAACCCAGG GGAAAATTGA AGAGCTGTTC AAGTACCTTT CCCCGAGAAC AGAGTTGGTG 
CTAGTGAATT ACATCTACTT TAAAGCCCAA TGGAAGACCC CCTTTGACCC CAAACACACT 
GAGCAGGCAG AGTTCCACGT GAGCGACAAC AAGACGGTGG AGGTGCCCAT GATGACCCTT 
GACCTGGAAA CCCCTTACTT CCGGGACGAG GAGCTGGGCT GCACGCTGGT GGAGCTCACG 
TACACCAGCA ACGACAGCGC CCTCTTCATC CTCCCCGACG AGGGCAAAAT GCGGGACCTG 
GAAGCCAAGC TGACCCCGGA GACGCTGACG AGGTGGCGAA ACTCCCTGCA GCCCAGACGA 
ATACATGAAC TCTACCTGCC AAAATTTTCC ATCAAAAGCA ACTATGAACT GAATGACATC 
CTCTCCCAGC TGGGCATTAG GAAAATATTT GCCAACGCTG ACTTGTCAGG AATCACAGGG 
ACCGCGGACC TGGTAGTCTC CCAGGTGGTC CACGGCGCTG CGCTGGACGT GGACGAGGAG 
GGCACGGAAG GAGCTGCTGC CACGGGAATC AGCATGGAAA GAACGATCTT GAGAATCATT 
GTGCGTGTCA ACAGGCCCTT CCTGATTGCC ATAGTTCTCA AAGACACCCA GAGCATCATC 
TTTTTGGGGA AAGTCACCAA CCCCAGTGAA GCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of human initiator caspase 8 and effector caspase 3 by cross-class inhibitory bovSERPINA3-1 and A3-3.
FEBS letters583(17)2743-8(2009 Sep)
Herrera-Mendez CH,Becila S,Blanchet X,Pelissier P,Delourme D,Coulis G,Sentandreu MA,Boudjellal A,Bremaud L,Ouali A

Muscle endopin 1, a muscle intracellular serpin which strongly inhibits elastase: purification, characterization, cellular localization and tissue distribution.
The Biochemical journal388(Pt 1)273-80(2005 May)
Tassy C,Herrera-Mendez CH,Sentandreu MA,Aubry L,Br?maud L,P?lissier P,Delourme D,Brillard M,Gauthier F,Lev?ziel H,Ouali A

Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1.
The Journal of biological chemistry274(48)34164-73(1999 Nov)
Hwang SR,Steineckert B,Yasothornsrikul S,Sei CA,Toneff T,Rattan J,Hook VY

Unique reactive site domains of neuroendocrine isoforms of alpha 1-antichymotrypsin from bovine adrenal medulla and pituitary revealed by molecular cloning.
FEBS letters368(3)471-6(1995 Jul)
Hwang SR,Kohn AB,Hook VY

Molecular cloning reveals isoforms of bovine alpha 1-antichymotrypsin.
Proceedings of the National Academy of Sciences of the United States of America91(20)9579-83(1994 Sep)
Hwang SR,Kohn AB,Hook VY

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SERPINA3-1 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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