IL17A cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL17A
Entrez Gene ID	282863
Full Name	interleukin 17A
Synonyms	IL-17,IL17
General protein information	Preferred Names interleukin 17A Names interleukin-17A IL-17A interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008412.2	NP_001008412.1	interleukin-17A precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL17A	NP_002181.1
Canis lupus familiaris (dog)	IL17A	NP_001159350.1
Mus musculus (house mouse)	Il17a	NP_034682.1
Xenopus tropicalis (tropical clawed frog)	LOC101734167	XP_004915038.1
Pan troglodytes (chimpanzee)	IL17A	XP_527408.2
Bos taurus (cattle)	IL17A	NP_001008412.1
	IL17A	XP_001106391.1
Rattus norvegicus (Norway rat)	Il17a	NP_001100367.1

Gene Ontology
Bibliography

Related articles in PubMed

CD4+ and ?? T Cells are the main Producers of IL-22 and IL-17A in Lymphocytes from Mycobacterium bovis-infected Cattle.
Steinbach S, Vordermeier HM, Jones GJ
Scientific reports629990(2016 Jul)

Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica.
McGill JL, Rusk RA, Guerra-Maupome M, Briggs RE, Sacco RE
PloS one11(3)e0151083(2016)

Two distinct populations of bovine IL-17? T-cells can be induced and WC1?IL-17??? T-cells are effective killers of protozoan parasites.
Peckham RK, Brill R, Foster DS, Bowen AL, Leigh JA, Coffey TJ, Flynn RJ
Scientific reports45431(2014 Jun)

Upregulation of IL-17A, CXCL9 and CXCL10 in early-stage granulomas induced by Mycobacterium bovis in cattle.
Aranday-Cortes E, Bull NC, Villarreal-Ramos B, Gough J, Hicks D, Ortiz-Pel?ez A, Vordermeier HM, Salguero FJ
Transboundary and emerging diseases60(6)525-37(2013 Dec)

Staphylococcal-associated molecular patterns enhance expression of immune defense genes induced by IL-17 in mammary epithelial cells.
Bougarn S, Cunha P, Gilbert FB, Harmache A, Foucras G, Rainard P
Cytokine56(3)749-59(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.
Title: Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica.

Data show that CD4(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.
Title: Two distinct populations of bovine IL-17? T-cells can be induced and WC1?IL-17??? T-cells are effective killers of protozoan parasites.

IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.
Title: Upregulation of IL-17A, CXCL9 and CXCL10 in early-stage granulomas induced by Mycobacterium bovis in cattle.

IL-17A and IL-17F have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.
Title: Staphylococcal-associated molecular patterns enhance expression of immune defense genes induced by IL-17 in mammary epithelial cells.

The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.
Title: Increased IL-17 expression is associated with pathology in a bovine model of tuberculosis.

The following IL17A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL17A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa44958	NM_001008412.2 Latest version!	Bos taurus interleukin 17A (IL17A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL17A ( NM_001008412.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001008412.1 Bos taurus interleukin 17A (IL17A), mRNA.

Price & Availability↑

CloneID	OBa44958
Clone ID Related Accession (Same CDS sequence)	NM_001008412.2
Accession Version	NM_001008412.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Bos taurus(cattle)
Product	interleukin-17A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF412040.1. On Aug 30, 2012 this sequence version replaced NM_001008412.1. ##Evidence-Data-START## Transcript exon combination :: AF412040.1, EU682381.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145467, SAMN04335740 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCTA TGAGAACTTC ATCTATGTCA CTGCTACTGC TTCTGAGTCT GGTGGCTCTT 
GTGAAGGCAG GAGTCATCAT CCCACAGAGT CCAGGCTGCC CACCTACTGA GGACAAGAAC 
TTCCCACAGC ATGTGAGGGT CAACCTAAAC ATCGTTAACC GGAGCACAAA CTCCAGAAGG 
CCCACCGATT ATCACAAGCG CTCCACCTCA CCTTGGACTC TCCACCGCAA TGAGGACCCT 
GAGAGGTACC CCTCTGTGAT CTGGGAGGCC AAGTGCAGCC ACTCAGGCTG TATCAATGCT 
GAAGGGAAGG TGGACCATCA CATGAACTCT GTCACCATCC AGCAAGAGAT CCTGGTCCTC 
CGAAGGGAGT CTCAGCACTG CCCTCACTCC TTCCGGCTGG AGAAGATGCT GGTGGCCGTG 
GGCTGCACCT GCGTCACCCC CATTGTCCGC CATTTGGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008412.1
CDS	58..519
Translation	MASMRTSSMSLLLLLSLVALVKAGVIIPQSPGCPPTEDKNFPQHVRVNLNIVNRSTNSRRPTDYHKRSTSPWTLHRNEDPERYPSVIWEAKCSHSGCINAEGKVDHHMNSVTIQQEILVLRRESQHCPHSFRLEKMLVAVGCTCVTPIVRHLA

Target ORF information:

RefSeq Version	NM_001008412.2
Organism	Bos taurus(cattle)
Definition	Bos taurus interleukin 17A (IL17A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008412.2

ORF Insert Sequence:

ATGGCTTCTA TGAGAACTTC ATCTATGTCA CTGCTACTGC TTCTGAGTCT GGTGGCTCTT 
GTGAAGGCAG GAGTCATCAT CCCACAGAGT CCAGGCTGCC CACCTACTGA GGACAAGAAC 
TTCCCACAGC ATGTGAGGGT CAACCTAAAC ATCGTTAACC GGAGCACAAA CTCCAGAAGG 
CCCACCGATT ATCACAAGCG CTCCACCTCA CCTTGGACTC TCCACCGCAA TGAGGACCCT 
GAGAGGTACC CCTCTGTGAT CTGGGAGGCC AAGTGCAGCC ACTCAGGCTG TATCAATGCT 
GAAGGGAAGG TGGACCATCA CATGAACTCT GTCACCATCC AGCAAGAGAT CCTGGTCCTC 
CGAAGGGAGT CTCAGCACTG CCCTCACTCC TTCCGGCTGG AGAAGATGCT GGTGGCCGTG 
GGCTGCACCT GCGTCACCCC CATTGTCCGC CATTTGGCTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD4+ and ?? T Cells are the main Producers of IL-22 and IL-17A in Lymphocytes from Mycobacterium bovis-infected Cattle.
Scientific reports629990(2016 Jul)
Steinbach S,Vordermeier HM,Jones GJ

Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica.
PloS one11(3)e0151083(2016)
McGill JL,Rusk RA,Guerra-Maupome M,Briggs RE,Sacco RE

Two distinct populations of bovine IL-17? T-cells can be induced and WC1?IL-17??? T-cells are effective killers of protozoan parasites.
Scientific reports45431(2014 Jun)
Peckham RK,Brill R,Foster DS,Bowen AL,Leigh JA,Coffey TJ,Flynn RJ

Upregulation of IL-17A, CXCL9 and CXCL10 in early-stage granulomas induced by Mycobacterium bovis in cattle.
Transboundary and emerging diseases60(6)525-37(2013 Dec)
Aranday-Cortes E,Bull NC,Villarreal-Ramos B,Gough J,Hicks D,Ortiz-Pel?ez A,Vordermeier HM,Salguero FJ

Staphylococcal-associated molecular patterns enhance expression of immune defense genes induced by IL-17 in mammary epithelial cells.
Cytokine56(3)749-59(2011 Dec)
Bougarn S,Cunha P,Gilbert FB,Harmache A,Foucras G,Rainard P

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IL17A cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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