ANXA2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	ANXA2
Entrez Gene ID	282689
Full Name	annexin A2
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024997284.1	XP_024853052.1	annexin A2 isoform X1
NM_174716.1	NP_777141.1	annexin A2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ANXA2	NP_004030.1
Pan troglodytes (chimpanzee)	ANXA2	XP_001155637.2
Danio rerio (zebrafish)	anxa2a	NP_861426.1
Danio rerio (zebrafish)	anxa2b	NP_001099070.1
Bos taurus (cattle)	ANXA2	NP_777141.1
Gallus gallus (chicken)	ANXA2	NP_990682.1
Xenopus tropicalis (tropical clawed frog)	anxa2	NP_988921.1
Canis lupus familiaris (dog)	ANXA2	NP_001002961.1
Mus musculus (house mouse)	Anxa2	NP_031611.1
	ANXA2	XP_002804841.1
Rattus norvegicus (Norway rat)	Anxa2	NP_063970.1

Gene Ontology
Bibliography

Related articles in PubMed

Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.
Zhang M, Chen D, Zhen Z, Ao J, Yuan X, Gao X
Journal of cellular physiology233(3)2464-2475(2018 Mar)

Clumping factor A of Staphylococcus aureus interacts with AnnexinA2 on mammary epithelial cells.
Ashraf S, Cheng J, Zhao X
Scientific reports740608(2017 Jan)

Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.
Gabel M, Delavoie F, Demais V, Royer C, Bailly Y, Vitale N, Bader MF, Chasserot-Golaz S
The Journal of cell biology210(5)785-800(2015 Aug)

Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.
Senthilkumaran C, Hewson J, Ollivett TL, Bienzle D, Lillie BN, Clark M, Caswell JL
Veterinary research466(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AnxA2 functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c/Cyclin D1 signaling pathway.
Title: Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.

annexin A2-induced actin bundling is apparently essential for generating active exocytotic sites.
Title: Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.

Annexins A1 and A2 are proteins produced by airway epithelial cells that may prevent inflammation in the healthy lung and be relevant to development of pneumonia in stressed cattle.
Title: Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.

Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle.
Title: Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves.

Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer) trophectoderm may be related to the frequent failures of NT pregnancies.
Title: Proteomic analysis of the major cellular proteins of bovine trophectoderm cell lines derived from IVP, parthenogenetic and nuclear transfer embryos: Reduced expression of annexins I and II in nuclear transfer-derived cell lines.

The following ANXA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ANXA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41663	NM_174716.1 Latest version!	Bos taurus annexin A2 (ANXA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa41663	XM_024997284.1 Latest version!	Bos taurus annexin A2 (ANXA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ANXA2 ( NM_174716.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777141.1 Bos taurus annexin A2 (ANXA2), mRNA.

Price & Availability↑

CloneID	OBa41663
Clone ID Related Accession (Same CDS sequence)	XM_024997284.1 , NM_174716.1
Accession Version	NM_174716.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	annexin A2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M14056.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M14056.1, BC102516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGTCTACCG TTCATGAAAT TCTGTGCAAG CTCAGTTTGG AGGGTGATCA CTCCACACCT 
CCAAGTGCAT ACGGGTCAGT CAAAGCGTAC ACTAACTTTG ATGCTGAGCG GGATGCTCTG 
AACATTGAAA CAGCCATCAA GACCAAAGGT GTGGATGAGG TCACCATCGT CAACATCCTG 
ACCAACCGCA GCAATGAACA GAGACAGGAT ATTGCCTTCG CCTACCAGAG AAGGACCAAG 
AAGGAACTTG CATCAGCACT GAAGTCAGCC TTGTCTGGCC ACCTGGAGAC AGTGATTTTG 
GGCCTATTGA AAACACCTGC TCAGTATGAT GCTTCTGAGC TGAAAGCGTC CATGAAGGGG 
CTGGGGACTG ATGAGGACTC TCTCATTGAG ATCATCTGCT CAAGGACCAA CCAGGAGCTG 
CAGGAAATCA ACAGAGTCTA CAAGGAAATG TACAAGACCG ATCTGGAGAA GGACATCGTT 
TCCGACACAT CTGGCGACTT CCGCAAGCTG ATGGTCGCCC TCGCAAAGGG TCGGAGAGCA 
GAGGATGGCT CTGTCATTGA TTATGAACTG ATTGACCAGG ATGCCAGGGA TCTCTATGAT 
GCTGGTGTGA AGAGGAAAGG AACTGATGTT CCCAAGTGGA TCAGCATCAT GACCGAGCGG 
AGCGTGTGCC ACCTCCAGAA AGTATTTGAA AGGTACAAGA GCTACAGCCC TTACGACATG 
CTGGAGAGCA TCAAGAAGGA GGTCAAAGGA GACCTGGAAA ATGCCTTTCT GAATCTGGTT 
CAGTGCATTC AGAACAAGCC CCTGTATTTT GCTGACAGAC TGTATGACTC CATGAAGGGC 
AAGGGCACTC GCGACAAGGT CCTGATTAGA ATCATGGTCT CGCGCAGTGA AGTGGACATG 
TTGAAAATTA GATCTGAGTT CAAGAAAAAG TACGGCAAGT CCCTGTACTA CTATATTCAG 
CAAGACACCA AGGGCGACTA CCAGAAAGCG CTGCTGTACC TGTGTGGTGG GGATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777141.1
CDS	55..1074
Translation	MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Target ORF information:

RefSeq Version	NM_174716.1
Organism	Bos taurus(cattle)
Definition	Bos taurus annexin A2 (ANXA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174716.1

ORF Insert Sequence:

ATGTCTACCG TTCATGAAAT TCTGTGCAAG CTCAGTTTGG AGGGTGATCA CTCCACACCT 
CCAAGTGCAT ACGGGTCAGT CAAAGCGTAC ACTAACTTTG ATGCTGAGCG GGATGCTCTG 
AACATTGAAA CAGCCATCAA GACCAAAGGT GTGGATGAGG TCACCATCGT CAACATCCTG 
ACCAACCGCA GCAATGAACA GAGACAGGAT ATTGCCTTCG CCTACCAGAG AAGGACCAAG 
AAGGAACTTG CATCAGCACT GAAGTCAGCC TTGTCTGGCC ACCTGGAGAC AGTGATTTTG 
GGCCTATTGA AAACACCTGC TCAGTATGAT GCTTCTGAGC TGAAAGCGTC CATGAAGGGG 
CTGGGGACTG ATGAGGACTC TCTCATTGAG ATCATCTGCT CAAGGACCAA CCAGGAGCTG 
CAGGAAATCA ACAGAGTCTA CAAGGAAATG TACAAGACCG ATCTGGAGAA GGACATCGTT 
TCCGACACAT CTGGCGACTT CCGCAAGCTG ATGGTCGCCC TCGCAAAGGG TCGGAGAGCA 
GAGGATGGCT CTGTCATTGA TTATGAACTG ATTGACCAGG ATGCCAGGGA TCTCTATGAT 
GCTGGTGTGA AGAGGAAAGG AACTGATGTT CCCAAGTGGA TCAGCATCAT GACCGAGCGG 
AGCGTGTGCC ACCTCCAGAA AGTATTTGAA AGGTACAAGA GCTACAGCCC TTACGACATG 
CTGGAGAGCA TCAAGAAGGA GGTCAAAGGA GACCTGGAAA ATGCCTTTCT GAATCTGGTT 
CAGTGCATTC AGAACAAGCC CCTGTATTTT GCTGACAGAC TGTATGACTC CATGAAGGGC 
AAGGGCACTC GCGACAAGGT CCTGATTAGA ATCATGGTCT CGCGCAGTGA AGTGGACATG 
TTGAAAATTA GATCTGAGTT CAAGAAAAAG TACGGCAAGT CCCTGTACTA CTATATTCAG 
CAAGACACCA AGGGCGACTA CCAGAAAGCG CTGCTGTACC TGTGTGGTGG GGATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ANXA2 ( XM_024997284.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024853052.1 Bos taurus annexin A2 (ANXA2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa41663
Clone ID Related Accession (Same CDS sequence)	XM_024997284.1 , NM_174716.1
Accession Version	XM_024997284.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	annexin A2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037337.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTACCG TTCATGAAAT TCTGTGCAAG CTCAGTTTGG AGGGTGATCA CTCCACACCT 
CCAAGTGCAT ACGGGTCAGT CAAAGCGTAC ACTAACTTTG ATGCTGAGCG GGATGCTCTG 
AACATTGAAA CAGCCATCAA GACCAAAGGT GTGGATGAGG TCACCATCGT CAACATCCTG 
ACCAACCGCA GCAATGAACA GAGACAGGAT ATTGCCTTCG CCTACCAGAG AAGGACCAAG 
AAGGAACTTG CATCAGCACT GAAGTCAGCC TTGTCTGGCC ACCTGGAGAC AGTGATTTTG 
GGCCTATTGA AAACACCTGC TCAGTATGAT GCTTCTGAGC TGAAAGCGTC CATGAAGGGG 
CTGGGGACTG ATGAGGACTC TCTCATTGAG ATCATCTGCT CAAGGACCAA CCAGGAGCTG 
CAGGAAATCA ACAGAGTCTA CAAGGAAATG TACAAGACCG ATCTGGAGAA GGACATCGTT 
TCCGACACAT CTGGCGACTT CCGCAAGCTG ATGGTCGCCC TCGCAAAGGG TCGGAGAGCA 
GAGGATGGCT CTGTCATTGA TTATGAACTG ATTGACCAGG ATGCCAGGGA TCTCTATGAT 
GCTGGTGTGA AGAGGAAAGG AACTGATGTT CCCAAGTGGA TCAGCATCAT GACCGAGCGG 
AGCGTGTGCC ACCTCCAGAA AGTATTTGAA AGGTACAAGA GCTACAGCCC TTACGACATG 
CTGGAGAGCA TCAAGAAGGA GGTCAAAGGA GACCTGGAAA ATGCCTTTCT GAATCTGGTT 
CAGTGCATTC AGAACAAGCC CCTGTATTTT GCTGACAGAC TGTATGACTC CATGAAGGGC 
AAGGGCACTC GCGACAAGGT CCTGATTAGA ATCATGGTCT CGCGCAGTGA AGTGGACATG 
TTGAAAATTA GATCTGAGTT CAAGAAAAAG TACGGCAAGT CCCTGTACTA CTATATTCAG 
CAAGACACCA AGGGCGACTA CCAGAAAGCG CTGCTGTACC TGTGTGGTGG GGATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024853052.1
CDS	141..1160
Translation	MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Target ORF information:

RefSeq Version	XM_024997284.1
Organism	Bos taurus(cattle)
Definition	Bos taurus annexin A2 (ANXA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024997284.1

ORF Insert Sequence:

ATGTCTACCG TTCATGAAAT TCTGTGCAAG CTCAGTTTGG AGGGTGATCA CTCCACACCT 
CCAAGTGCAT ACGGGTCAGT CAAAGCGTAC ACTAACTTTG ATGCTGAGCG GGATGCTCTG 
AACATTGAAA CAGCCATCAA GACCAAAGGT GTGGATGAGG TCACCATCGT CAACATCCTG 
ACCAACCGCA GCAATGAACA GAGACAGGAT ATTGCCTTCG CCTACCAGAG AAGGACCAAG 
AAGGAACTTG CATCAGCACT GAAGTCAGCC TTGTCTGGCC ACCTGGAGAC AGTGATTTTG 
GGCCTATTGA AAACACCTGC TCAGTATGAT GCTTCTGAGC TGAAAGCGTC CATGAAGGGG 
CTGGGGACTG ATGAGGACTC TCTCATTGAG ATCATCTGCT CAAGGACCAA CCAGGAGCTG 
CAGGAAATCA ACAGAGTCTA CAAGGAAATG TACAAGACCG ATCTGGAGAA GGACATCGTT 
TCCGACACAT CTGGCGACTT CCGCAAGCTG ATGGTCGCCC TCGCAAAGGG TCGGAGAGCA 
GAGGATGGCT CTGTCATTGA TTATGAACTG ATTGACCAGG ATGCCAGGGA TCTCTATGAT 
GCTGGTGTGA AGAGGAAAGG AACTGATGTT CCCAAGTGGA TCAGCATCAT GACCGAGCGG 
AGCGTGTGCC ACCTCCAGAA AGTATTTGAA AGGTACAAGA GCTACAGCCC TTACGACATG 
CTGGAGAGCA TCAAGAAGGA GGTCAAAGGA GACCTGGAAA ATGCCTTTCT GAATCTGGTT 
CAGTGCATTC AGAACAAGCC CCTGTATTTT GCTGACAGAC TGTATGACTC CATGAAGGGC 
AAGGGCACTC GCGACAAGGT CCTGATTAGA ATCATGGTCT CGCGCAGTGA AGTGGACATG 
TTGAAAATTA GATCTGAGTT CAAGAAAAAG TACGGCAAGT CCCTGTACTA CTATATTCAG 
CAAGACACCA AGGGCGACTA CCAGAAAGCG CTGCTGTACC TGTGTGGTGG GGATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Annexin A2 positively regulates milk synthesis and proliferation of bovine mammary epithelial cells through the mTOR signaling pathway.
Journal of cellular physiology233(3)2464-2475(2018 Mar)
Zhang M,Chen D,Zhen Z,Ao J,Yuan X,Gao X

Clumping factor A of Staphylococcus aureus interacts with AnnexinA2 on mammary epithelial cells.
Scientific reports740608(2017 Jan)
Ashraf S,Cheng J,Zhao X

Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.
The Journal of cell biology210(5)785-800(2015 Aug)
Gabel M,Delavoie F,Demais V,Royer C,Bailly Y,Vitale N,Bader MF,Chasserot-Golaz S

Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica.
Veterinary research466(2015 Feb)
Senthilkumaran C,Hewson J,Ollivett TL,Bienzle D,Lillie BN,Clark M,Caswell JL

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ANXA2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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