Gene Symbol | GRK2 |
Entrez Gene ID | 282682 |
Full Name | G protein-coupled receptor kinase 2 |
Synonyms | ADRBK1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » GRK2 cDNA ORF clone
Gene Symbol | GRK2 |
Entrez Gene ID | 282682 |
Full Name | G protein-coupled receptor kinase 2 |
Synonyms | ADRBK1 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_174710.2 | NP_777135.1 | beta-adrenergic receptor kinase 1 |
XM_024986987.1 | XP_024842755.1 | beta-adrenergic receptor kinase 1 isoform X1 |
ADRBK1 | XP_001117955.2 | |
Bos taurus (cattle) | ADRBK1 | NP_777135.1 |
Pan troglodytes (chimpanzee) | ADRBK1 | XP_508589.3 |
Canis lupus familiaris (dog) | ADRBK1 | XP_852085.1 |
Mus musculus (house mouse) | Adrbk1 | NP_570933.1 |
Homo sapiens (human) | ADRBK1 | NP_001610.2 |
Rattus norvegicus (Norway rat) | Adrbk1 | NP_036908.1 |
Gallus gallus (chicken) | ADRBK1 | NP_001026524.1 |
Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-G?1?2 Complex.
Yang P, Homan KT, Li Y, Cruz-Rodr?guez O, Tesmer JJ, Chen Z
Biochemistry55(20)2841-8(2016 05)
Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.
Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ
Circulation research112(8)1121-34(2013 Apr)
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.
Wei Z, Hurtt R, Ciccarelli M, Koch WJ, Doria C
Journal of cellular physiology227(6)2371-7(2012 Jun)
A novel GRK2/HDAC6 interaction modulates cell spreading and motility.
Lafarga V, Aymerich I, Tapia O, Mayor F Jr, Penela P
The EMBO journal31(4)856-69(2012 Feb)
Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.
Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W, Caron MG
The Journal of biological chemistry286(31)27676-86(2011 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The PIP2-induced orientation of the GRK2-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 PH domain.
Title: Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-G?1?2 Complex.
Mitochondrial-targeted GRK2 is essential for prodeath signaling occurring after oxidative stress in myocytes and assigning a novel role for this GRK.
Title: Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.
Indicate that the anti-proliferative function of elevated GRK2 in hepatocellular carcinoma is associated with delayed cell cycle progression and is GRK2 kinase activity-dependent.
Title: Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.
G protein-coupled receptor kinase 2 plays a positive role in Smoothened signaling, at least in part, through the promotion of an association between beta-arrestin 2 and Smoothened
Title: Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
atomic structure of GRK2 in complex with Galphaq and Gbetagamma, in which activated Galpha subunit of Gq is fully dissociated from Gbetagamma and dramatically reoriented from its position in the inactive Galphabetagamma heterotrimer [Galphaq, Gbetagamma
Title: Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex.
The following GRK2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GRK2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa01398 | |
Clone ID Related Accession (Same CDS sequence) | NM_174710.2 | |
Accession Version | NM_174710.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2070bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Bos taurus(cattle) | |
Product | beta-adrenergic receptor kinase 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M34019.1. On Jun 3, 2003 this sequence version replaced NM_174710.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M34019.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGACC TGGAGGCGGT GCTGGCCGAC GTGAGCTACC TGATGGCCAT GGAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_777135.1 |
CDS | 85..2154 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174710.2 |
1 | ATGGCGGACC TGGAGGCGGT GCTGGCCGAC GTGAGCTACC TGATGGCCAT GGAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa231844 | |
Clone ID Related Accession (Same CDS sequence) | XM_024986987.1 | |
Accession Version | XM_024986987.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | beta-adrenergic receptor kinase 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037356.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGACC TGGAGGCGGT GCTGGCCGAC GTGAGCTACC TGATGGCCAT GGAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024842755.1 |
CDS | 220..2286 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024986987.1 |
1 | ATGGCGGACC TGGAGGCGGT GCTGGCCGAC GTGAGCTACC TGATGGCCAT GGAGAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Effect of Lipid Composition on the Membrane Orientation of the G Protein-Coupled Receptor Kinase 2-G?1?2 Complex. |
Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. |
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2. |
A novel GRK2/HDAC6 interaction modulates cell spreading and motility. |
Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. |