MGP cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MGP
Entrez Gene ID	282660
Full Name	matrix Gla protein
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174707.3	NP_777132.1	matrix Gla protein precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	MGP	NP_000891.2
	MGP	XP_001090877.1
Canis lupus familiaris (dog)	MGP	XP_003640024.1
Bos taurus (cattle)	MGP	NP_777132.1
Mus musculus (house mouse)	Mgp	NP_032623.1
Pan troglodytes (chimpanzee)	MGP	XP_003952171.1
Rattus norvegicus (Norway rat)	Mgp	NP_036994.1

Gene Ontology
Bibliography

Related articles in PubMed

Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.
Mendoza FJ, Martinez-Moreno J, Almaden Y, Rodriguez-Ortiz ME, Lopez I, Estepa JC, Henley C, Rodriguez M, Aguilera-Tejero E
Calcified tissue international88(3)169-78(2011 Mar)

Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
Yao Y, Watson AD, Ji S, Bostr?m KI
Circulation research105(6)575-84(2009 Sep)

Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development.
Nishimoto SK, Nishimoto M
Matrix biology : journal of the International Society for Matrix Biology24(5)353-61(2005 Aug)

Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells.
Bostr?m K, Zebboudj AF, Yao Y, Lin TS, Torres A
The Journal of biological chemistry279(51)52904-13(2004 Dec)

Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells.
Zebboudj AF, Shin V, Bostr?m K
Journal of cellular biochemistry90(4)756-65(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Selective CaSR activation, either by extracellular calcium or AMG 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.
Title: Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.

Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
Title: Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.

MGP has a novel binding activity for vitronectin
Title: Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development.

MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression
Title: Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells.

the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2
Title: Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells.

The following MGP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MGP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa00625	NM_174707.3 Latest version!	Bos taurus matrix Gla protein (MGP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MGP ( NM_174707.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777132.1 Bos taurus matrix Gla protein (MGP), mRNA.

Price & Availability↑

CloneID	OBa00625
Clone ID Related Accession (Same CDS sequence)	NM_174707.3
Accession Version	NM_174707.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	matrix Gla protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF210379.1. On Feb 21, 2013 this sequence version replaced NM_174707.2. ##Evidence-Data-START## Transcript exon combination :: AF210379.1, DW521639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGAAGAGCC TGCTCCTTCT CTCCATCCTG GCTGCCTTGG CCGTGGCAGC TCTGTGTTAT 
GAATCTCACG AAAGCCTGGA ATCCTATGAA ATCAATCCCT TCATTAACAG GAGAAACGCT 
AACAGCTTTA TATCACCACA ACAGAGATGG AGAGCAAAAG CCCAAGAGAG AATCCGAGAA 
CTCAACAAGC CTCAATACGA GCTCAACCGG GAAGCTTGTG ATGACTTCAA ACTTTGCGAA 
CGCTATGCCA TGGTGTATGG ATACAATGCT GCCTACGACC GTTATTTCCG GCAGCGCCGA 
GGGGCCAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777132.1
CDS	35..346
Translation	MKSLLLLSILAALAVAALCYESHESLESYEINPFINRRNANSFISPQQRWRAKAQERIRELNKPQYELNREACDDFKLCERYAMVYGYNAAYDRYFRQRRGAK

Target ORF information:

RefSeq Version	NM_174707.3
Organism	Bos taurus(cattle)
Definition	Bos taurus matrix Gla protein (MGP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174707.3

ORF Insert Sequence:

ATGAAGAGCC TGCTCCTTCT CTCCATCCTG GCTGCCTTGG CCGTGGCAGC TCTGTGTTAT 
GAATCTCACG AAAGCCTGGA ATCCTATGAA ATCAATCCCT TCATTAACAG GAGAAACGCT 
AACAGCTTTA TATCACCACA ACAGAGATGG AGAGCAAAAG CCCAAGAGAG AATCCGAGAA 
CTCAACAAGC CTCAATACGA GCTCAACCGG GAAGCTTGTG ATGACTTCAA ACTTTGCGAA 
CGCTATGCCA TGGTGTATGG ATACAATGCT GCCTACGACC GTTATTTCCG GCAGCGCCGA 
GGGGCCAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.
Calcified tissue international88(3)169-78(2011 Mar)
Mendoza FJ,Martinez-Moreno J,Almaden Y,Rodriguez-Ortiz ME,Lopez I,Estepa JC,Henley C,Rodriguez M,Aguilera-Tejero E

Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
Circulation research105(6)575-84(2009 Sep)
Yao Y,Watson AD,Ji S,Bostr?m KI

Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development.
Matrix biology : journal of the International Society for Matrix Biology24(5)353-61(2005 Aug)
Nishimoto SK,Nishimoto M

Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-beta1 activity in endothelial cells.
The Journal of biological chemistry279(51)52904-13(2004 Dec)
Bostr?m K,Zebboudj AF,Yao Y,Lin TS,Torres A

Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells.
Journal of cellular biochemistry90(4)756-65(2003 Nov)
Zebboudj AF,Shin V,Bostr?m K

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MGP cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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