CSNK2A1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSNK2A1
Entrez Gene ID	282419
Full Name	casein kinase 2 alpha 1
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Summary	Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014].

mRNA and Protein(s)

mRNA	Protein	Name
XM_025000323.1	XP_024856091.1	casein kinase II subunit alpha isoform X1
NM_174635.2	NP_777060.2	casein kinase II subunit alpha

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CSNK2A1	XP_005634959.1
Rattus norvegicus (Norway rat)	Csnk2a1	NP_446276.1
Drosophila melanogaster (fruit fly)	CkIIalpha	NP_730775.1
Saccharomyces cerevisiae (baker's yeast)	CKA2	NP_014704.1
Magnaporthe oryzae (rice blast fungus)	MGG_03696	XP_003716185.1
Mus musculus (house mouse)	Csnk2a1	NP_031814.2
Gallus gallus (chicken)	CSNK2A1	NP_001002242.1
Arabidopsis thaliana (thale cress)	AT2G23070	NP_179889.1
Xenopus tropicalis (tropical clawed frog)	LOC100498392	XP_004920495.1
Homo sapiens (human)	CSNK2A1	NP_808227.1
Danio rerio (zebrafish)	LOC100535532	XP_003199454.1
Eremothecium gossypii	AGOS_ADR204W	NP_984300.1
Neurospora crassa	NCU03124	XP_964983.2
Bos taurus (cattle)	CSNK2A1	NP_777060.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005569	XP_315576.4
Caenorhabditis elegans (roundworm)	kin-3	NP_492811.1
Pan troglodytes (chimpanzee)	CSNK2A1	XP_003953729.1
	CSNK2A1	XP_002798227.1
Kluyveromyces lactis	KLLA0F16467g	XP_455820.1
Schizosaccharomyces pombe (fission yeast)	cka1	NP_593642.1

Gene Ontology
Bibliography

Related articles in PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization.
Ljubimov AV, Caballero S, Aoki AM, Pinna LA, Grant MB, Castellon R
Investigative ophthalmology & visual science45(12)4583-91(2004 Dec)

Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva.
ole-MoiYoi OK, Brown WC, Iams KP, Nayar A, Tsukamoto T, Macklin MD
The EMBO journal12(4)1621-31(1993 Apr)

Subunit structure of casein kinase II from bovine testis. Demonstration that the alpha and alpha' subunits are distinct polypeptides.
Litchfield DW, Lozeman FJ, Piening C, Sommercorn J, Takio K, Walsh KA, Krebs EG
The Journal of biological chemistry265(13)7638-44(1990 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Involvement of ubiquitous protein kinase CK2 in angiogenesis. Naturally derived CK2 inhibitors may be useful for treatment of proliferative retinopathies. (Protein kinase CK2)
Title: Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization.

The following CSNK2A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSNK2A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa00006	NM_174635.2 Latest version!	Bos taurus casein kinase 2 alpha 1 (CSNK2A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa221448	XM_025000323.1 Latest version!	Bos taurus casein kinase 2 alpha 1 (CSNK2A1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSNK2A1 ( NM_174635.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777060.2 Bos taurus casein kinase 2 alpha 1 (CSNK2A1), mRNA.

Price & Availability↑

CloneID	OBa00006
Clone ID Related Accession (Same CDS sequence)	NM_174635.2
Accession Version	NM_174635.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	casein kinase II subunit alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC112816.1. On Feb 19, 2006 this sequence version replaced NM_174635.1. ##Evidence-Data-START## Transcript exon combination :: BC112816.1, X54962.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGTCGGGAC CCGTGCCAAG CAGAGCCAGA GTTTACACAG ATGTTAATAC ACACAGACCC 
CGAGAGTACT GGGATTACGA GTCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTGGTTAGAA AATTAGGTCG GGGTAAATAC AGTGAAGTAT TTGAAGCCAT CAACATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AGAAGAAGAA AATCAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTGCGAGGC GGTCCCAACA TCATCACACT GGCAGACATT 
GTAAAAGACC CTGTGTCACG AACTCCCGCC TTGGTTTTTG AACACGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGATATTC GATTTTACAT GTATGAGATT 
CTAAAGGCCC TTGATTACTG CCATAGCATG GGGATTATGC ATAGAGATGT CAAGCCCCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTACGGCTAA TAGACTGGGG TTTGGCTGAG 
TTTTACCATC CTGGCCAAGA ATATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCT 
GAGCTACTTG TAGACTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ACGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGG ACAGAAGATT TATATGACTA TATTGACAAA 
TACAACATTG AATTAGATCC ACGTTTCAAT GATATCTTGG GCAGACATTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GTCCTGAGGC CTTGGATTTC 
CTGGACAAGC TGCTGCGATA CGACCACCAA TCACGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTATT TCTACACTGT TGTGAAGGAC CAGGCTCGAA TGGGCTCATC TAGCATGCCA 
GGGGGCAGTA CGCCAGTCAG CAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TTGGACCTCT GGCGGGCTCA CCAGTGATTG CTGCTGCCAA CCCCCTTGGG 
ATGTCTGTTC CAGCTGCCGC CGGCGCCCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777060.2
CDS	232..1407
Translation	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMSVPAAAGAQQ

Target ORF information:

RefSeq Version	NM_174635.2
Organism	Bos taurus(cattle)
Definition	Bos taurus casein kinase 2 alpha 1 (CSNK2A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174635.2

ORF Insert Sequence:

ATGTCGGGAC CCGTGCCAAG CAGAGCCAGA GTTTACACAG ATGTTAATAC ACACAGACCC 
CGAGAGTACT GGGATTACGA GTCACATGTG GTGGAATGGG GAAATCAAGA TGACTACCAG 
CTGGTTAGAA AATTAGGTCG GGGTAAATAC AGTGAAGTAT TTGAAGCCAT CAACATCACA 
AATAATGAAA AAGTTGTTGT TAAAATTCTC AAGCCAGTAA AGAAGAAGAA AATCAAGCGT 
GAAATAAAGA TTTTGGAGAA TTTGCGAGGC GGTCCCAACA TCATCACACT GGCAGACATT 
GTAAAAGACC CTGTGTCACG AACTCCCGCC TTGGTTTTTG AACACGTAAA CAACACAGAC 
TTCAAGCAAT TGTACCAGAC GTTAACAGAC TATGATATTC GATTTTACAT GTATGAGATT 
CTAAAGGCCC TTGATTACTG CCATAGCATG GGGATTATGC ATAGAGATGT CAAGCCCCAT 
AATGTCATGA TTGATCATGA GCACAGAAAG CTACGGCTAA TAGACTGGGG TTTGGCTGAG 
TTTTACCATC CTGGCCAAGA ATATAATGTC CGAGTTGCTT CCCGATATTT CAAAGGTCCT 
GAGCTACTTG TAGACTATCA GATGTACGAT TATAGTTTGG ATATGTGGAG CTTGGGTTGT 
ATGCTGGCAA GTATGATCTT CCGGAAGGAG CCATTTTTCC ACGGACATGA CAATTATGAT 
CAGTTGGTGA GGATAGCCAA GGTTCTGGGG ACAGAAGATT TATATGACTA TATTGACAAA 
TACAACATTG AATTAGATCC ACGTTTCAAT GATATCTTGG GCAGACATTC CCGTAAGCGA 
TGGGAACGCT TTGTCCACAG TGAAAACCAG CACCTTGTCA GTCCTGAGGC CTTGGATTTC 
CTGGACAAGC TGCTGCGATA CGACCACCAA TCACGGCTCA CTGCAAGAGA GGCCATGGAG 
CACCCTTATT TCTACACTGT TGTGAAGGAC CAGGCTCGAA TGGGCTCATC TAGCATGCCA 
GGGGGCAGTA CGCCAGTCAG CAGCGCCAAT ATGATGTCAG GGATTTCTTC AGTGCCAACC 
CCTTCACCCC TTGGACCTCT GGCGGGCTCA CCAGTGATTG CTGCTGCCAA CCCCCTTGGG 
ATGTCTGTTC CAGCTGCCGC CGGCGCCCAG CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSNK2A1 ( XM_025000323.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024856091.1 Bos taurus casein kinase 2 alpha 1 (CSNK2A1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa221448
Clone ID Related Accession (Same CDS sequence)	XM_025000323.1
Accession Version	XM_025000323.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	casein kinase II subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037340.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTATGAGA TTCTAAAGGC CCTTGATTAC TGCCATAGCA TGGGGATTAT GCACAGAGAT 
GTCAAGCCCC ATAATGTCAT GATTGATCAT GAGCACAGAA AGCTACGGCT AATAGACTGG 
GGTTTGGCTG AGTTTTACCA TCCTGGCCAA GAATATAATG TCCGAGTTGC TTCCCGATAT 
TTCAAAGGTC CTGAGCTACT TGTAGACTAT CAGATGTACG ATTATAGTTT GGATATGTGG 
AGCTTGGGTT GTATGCTGGC AAGTATGATC TTCCGGAAGG AGCCATTTTT CCACGGACAT 
GACAATTATG ATCAGTTGGT GAGGATAGCC AAGGTTCTGG GGACAGAAGA TTTATATGAC 
TATATTGACA AATACAACAT TGAATTAGAT CCACGTTTCA ATGATATCTT GGGCAGACAT 
TCCCGTAAGC GATGGGAACG CTTTGTCCAC AGTGAAAACC AGCACCTTGT CAGTCCTGAG 
GCCTTGGATT TCCTGGACAA GCTGCTGCGA TACGACCACC AATCACGGCT CACTGCAAGA 
GAGGCCATGG AGCACCCTTA TTTCTACACT GTTGTGAAGG ACCAGGCTCG AATGGGCTCA 
TCTAGCATGC CAGGGGGCAG TACGCCAGTC AGCAGCGCCA ATATGATGTC AGGGATTTCT 
TCAGTGCCAA CCCCTTCACC CCTTGGACCT CTGGCGGGCT CACCAGTGAT TGCTGCTGCC 
AACCCCCTTG GGATGCCTGT TCCAGCTGCC GCCGGCGCTC AGCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024856091.1
CDS	455..1222
Translation	MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ

Target ORF information:

RefSeq Version	XM_025000323.1
Organism	Bos taurus(cattle)
Definition	Bos taurus casein kinase 2 alpha 1 (CSNK2A1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_025000323.1

ORF Insert Sequence:

ATGTATGAGA TTCTAAAGGC CCTTGATTAC TGCCATAGCA TGGGGATTAT GCACAGAGAT 
GTCAAGCCCC ATAATGTCAT GATTGATCAT GAGCACAGAA AGCTACGGCT AATAGACTGG 
GGTTTGGCTG AGTTTTACCA TCCTGGCCAA GAATATAATG TCCGAGTTGC TTCCCGATAT 
TTCAAAGGTC CTGAGCTACT TGTAGACTAT CAGATGTACG ATTATAGTTT GGATATGTGG 
AGCTTGGGTT GTATGCTGGC AAGTATGATC TTCCGGAAGG AGCCATTTTT CCACGGACAT 
GACAATTATG ATCAGTTGGT GAGGATAGCC AAGGTTCTGG GGACAGAAGA TTTATATGAC 
TATATTGACA AATACAACAT TGAATTAGAT CCACGTTTCA ATGATATCTT GGGCAGACAT 
TCCCGTAAGC GATGGGAACG CTTTGTCCAC AGTGAAAACC AGCACCTTGT CAGTCCTGAG 
GCCTTGGATT TCCTGGACAA GCTGCTGCGA TACGACCACC AATCACGGCT CACTGCAAGA 
GAGGCCATGG AGCACCCTTA TTTCTACACT GTTGTGAAGG ACCAGGCTCG AATGGGCTCA 
TCTAGCATGC CAGGGGGCAG TACGCCAGTC AGCAGCGCCA ATATGATGTC AGGGATTTCT 
TCAGTGCCAA CCCCTTCACC CCTTGGACCT CTGGCGGGCT CACCAGTGAT TGCTGCTGCC 
AACCCCCTTG GGATGCCTGT TCCAGCTGCC GCCGGCGCTC AGCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Involvement of protein kinase CK2 in angiogenesis and retinal neovascularization.
Investigative ophthalmology & visual science45(12)4583-91(2004 Dec)
Ljubimov AV,Caballero S,Aoki AM,Pinna LA,Grant MB,Castellon R

Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva.
The EMBO journal12(4)1621-31(1993 Apr)
ole-MoiYoi OK,Brown WC,Iams KP,Nayar A,Tsukamoto T,Macklin MD

Subunit structure of casein kinase II from bovine testis. Demonstration that the alpha and alpha' subunits are distinct polypeptides.
The Journal of biological chemistry265(13)7638-44(1990 May)
Litchfield DW,Lozeman FJ,Piening C,Sommercorn J,Takio K,Walsh KA,Krebs EG

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CSNK2A1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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