COL10A1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	COL10A1
Entrez Gene ID	282416
Full Name	collagen type X alpha 1 chain
General protein information	Preferred Names collagen type X alpha 1 chain Names collagen alpha-1(X) chain collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia) type X collagen alpha 1
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174634.1	NP_777059.1	collagen alpha-1(X) chain precursor

Pathways from BioSystems

Homologies

	COL10A1	XP_001112119.1
Danio rerio (zebrafish)	col10a1a	NP_001077296.1
Pan troglodytes (chimpanzee)	COL10A1	XP_001161595.1
Gallus gallus (chicken)	LOC100858979	XP_004940348.1
Mus musculus (house mouse)	Col10a1	NP_034055.1
Homo sapiens (human)	COL10A1	NP_000484.2
Canis lupus familiaris (dog)	COL10A1	XP_003639449.1
Bos taurus (cattle)	COL10A1	NP_777059.1
Danio rerio (zebrafish)	col10a1b	XP_683515.5

Gene Ontology
Bibliography

Related articles in PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo.
Schmidl M, Adam N, Surmann-Schmitt C, Hattori T, Stock M, Dietz U, de Crombrugghe B, P?schl E, von der Mark K
The Journal of biological chemistry281(42)31790-800(2006 Oct)

A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.
Gebhard S, P?schl E, Riemer S, Bauer E, Hattori T, Eberspaecher H, Zhang Z, Lefebvre V, de Crombrugghe B, von der Mark K
Matrix biology : journal of the International Society for Matrix Biology23(5)309-22(2004 Aug)

Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes.
Thomas JT, Kwan AP, Grant ME, Boot-Handford RP
The Biochemical journal273(Pt 1)141-8(1991 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation
Title: Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo.

The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.
Title: A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.

The following COL10A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COL10A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43787	NM_174634.1 Latest version!	Bos taurus collagen type X alpha 1 chain (COL10A1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COL10A1 ( NM_174634.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777059.1 Bos taurus collagen type X alpha 1 chain (COL10A1), mRNA.

Price & Availability↑

CloneID	OBa43787
Clone ID Related Accession (Same CDS sequence)	NM_174634.1
Accession Version	NM_174634.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	collagen alpha-1(X) chain precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X53556.1. ##Evidence-Data-START## Transcript exon combination :: ES597199.1, ES597208.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06299471, SAMN06299472 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCCAC AAACAGCACT TTTGCTGCTA ATGTCCTTGA ACTTGGTTCA TGGAGTGTTT 
TATACTGAGC GATACCAAAC ACCTACAGGC ATAAAAGGCC CACCATCCAA CACCAAGACA 
CAGTTCTTCA TCCCGTATGC CATAAAGGGT AAAGGTGTAT CACTGAGAGG AGAGCAAGGC 
ATCCCTGGTC CACCAGGCCC CGCTGGACCT CGAGGGCACC CAGGCCCGTC AGGACCACCA 
GGAAAGCCCG GCACCGGAAG TCCTGGGCCC CAAGGACAGC CAGGGTTGCC AGGACCACCG 
GGACCGTCAG CCACTGGGAA GCCAGGTTTG CCAGGACTCC CAGGAAAACA AGGGGAGAGA 
GGACTAAATG GACCAAAAGG AGATATTGGA CCAGCTGGTT TACCAGGACC ACGGGGCCCA 
CCAGGACCAC CCGGAATCCC CGGCCCAGCT GGAATTTCTG TTCCAGGAAA ACCTGGGCCA 
CAAGGACCTA CAGGAGAACC AGGTCCCAGG GGCTTTCCTG GAGAAAAGGG TACGTCAGGG 
GTCCCTGGAC TGAATGGACA GAAAGGGGAA ATGGGGCATT GTACTCCTTG CCGCCCAGGT 
GAGAGGGGCC TCCCAGGTCC TCAGGGTCCC ACGGGACCAC CTGGCCCTCC TGGAGTGGGG 
AAAAGAGGTG AAAATGGGTT ACCAGGACAG CCAGGCCTCA AAGGTGATCA GGGTGTTCCA 
GGGGAAAGGG GAGCAGCCGG CCCATCAGGC CCTCAAGGCC CTCCTGGGGA ACAAGGACCA 
GAAGGCATTG GAAAGCCAGG AGCCCCTGGA ATTCCAGGCC AGCCAGGGAT CCCAGGGATG 
AAAGGTCAGC CAGGGGCTCC AGGAACAGCT GGGCTCCCGG GGGCTCCCGG CTTTGGGAAA 
CCAGGCTTGC CAGGCCTGAA GGGACAAAGG GGACCTGTGG GCCTTCCAGG GAGTCCAGGT 
GCCAAAGGGG AACAAGGCCC AGCAGGTCAT CCTGGGGAAG CAGGTCTGCC CGGACCCTCA 
GGGAATATGG GACCCCAAGG ACCAAAAGGC ATTCCAGGCA ACCCCGGGCT CCCAGGCCCT 
AAAGGTGAGA TGGGGCCAGT GGGGCCTGCA GGAAACCCTG GGGCGAAGGG AGAAAGGGGC 
TCCTCTGGCT TAGATGGAAA ACCAGGGTAC CCAGGAGAAC CAGGTCTCAA TGGTCCCAAG 
GGTAACCCAG GGTTGCCAGG CCCAAAAGGT GACCCTGGAA TTGCAGGATC CCCTGGTCTC 
CCAGGCCCCG TGGGTCCAGC AGGAGCTAAG GGAGTGCCTG GACACAATGG CGAAGCTGGG 
CCCAGAGGTG TCCCTGGAAT ACCAGGTACT AGAGGTCCCA TTGGGCCACC AGGCATTCCA 
GGATTCCCTG GATCCAAAGG CGATGTGGGA ACTCCAGGGC CTCCTGGCCC AGCTGGCATA 
GCAGTCAAGG GCCTTAATGG ACCTACTGGG CCACCAGGGC CTCCGGGGCC AAGAGGCAAT 
GCTGGGGAGC CTGGCCTCCC AGGGCCCCCA GGGCCCCCAG GCCCTCCAGG CCAAGTAGCC 
CTGCCCGAGG ACTTTGTAAA GGCAGGCCAA AGGCCGTTTG TTAGTGCCAA TCAGGGAGTA 
ACAGGAATGC CTGTGTCTGC TTTCACTGTT ATCCTCTCCA AAGCTTACCC AGCTATAGGT 
ACTCCTATCC CATTCGATAA GATTTTATAT AACAAGCAAC AGCATTATGA CCCAAGAACT 
GGAATCTTCA CCTGTAAGAT TCCAGGGATA TATTACTTCT CTTACCACAT ACACGTGAAA 
GGGACCCATG CTTGGGTAGG TCTGTATAAG AACGGCACCC CTGTAATGTA CACATATGAT 
GAGTACATCA AGGGCTACCT GGATCAGGCT TCAGGGAGCG CCGTGATCGA CCTCACCGAG 
AACGACCAGG TATGGCTCCA GCTGCCCAAT GCAGGCTCGA ACGGGCTGTA TTCCCCTGAG 
TACGTCCACT CCTCTTTCTC AGGATTCTTG GTGGCTCCAA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777059.1
CDS	149..2173
Translation	MLPQTALLLLMSLNLVHGVFYTERYQTPTGIKGPPSNTKTQFFIPYAIKGKGVSLRGEQGIPGPPGPAGPRGHPGPSGPPGKPGTGSPGPQGQPGLPGPPGPSATGKPGLPGLPGKQGERGLNGPKGDIGPAGLPGPRGPPGPPGIPGPAGISVPGKPGPQGPTGEPGPRGFPGEKGTSGVPGLNGQKGEMGHCTPCRPGERGLPGPQGPTGPPGPPGVGKRGENGLPGQPGLKGDQGVPGERGAAGPSGPQGPPGEQGPEGIGKPGAPGIPGQPGIPGMKGQPGAPGTAGLPGAPGFGKPGLPGLKGQRGPVGLPGSPGAKGEQGPAGHPGEAGLPGPSGNMGPQGPKGIPGNPGLPGPKGEMGPVGPAGNPGAKGERGSSGLDGKPGYPGEPGLNGPKGNPGLPGPKGDPGIAGSPGLPGPVGPAGAKGVPGHNGEAGPRGVPGIPGTRGPIGPPGIPGFPGSKGDVGTPGPPGPAGIAVKGLNGPTGPPGPPGPRGNAGEPGLPGPPGPPGPPGQVALPEDFVKAGQRPFVSANQGVTGMPVSAFTVILSKAYPAIGTPIPFDKILYNKQQHYDPRTGIFTCKIPGIYYFSYHIHVKGTHAWVGLYKNGTPVMYTYDEYIKGYLDQASGSAVIDLTENDQVWLQLPNAGSNGLYSPEYVHSSFSGFLVAPM

Target ORF information:

RefSeq Version	NM_174634.1
Organism	Bos taurus(cattle)
Definition	Bos taurus collagen type X alpha 1 chain (COL10A1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174634.1

ORF Insert Sequence:

ATGCTGCCAC AAACAGCACT TTTGCTGCTA ATGTCCTTGA ACTTGGTTCA TGGAGTGTTT 
TATACTGAGC GATACCAAAC ACCTACAGGC ATAAAAGGCC CACCATCCAA CACCAAGACA 
CAGTTCTTCA TCCCGTATGC CATAAAGGGT AAAGGTGTAT CACTGAGAGG AGAGCAAGGC 
ATCCCTGGTC CACCAGGCCC CGCTGGACCT CGAGGGCACC CAGGCCCGTC AGGACCACCA 
GGAAAGCCCG GCACCGGAAG TCCTGGGCCC CAAGGACAGC CAGGGTTGCC AGGACCACCG 
GGACCGTCAG CCACTGGGAA GCCAGGTTTG CCAGGACTCC CAGGAAAACA AGGGGAGAGA 
GGACTAAATG GACCAAAAGG AGATATTGGA CCAGCTGGTT TACCAGGACC ACGGGGCCCA 
CCAGGACCAC CCGGAATCCC CGGCCCAGCT GGAATTTCTG TTCCAGGAAA ACCTGGGCCA 
CAAGGACCTA CAGGAGAACC AGGTCCCAGG GGCTTTCCTG GAGAAAAGGG TACGTCAGGG 
GTCCCTGGAC TGAATGGACA GAAAGGGGAA ATGGGGCATT GTACTCCTTG CCGCCCAGGT 
GAGAGGGGCC TCCCAGGTCC TCAGGGTCCC ACGGGACCAC CTGGCCCTCC TGGAGTGGGG 
AAAAGAGGTG AAAATGGGTT ACCAGGACAG CCAGGCCTCA AAGGTGATCA GGGTGTTCCA 
GGGGAAAGGG GAGCAGCCGG CCCATCAGGC CCTCAAGGCC CTCCTGGGGA ACAAGGACCA 
GAAGGCATTG GAAAGCCAGG AGCCCCTGGA ATTCCAGGCC AGCCAGGGAT CCCAGGGATG 
AAAGGTCAGC CAGGGGCTCC AGGAACAGCT GGGCTCCCGG GGGCTCCCGG CTTTGGGAAA 
CCAGGCTTGC CAGGCCTGAA GGGACAAAGG GGACCTGTGG GCCTTCCAGG GAGTCCAGGT 
GCCAAAGGGG AACAAGGCCC AGCAGGTCAT CCTGGGGAAG CAGGTCTGCC CGGACCCTCA 
GGGAATATGG GACCCCAAGG ACCAAAAGGC ATTCCAGGCA ACCCCGGGCT CCCAGGCCCT 
AAAGGTGAGA TGGGGCCAGT GGGGCCTGCA GGAAACCCTG GGGCGAAGGG AGAAAGGGGC 
TCCTCTGGCT TAGATGGAAA ACCAGGGTAC CCAGGAGAAC CAGGTCTCAA TGGTCCCAAG 
GGTAACCCAG GGTTGCCAGG CCCAAAAGGT GACCCTGGAA TTGCAGGATC CCCTGGTCTC 
CCAGGCCCCG TGGGTCCAGC AGGAGCTAAG GGAGTGCCTG GACACAATGG CGAAGCTGGG 
CCCAGAGGTG TCCCTGGAAT ACCAGGTACT AGAGGTCCCA TTGGGCCACC AGGCATTCCA 
GGATTCCCTG GATCCAAAGG CGATGTGGGA ACTCCAGGGC CTCCTGGCCC AGCTGGCATA 
GCAGTCAAGG GCCTTAATGG ACCTACTGGG CCACCAGGGC CTCCGGGGCC AAGAGGCAAT 
GCTGGGGAGC CTGGCCTCCC AGGGCCCCCA GGGCCCCCAG GCCCTCCAGG CCAAGTAGCC 
CTGCCCGAGG ACTTTGTAAA GGCAGGCCAA AGGCCGTTTG TTAGTGCCAA TCAGGGAGTA 
ACAGGAATGC CTGTGTCTGC TTTCACTGTT ATCCTCTCCA AAGCTTACCC AGCTATAGGT 
ACTCCTATCC CATTCGATAA GATTTTATAT AACAAGCAAC AGCATTATGA CCCAAGAACT 
GGAATCTTCA CCTGTAAGAT TCCAGGGATA TATTACTTCT CTTACCACAT ACACGTGAAA 
GGGACCCATG CTTGGGTAGG TCTGTATAAG AACGGCACCC CTGTAATGTA CACATATGAT 
GAGTACATCA AGGGCTACCT GGATCAGGCT TCAGGGAGCG CCGTGATCGA CCTCACCGAG 
AACGACCAGG TATGGCTCCA GCTGCCCAAT GCAGGCTCGA ACGGGCTGTA TTCCCCTGAG 
TACGTCCACT CCTCTTTCTC AGGATTCTTG GTGGCTCCAA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo.
The Journal of biological chemistry281(42)31790-800(2006 Oct)
Schmidl M,Adam N,Surmann-Schmitt C,Hattori T,Stock M,Dietz U,de Crombrugghe B,P?schl E,von der Mark K

A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.
Matrix biology : journal of the International Society for Matrix Biology23(5)309-22(2004 Aug)
Gebhard S,P?schl E,Riemer S,Bauer E,Hattori T,Eberspaecher H,Zhang Z,Lefebvre V,de Crombrugghe B,von der Mark K

Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes.
The Biochemical journal273(Pt 1)141-8(1991 Jan)
Thomas JT,Kwan AP,Grant ME,Boot-Handford RP

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COL10A1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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