OPN1LW cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	OPN1LW
Entrez Gene ID	282293
Full Name	opsin 1 (cone pigments), long-wave-sensitive
Synonyms	OPSN
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174566.1	NP_776991.1	long-wave-sensitive opsin 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OPN1LW	NP_776991.1
Gallus gallus (chicken)	OPN1LW	NP_990771.1
Danio rerio (zebrafish)	opn1lw1	NP_571250.1
Pan troglodytes (chimpanzee)	OPN1LW	XP_003317827.1
Rattus norvegicus (Norway rat)	Opn1mw	NP_446000.1
Mus musculus (house mouse)	Opn1mw	NP_032132.1
Danio rerio (zebrafish)	opn1lw2	NP_001002443.1
Homo sapiens (human)	OPN1LW	NP_064445.2
Canis lupus familiaris (dog)	OPN1LW	NP_001184001.1
Xenopus tropicalis (tropical clawed frog)	opn1lw	NP_001096331.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynamics of bovine opsin bound to G-protein fragments.
Sugihara M, Suwa M, Bondar AN
Journal of structural biology188(1)79-86(2014 Oct)

Inherent instability of the retinitis pigmentosa P23H mutant opsin.
Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K
The Journal of biological chemistry289(13)9288-303(2014 Mar)

Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein.
Ray-Sinha A, Cross BC, Mironov A, Wiertz E, High S
Molecular membrane biology26(8)448-64(2009 Dec)

Crystal structure of opsin in its G-protein-interacting conformation.
Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW, Hofmann KP, Ernst OP
Nature455(7212)497-502(2008 Sep)

Calnexin is not essential for mammalian rod opsin biogenesis.
Kosmaoglou M, Cheetham ME
Molecular vision142466-74(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

an extended network of hydrogen bonds connects the agonist retinal binding site to the G protein binding site via conserved amino acid residues. dynamics of the hydrogen-bonding network inside opsin couples to interactions at the G protein binding site
Title: Dynamics of bovine opsin bound to G-protein fragments.

instability of the retinitis pigmentosa P23H mutant opsin
Title: Inherent instability of the retinitis pigmentosa P23H mutant opsin.

a single dibasic degron motif is sufficient to initiate both the ER retention and subsequent degradation of ospin via an endoplasmic reticulum associated degradation pathway
Title: Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein.

3.2 A crystal structure of the bovine Ops*-GalphaCT peptide complex
Title: Crystal structure of opsin in its G-protein-interacting conformation.

Mammalian rod opsin biogenesis does not appear to have an absolute requirement for Cnx.
Title: Calnexin is not essential for mammalian rod opsin biogenesis.

The following OPN1LW gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OPN1LW cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa01522	NM_174566.1 Latest version!	Bos taurus opsin 1, long wave sensitive (OPN1LW), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OPN1LW ( NM_174566.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776991.1 Bos taurus opsin 1, long wave sensitive (OPN1LW), mRNA.

Price & Availability↑

CloneID	OBa01522
Clone ID Related Accession (Same CDS sequence)	NM_174566.1
Accession Version	NM_174566.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	long-wave-sensitive opsin 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF280398.1. ##Evidence-Data-START## Transcript exon combination :: AF280398.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCCCACG CGTGGGGCCC CCAAAGGCTT GCAGGTGGGC AGCCGCAGGC CAACTTTGAG 
GAGAGCACCC AGGGGAGCAT CTTTACCTAC ACCAACAGCA ACTCCACCAG AGATCCCTTT 
GAAGGCCCCA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG CGCCTGGATG 
GTCTTCGTGG TCATCGCGTC TGTCTTCACT AATGGGCTCG TGCTGGCAGC CACCATGAGG 
TTCAAGAAGC TCCGCCACCC TCTCAACTGG ATCCTGGTCA ACTTGGCCAT TGCTGACCTG 
GCAGAGACCA TCATCGCCAG CACCATCAGC GTTGTGAACC AGATGTATGG CTACTTTGTG 
CTGGGCCACC CCTTGTGTGT TGTGGAGGGC TACACTGTCT CCTTGTGTGG GATCACCGGT 
CTCTGGTCCT TGGCCATCAT CTCCTGGGAG AGGTGGATGG TGGTCTGCAA GCCCTTTGGC 
AACGTCAGAT TTGATGCCAA GTTGGCCATC ACAGGCATCG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CGGCTCCGCC CATCTTTGGT TGGAGTAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGTG GCCCCGATGT GTTCAGCGGC AGCTCCTACC CAGGGGTGCA GTCGTACATG 
ATCGTTCTCA TGATCACGTG TTGCTTCATC CCACTCAGCG TCATCATCCT CTGCTACCTG 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAATCTGA GTCCACCCAG 
AAGGCGGAGA AGGAGGTAAC CCGCATGGTG ATGGTGATGA TCTTCGCCTA CTGTCTCTGC 
TGGGGGCCCT ACACCTTCTT TGCCTGCTTT GCTGCTGCAC ACCCCGGCTA CGCCTTCCAC 
CCTCTGGTGG CTGCCCTGCC AGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCATT 
ATCTATGTCT TCATGAACCG CCAGTTTCGA AACTGCATCT TGCAACTTTT TGGGAAGAAG 
GTGGACGACA GCTCTGAACT CTCCAGTGTT TCCAAAACAG AGGCGTCATC TGTTTCTTCG 
GTGTCACCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776991.1
CDS	1..1095
Translation	MAHAWGPQRLAGGQPQANFEESTQGSIFTYTNSNSTRDPFEGPNYHIAPRWVYHLTSAWMVFVVIASVFTNGLVLAATMRFKKLRHPLNWILVNLAIADLAETIIASTISVVNQMYGYFVLGHPLCVVEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAITGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMITCCFIPLSVIILCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVMVMIFAYCLCWGPYTFFACFAAAHPGYAFHPLVAALPAYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDSSELSSVSKTEASSVSSVSPA

Target ORF information:

RefSeq Version	NM_174566.1
Organism	Bos taurus(cattle)
Definition	Bos taurus opsin 1, long wave sensitive (OPN1LW), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174566.1

ORF Insert Sequence:

ATGGCCCACG CGTGGGGCCC CCAAAGGCTT GCAGGTGGGC AGCCGCAGGC CAACTTTGAG 
GAGAGCACCC AGGGGAGCAT CTTTACCTAC ACCAACAGCA ACTCCACCAG AGATCCCTTT 
GAAGGCCCCA ATTACCACAT CGCTCCCAGA TGGGTGTACC ACCTCACCAG CGCCTGGATG 
GTCTTCGTGG TCATCGCGTC TGTCTTCACT AATGGGCTCG TGCTGGCAGC CACCATGAGG 
TTCAAGAAGC TCCGCCACCC TCTCAACTGG ATCCTGGTCA ACTTGGCCAT TGCTGACCTG 
GCAGAGACCA TCATCGCCAG CACCATCAGC GTTGTGAACC AGATGTATGG CTACTTTGTG 
CTGGGCCACC CCTTGTGTGT TGTGGAGGGC TACACTGTCT CCTTGTGTGG GATCACCGGT 
CTCTGGTCCT TGGCCATCAT CTCCTGGGAG AGGTGGATGG TGGTCTGCAA GCCCTTTGGC 
AACGTCAGAT TTGATGCCAA GTTGGCCATC ACAGGCATCG CCTTCTCCTG GATCTGGGCT 
GCTGTGTGGA CGGCTCCGCC CATCTTTGGT TGGAGTAGGT ACTGGCCCCA CGGCCTGAAG 
ACTTCATGTG GCCCCGATGT GTTCAGCGGC AGCTCCTACC CAGGGGTGCA GTCGTACATG 
ATCGTTCTCA TGATCACGTG TTGCTTCATC CCACTCAGCG TCATCATCCT CTGCTACCTG 
CAAGTGTGGC TGGCCATCCG AGCGGTGGCA AAGCAGCAGA AAGAATCTGA GTCCACCCAG 
AAGGCGGAGA AGGAGGTAAC CCGCATGGTG ATGGTGATGA TCTTCGCCTA CTGTCTCTGC 
TGGGGGCCCT ACACCTTCTT TGCCTGCTTT GCTGCTGCAC ACCCCGGCTA CGCCTTCCAC 
CCTCTGGTGG CTGCCCTGCC AGCCTACTTT GCCAAAAGTG CCACTATCTA CAACCCCATT 
ATCTATGTCT TCATGAACCG CCAGTTTCGA AACTGCATCT TGCAACTTTT TGGGAAGAAG 
GTGGACGACA GCTCTGAACT CTCCAGTGTT TCCAAAACAG AGGCGTCATC TGTTTCTTCG 
GTGTCACCTG CATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamics of bovine opsin bound to G-protein fragments.
Journal of structural biology188(1)79-86(2014 Oct)
Sugihara M,Suwa M,Bondar AN

Inherent instability of the retinitis pigmentosa P23H mutant opsin.
The Journal of biological chemistry289(13)9288-303(2014 Mar)
Chen Y,Jastrzebska B,Cao P,Zhang J,Wang B,Sun W,Yuan Y,Feng Z,Palczewski K

Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein.
Molecular membrane biology26(8)448-64(2009 Dec)
Ray-Sinha A,Cross BC,Mironov A,Wiertz E,High S

Crystal structure of opsin in its G-protein-interacting conformation.
Nature455(7212)497-502(2008 Sep)
Scheerer P,Park JH,Hildebrand PW,Kim YJ,Krauss N,Choe HW,Hofmann KP,Ernst OP

Calnexin is not essential for mammalian rod opsin biogenesis.
Molecular vision142466-74(2008)
Kosmaoglou M,Cheetham ME

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OPN1LW cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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