NFKBIA cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	NFKBIA
Entrez Gene ID	282291
Full Name	NFKB inhibitor alpha
General protein information	Preferred Names NFKB inhibitor alpha Names NF-kappa-B inhibitor alpha IkappaB alpha nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001045868.1	NP_001039333.1	NF-kappa-B inhibitor alpha

Pathways from BioSystems

Homologies

	NFKBIA	XP_001087842.1
Canis lupus familiaris (dog)	NFKBIA	XP_537413.3
Bos taurus (cattle)	NFKBIA	NP_001039333.1
Danio rerio (zebrafish)	nfkbiaa	NP_998349.1
Pan troglodytes (chimpanzee)	NFKBIA	XP_522823.2
Rattus norvegicus (Norway rat)	Nfkbia	NP_001099190.2
Gallus gallus (chicken)	NFKBIA	NP_001001472.2
Danio rerio (zebrafish)	nfkbiab	NP_955923.1
Anopheles gambiae (African malaria mosquito)	CACT	XP_317542.4
Homo sapiens (human)	NFKBIA	NP_065390.1
Mus musculus (house mouse)	Nfkbia	NP_035037.2
Xenopus tropicalis (tropical clawed frog)	nfkbia	NP_001004851.1
Drosophila melanogaster (fruit fly)	cact	NP_001260496.1

Gene Ontology
Bibliography

Related articles in PubMed

COMMD1/Murr1 reinforces HIV-1 latent infection through I?B-? stabilization.
Taura M, Kudo E, Kariya R, Goto H, Matsuda K, Hattori S, Vaeteewoottacharn K, McDonald F, Suico MA, Shuto T, Kai H, Okada S
Journal of virology89(5)2643-58(2015 Mar)

Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF-?B/p65 activation during in vitro oocyte maturation and early embryogenesis.
Paciolla M, Boni R, Fusco F, Pescatore A, Poeta L, Ursini MV, Lioi MB, Miano MG
Human reproduction (Oxford, England)26(5)1191-201(2011 May)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
Proceedings of the National Academy of Sciences of the United States of America105(46)17818-23(2008 Nov)

Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2.
Gonz?lez-Pacheco FR, Deudero JJ, Castellanos MC, Castilla MA, Alvarez-Arroyo MV, Yag?e S, Caramelo C
American journal of physiology. Heart and circulatory physiology291(3)H1395-401(2006 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IkappaB-alpha protein was stabilized by COMMD1, which attenuated NF-kappaB signaling during Toll-like receptor ligand and tumor necrosis factor alpha treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
Title: COMMD1/Murr1 reinforces HIV-1 latent infection through I?B-? stabilization.

NFKBIA has a role as a marker of NF-kappaB/p65 activation in the early embryo.
Title: Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF-?B/p65 activation during in vitro oocyte maturation and early embryogenesis.

GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
Title: The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.

AIP1 is a novel transducer in TNF-induced TRAF2-dependent activation of ASK1 that mediates a balance between JNK versus NF-kappaB signaling
Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.

NF-kappaB has a role in increasing PDGF-B transcription
Title: Diminished NF-kappaB activation and PDGF-B expression in glomerular endothelial cells subjected to chronic shear stress.

The following NFKBIA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NFKBIA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa37870	NM_001045868.1 Latest version!	Bos taurus NFKB inhibitor alpha (NFKBIA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NFKBIA ( NM_001045868.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001039333.1 Bos taurus NFKB inhibitor alpha (NFKBIA), mRNA.

Price & Availability↑

CloneID	OBa37870
Clone ID Related Accession (Same CDS sequence)	NM_001045868.1
Accession Version	NM_001045868.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-13
Organism	Bos taurus(cattle)
Product	NF-kappa-B inhibitor alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105484.1. On or before Sep 7, 2006 this sequence version replaced XM_587330.2, XM_873968.1, XM_874056.1. ##Evidence-Data-START## Transcript exon combination :: BC105484.1, AJ420928.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145429, SAMN03145436 [ECO:0000348] ##Evidence-Data-END##

ATGTTCCAGC CTGCCGAGCC CGGCCAAGAT TGGGCCATGG AGGGCCCCCG GGACGCGCTC 
AAGAAGGAGC GGCTGCTGGA CGACCGCCAC GACAGCGGCC TGGACTCCAT GAAGGACGAG 
GAGTATGAGC AGATGGTGAA GGAGCTGCGA GAGATCCGCC TCGAGCCGCA GGAGGCGCCG 
CGCGGCGCCG AGCCCTGGAA ACAGCAGCTC ACCGAGGACG GAGACTCGTT CCTGCACTTA 
GCCATCATCC ATGAAGAGAA GGCGCTGACC ATGGAAGTGG TCCGCCAAGT GAAGGGAGAC 
CTGGCCTTCC TCAACTTCCA GAACAACCTG CAGCAGACGC CACTCCACTT GGCTGTGATC 
ACTAACCAGC CAGAAATCGC TGAGGCACTT CTGGAAGCTG GCTGTGATCC TGAGCTGCGA 
GACTTTCGAG GAAATACCCC CCTACACCTT GCCTGTGAGC AGGGCTGCCT GGCCAGTGTG 
GGAGTCCTGA CTCAGCCCCG GGGGACCCAG CACCTCCACT CCATCCTGCA GGCCACCAAC 
TACAATGGCC ACACGTGTCT GCACTTGGCC TCTATTCATG GCTACCTGGG CATCGTGGAG 
CTGTTGGTGT CCTTGGGCGC TGATGTCAAC GCTCAGGAGC CCTGCAATGG CCGAACTGCC 
CTCCATCTGG CAGTGGACCT GCAGAATCCC GACCTGGTGT CACTCCTATT GAAGTGTGGG 
GCTGATGTCA ACAGAGTCAC CTACCAGGGC TACTCCCCGT ACCAGCTCAC GTGGGGCCGC 
CCCAGCACCC GGATACAGCA GCAGCTGGGC CAGCTGACCC TAGAGAACCT TCAGACACTG 
CCGGAGAGCG AGGATGAGGA GAGCTATGAC ACCGAATCAG AGTTCACAGA GGACGAGCTT 
CCCTACGATG ACTGTGTGCT TGGAGGCCAG CGTCTGACGT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001039333.1
CDS	113..1057
Translation	MFQPAEPGQDWAMEGPRDALKKERLLDDRHDSGLDSMKDEEYEQMVKELREIRLEPQEAPRGAEPWKQQLTEDGDSFLHLAIIHEEKALTMEVVRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLEAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQPRGTQHLHSILQATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVLGGQRLTL

Target ORF information:

RefSeq Version	NM_001045868.1
Organism	Bos taurus(cattle)
Definition	Bos taurus NFKB inhibitor alpha (NFKBIA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001045868.1

ORF Insert Sequence:

ATGTTCCAGC CTGCCGAGCC CGGCCAAGAT TGGGCCATGG AGGGCCCCCG GGACGCGCTC 
AAGAAGGAGC GGCTGCTGGA CGACCGCCAC GACAGCGGCC TGGACTCCAT GAAGGACGAG 
GAGTATGAGC AGATGGTGAA GGAGCTGCGA GAGATCCGCC TCGAGCCGCA GGAGGCGCCG 
CGCGGCGCCG AGCCCTGGAA ACAGCAGCTC ACCGAGGACG GAGACTCGTT CCTGCACTTA 
GCCATCATCC ATGAAGAGAA GGCGCTGACC ATGGAAGTGG TCCGCCAAGT GAAGGGAGAC 
CTGGCCTTCC TCAACTTCCA GAACAACCTG CAGCAGACGC CACTCCACTT GGCTGTGATC 
ACTAACCAGC CAGAAATCGC TGAGGCACTT CTGGAAGCTG GCTGTGATCC TGAGCTGCGA 
GACTTTCGAG GAAATACCCC CCTACACCTT GCCTGTGAGC AGGGCTGCCT GGCCAGTGTG 
GGAGTCCTGA CTCAGCCCCG GGGGACCCAG CACCTCCACT CCATCCTGCA GGCCACCAAC 
TACAATGGCC ACACGTGTCT GCACTTGGCC TCTATTCATG GCTACCTGGG CATCGTGGAG 
CTGTTGGTGT CCTTGGGCGC TGATGTCAAC GCTCAGGAGC CCTGCAATGG CCGAACTGCC 
CTCCATCTGG CAGTGGACCT GCAGAATCCC GACCTGGTGT CACTCCTATT GAAGTGTGGG 
GCTGATGTCA ACAGAGTCAC CTACCAGGGC TACTCCCCGT ACCAGCTCAC GTGGGGCCGC 
CCCAGCACCC GGATACAGCA GCAGCTGGGC CAGCTGACCC TAGAGAACCT TCAGACACTG 
CCGGAGAGCG AGGATGAGGA GAGCTATGAC ACCGAATCAG AGTTCACAGA GGACGAGCTT 
CCCTACGATG ACTGTGTGCT TGGAGGCCAG CGTCTGACGT TATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

COMMD1/Murr1 reinforces HIV-1 latent infection through I?B-? stabilization.
Journal of virology89(5)2643-58(2015 Mar)
Taura M,Kudo E,Kariya R,Goto H,Matsuda K,Hattori S,Vaeteewoottacharn K,McDonald F,Suico MA,Shuto T,Kai H,Okada S

Nuclear factor-kappa-B-inhibitor alpha (NFKBIA) is a developmental marker of NF-?B/p65 activation during in vitro oocyte maturation and early embryogenesis.
Human reproduction (Oxford, England)26(5)1191-201(2011 May)
Paciolla M,Boni R,Fusco F,Pescatore A,Poeta L,Ursini MV,Lioi MB,Miano MG

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.
Proceedings of the National Academy of Sciences of the United States of America105(46)17818-23(2008 Nov)
Sorriento D,Ciccarelli M,Santulli G,Campanile A,Altobelli GG,Cimini V,Galasso G,Astone D,Piscione F,Pastore L,Trimarco B,Iaccarino G

Mechanisms of endothelial response to oxidative aggression: protective role of autologous VEGF and induction of VEGFR2 by H2O2.
American journal of physiology. Heart and circulatory physiology291(3)H1395-401(2006 Sep)
Gonz?lez-Pacheco FR,Deudero JJ,Castellanos MC,Castilla MA,Alvarez-Arroyo MV,Yag?e S,Caramelo C

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NFKBIA cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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