CSN1S2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CSN1S2
Entrez Gene ID	282209
Full Name	casein alpha-S2
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Genome	Chromosome: 6 Map Location: 6q31

mRNA and Protein(s)

mRNA	Protein	Name
XM_024993018.1	XP_024848786.1	alpha-S2-casein isoform X2
XM_015471657.1	XP_015327143.1	alpha-S2-casein isoform X1
XM_015471657.2	XP_015327143.1	alpha-S2-casein isoform X3
XM_024993017.1	XP_024848785.1	alpha-S2-casein isoform X1
NM_174528.2	NP_776953.1	alpha-S2-casein precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Translation attenuation via 3' terminal codon usage in bovine csn1s2 is responsible for the difference in ?s2- and ?-casein profile in milk.
Kim JJ, Yu J, Bag J, Bakovic M, Cant JP
RNA biology12(3)354-67(2015)

Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine ?S-casein.
Mizushige T, Sawashi Y, Yamada A, Kanamoto R, Ohinata K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(7)2911-7(2013 Jul)

The chaperone action of bovine milk ?S1- and ?S2-caseins and their associated form ?S-casein.
Treweek TM, Thorn DC, Price WE, Carver JA
Archives of biochemistry and biophysics510(1)42-52(2011 Jun)

Amyloid fibril formation by bovine milk alpha s2-casein occurs under physiological conditions yet is prevented by its natural counterpart, alpha s1-casein.
Thorn DC, Ecroyd H, Sunde M, Poon S, Carver JA
Biochemistry47(12)3926-36(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Translation attenuation via 3' terminal codon usage in bovine mRNA is responsible for the difference in alpha-S2- and beta-casein profile in milk.
Title: Translation attenuation via 3' terminal codon usage in bovine csn1s2 is responsible for the difference in ?s2- and ?-casein profile in milk.

Data indicate that the pepsin-pancreatin digest of alphaS-Casein exhibited anxiolytic-like activity.
Title: Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine ?S-casein.

Alpha-S2-casein was less effective at preventing fibril formation by modified kappa-casein, whereas alpha- and alpha-S1 casein were comparably potent inhibitors.
Title: The chaperone action of bovine milk ?S1- and ?S2-caseins and their associated form ?S-casein.

bovine milk alpha s2-casein readily forms fibrils in vitro. Upon incubation at neutral pH & 37 degrees C, spherical particles typical of alpha s2-casein rapidly converted to twisted, ribbon-like fibrils approximately 12 nm in diameter.
Title: Amyloid fibril formation by bovine milk alpha s2-casein occurs under physiological conditions yet is prevented by its natural counterpart, alpha s1-casein.

Substitution effects of paternal CSN2alpha(s1) allele versus CSN2alpha(s2) allele on protein yield deviations (YDs) are significant, whereas their effects on milk and fat YDs are not.
Title: Associations between 2 paternal casein haplotypes and milk yield traits of Swiss Fleckvieh cattle.

The following CSN1S2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CSN1S2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa01235	NM_174528.2 Latest version!	Bos taurus casein alpha-S2 (CSN1S2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OBa235133	XM_024993017.1 Latest version!	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OBa235134	XM_024993018.1 Latest version!	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OBa90943	XM_015471657.2 Latest version!	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
View Old Accession Versions >>
OBa90943	XM_015471657.1	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CSN1S2 ( NM_174528.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776953.1 Bos taurus casein alpha-S2 (CSN1S2), mRNA.

Price & Availability↑

CloneID	OBa01235
Clone ID Related Accession (Same CDS sequence)	NM_174528.2
Accession Version	NM_174528.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	alpha-S2-casein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M16644.1. On Jun 3, 2003 this sequence version replaced NM_174528.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M16644.1, BC114773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145447 [ECO:0000348] ##Evidence-Data-END##

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAGAACCTT TGCTCCACAT TCTGCAAGGA AGTTGTAAGG 
AACGCAAATG AAGAGGAATA TTCTATCGGC TCATCTAGTG AGGAATCTGC TGAAGTTGCC 
ACTGAGGAAG TTAAGATTAC TGTGGACGAT AAGCACTACC AGAAAGCACT GAATGAAATC 
AATCAGTTTT ATCAGAAGTT CCCCCAGTAT CTCCAGTATC TGTATCAAGG TCCAATTGTT 
TTGAACCCAT GGGATCAGGT TAAGAGGAAT GCTGTTCCCA TTACTCCCAC TCTGAACAGA 
GAGCAGCTCT CCACCAGTGA GGAAAATTCA AAGAAGACCG TTGACATGGA ATCAACAGAA 
GTATTCACTA AGAAAACTAA ACTGACTGAA GAAGAAAAGA ATCGCCTAAA TTTTCTGAAA 
AAAATCAGCC AGCGTTACCA GAAATTCGCC TTGCCCCAGT ATCTCAAGAC TGTTTATCAG 
CATCAGAAAG CTATGAAGCC ATGGATTCAA CCTAAGACAA AGGTTATTCC CTATGTGAGG 
TACCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776953.1
CDS	57..725
Translation	MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKENLCSTFCKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENSKKTVDMESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL

Target ORF information:

RefSeq Version	NM_174528.2
Organism	Bos taurus(cattle)
Definition	Bos taurus casein alpha-S2 (CSN1S2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174528.2

ORF Insert Sequence:

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAGAACCTT TGCTCCACAT TCTGCAAGGA AGTTGTAAGG 
AACGCAAATG AAGAGGAATA TTCTATCGGC TCATCTAGTG AGGAATCTGC TGAAGTTGCC 
ACTGAGGAAG TTAAGATTAC TGTGGACGAT AAGCACTACC AGAAAGCACT GAATGAAATC 
AATCAGTTTT ATCAGAAGTT CCCCCAGTAT CTCCAGTATC TGTATCAAGG TCCAATTGTT 
TTGAACCCAT GGGATCAGGT TAAGAGGAAT GCTGTTCCCA TTACTCCCAC TCTGAACAGA 
GAGCAGCTCT CCACCAGTGA GGAAAATTCA AAGAAGACCG TTGACATGGA ATCAACAGAA 
GTATTCACTA AGAAAACTAA ACTGACTGAA GAAGAAAAGA ATCGCCTAAA TTTTCTGAAA 
AAAATCAGCC AGCGTTACCA GAAATTCGCC TTGCCCCAGT ATCTCAAGAC TGTTTATCAG 
CATCAGAAAG CTATGAAGCC ATGGATTCAA CCTAAGACAA AGGTTATTCC CTATGTGAGG 
TACCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S2 ( XM_024993017.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024848785.1 Bos taurus casein alpha-S2 (CSN1S2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa235133
Clone ID Related Accession (Same CDS sequence)	XM_024993017.1
Accession Version	XM_024993017.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	alpha-S2-casein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037333.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAGAACCTT TGCTCCACAT TCTGCAAGGA AGTTGTAAGG 
AACGCAAATG AAGAGGAATA TTCTATCGGC TCATCTAGTG AGGAATCTGC TGAAGTTGCC 
ACAGAGGAAG TTAAGATTAC TGTGGACGAT AAGCACTACC AGAAAGCACT GAATGAAATC 
AATCAGTTTT ATCAGAAGTT CCCCCAGTAT CTCCAGTATC TGTATCAAGG TCCAATTGTT 
TTGAACCCAT GGGATCAGGT TAAGAGAAAT GCTGTTCCCA TTACTCCCAC TCTGAACAGA 
GAGCAGCTCT CCACCAGTGA GGAAAATTCA AAGAAGACCG TTGACATGGA ATCAACAGAA 
GTATTCACTA AGAAAACTAA ACTGACTGAA GAAGAAAAGA ATCGCCTAAA TTTTCTGAAA 
AAAATCAGCC AGCGTTACCA GAAATTCGCC TTGCCCCAGT ATCTCAAGAC TGTTTATCAG 
CATCAGAAAG CTATGAAGCC ATGGATTCAA CCTAAGACAA AGGTTATTCC CTATGTGAGG 
TACCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024848785.1
CDS	63..731
Translation	MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKENLCSTFCKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENSKKTVDMESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL

Target ORF information:

RefSeq Version	XM_024993017.1
Organism	Bos taurus(cattle)
Definition	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024993017.1

ORF Insert Sequence:

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAGAACCTT TGCTCCACAT TCTGCAAGGA AGTTGTAAGG 
AACGCAAATG AAGAGGAATA TTCTATCGGC TCATCTAGTG AGGAATCTGC TGAAGTTGCC 
ACAGAGGAAG TTAAGATTAC TGTGGACGAT AAGCACTACC AGAAAGCACT GAATGAAATC 
AATCAGTTTT ATCAGAAGTT CCCCCAGTAT CTCCAGTATC TGTATCAAGG TCCAATTGTT 
TTGAACCCAT GGGATCAGGT TAAGAGAAAT GCTGTTCCCA TTACTCCCAC TCTGAACAGA 
GAGCAGCTCT CCACCAGTGA GGAAAATTCA AAGAAGACCG TTGACATGGA ATCAACAGAA 
GTATTCACTA AGAAAACTAA ACTGACTGAA GAAGAAAAGA ATCGCCTAAA TTTTCTGAAA 
AAAATCAGCC AGCGTTACCA GAAATTCGCC TTGCCCCAGT ATCTCAAGAC TGTTTATCAG 
CATCAGAAAG CTATGAAGCC ATGGATTCAA CCTAAGACAA AGGTTATTCC CTATGTGAGG 
TACCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S2 ( XM_024993018.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024848786.1 Bos taurus casein alpha-S2 (CSN1S2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OBa235134
Clone ID Related Accession (Same CDS sequence)	XM_024993018.1
Accession Version	XM_024993018.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	alpha-S2-casein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037333.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAGAACCTT TGCTCCACAT TCTGCAAGGA AGTTGTAAGG 
AACGCAAATG AAGAGGAATA TTCTATCGGC TCATCTAGTG AGGAATCTGC TGAAGTTGCC 
ACAGAGGAAG TTAAGATTAC TGTGGACGAT AAGCACTACC AGAAAGCACT GAATGAAATC 
AATCAGTTTT ATCAGAAGTT CCCCCAGTAT CTCCAGTATC TGTATCAAGG TCCAATTGTT 
TTGAACCCAT GGGATCAGGT TAAGAGAAAT GCTGTTCCCA TTACTCCCAC TCTGAACAGA 
GAGCAGCTCT CCACCAGTGA GGAATCAACA GAAGTATTCA CTAAGAAAAC TAAACTGACT 
GAAGAAGAAA AGAATCGCCT AAATTTTCTG AAAAAAATCA GCCAGCGTTA CCAGAAATTC 
GCCTTGCCCC AGTATCTCAA GACTGTTTAT CAGCATCAGA AAGCTATGAA GCCATGGATT 
CAACCTAAGA CAAAGGTTAT TCCCTATGTG AGGTACCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024848786.1
CDS	101..742
Translation	MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKENLCSTFCKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL

Target ORF information:

RefSeq Version	XM_024993018.1
Organism	Bos taurus(cattle)
Definition	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024993018.1

ORF Insert Sequence:

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAGAACCTT TGCTCCACAT TCTGCAAGGA AGTTGTAAGG 
AACGCAAATG AAGAGGAATA TTCTATCGGC TCATCTAGTG AGGAATCTGC TGAAGTTGCC 
ACAGAGGAAG TTAAGATTAC TGTGGACGAT AAGCACTACC AGAAAGCACT GAATGAAATC 
AATCAGTTTT ATCAGAAGTT CCCCCAGTAT CTCCAGTATC TGTATCAAGG TCCAATTGTT 
TTGAACCCAT GGGATCAGGT TAAGAGAAAT GCTGTTCCCA TTACTCCCAC TCTGAACAGA 
GAGCAGCTCT CCACCAGTGA GGAATCAACA GAAGTATTCA CTAAGAAAAC TAAACTGACT 
GAAGAAGAAA AGAATCGCCT AAATTTTCTG AAAAAAATCA GCCAGCGTTA CCAGAAATTC 
GCCTTGCCCC AGTATCTCAA GACTGTTTAT CAGCATCAGA AAGCTATGAA GCCATGGATT 
CAACCTAAGA CAAAGGTTAT TCCCTATGTG AGGTACCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S2 ( XM_015471657.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_015327143.1 Bos taurus casein alpha-S2 (CSN1S2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa90943
Clone ID Related Accession (Same CDS sequence)	XM_015471657.1 , XM_015471657.2
Accession Version	XM_015471657.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	alpha-S2-casein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003103978.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAAGTTGTA AGGAACGCAA ATGAAGAGGA ATATTCTATC 
GGCTCATCTA GTGAGGAATC TGCTGAAGTT GCCACAGAGG AAGTTAAGAT TACTGTGGAC 
GATAAGCACT ACCAGAAAGC ACTGAATGAA ATCAATCAGT TTTATCAGAA GTTCCCCCAG 
TATCTCCAGT ATCTGTATCA AGGTCCAATT GTTTTGAACC CATGGGATCA GGTTAAGAGA 
AATGCTGTTC CCATTACTCC CACTCTGAAC AGAGAGCAGC TCTCCACCAG TGAGGAAAAT 
TCAAAGAAGA CCGTTGACAT GGAATCAACA GAAGTATTCA CTAAGAAAAC TAAACTGACT 
GAAGAAGAAA AGAATCGCCT AAATTTTCTG AAAAAAATCA GCCAGCGTTA CCAGAAATTC 
GCCTTGCCCC AGTATCTCAA GACTGTTTAT CAGCATCAGA AAGCTATGAA GCCATGGATT 
CAACCTAAGA CAAAGGTTAT TCCCTATGTG AGGTACCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015327143.1
CDS	118..759
Translation	MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENSKKTVDMESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL

Target ORF information:

RefSeq Version	XM_015471657.1
Organism	Bos taurus(cattle)
Definition	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015471657.1

ORF Insert Sequence:

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAAGTTGTA AGGAACGCAA ATGAAGAGGA ATATTCTATC 
GGCTCATCTA GTGAGGAATC TGCTGAAGTT GCCACAGAGG AAGTTAAGAT TACTGTGGAC 
GATAAGCACT ACCAGAAAGC ACTGAATGAA ATCAATCAGT TTTATCAGAA GTTCCCCCAG 
TATCTCCAGT ATCTGTATCA AGGTCCAATT GTTTTGAACC CATGGGATCA GGTTAAGAGA 
AATGCTGTTC CCATTACTCC CACTCTGAAC AGAGAGCAGC TCTCCACCAG TGAGGAAAAT 
TCAAAGAAGA CCGTTGACAT GGAATCAACA GAAGTATTCA CTAAGAAAAC TAAACTGACT 
GAAGAAGAAA AGAATCGCCT AAATTTTCTG AAAAAAATCA GCCAGCGTTA CCAGAAATTC 
GCCTTGCCCC AGTATCTCAA GACTGTTTAT CAGCATCAGA AAGCTATGAA GCCATGGATT 
CAACCTAAGA CAAAGGTTAT TCCCTATGTG AGGTACCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CSN1S2 ( XM_015471657.2 ) cDNA ORF clone, Bos taurus(cattle) -> XP_015327143.1 Bos taurus casein alpha-S2 (CSN1S2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OBa90943
Clone ID Related Accession (Same CDS sequence)	XM_015471657.1 , XM_015471657.2
Accession Version	XM_015471657.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	alpha-S2-casein isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037333.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_015471657.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAAGTTGTA AGGAACGCAA ATGAAGAGGA ATATTCTATC 
GGCTCATCTA GTGAGGAATC TGCTGAAGTT GCCACAGAGG AAGTTAAGAT TACTGTGGAC 
GATAAGCACT ACCAGAAAGC ACTGAATGAA ATCAATCAGT TTTATCAGAA GTTCCCCCAG 
TATCTCCAGT ATCTGTATCA AGGTCCAATT GTTTTGAACC CATGGGATCA GGTTAAGAGA 
AATGCTGTTC CCATTACTCC CACTCTGAAC AGAGAGCAGC TCTCCACCAG TGAGGAAAAT 
TCAAAGAAGA CCGTTGACAT GGAATCAACA GAAGTATTCA CTAAGAAAAC TAAACTGACT 
GAAGAAGAAA AGAATCGCCT AAATTTTCTG AAAAAAATCA GCCAGCGTTA CCAGAAATTC 
GCCTTGCCCC AGTATCTCAA GACTGTTTAT CAGCATCAGA AAGCTATGAA GCCATGGATT 
CAACCTAAGA CAAAGGTTAT TCCCTATGTG AGGTACCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015327143.1
CDS	101..742
Translation	MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENSKKTVDMESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL

Target ORF information:

RefSeq Version	XM_015471657.2
Organism	Bos taurus(cattle)
Definition	Bos taurus casein alpha-S2 (CSN1S2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015471657.2

ORF Insert Sequence:

ATGAAGTTCT TCATCTTTAC CTGCCTTTTG GCTGTTGCCC TTGCAAAGAA TACGATGGAA 
CATGTCTCCT CCAGTGAGGA ATCTATCATC TCCCAGGAAA CATATAAGCA GGAAAAGAAT 
ATGGCCATTA ATCCCAGCAA GGAAGTTGTA AGGAACGCAA ATGAAGAGGA ATATTCTATC 
GGCTCATCTA GTGAGGAATC TGCTGAAGTT GCCACAGAGG AAGTTAAGAT TACTGTGGAC 
GATAAGCACT ACCAGAAAGC ACTGAATGAA ATCAATCAGT TTTATCAGAA GTTCCCCCAG 
TATCTCCAGT ATCTGTATCA AGGTCCAATT GTTTTGAACC CATGGGATCA GGTTAAGAGA 
AATGCTGTTC CCATTACTCC CACTCTGAAC AGAGAGCAGC TCTCCACCAG TGAGGAAAAT 
TCAAAGAAGA CCGTTGACAT GGAATCAACA GAAGTATTCA CTAAGAAAAC TAAACTGACT 
GAAGAAGAAA AGAATCGCCT AAATTTTCTG AAAAAAATCA GCCAGCGTTA CCAGAAATTC 
GCCTTGCCCC AGTATCTCAA GACTGTTTAT CAGCATCAGA AAGCTATGAA GCCATGGATT 
CAACCTAAGA CAAAGGTTAT TCCCTATGTG AGGTACCTTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Translation attenuation via 3' terminal codon usage in bovine csn1s2 is responsible for the difference in ?s2- and ?-casein profile in milk.
RNA biology12(3)354-67(2015)
Kim JJ,Yu J,Bag J,Bakovic M,Cant JP

Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine ?S-casein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(7)2911-7(2013 Jul)
Mizushige T,Sawashi Y,Yamada A,Kanamoto R,Ohinata K

The chaperone action of bovine milk ?S1- and ?S2-caseins and their associated form ?S-casein.
Archives of biochemistry and biophysics510(1)42-52(2011 Jun)
Treweek TM,Thorn DC,Price WE,Carver JA

Amyloid fibril formation by bovine milk alpha s2-casein occurs under physiological conditions yet is prevented by its natural counterpart, alpha s1-casein.
Biochemistry47(12)3926-36(2008 Mar)
Thorn DC,Ecroyd H,Sunde M,Poon S,Carver JA

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CSN1S2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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