Gene Symbol | CHRNA7 |
Entrez Gene ID | 282178 |
Full Name | cholinergic receptor, nicotinic, alpha 7 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » CHRNA7 cDNA ORF clone
Gene Symbol | CHRNA7 |
Entrez Gene ID | 282178 |
Full Name | cholinergic receptor, nicotinic, alpha 7 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_174515.2 | NP_776940.1 | neuronal acetylcholine receptor subunit alpha-7 precursor |
Mus musculus (house mouse) | Chrna7 | NP_031416.3 |
Rattus norvegicus (Norway rat) | Chrna7 | NP_036964.3 |
Drosophila melanogaster (fruit fly) | nAcRalpha-34E | NP_001246027.1 |
Caenorhabditis elegans (roundworm) | acr-16 | NP_505207.1 |
Caenorhabditis elegans (roundworm) | acr-25 | NP_001023570.2 |
Caenorhabditis elegans (roundworm) | acr-7 | NP_495647.1 |
Pan troglodytes (chimpanzee) | CHRNA7 | XP_001164138.1 |
CHRNA7 | NP_001028055.1 | |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008588 | XP_314691.2 |
Caenorhabditis elegans (roundworm) | acr-11 | NP_491906.1 |
Caenorhabditis elegans (roundworm) | acr-9 | NP_510285.2 |
Caenorhabditis elegans (roundworm) | acr-14 | NP_495716.1 |
Homo sapiens (human) | CHRNA7 | NP_000737.1 |
Bos taurus (cattle) | CHRNA7 | NP_776940.1 |
Gallus gallus (chicken) | CHRNA7 | NP_989512.2 |
Caenorhabditis elegans (roundworm) | acr-10 | NP_508692.2 |
Canis lupus familiaris (dog) | CHRNA7 | XP_545813.4 |
Danio rerio (zebrafish) | chrna7 | NP_957513.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100493611 | XP_002937717.2 |
Substitutions of amino acids in the pore domain of homomeric ?7 nicotinic receptors for analogous residues present in heteromeric receptors modify gating, rectification and binding properties.
Criado M, Svobodov? L, Mulet J, Sala F, Sala S
Journal of neurochemistry119(1)40-9(2011 Oct)
A small cytoplasmic region adjacent to the fourth transmembrane segment of the ?7 nicotinic receptor is essential for its biogenesis.
Criado M, Mulet J, Gerber S, Sala S, Sala F
FEBS letters585(15)2477-80(2011 Aug)
An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors.
Alves DS, Castello-Banyuls J, Faura CC, Ballesta JJ
FEBS letters585(8)1169-74(2011 Apr)
Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells.
Maneu V, Gerona G, Fern?ndez L, Cuenca N, Lax P
Visual neuroscience27(5-6)139-47(2010 Nov)
Role of loop 9 on the function of neuronal nicotinic receptors.
Criado M, Castillo M, Mulet J, Sala F, Sala S
Biochimica et biophysica acta1798(3)654-9(2010 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We conclude that residues in the M2 segment and flanking regions contribute to the unusual properties of the CHRNA7 receptor
Title: Substitutions of amino acids in the pore domain of homomeric ?7 nicotinic receptors for analogous residues present in heteromeric receptors modify gating, rectification and binding properties.
Deletion of a small cytoplasmic fragment close to the fourth transmembrane segment of the nicotinic alpha7 receptor (Glu437 to Arg447) abolished membrane expression
Title: A small cytoplasmic region adjacent to the fourth transmembrane segment of the ?7 nicotinic receptor is essential for its biogenesis.
Data show that basic residues at positions 208 and 210 are necessary for the assembly of alpha7 receptors.
Title: An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors.
Cultured bovine retinal pigment epitheliumcells expressed nicotinic receptors containing alpha7 subunit
Title: Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells.
Loop 9 has a different role in the function of homomeric and heteromeric receptors.
Title: Role of loop 9 on the function of neuronal nicotinic receptors.
The following CHRNA7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHRNA7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa41669 | |
Clone ID Related Accession (Same CDS sequence) | NM_174515.2 | |
Accession Version | NM_174515.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1500bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Bos taurus(cattle) | |
Product | neuronal acetylcholine receptor subunit alpha-7 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X93604.1. On Jun 3, 2003 this sequence version replaced NM_174515.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X93604.1, BC149340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145497 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCGCGGCT CGTTGTGCCT GGCGCTGGCA GCGTCGATCT TGCACGTGTC CCTGCAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776940.1 |
CDS | 43..1542 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174515.2 |
1 | ATGCGCGGCT CGTTGTGCCT GGCGCTGGCA GCGTCGATCT TGCACGTGTC CCTGCAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Substitutions of amino acids in the pore domain of homomeric ?7 nicotinic receptors for analogous residues present in heteromeric receptors modify gating, rectification and binding properties. |
A small cytoplasmic region adjacent to the fourth transmembrane segment of the ?7 nicotinic receptor is essential for its biogenesis. |
An extracellular RRR motif flanking the M1 transmembrane domain governs the biogenesis of homomeric neuronal nicotinic acetylcholine receptors. |
Evidence of alpha 7 nicotinic acetylcholine receptor expression in retinal pigment epithelial cells. |
Role of loop 9 on the function of neuronal nicotinic receptors. |