MMP14 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP14
Entrez Gene ID	281915
Full Name	matrix metallopeptidase 14
General protein information	Preferred Names matrix metallopeptidase 14 Names matrix metalloproteinase-14 MMP-14 MT-MMP 1 MT1-MMP MT1MMP MTMMP1 matrix metallopeptidase 14 (membrane-inserted) matrix metalloproteinase 14 (membrane-inserted) matrix metalloproteinase 14 preproprotein membrane-type matrix metalloproteinase 1 membrane-type-1 matrix metalloproteinase
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174390.2	NP_776815.1	matrix metalloproteinase-14 precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	mmp14b	NP_919395.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006904	XP_001688107.1
Pan troglodytes (chimpanzee)	MMP14	XP_001157686.1
Bos taurus (cattle)	MMP14	NP_776815.1
Mus musculus (house mouse)	Mmp14	NP_032634.3
Caenorhabditis elegans (roundworm)	H36L18.1	NP_510112.2
Xenopus tropicalis (tropical clawed frog)	mmp14	NP_001025559.1
Homo sapiens (human)	MMP14	NP_004986.1
	MMP14	XP_001100232.1
Rattus norvegicus (Norway rat)	Mmp14	NP_112318.1
Danio rerio (zebrafish)	mmp14a	NP_919397.1
Drosophila melanogaster (fruit fly)	Mmp1	NP_726473.2
Canis lupus familiaris (dog)	MMP14	XP_856947.1

Gene Ontology
Bibliography

Related articles in PubMed

Cross-talk between NADPH oxidase-PKC?-p(38)MAPK and NF-?B-MT1MMP in activating proMMP-2 by ET-1 in pulmonary artery smooth muscle cells.
Sarkar J, Chowdhury A, Chakraborti T, Chakraborti S
Molecular and cellular biochemistry415(1-2)13-28(2016 Apr)

Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells.
Roy S, Chakraborti T, Chowdhury A, Chakraborti S
Journal of biochemistry153(3)289-302(2013 Mar)

The role of extracellular matrix metalloproteinase inducer (EMMPRIN) in the regulation of bovine endometrial cell functions.
Mishra B, Kizaki K, Sato T, Ito A, Hashizume K
Biology of reproduction87(6)149(2012 Jun)

Expression of matrix metalloproteinase (MMP)-2, MMP-14 and tissue inhibitor of matrix metalloproteinase (TIMP)-2 during bovine placentation and at term with or without placental retention.
Dilly M, Hambruch N, Shenavai S, Schuler G, Froehlich R, Haeger JD, Ozalp GR, Pfarrer C
Theriogenology75(6)1104-14(2011 Apr)

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.
Ulbrich SE, Meyer SU, Zitta K, Hiendleder S, Sinowatz F, Bauersachs S, B?ttner M, Fr?hlich T, Arnold GJ, Reichenbach HD, Wolf E, Meyer HH
Molecular and cellular endocrinology332(1-2)48-57(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCalpha-p(38)MAPK and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells
Title: Cross-talk between NADPH oxidase-PKC?-p(38)MAPK and NF-?B-MT1MMP in activating proMMP-2 by ET-1 in pulmonary artery smooth muscle cells.

Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.
Title: Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells.

Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Title: The role of extracellular matrix metalloproteinase inducer (EMMPRIN) in the regulation of bovine endometrial cell functions.

MMP-14, MMP-2 and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
Title: Expression of matrix metalloproteinase (MMP)-2, MMP-14 and tissue inhibitor of matrix metalloproteinase (TIMP)-2 during bovine placentation and at term with or without placental retention.

Results describe distinct changes in expression of MMP2, MMP14, and the metallopeptidase inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation.
Title: Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.

The following MMP14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41810	NM_174390.2 Latest version!	Bos taurus matrix metallopeptidase 14 (MMP14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP14 ( NM_174390.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776815.1 Bos taurus matrix metallopeptidase 14 (MMP14), mRNA.

Price & Availability↑

CloneID	OBa41810
Clone ID Related Accession (Same CDS sequence)	NM_174390.2
Accession Version	NM_174390.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Bos taurus(cattle)
Product	matrix metalloproteinase-14 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF290429.1. On Jun 3, 2003 this sequence version replaced NM_174390.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF290429.1, BT026217.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05861804, SAMN05861818 [ECO:0000348] ##Evidence-Data-END##

ATGTCTCCCG CCCCACGACC CGCCTGCAGT CTGCTGCTCC CCGTGCTCAC GCTCGCCTCC 
GCGCTCGCCT CCCTCAGCTC TGCCCAGAGC AGCTTCAGCC CCGAAGCCTG GCTGCAGCAG 
CATGGCTACC TGCCCCCTGG AGACCTGCGG ACCCACACAC AGCGCTCACC CCAGTCCCTC 
TCAGCTGCCA TTGCTGCCAT GCAGAGGTTC TATGGTCTGC GAGTGACAGG CAAGGCTGAT 
GCAGACACCA TGAAGGCCAT GAGGCGCCCC CGCTGTGGTG TTCCAGACAA GTTTGGGGCT 
GAAATCAAGG CCAATGTTCG AAGGAAGCGC TATGCCATCC AGGGACTCAA ATGGCAGCAT 
AATGAGATCA CTTTCTGCAT CCAGAACTAC ACCCCCAATG TGGGCGAGTA TGCCACATTT 
GAGGCCATCC GCAAGGCATT CCGAGTGTGG GAGAGTGCAA CGCCACTGCG CTTCCGAGAG 
GTACCCTATG CCTACATCCG TGAGGGCCAC GAGAAGCAGG CCGACATCAT GATCTTCTTT 
GCTGAAGGCT TCCATGGTGA CAGCACGCCT TTCGACGGCG AGGGTGGCTT CCTGGCCCAT 
GCCTACTTCC CAGGCCCCAA CATTGGAGGG GACACCCACT TTGACTCTGC CGAGCCTTGG 
ACTGTCCGGA ATGAGGATCT AAATGGGAAT GACATCTTTC TGGTGGCTGT GCACGAGCTG 
GGCCATGCCC TGGGCCTTGA GCATTCCAAC GATCCCTCGG CCATCATGGC ACCCTTTTAC 
CAGTGGATGG ACACAGAGAA CTTCGTGCTG CCTGATGACG ACCGCCGGGG CATCCAGCAA 
CTTTATGGGA GTAAGTCAGG ATCCCCCACT AAGATGCCCC CTCAACCCAG GACCACCTCC 
AGGCCTTCCG TCCCCGATAA GCCCAAAAAT CCCACCTACG GGCCCAACAT CTGTGATGGG 
AACTTTGACA CCGTGGCCAT GCTTCGAGGG GAGATGTTTG TCTTCAAGGA GCGTTGGTTC 
TGGCGCGTAA GGAAAAACCA GGTGATGGAC GGATACCCCA TGCCCATCGG CCAGTTCTGG 
CGGGGCCTGC CCGCATCCAT CAACACTGCC TATGAGAGGA AGGATGGCAA GTTTGTCTTC 
TTCAAAGGAG ACAAGCACTG GGTGTTTGAC GAAGCTTCCC TGGAGCCTGG CTACCCCAAG 
CACATTAAGG AGCTGGGCCG AGGACTGCCT ACTGACAGGA TTGATGCTGC TCTCTTCTGG 
ATGCCCAATG GAAAGACCTA TTTCTTCCGA GGAAACAAGT ACTACCGTTT CAACGAGGAG 
CTCAGGATAG TGGAAAGCGA ATACCCCAAA AACATCAAGG TCTGGGAAGG AATCCCTGAG 
TCTCCCAGAG GGTCATTCAT GGGCAGTGAC GAAGTCTTCA CTTACTTCTA CAAGGGGAAC 
AAGTACTGGA AATTCAACAA CCAGAAGCTG AAGGTTGAGC CGGGCTACCC CAAGTCAGCC 
CTGCGGGACT GGATGGGCTG CCCATCATCG GGGGGCCAGC CGGATGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT CGAGGTGGAC GAGGAAGGCA GCGGGGCAGT GAGCGCGGCC 
GCCGTGGTGC TCCCCGTGCT GCTGCTGCTC CTGGTGCTGG CGGTGGGCCT CGCCGTCTTC 
TTCTTCAGAC GTCACGGGAC CCCCAAGCGA CTGCTCTACT GCCAGCGCTC CCTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776815.1
CDS	57..1805
Translation	MSPAPRPACSLLLPVLTLASALASLSSAQSSFSPEAWLQQHGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLRVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPNVGEYATFEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGSKSGSPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRKNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDRIDAALFWMPNGKTYFFRGNKYYRFNEELRIVESEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSSGGQPDEGTEEETEVIIIEVDEEGSGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPKRLLYCQRSLLDKV

Target ORF information:

RefSeq Version	NM_174390.2
Organism	Bos taurus(cattle)
Definition	Bos taurus matrix metallopeptidase 14 (MMP14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174390.2

ORF Insert Sequence:

ATGTCTCCCG CCCCACGACC CGCCTGCAGT CTGCTGCTCC CCGTGCTCAC GCTCGCCTCC 
GCGCTCGCCT CCCTCAGCTC TGCCCAGAGC AGCTTCAGCC CCGAAGCCTG GCTGCAGCAG 
CATGGCTACC TGCCCCCTGG AGACCTGCGG ACCCACACAC AGCGCTCACC CCAGTCCCTC 
TCAGCTGCCA TTGCTGCCAT GCAGAGGTTC TATGGTCTGC GAGTGACAGG CAAGGCTGAT 
GCAGACACCA TGAAGGCCAT GAGGCGCCCC CGCTGTGGTG TTCCAGACAA GTTTGGGGCT 
GAAATCAAGG CCAATGTTCG AAGGAAGCGC TATGCCATCC AGGGACTCAA ATGGCAGCAT 
AATGAGATCA CTTTCTGCAT CCAGAACTAC ACCCCCAATG TGGGCGAGTA TGCCACATTT 
GAGGCCATCC GCAAGGCATT CCGAGTGTGG GAGAGTGCAA CGCCACTGCG CTTCCGAGAG 
GTACCCTATG CCTACATCCG TGAGGGCCAC GAGAAGCAGG CCGACATCAT GATCTTCTTT 
GCTGAAGGCT TCCATGGTGA CAGCACGCCT TTCGACGGCG AGGGTGGCTT CCTGGCCCAT 
GCCTACTTCC CAGGCCCCAA CATTGGAGGG GACACCCACT TTGACTCTGC CGAGCCTTGG 
ACTGTCCGGA ATGAGGATCT AAATGGGAAT GACATCTTTC TGGTGGCTGT GCACGAGCTG 
GGCCATGCCC TGGGCCTTGA GCATTCCAAC GATCCCTCGG CCATCATGGC ACCCTTTTAC 
CAGTGGATGG ACACAGAGAA CTTCGTGCTG CCTGATGACG ACCGCCGGGG CATCCAGCAA 
CTTTATGGGA GTAAGTCAGG ATCCCCCACT AAGATGCCCC CTCAACCCAG GACCACCTCC 
AGGCCTTCCG TCCCCGATAA GCCCAAAAAT CCCACCTACG GGCCCAACAT CTGTGATGGG 
AACTTTGACA CCGTGGCCAT GCTTCGAGGG GAGATGTTTG TCTTCAAGGA GCGTTGGTTC 
TGGCGCGTAA GGAAAAACCA GGTGATGGAC GGATACCCCA TGCCCATCGG CCAGTTCTGG 
CGGGGCCTGC CCGCATCCAT CAACACTGCC TATGAGAGGA AGGATGGCAA GTTTGTCTTC 
TTCAAAGGAG ACAAGCACTG GGTGTTTGAC GAAGCTTCCC TGGAGCCTGG CTACCCCAAG 
CACATTAAGG AGCTGGGCCG AGGACTGCCT ACTGACAGGA TTGATGCTGC TCTCTTCTGG 
ATGCCCAATG GAAAGACCTA TTTCTTCCGA GGAAACAAGT ACTACCGTTT CAACGAGGAG 
CTCAGGATAG TGGAAAGCGA ATACCCCAAA AACATCAAGG TCTGGGAAGG AATCCCTGAG 
TCTCCCAGAG GGTCATTCAT GGGCAGTGAC GAAGTCTTCA CTTACTTCTA CAAGGGGAAC 
AAGTACTGGA AATTCAACAA CCAGAAGCTG AAGGTTGAGC CGGGCTACCC CAAGTCAGCC 
CTGCGGGACT GGATGGGCTG CCCATCATCG GGGGGCCAGC CGGATGAGGG GACTGAGGAG 
GAGACGGAGG TGATCATCAT CGAGGTGGAC GAGGAAGGCA GCGGGGCAGT GAGCGCGGCC 
GCCGTGGTGC TCCCCGTGCT GCTGCTGCTC CTGGTGCTGG CGGTGGGCCT CGCCGTCTTC 
TTCTTCAGAC GTCACGGGAC CCCCAAGCGA CTGCTCTACT GCCAGCGCTC CCTGCTGGAC 
AAGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cross-talk between NADPH oxidase-PKC?-p(38)MAPK and NF-?B-MT1MMP in activating proMMP-2 by ET-1 in pulmonary artery smooth muscle cells.
Molecular and cellular biochemistry415(1-2)13-28(2016 Apr)
Sarkar J,Chowdhury A,Chakraborti T,Chakraborti S

Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells.
Journal of biochemistry153(3)289-302(2013 Mar)
Roy S,Chakraborti T,Chowdhury A,Chakraborti S

The role of extracellular matrix metalloproteinase inducer (EMMPRIN) in the regulation of bovine endometrial cell functions.
Biology of reproduction87(6)149(2012 Jun)
Mishra B,Kizaki K,Sato T,Ito A,Hashizume K

Expression of matrix metalloproteinase (MMP)-2, MMP-14 and tissue inhibitor of matrix metalloproteinase (TIMP)-2 during bovine placentation and at term with or without placental retention.
Theriogenology75(6)1104-14(2011 Apr)
Dilly M,Hambruch N,Shenavai S,Schuler G,Froehlich R,Haeger JD,Ozalp GR,Pfarrer C

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy.
Molecular and cellular endocrinology332(1-2)48-57(2011 Jan)
Ulbrich SE,Meyer SU,Zitta K,Hiendleder S,Sinowatz F,Bauersachs S,B?ttner M,Fr?hlich T,Arnold GJ,Reichenbach HD,Wolf E,Meyer HH

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MMP14 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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