ITGB2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITGB2
Entrez Gene ID	281877
Full Name	integrin subunit beta 2
Synonyms	CD18
General protein information	Preferred Names integrin subunit beta 2 Names integrin beta-2 CD18 subunit Leu-CAM receptor cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta complement receptor C3 subunit beta integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2) integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_015473717.1	XP_015329203.1	integrin beta-2 isoform X1
NM_175781.1	NP_786975.1	integrin beta-2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ITGB2	NP_786975.1
Danio rerio (zebrafish)	itgb2	XP_686012.3
Xenopus tropicalis (tropical clawed frog)	itgb2	XP_002936570.2
Pan troglodytes (chimpanzee)	ITGB2	NP_001029294.1
Canis lupus familiaris (dog)	ITGB2	XP_005639033.1
Homo sapiens (human)	ITGB2	NP_001120963.1
Mus musculus (house mouse)	Itgb2	NP_032430.2
Gallus gallus (chicken)	ITGB2	NP_990582.1
Rattus norvegicus (Norway rat)	Itgb2	NP_001032869.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a null allele in genetic tests for bovine leukocyte adhesion deficiency in Pakistani Bos indicus ? Bos taurus cattle.
Nasreen F, Malik NA, Qureshi JA, Raadsma HW, Tammen I
Molecular and cellular probes26(6)259-62(2012 Dec)

Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
Shanthalingam S, Srikumaran S
Proceedings of the National Academy of Sciences of the United States of America106(36)15448-53(2009 Sep)

Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods.
Nasreen F, Altaf Malik N, Naeem Riaz M, Anver Qureshi J
Hereditas146(2)74-8(2009 May)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
Title: Identification of a null allele in genetic tests for bovine leukocyte adhesion deficiency in Pakistani Bos indicus ? Bos taurus cattle.

Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
Title: Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.

Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Title: Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods.

study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein and inhibited the chemotaxis of monocytes
Title: Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression.

These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
Title: Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects.

The following ITGB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITGB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43359	NM_175781.1 Latest version!	Bos taurus integrin subunit beta 2 (ITGB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00
OBa87825	XM_015473717.1 Latest version!	Bos taurus integrin subunit beta 2 (ITGB2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$426.30 $609.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITGB2 ( NM_175781.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_786975.1 Bos taurus integrin subunit beta 2 (ITGB2), mRNA.

Price & Availability↑

CloneID	OBa43359
Clone ID Related Accession (Same CDS sequence)	NM_175781.1
Accession Version	NM_175781.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2310bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	integrin beta-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M81233.1. On Mar 29, 2005 this sequence version replaced XM_585445.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M81233.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END##

ATGCTGCGCC AGCGCCCCCA GCTGCTGCTC CTAGCGGGCC TGCTTGCCCT CCAGTCCGTC 
CTGTCCCAGG AGTGCACCAA CTACAAGGTC AGCACCTGCC GGGACTGCAT CGAGTCGGGC 
CCCGGCTGCG CCTGGTGCCA GAAACTGAAC TTCACAGGGC AAGGGGAGCC CGACTCCATT 
CGCTGTGACA CACGAGCGGA GCTGCTGTCA AAGGGCTGCC CAGCTGATGA CATCATGGAA 
CCCAAGAGCC TCGCTGAGAC CCGGGACAGC CAGGCGGGCA GTCGGAAGCA GCTGTCCCCA 
CAGGAAGTGA CGCTCTACCT GAGACCAGGT CAGGCAGTTG CGTTCAACGT GACCTTCCGG 
AGGGCCAAGG GCTACCCCAT CGACCTGTAC TACCTGATGG ACCTCTCCTA CTCCATGGTG 
GATGACCTCG TCAACGTCAA GAAGCTGGGG GGTGACCTGC TCCGGGCCCT CAATGGCATC 
ACCGAGTCGG GCCGCATTGG TTTCGGGTCC TTCGTGGACA AGACGGTGCT CCCCTTCGTC 
AACACGCACC CCGAGAAGCT GCGGAACCCC TGCCCCAACA AGGAGAAGGA GTGCCAGCCC 
CCGTTCGCCT TCAGGCACGT GTTGAAGCTC ACTGACAACT CCAAACAGTT CGAGACAGAA 
GTCGGGAAGC AGCTGATCTC GGGGAACCTG GACGCCCCTG AGGGTGGGCT GGACGCCATG 
ATGCAGGTGG CCGCGTGCCC GGAGGAAATC GGCTGGCGCA ATGTCACCAG GCTGCTGGTG 
TTCGCCACGG ACGATGGGTT CCACTTTGCG GGCGATGGAA AGCTGGGTGC CATCCTCACC 
CCCAATGACG GCCGCTGCCA CCTGGAAGAC AACCTGTACA AAAGCAGCAA CGAATTTGAC 
TACCCATCGG TGGGCCAGCT GGCACACAAA CTGGCAGAAA GCAACATCCA GCCCATCTTT 
GCAGTAACCA AGAAGATGGT GAAAACGTAC GAGAAGCTGA CAGAGATCAT CCCCAAGTCT 
GCAGTCGGGG AGCTGTCTGA AGATTCCAGG AACGTGGTGG AGCTTATCAA GAATGCCTAC 
AATAAACTGT CCTCCAGAGT CTTCCTGGAT CACAGCACCC TCCCTGACAC CCTGAAAGTC 
ACCTACGACT CCTTCTGCAG TAACGGGAAA TCGCAGGTGG ACCAGCCCAG AGGGGACTGC 
GACGGCGTCC AGATCAACGT CCCGATCACC TTCCAGGTGA AGGTCACAGC CACCGAGTGC 
ATCCAGCAGC AGTCCTTCAC CATCCGGGCG CTGGGCTTCA CGGACACGGT GACCGTGCGG 
GTCCTCCCCC AGTGCGAGTG CCAATGCCGG GACGCCAGCA GGGACGGCAG CATCTGCGGC 
GGCAGAGGCT CGATGGAGTG CGGCGTCTGC AGGTGTGACG CCGGCTACAT CGGGAAGAAC 
TGCGAGTGCC AGACGCAGGG CCGGAGCAGC CAGGAGCTGG AGGGCAGCTG CCGCAAGGAC 
AACAGCTCCA TCATCTGCTC GGGGCTGGGG GACTGCATCT GCGGGCAGTG CGTGTGCCAC 
ACGAGCGACG TGCCCAACAA GAAGATCTAC GGCCAGTTCT GCGAGTGCGA CAACGTCAAC 
TGCGAACGCT ACGACGGCCA AGTCTGCGGG GGCGAAAAGA GGGGGCTCTG CTTCTGCGGC 
ACCTGCAGGT GCGACGAGCA GTATGAGGGT TCGGCATGCC AGTGCCTCAA GTCCACTCAG 
GGCTGCCTCA ACTTGGACGG CGTCGAGTGC AGCGGCCGCG GCCGATGCCG CTGCAATGTG 
TGCCAGTGCG ACCCCGGCTA CCAGCCGCCC CTGTGCAGCG AGTGCCCGGG CTGCCCCGTG 
CCCTGTGCGG GCTTCGCCCC CTGCACAGAG TGCCTGAAGT TCGACAAGGG CCCCTTCGCC 
AAGAACTGCA GCGCAGCGTG CGGGCAGACG AAGCTGCTGT CCAGCCCGGT GCCCGGCCGC 
AAGTGCAAGG AGCGCGACTC CGAGGGCTGC TGGATGACCT ACACCCTGGT GCAGCGCGAC 
GGGCGGGACA GATACGACGT GCACGTGGAC GACATGCTCG AGTGTGTGAA GGGCCCCAAC 
ATCGCTGCCA TCGTGGGGGG CACCGTGGGG GGCGTCGTGC TCGTCGGCAT CCTCCTGCTG 
GTCATCTGGA AGGCCCTGAC ACACCTGAGC GACCTCAGGG AGTACCATCG CTTTGAGAAG 
GAGAAGCTCA AGTCCCAGTG GAACAACGAT AACCCTCTTT TCAAGAGTGC CACCACGACA 
GTCATGAACC CTAAGTTTGC CGAGAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_786975.1
CDS	106..2415
Translation	MLRQRPQLLLLAGLLALQSVLSQECTNYKVSTCRDCIESGPGCAWCQKLNFTGQGEPDSIRCDTRAELLSKGCPADDIMEPKSLAETRDSQAGSRKQLSPQEVTLYLRPGQAVAFNVTFRRAKGYPIDLYYLMDLSYSMVDDLVNVKKLGGDLLRALNGITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKECQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKSSNEFDYPSVGQLAHKLAESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSEDSRNVVELIKNAYNKLSSRVFLDHSTLPDTLKVTYDSFCSNGKSQVDQPRGDCDGVQINVPITFQVKVTATECIQQQSFTIRALGFTDTVTVRVLPQCECQCRDASRDGSICGGRGSMECGVCRCDAGYIGKNCECQTQGRSSQELEGSCRKDNSSIICSGLGDCICGQCVCHTSDVPNKKIYGQFCECDNVNCERYDGQVCGGEKRGLCFCGTCRCDEQYEGSACQCLKSTQGCLNLDGVECSGRGRCRCNVCQCDPGYQPPLCSECPGCPVPCAGFAPCTECLKFDKGPFAKNCSAACGQTKLLSSPVPGRKCKERDSEGCWMTYTLVQRDGRDRYDVHVDDMLECVKGPNIAAIVGGTVGGVVLVGILLLVIWKALTHLSDLREYHRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES

Target ORF information:

RefSeq Version	NM_175781.1
Organism	Bos taurus(cattle)
Definition	Bos taurus integrin subunit beta 2 (ITGB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175781.1

ORF Insert Sequence:

ATGCTGCGCC AGCGCCCCCA GCTGCTGCTC CTAGCGGGCC TGCTTGCCCT CCAGTCCGTC 
CTGTCCCAGG AGTGCACCAA CTACAAGGTC AGCACCTGCC GGGACTGCAT CGAGTCGGGC 
CCCGGCTGCG CCTGGTGCCA GAAACTGAAC TTCACAGGGC AAGGGGAGCC CGACTCCATT 
CGCTGTGACA CACGAGCGGA GCTGCTGTCA AAGGGCTGCC CAGCTGATGA CATCATGGAA 
CCCAAGAGCC TCGCTGAGAC CCGGGACAGC CAGGCGGGCA GTCGGAAGCA GCTGTCCCCA 
CAGGAAGTGA CGCTCTACCT GAGACCAGGT CAGGCAGTTG CGTTCAACGT GACCTTCCGG 
AGGGCCAAGG GCTACCCCAT CGACCTGTAC TACCTGATGG ACCTCTCCTA CTCCATGGTG 
GATGACCTCG TCAACGTCAA GAAGCTGGGG GGTGACCTGC TCCGGGCCCT CAATGGCATC 
ACCGAGTCGG GCCGCATTGG TTTCGGGTCC TTCGTGGACA AGACGGTGCT CCCCTTCGTC 
AACACGCACC CCGAGAAGCT GCGGAACCCC TGCCCCAACA AGGAGAAGGA GTGCCAGCCC 
CCGTTCGCCT TCAGGCACGT GTTGAAGCTC ACTGACAACT CCAAACAGTT CGAGACAGAA 
GTCGGGAAGC AGCTGATCTC GGGGAACCTG GACGCCCCTG AGGGTGGGCT GGACGCCATG 
ATGCAGGTGG CCGCGTGCCC GGAGGAAATC GGCTGGCGCA ATGTCACCAG GCTGCTGGTG 
TTCGCCACGG ACGATGGGTT CCACTTTGCG GGCGATGGAA AGCTGGGTGC CATCCTCACC 
CCCAATGACG GCCGCTGCCA CCTGGAAGAC AACCTGTACA AAAGCAGCAA CGAATTTGAC 
TACCCATCGG TGGGCCAGCT GGCACACAAA CTGGCAGAAA GCAACATCCA GCCCATCTTT 
GCAGTAACCA AGAAGATGGT GAAAACGTAC GAGAAGCTGA CAGAGATCAT CCCCAAGTCT 
GCAGTCGGGG AGCTGTCTGA AGATTCCAGG AACGTGGTGG AGCTTATCAA GAATGCCTAC 
AATAAACTGT CCTCCAGAGT CTTCCTGGAT CACAGCACCC TCCCTGACAC CCTGAAAGTC 
ACCTACGACT CCTTCTGCAG TAACGGGAAA TCGCAGGTGG ACCAGCCCAG AGGGGACTGC 
GACGGCGTCC AGATCAACGT CCCGATCACC TTCCAGGTGA AGGTCACAGC CACCGAGTGC 
ATCCAGCAGC AGTCCTTCAC CATCCGGGCG CTGGGCTTCA CGGACACGGT GACCGTGCGG 
GTCCTCCCCC AGTGCGAGTG CCAATGCCGG GACGCCAGCA GGGACGGCAG CATCTGCGGC 
GGCAGAGGCT CGATGGAGTG CGGCGTCTGC AGGTGTGACG CCGGCTACAT CGGGAAGAAC 
TGCGAGTGCC AGACGCAGGG CCGGAGCAGC CAGGAGCTGG AGGGCAGCTG CCGCAAGGAC 
AACAGCTCCA TCATCTGCTC GGGGCTGGGG GACTGCATCT GCGGGCAGTG CGTGTGCCAC 
ACGAGCGACG TGCCCAACAA GAAGATCTAC GGCCAGTTCT GCGAGTGCGA CAACGTCAAC 
TGCGAACGCT ACGACGGCCA AGTCTGCGGG GGCGAAAAGA GGGGGCTCTG CTTCTGCGGC 
ACCTGCAGGT GCGACGAGCA GTATGAGGGT TCGGCATGCC AGTGCCTCAA GTCCACTCAG 
GGCTGCCTCA ACTTGGACGG CGTCGAGTGC AGCGGCCGCG GCCGATGCCG CTGCAATGTG 
TGCCAGTGCG ACCCCGGCTA CCAGCCGCCC CTGTGCAGCG AGTGCCCGGG CTGCCCCGTG 
CCCTGTGCGG GCTTCGCCCC CTGCACAGAG TGCCTGAAGT TCGACAAGGG CCCCTTCGCC 
AAGAACTGCA GCGCAGCGTG CGGGCAGACG AAGCTGCTGT CCAGCCCGGT GCCCGGCCGC 
AAGTGCAAGG AGCGCGACTC CGAGGGCTGC TGGATGACCT ACACCCTGGT GCAGCGCGAC 
GGGCGGGACA GATACGACGT GCACGTGGAC GACATGCTCG AGTGTGTGAA GGGCCCCAAC 
ATCGCTGCCA TCGTGGGGGG CACCGTGGGG GGCGTCGTGC TCGTCGGCAT CCTCCTGCTG 
GTCATCTGGA AGGCCCTGAC ACACCTGAGC GACCTCAGGG AGTACCATCG CTTTGAGAAG 
GAGAAGCTCA AGTCCCAGTG GAACAACGAT AACCCTCTTT TCAAGAGTGC CACCACGACA 
GTCATGAACC CTAAGTTTGC CGAGAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITGB2 ( XM_015473717.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_015329203.1 Bos taurus integrin subunit beta 2 (ITGB2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa87825
Clone ID Related Accession (Same CDS sequence)	XM_015473717.1
Accession Version	XM_015473717.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2310bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	integrin beta-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003103825.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCGCC AGCGCCCCCA GCTGCTGCTC CTAGCGGGCC TGCTTGCCCT CCAGTCCGTC 
CTGTCCCAGG AGTGCACCAA CTACAAGGTC AGCACCTGCC GGGACTGCAT CGAGTCGGGC 
CCCGGCTGCG CCTGGTGCCA GAAACTGAAC TTCACAGGGC AAGGGGAGCC CGACTCCATT 
CGCTGTGACA CACGAGCGGA GCTGCTGTCA AAGGGCTGCC CAGCTGATGA CATCATGGAA 
CCCAAGAGCC TCGCTGAGAC CCGGGACAGC CAGGCGGGCA GTCGGAAGCA GCTGTCCCCA 
CAGGAAGTGA CGCTCTACCT GAGACCAGGT CAGGCAGTTG CGTTCAATGT GACCTTCCGG 
AGGGCCAAGG GCTACCCCAT CGACCTGTAC TACCTGATGG ACCTCTCCTA CTCCATGGTG 
GATGACCTCG TCAACGTCAA GAAGCTGGGG GGTGACCTGC TCCGGGCCCT CAATGGCATC 
ACCGAGTCGG GCCGCATTGG TTTCGGGTCC TTCGTGGACA AGACGGTGCT CCCCTTCGTC 
AACACGCACC CCGAGAAGCT GCGGAACCCC TGCCCCAACA AGGAGAAGGA GTGCCAGCCC 
CCGTTCGCCT TCAGGCACGT GTTGAAGCTC ACTGACAACT CCAAACAGTT CGAGACAGAA 
GTCGGGAAGC AGCTGATCTC GGGGAACCTG GACGCCCCTG AGGGTGGGCT GGACGCCATG 
ATGCAGGTGG CCGCGTGCCC GGAGGAAATC GGCTGGCGCA ATGTCACCAG GCTGCTGGTG 
TTCGCCACGG ACGATGGGTT CCACTTTGCG GGCGATGGAA AGCTGGGTGC CATCCTCACC 
CCCAATGACG GCCGCTGCCA CCTGGAAGAC AACCTGTACA AAAGCAGCAA CGAATTTGAC 
TACCCATCGG TGGGCCAGCT GGCACACAAA CTGGCAGAAA GCAACATCCA GCCCATCTTT 
GCAGTAACCA AGAAGATGGT GAAAACGTAC GAGAAGCTGA CAGAGATCAT CCCCAAGTCT 
GCAGTCGGGG AGCTGTCTGA AGATTCCAGG AACGTGGTGG AGCTTATCAA GAATGCCTAC 
AATAAACTGT CCTCCAGAGT CTTCCTGGAT CACAGCACCC TCCCTGACAC CCTGAAAGTC 
ACCTACGACT CCTTCTGCAG TAACGGGAAA TCGCAGGTGG ACCAGCCCAG AGGGGACTGC 
GACGGCGTCC AGATCAACGT CCCGATCACC TTCCAGGTGA AGGTCACAGC CACCGAGTGC 
ATCCAGCAGC AGTCCTTCAC CATCCGGGCG CTGGGCTTCA CGGACACGGT GACCGTGCGG 
GTCCTCCCCC AGTGCGAGTG CCAATGCCGG GACGCCAGCA GGGACGGCAG CATCTGCGGC 
GGCAGAGGCT CGATGGAGTG CGGCGTCTGC AGGTGTGACG CCGGCTACAT CGGGAAGAAC 
TGCGAGTGCC AGACGCAGGG CCGGAGCAGC CAGGAGCTGG AGGGCAGCTG CCGCAAGGAC 
AACAGCTCCA TCATCTGCTC GGGGCTGGGG GACTGCATCT GCGGGCAGTG CGTGTGCCAC 
ACGAGCGACG TGCCCAACAA GAAGATCTAC GGCCAGTTCT GCGAGTGCGA CAACGTCAAC 
TGCGAACGCT ACGACGGCCA AGTCTGCGGG GGCGAAAAGA GGGGGCTCTG CTTCTGCGGC 
ACCTGCAGGT GCGACGAGCA GTATGAGGGT TCGGCATGCC AGTGCCTCAA GTCCACTCAG 
GGCTGCCTCA ACTTGGACGG CGTCGAGTGC AGCGGCCGCG GCCGATGCCG CTGCAATGTG 
TGCCAGTGCG ACCCCGGCTA CCAGCCGCCC CTGTGCAGCG AGTGCCCGGG CTGCCCCGTG 
CCCTGTGCGG GCTTCGCCCC CTGCACAGAG TGCCTGAAGT TCGACAAGGG CCCCTTCGCC 
AAGAACTGCA GCGCAGCGTG CGGGCAGACG AAGCTGCTGT CCAGCCCGGT GCCCGGCCGC 
AAGTGCAAGG AGCGCGACTC CGAGGGCTGC TGGATGACCT ACACCCTGGT GCAGCGCGAC 
GGGCGGGACA GATACGACGT GCACGTGGAC GACATGCTCG AGTGTGTGAA GGGCCCCAAC 
ATCGCTGCCA TCGTGGGGGG CACCGTGGGG GGCGTCGTGC TCGTCGGCAT CCTCCTGCTG 
GTCATCTGGA AGGCCCTGAC ACACCTGAGC GACCTCAGGG AGTACCATCG CTTTGAGAAG 
GAGAAGCTCA AGTCCCAGTG GAACAACGAT AACCCTCTTT TCAAGAGTGC CACCACGACA 
GTCATGAACC CTAAGTTTGC CGAGAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015329203.1
CDS	148..2457
Translation	MLRQRPQLLLLAGLLALQSVLSQECTNYKVSTCRDCIESGPGCAWCQKLNFTGQGEPDSIRCDTRAELLSKGCPADDIMEPKSLAETRDSQAGSRKQLSPQEVTLYLRPGQAVAFNVTFRRAKGYPIDLYYLMDLSYSMVDDLVNVKKLGGDLLRALNGITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKECQPPFAFRHVLKLTDNSKQFETEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKSSNEFDYPSVGQLAHKLAESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSEDSRNVVELIKNAYNKLSSRVFLDHSTLPDTLKVTYDSFCSNGKSQVDQPRGDCDGVQINVPITFQVKVTATECIQQQSFTIRALGFTDTVTVRVLPQCECQCRDASRDGSICGGRGSMECGVCRCDAGYIGKNCECQTQGRSSQELEGSCRKDNSSIICSGLGDCICGQCVCHTSDVPNKKIYGQFCECDNVNCERYDGQVCGGEKRGLCFCGTCRCDEQYEGSACQCLKSTQGCLNLDGVECSGRGRCRCNVCQCDPGYQPPLCSECPGCPVPCAGFAPCTECLKFDKGPFAKNCSAACGQTKLLSSPVPGRKCKERDSEGCWMTYTLVQRDGRDRYDVHVDDMLECVKGPNIAAIVGGTVGGVVLVGILLLVIWKALTHLSDLREYHRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES

Target ORF information:

RefSeq Version	XM_015473717.1
Organism	Bos taurus(cattle)
Definition	Bos taurus integrin subunit beta 2 (ITGB2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015473717.1

ORF Insert Sequence:

ATGCTGCGCC AGCGCCCCCA GCTGCTGCTC CTAGCGGGCC TGCTTGCCCT CCAGTCCGTC 
CTGTCCCAGG AGTGCACCAA CTACAAGGTC AGCACCTGCC GGGACTGCAT CGAGTCGGGC 
CCCGGCTGCG CCTGGTGCCA GAAACTGAAC TTCACAGGGC AAGGGGAGCC CGACTCCATT 
CGCTGTGACA CACGAGCGGA GCTGCTGTCA AAGGGCTGCC CAGCTGATGA CATCATGGAA 
CCCAAGAGCC TCGCTGAGAC CCGGGACAGC CAGGCGGGCA GTCGGAAGCA GCTGTCCCCA 
CAGGAAGTGA CGCTCTACCT GAGACCAGGT CAGGCAGTTG CGTTCAATGT GACCTTCCGG 
AGGGCCAAGG GCTACCCCAT CGACCTGTAC TACCTGATGG ACCTCTCCTA CTCCATGGTG 
GATGACCTCG TCAACGTCAA GAAGCTGGGG GGTGACCTGC TCCGGGCCCT CAATGGCATC 
ACCGAGTCGG GCCGCATTGG TTTCGGGTCC TTCGTGGACA AGACGGTGCT CCCCTTCGTC 
AACACGCACC CCGAGAAGCT GCGGAACCCC TGCCCCAACA AGGAGAAGGA GTGCCAGCCC 
CCGTTCGCCT TCAGGCACGT GTTGAAGCTC ACTGACAACT CCAAACAGTT CGAGACAGAA 
GTCGGGAAGC AGCTGATCTC GGGGAACCTG GACGCCCCTG AGGGTGGGCT GGACGCCATG 
ATGCAGGTGG CCGCGTGCCC GGAGGAAATC GGCTGGCGCA ATGTCACCAG GCTGCTGGTG 
TTCGCCACGG ACGATGGGTT CCACTTTGCG GGCGATGGAA AGCTGGGTGC CATCCTCACC 
CCCAATGACG GCCGCTGCCA CCTGGAAGAC AACCTGTACA AAAGCAGCAA CGAATTTGAC 
TACCCATCGG TGGGCCAGCT GGCACACAAA CTGGCAGAAA GCAACATCCA GCCCATCTTT 
GCAGTAACCA AGAAGATGGT GAAAACGTAC GAGAAGCTGA CAGAGATCAT CCCCAAGTCT 
GCAGTCGGGG AGCTGTCTGA AGATTCCAGG AACGTGGTGG AGCTTATCAA GAATGCCTAC 
AATAAACTGT CCTCCAGAGT CTTCCTGGAT CACAGCACCC TCCCTGACAC CCTGAAAGTC 
ACCTACGACT CCTTCTGCAG TAACGGGAAA TCGCAGGTGG ACCAGCCCAG AGGGGACTGC 
GACGGCGTCC AGATCAACGT CCCGATCACC TTCCAGGTGA AGGTCACAGC CACCGAGTGC 
ATCCAGCAGC AGTCCTTCAC CATCCGGGCG CTGGGCTTCA CGGACACGGT GACCGTGCGG 
GTCCTCCCCC AGTGCGAGTG CCAATGCCGG GACGCCAGCA GGGACGGCAG CATCTGCGGC 
GGCAGAGGCT CGATGGAGTG CGGCGTCTGC AGGTGTGACG CCGGCTACAT CGGGAAGAAC 
TGCGAGTGCC AGACGCAGGG CCGGAGCAGC CAGGAGCTGG AGGGCAGCTG CCGCAAGGAC 
AACAGCTCCA TCATCTGCTC GGGGCTGGGG GACTGCATCT GCGGGCAGTG CGTGTGCCAC 
ACGAGCGACG TGCCCAACAA GAAGATCTAC GGCCAGTTCT GCGAGTGCGA CAACGTCAAC 
TGCGAACGCT ACGACGGCCA AGTCTGCGGG GGCGAAAAGA GGGGGCTCTG CTTCTGCGGC 
ACCTGCAGGT GCGACGAGCA GTATGAGGGT TCGGCATGCC AGTGCCTCAA GTCCACTCAG 
GGCTGCCTCA ACTTGGACGG CGTCGAGTGC AGCGGCCGCG GCCGATGCCG CTGCAATGTG 
TGCCAGTGCG ACCCCGGCTA CCAGCCGCCC CTGTGCAGCG AGTGCCCGGG CTGCCCCGTG 
CCCTGTGCGG GCTTCGCCCC CTGCACAGAG TGCCTGAAGT TCGACAAGGG CCCCTTCGCC 
AAGAACTGCA GCGCAGCGTG CGGGCAGACG AAGCTGCTGT CCAGCCCGGT GCCCGGCCGC 
AAGTGCAAGG AGCGCGACTC CGAGGGCTGC TGGATGACCT ACACCCTGGT GCAGCGCGAC 
GGGCGGGACA GATACGACGT GCACGTGGAC GACATGCTCG AGTGTGTGAA GGGCCCCAAC 
ATCGCTGCCA TCGTGGGGGG CACCGTGGGG GGCGTCGTGC TCGTCGGCAT CCTCCTGCTG 
GTCATCTGGA AGGCCCTGAC ACACCTGAGC GACCTCAGGG AGTACCATCG CTTTGAGAAG 
GAGAAGCTCA AGTCCCAGTG GAACAACGAT AACCCTCTTT TCAAGAGTGC CACCACGACA 
GTCATGAACC CTAAGTTTGC CGAGAGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of a null allele in genetic tests for bovine leukocyte adhesion deficiency in Pakistani Bos indicus ? Bos taurus cattle.
Molecular and cellular probes26(6)259-62(2012 Dec)
Nasreen F,Malik NA,Qureshi JA,Raadsma HW,Tammen I

Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
Proceedings of the National Academy of Sciences of the United States of America106(36)15448-53(2009 Sep)
Shanthalingam S,Srikumaran S

Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods.
Hereditas146(2)74-8(2009 May)
Nasreen F,Altaf Malik N,Naeem Riaz M,Anver Qureshi J

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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ITGB2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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