Gene Symbol | IKBKB |
Entrez Gene ID | 281854 |
Full Name | inhibitor of nuclear factor kappa B kinase subunit beta |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » IKBKB cDNA ORF clone
Gene Symbol | IKBKB |
Entrez Gene ID | 281854 |
Full Name | inhibitor of nuclear factor kappa B kinase subunit beta |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
XM_005226099.4 | XP_005226156.1 | inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 |
NM_174353.2 | NP_776778.1 | inhibitor of nuclear factor kappa-B kinase subunit beta |
XM_005226099.3 | XP_005226156.1 | inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 |
IKBKB | XP_001096913.1 | |
Mus musculus (house mouse) | Ikbkb | NP_001153246.1 |
Xenopus tropicalis (tropical clawed frog) | ikbkb | NP_001005651.1 |
Canis lupus familiaris (dog) | IKBKB | XP_005629860.1 |
Rattus norvegicus (Norway rat) | Ikbkb | NP_445807.2 |
Danio rerio (zebrafish) | ikbkb | NP_001116737.1 |
Bos taurus (cattle) | IKBKB | NP_776778.1 |
Gallus gallus (chicken) | IKBKB | NP_001026568.1 |
Homo sapiens (human) | IKBKB | NP_001547.1 |
Pan troglodytes (chimpanzee) | IKBKB | XP_001142461.2 |
Staphylococcus aureus inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
Lara-Z?rate L, L?pez-Meza JE, Ochoa-Zarzosa A
Microbial pathogenesis51(5)313-8(2011 Nov)
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
Mohan S, Konopinski R, Yan B, Centonze VE, Natarajan M
American journal of physiology. Cell physiology296(1)C182-92(2009 Jan)
A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)
Characterization of 954 bovine full-CDS cDNA sequences.
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP
BMC genomics6166(2005 Nov)
Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells.
Kim F, Tysseling KA, Rice J, Gallis B, Haji L, Giachelli CM, Raines EW, Corson MA, Schwartz MW
Journal of molecular and cellular cardiology39(2)327-34(2005 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
Title: Staphylococcus aureus inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
Title: High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin-mediated NO production.
Title: Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
Title: Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.
The following IKBKB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IKBKB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa41584 | |
Clone ID Related Accession (Same CDS sequence) | NM_174353.2 | |
Accession Version | NM_174353.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2271bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Bos taurus(cattle) | |
Product | inhibitor of nuclear factor kappa-B kinase subunit beta | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ414556.1. On Jun 3, 2003 this sequence version replaced NM_174353.1. ##Evidence-Data-START## Transcript exon combination :: AJ414556.1, BT021585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGCTGGT CACCTTCCCT GCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776778.1 |
CDS | 36..2306 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174353.2 |
1 | ATGAGCTGGT CACCTTCCCT GCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa34007 | |
Clone ID Related Accession (Same CDS sequence) | XM_005226099.4 , XM_005226099.3 | |
Accession Version | XM_005226099.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2574bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037354.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005226099.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCTGGT CACCTTCCCT GCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005226156.1 |
CDS | 178..2751 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005226099.4 |
1 | ATGAGCTGGT CACCTTCCCT GCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa34007 | |
Clone ID Related Accession (Same CDS sequence) | XM_005226099.4 , XM_005226099.3 | |
Accession Version | XM_005226099.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2574bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-01-25 | |
Organism | Bos taurus(cattle) | |
Product | inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104610.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005226099.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCTGGT CACCTTCCCT GCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005226156.1 |
CDS | 216..2789 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005226099.3 |
1 | ATGAGCTGGT CACCTTCCCT GCCAACCCAG ACATGTGGGG CCTGGGAAAT GAAAGAGCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Staphylococcus aureus inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells. |
High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Characterization of 954 bovine full-CDS cDNA sequences. |
Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells. |