Gene Symbol | HSPA8 |
Entrez Gene ID | 281831 |
Full Name | heat shock protein family A (Hsp70) member 8 |
Synonyms | HSPA10,Hsc70 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » HSPA8 cDNA ORF clone
Gene Symbol | HSPA8 |
Entrez Gene ID | 281831 |
Full Name | heat shock protein family A (Hsp70) member 8 |
Synonyms | HSPA10,Hsc70 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_174345.4 | NP_776770.2 | heat shock cognate 71 kDa protein |
Homo sapiens (human) | HSPA8 | NP_006588.1 |
HSPA8 | XP_002799868.1 | |
Canis lupus familiaris (dog) | HSPA8 | XP_005619707.1 |
Bos taurus (cattle) | HSPA8 | NP_776770.2 |
Rattus norvegicus (Norway rat) | Hspa8 | NP_077327.1 |
Gallus gallus (chicken) | HSPA8 | NP_990334.1 |
Caenorhabditis elegans (roundworm) | hsp-1 | NP_503068.1 |
Mus musculus (house mouse) | Hspa8 | NP_112442.2 |
Danio rerio (zebrafish) | hspa8 | NP_001103873.1 |
Xenopus tropicalis (tropical clawed frog) | hspa8 | XP_004916187.1 |
Pan troglodytes (chimpanzee) | HSPA8 | XP_003313441.2 |
Drosophila melanogaster (fruit fly) | Hsc70-1 | NP_524063.1 |
Arabidopsis thaliana (thale cress) | AT3G09440 | NP_001189847.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004944 | XP_315042.3 |
Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.
B?cking T, Aguet F, Harrison SC, Kirchhausen T
Nature structural & molecular biology18(3)295-301(2011 Mar)
The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.
Wilkins S, Choglay AA, Chapple JP, van der Spuy J, Rhie A, Birkett CR, Cheetham ME
The international journal of biochemistry & cell biology42(7)1226-32(2010 Jul)
Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
Xing Y, B?cking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC
The EMBO journal29(3)655-65(2010 Feb)
Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone.
Scott-Ward TS, Amaral MD
The FEBS journal276(23)7097-109(2009 Dec)
Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage.
Alam MU, Harken JA, Knorn AM, Elford AR, Wigmore K, Ohashi PS, Millar DG
Journal of immunology (Baltimore, Md. : 1950)183(9)5728-37(2009 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Single-particle fluorescence imaging tracks the dynamics of Hsc70 and its clathrin substrate in real time.
Title: Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.
The interaction of the molecular chaperone Hsc70 (HSPA8) with recombinant PrP was investigated.
Title: The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper.
Structure of clathrin coat with bound Hsc70 and auxilin.
Title: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
Elevated expression of bovine heat shock cognate (hsc)70 protein increases diabetes and inflammation following islet beta cell damage in a transgenic mouse model.
Title: Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage.
analysis of the formation of a stable complex between chaperonin-containing TCP-1 (CCT) and Hsc70
Title: The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.
The following HSPA8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSPA8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa44679 | |
Clone ID Related Accession (Same CDS sequence) | NM_174345.4 | |
Accession Version | NM_174345.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1953bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Bos taurus(cattle) | |
Product | heat shock cognate 71 kDa protein | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105182.1. On Aug 30, 2012 this sequence version replaced NM_174345.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC105182.1, BT030487.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145482, SAMN04335740 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCTAAAG GACCTGCAGT TGGCATTGAT CTTGGCACCA CCTATTCTTG TGTGGGTGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776770.2 |
CDS | 76..2028 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174345.4 |
1 | ATGTCTAAAG GACCTGCAGT TGGCATTGAT CTTGGCACCA CCTATTCTTG TGTGGGTGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating. |
The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper. |
Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. |
Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone. |
Transgenic expression of Hsc70 in pancreatic islets enhances autoimmune diabetes in response to beta cell damage. |