EDNRA cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	EDNRA
Entrez Gene ID	281749
Full Name	endothelin receptor type A
General protein information	Preferred Names endothelin receptor type A Names endothelin-1 receptor ET-A ET-AR endothelin A receptor
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174308.2	NP_776733.1	endothelin-1 receptor precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ednra	NP_034462.1
Xenopus tropicalis (tropical clawed frog)	ednra	NP_001072275.1
Canis lupus familiaris (dog)	EDNRA	NP_001026802.1
Gallus gallus (chicken)	EDNRA	NP_989450.1
Danio rerio (zebrafish)	ednraa	NP_001092915.1
Homo sapiens (human)	EDNRA	NP_001948.1
Bos taurus (cattle)	EDNRA	NP_776733.1
Rattus norvegicus (Norway rat)	Ednra	NP_036682.1
Pan troglodytes (chimpanzee)	EDNRA	XP_001149597.1
	EDNRA	XP_001098827.1

Gene Ontology
Bibliography

Related articles in PubMed

Endothelin as a local regulating factor in the bovine oviduct.
Yamamoto Y, Kohka M, Kobayashi Y, Woclawek-Potocka I, Okuda K
Reproduction, fertility, and development28(6)673-81(2016 Apr)

Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy.
Hayashi KG, Hosoe M, Takahashi T
Animal reproduction science134(3-4)150-7(2012 Oct)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Expression of endothelin receptors in frog, chicken, mouse and human pigment cells.
Scarparo AC, Isoldi MC, de Lima LH, Visconti MA, Castrucci AM
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology147(3)640-6(2007 Jul)

Characterization of 954 bovine full-CDS cDNA sequences.
Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP
BMC genomics6166(2005 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
Title: Endothelin as a local regulating factor in the bovine oviduct.

Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Title: Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy.

ET receptors in pigment cells of vertebrate species were identified by RT-PCR assays, and the differential expression of the various subtypes in each species was compared by quantitative PCR.
Title: Expression of endothelin receptors in frog, chicken, mouse and human pigment cells.

Elevated local expression of ET-1 and Ednra/Ednrb during the peri-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Title: Endothelin-1 system in the bovine oviduct: a regulator of local contraction and gamete transport.

Brain microvessel endothelin type A receptors are coupled to ceramide production.
Title: Brain microvessel endothelin type A receptors are coupled to ceramide production.

The following EDNRA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EDNRA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41427	NM_174308.2 Latest version!	Bos taurus endothelin receptor type A (EDNRA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EDNRA ( NM_174308.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776733.1 Bos taurus endothelin receptor type A (EDNRA), mRNA.

Price & Availability↑

CloneID	OBa41427
Clone ID Related Accession (Same CDS sequence)	NM_174308.2
Accession Version	NM_174308.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1284bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	endothelin-1 receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X57765.1. On Jun 28, 2007 this sequence version replaced NM_174308.1. ##Evidence-Data-START## Transcript exon combination :: X57765.1, BC142309.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145497 [ECO:0000348] ##Evidence-Data-END##

ATGGAAACCT TTTGGCTCAG GTTGTCCTTC TGGGTGGCTC TGGTTGGAGG TGTCATCAGT 
GATAACCCTG AAAGCTACAG CACAAACCTA AGCATCCATG TGGACAGTGT CGCCACTTTC 
CATGGGACAG AACTCAGCTT CGTGGTCACC ACACATCAAC CCACGAATTT GGCCCTCCCC 
AGCAATGGCT CAATGCACAA CTATTGCCCA CAACAGACTA AGATTACTTC AGCTTTCAAA 
TACATTAACA CTGTGATATC ATGTACTATT TTCATCGTGG GAATGGTGGG GAATGCAACC 
CTGCTCAGGA TCATTTACCA GAACAAGTGC ATGAGGAATG GCCCCAACGC GCTGATAGCC 
AGCCTTGCCC TGGGAGACCT TATCTATGTG GTCATTGATC TCCCTATCAA TGTATTTAAG 
CTGCTGGCTG GGCGCTGGCC TTTTGAACAA AATGACTTTG GCGTTTTCCT CTGCAAGTTG 
TTCCCCTTTT TGCAGAAGTC CTCAGTGGGG ATCACCGTCC TTAATCTCTG CGCCCTAAGC 
GTTGACAGGT ACAGAGCAGT TGCCTCCTGG AGTCGTGTTC AGGGAATTGG GATTCCCTTG 
GTCACAGCCA TTGAGATTGT CTCCATCTGG ATCCTTTCTT TTATCCTGGC CATCCCTGAA 
GCCATCGGCT TTGTCATGGT ACCTTTTGAA TACAAGGGTG CACAGCACAG AACCTGTATG 
CTCAATGCCA CGTCGAAATT CATGGAGTTC TATCAGGATG TTAAGGACTG GTGGCTGTTC 
GGGTTCTACT TCTGCATGCC CCTGGTGTGC ACTGCGATCT TTTACACCCT CATGACTTGT 
GAGATGTTAA ACCGAAGGAA CGGCAGCCTG AGAATTGCCC TCAGTGAGCA TCTGAAACAG 
CGTCGAGAAG TGGCAAAAAC AGTTTTCTGC TTGGTTGTAA TTTTTGCTCT GTGCTGGTTC 
CCTCTTCATT TAAGCCGCAT TTTGAAGAAA ACCGTGTATG ATGAAATGGA CACGAACCGA 
TGTGAATTAC TTAGTTTCTT GCTGCTCATG GATTACATCG GTATTAACTT GGCAACCATG 
AATTCATGTA TCAACCCAAT AGCTCTATAT TTTGTGAGCA AGAAATTTAA AAATTGTTTC 
CAGTCTTGCC TCTGCTGCTG CTGTTACCAG TCCAAGAGCC TGATGACTTC GGTGCCCATG 
AATGGCACCA GCATCCAGTG GAAGAACCAT GAACAAAACA ACCATAACAC AGAGAGGAGC 
AGCCACAAGG ACAGTATCAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776733.1
CDS	454..1737
Translation	METFWLRLSFWVALVGGVISDNPESYSTNLSIHVDSVATFHGTELSFVVTTHQPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFEQNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGAQHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDTNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN

Target ORF information:

RefSeq Version	NM_174308.2
Organism	Bos taurus(cattle)
Definition	Bos taurus endothelin receptor type A (EDNRA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174308.2

ORF Insert Sequence:

ATGGAAACCT TTTGGCTCAG GTTGTCCTTC TGGGTGGCTC TGGTTGGAGG TGTCATCAGT 
GATAACCCTG AAAGCTACAG CACAAACCTA AGCATCCATG TGGACAGTGT CGCCACTTTC 
CATGGGACAG AACTCAGCTT CGTGGTCACC ACACATCAAC CCACGAATTT GGCCCTCCCC 
AGCAATGGCT CAATGCACAA CTATTGCCCA CAACAGACTA AGATTACTTC AGCTTTCAAA 
TACATTAACA CTGTGATATC ATGTACTATT TTCATCGTGG GAATGGTGGG GAATGCAACC 
CTGCTCAGGA TCATTTACCA GAACAAGTGC ATGAGGAATG GCCCCAACGC GCTGATAGCC 
AGCCTTGCCC TGGGAGACCT TATCTATGTG GTCATTGATC TCCCTATCAA TGTATTTAAG 
CTGCTGGCTG GGCGCTGGCC TTTTGAACAA AATGACTTTG GCGTTTTCCT CTGCAAGTTG 
TTCCCCTTTT TGCAGAAGTC CTCAGTGGGG ATCACCGTCC TTAATCTCTG CGCCCTAAGC 
GTTGACAGGT ACAGAGCAGT TGCCTCCTGG AGTCGTGTTC AGGGAATTGG GATTCCCTTG 
GTCACAGCCA TTGAGATTGT CTCCATCTGG ATCCTTTCTT TTATCCTGGC CATCCCTGAA 
GCCATCGGCT TTGTCATGGT ACCTTTTGAA TACAAGGGTG CACAGCACAG AACCTGTATG 
CTCAATGCCA CGTCGAAATT CATGGAGTTC TATCAGGATG TTAAGGACTG GTGGCTGTTC 
GGGTTCTACT TCTGCATGCC CCTGGTGTGC ACTGCGATCT TTTACACCCT CATGACTTGT 
GAGATGTTAA ACCGAAGGAA CGGCAGCCTG AGAATTGCCC TCAGTGAGCA TCTGAAACAG 
CGTCGAGAAG TGGCAAAAAC AGTTTTCTGC TTGGTTGTAA TTTTTGCTCT GTGCTGGTTC 
CCTCTTCATT TAAGCCGCAT TTTGAAGAAA ACCGTGTATG ATGAAATGGA CACGAACCGA 
TGTGAATTAC TTAGTTTCTT GCTGCTCATG GATTACATCG GTATTAACTT GGCAACCATG 
AATTCATGTA TCAACCCAAT AGCTCTATAT TTTGTGAGCA AGAAATTTAA AAATTGTTTC 
CAGTCTTGCC TCTGCTGCTG CTGTTACCAG TCCAAGAGCC TGATGACTTC GGTGCCCATG 
AATGGCACCA GCATCCAGTG GAAGAACCAT GAACAAAACA ACCATAACAC AGAGAGGAGC 
AGCCACAAGG ACAGTATCAA CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endothelin as a local regulating factor in the bovine oviduct.
Reproduction, fertility, and development28(6)673-81(2016 Apr)
Yamamoto Y,Kohka M,Kobayashi Y,Woclawek-Potocka I,Okuda K

Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy.
Animal reproduction science134(3-4)150-7(2012 Oct)
Hayashi KG,Hosoe M,Takahashi T

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Expression of endothelin receptors in frog, chicken, mouse and human pigment cells.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology147(3)640-6(2007 Jul)
Scarparo AC,Isoldi MC,de Lima LH,Visconti MA,Castrucci AM

Characterization of 954 bovine full-CDS cDNA sequences.
BMC genomics6166(2005 Nov)
Harhay GP,Sonstegard TS,Keele JW,Heaton MP,Clawson ML,Snelling WM,Wiedmann RT,Van Tassell CP,Smith TP

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EDNRA cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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