Gene Symbol | CYP17A1 |
Entrez Gene ID | 281739 |
Full Name | cytochrome P450, family 17, subfamily A, polypeptide 1 |
Synonyms | CYP17,CYPXVII,P450-C17,P450c17 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
ORF » Species Summary » Bos taurus » CYP17A1 cDNA ORF clone
Gene Symbol | CYP17A1 |
Entrez Gene ID | 281739 |
Full Name | cytochrome P450, family 17, subfamily A, polypeptide 1 |
Synonyms | CYP17,CYPXVII,P450-C17,P450c17 |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_024985465.1 | XP_024841233.1 | steroid 17-alpha-hydroxylase/17,20 lyase isoform X1 |
XM_024985466.1 | XP_024841234.1 | steroid 17-alpha-hydroxylase/17,20 lyase isoform X2 |
NM_174304.2 | NP_776729.1 | steroid 17-alpha-hydroxylase/17,20 lyase precursor |
CYP17A1 | NP_001035322.1 | |
Arabidopsis thaliana (thale cress) | CYP706A3 | NP_199275.1 |
Canis lupus familiaris (dog) | CYP17A1 | XP_535000.3 |
Arabidopsis thaliana (thale cress) | CYP706A4 | NP_192967.1 |
Arabidopsis thaliana (thale cress) | CYP706A2 | NP_194002.1 |
Homo sapiens (human) | CYP17A1 | NP_000093.1 |
Bos taurus (cattle) | CYP17A1 | NP_776729.1 |
Arabidopsis thaliana (thale cress) | CYP706A6 | NP_192969.4 |
Arabidopsis thaliana (thale cress) | CYP706A5 | NP_192968.3 |
Arabidopsis thaliana (thale cress) | CYP706A1 | NP_567665.2 |
Mus musculus (house mouse) | Cyp17a1 | NP_031835.3 |
Oryza sativa (rice) | Os08g0547900 | NP_001062431.2 |
Pan troglodytes (chimpanzee) | CYP17A1 | NP_001009052.1 |
Rattus norvegicus (Norway rat) | Cyp17a1 | NP_036885.1 |
Arabidopsis thaliana (thale cress) | CYP706A7 | NP_192970.1 |
Oryza sativa (rice) | Os01g0700500 | NP_001043985.2 |
Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.
Glister C, Satchell L, Bathgate RA, Wade JD, Dai Y, Ivell R, Anand-Ivell R, Rodgers RJ, Knight PG
Proceedings of the National Academy of Sciences of the United States of America110(15)E1426-35(2013 Apr)
A false single nucleotide polymorphism generated by gene duplication compromises meat traceability.
Sanz A, Ordov?s L, Zaragoza P, Sanz A, de Blas I, Rodellar C
Meat science91(3)347-51(2012 Jul)
Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells.
Murayama C, Miyazaki H, Miyamoto A, Shimizu T
Molecular and cellular endocrinology350(1)1-9(2012 Mar)
Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes.
Waterman MR, Kagawa N, Zanger UM, Momoi K, Lund J, Simpson ER
The Journal of steroid biochemistry and molecular biology43(8)931-5(1992 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
BMP6 has a role in downregulating INSL3 and CYP17A1 and other proteins that modulate ovarian androgen production
Title: Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production.
By alignment analysis and sequencing, we detected that the g.329C>T SNP is a false positive polymorphism, which allows us to explain the inflated heterozygotic value.
Title: A false single nucleotide polymorphism generated by gene duplication compromises meat traceability.
The binding of SF-1 to the CYP17 and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.
Title: Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells.
the bovine genome contains three paralogous copies of the CYP17A1 gene, of which two (CYP17A1b and CYP17A1x) might be silenced by epigenetic modification (promoter methylation).
Title: The bovine genome contains three differentially methylated paralogous copies of the P450c17 encoding gene (CYP17A1).
Data suggest that the upstream region of gene encoding CYP17 contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex. [REVIEW]
Title: Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes.
The following CYP17A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP17A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa00816 | |
Clone ID Related Accession (Same CDS sequence) | NM_174304.2 | |
Accession Version | NM_174304.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Bos taurus(cattle) | |
Product | steroid 17-alpha-hydroxylase/17,20 lyase precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M12547.1. On Feb 21, 2013 this sequence version replaced NM_174304.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M12547.1, BC110169.1 [ECO:0000332] ##Evidence-Data-END## |
1 | ATGTGGCTGC TCCTGGCTGT CTTTCTGCTC ACCCTCGCCT ATTTATTTTG GCCCAAGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776729.1 |
CDS | 47..1576 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174304.2 |
1 | ATGTGGCTGC TCCTGGCTGT CTTTCTGCTC ACCCTCGCCT ATTTATTTTG GCCCAAGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa61874 | |
Clone ID Related Accession (Same CDS sequence) | XM_024985465.1 | |
Accession Version | XM_024985465.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1461bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | steroid 17-alpha-hydroxylase/17,20 lyase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037353.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTGGCTGC TCCTGGCTGT CTTTCTGCTC ACCCTCGCCT ATTTATTTTG GCCCAAGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024841233.1 |
CDS | 179..1639 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024985465.1 |
1 | ATGTGGCTGC TCCTGGCTGT CTTTCTGCTC ACCCTCGCCT ATTTATTTTG GCCCAAGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa61875 | |
Clone ID Related Accession (Same CDS sequence) | XM_024985466.1 | |
Accession Version | XM_024985466.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | steroid 17-alpha-hydroxylase/17,20 lyase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037353.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTGGCTGC TCCTGGCTGT CTTTCTGCTC ACCCTCGCCT ATTTATTTTG GCCCAAGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024841234.1 |
CDS | 184..1626 |
Translation |
Target ORF information:
Target ORF information:
|
XM_024985466.1 |
1 | ATGTGGCTGC TCCTGGCTGT CTTTCTGCTC ACCCTCGCCT ATTTATTTTG GCCCAAGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. |
A false single nucleotide polymorphism generated by gene duplication compromises meat traceability. |
Luteinizing hormone (LH) regulates production of androstenedione and progesterone via control of histone acetylation of StAR and CYP17 promoters in ovarian theca cells. |
Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes. |