CXCR4 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CXCR4
Entrez Gene ID	281736
Full Name	C-X-C motif chemokine receptor 4
General protein information	Preferred Names C-X-C motif chemokine receptor 4 Names C-X-C chemokine receptor type 4 CXC-R4 CXCR-4 LCR1 LESTR SDF-1 receptor chemokine (C-X-C motif) receptor 4 fusin leukocyte-derived seven transmembrane domain receptor stromal cell-derived factor 1 receptor
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174301.3	NP_776726.1	C-X-C chemokine receptor type 4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CXCR4	NP_989948.2
Danio rerio (zebrafish)	cxcr4a	NP_571957.2
Danio rerio (zebrafish)	cxcr4b	NP_571909.1
Pan troglodytes (chimpanzee)	CXCR4	NP_001009047.1
Mus musculus (house mouse)	Cxcr4	NP_034041.2
Rattus norvegicus (Norway rat)	Cxcr4	NP_071541.2
Xenopus tropicalis (tropical clawed frog)	cxcr4	NP_001090831.1
Homo sapiens (human)	CXCR4	NP_003458.1
	CXCR4	NP_001036110.1
Canis lupus familiaris (dog)	CXCR4	NP_001041491.1
Bos taurus (cattle)	CXCR4	NP_776726.1

Gene Ontology
Bibliography

Related articles in PubMed

Lack of specific alleles for the bovine chemokine (C-X-C) receptor type 4 (CXCR4) gene in West African cattle questions its role as a candidate for trypanotolerance.
?lvarez I, P?rez-Pardal L, Traor? A, Fern?ndez I, Goyache F
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases4230-3(2016 08)

Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.
Sayasith K, Sirois J
Molecular and cellular endocrinology391(1-2)10-21(2014 Jun)

C-X-C chemokine receptor type 4 and cytokine expressions in cows of a dairy herd with high prevalence of calves persistently infected with bovine viral diarrhea virus.
Helal MA, Hoshino Y, Takagi S, Tajima M
The Japanese journal of veterinary research61(3)109-16(2013 Aug)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Sequence and expression of a neuropeptide Y receptor cDNA.
Rimland J, Xin W, Sweetnam P, Saijoh K, Nestler EJ, Duman RS
Molecular pharmacology40(6)869-75(1991 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2.
Title: Lack of specific alleles for the bovine chemokine (C-X-C) receptor type 4 (CXCR4) gene in West African cattle questions its role as a candidate for trypanotolerance.

There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses.
Title: Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.

The combination of low expression of CXCR4 and high expression of IL-10 might be closely concerned with some bias for the production of PI calves.
Title: C-X-C chemokine receptor type 4 and cytokine expressions in cows of a dairy herd with high prevalence of calves persistently infected with bovine viral diarrhea virus.

The following CXCR4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCR4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43036	NM_174301.3 Latest version!	Bos taurus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CXCR4 ( NM_174301.3 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776726.1 Bos taurus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.

Price & Availability↑

CloneID	OBa43036
Clone ID Related Accession (Same CDS sequence)	NM_174301.3
Accession Version	NM_174301.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	C-X-C chemokine receptor type 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105217.1. On Sep 25, 2005 this sequence version replaced NM_174301.2. ##Evidence-Data-START## Transcript exon combination :: BC105217.1, M86739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGGGA TCCGTATATT CACTTCCGAT AATTACACCG AGGATGACTT GGGCTCGGGT 
GACTATGATT CCATGAAGGA ACCCTGCTTC CGGGAAGAAA ATGCCCATTT CAACCGGATC 
TTCCTGCCCA CTGTCTACTC CATCATCTTC CTGACTGGCA TAGTGGGCAA CGGATTGGTC 
ATTCTGGTCA TGGGTTACCA GAAGAAACTA AGAAGCATGA CGGACAAGTA CAGACTGCAC 
CTGTCTGTGG CGGACCTCCT GTTTGTCCTC ACGCTTCCCT TCTGGGCAGT CGATGCTGTG 
GCAAACTGGT ACTTTGGGAA GTTCCTCTGC AAGGCAGTCC ATGTCATCTA CACAGTCAAC 
CTCTACAGCA GTGTCCTCAT CCTGGCCTTT ATCAGTCTGG ACCGGTACCT GGCTATCGTC 
CATGCTACCA ACAGTCAGAA GCCAAGGAAG CTGCTGGCTG AAAAGGTGGT CTATGTTGGT 
GTCTGGCTAC CTGCTGTCCT GTTGACTATT CCTGATCTCA TCTTTGCTGA CATCAAGGAG 
GTGGATGAGA GGTACATCTG TGATCGCTTC TATCCCAGCG ACCTGTGGCT AGTGGTGTTT 
CAGTTTCAGC ACATCGTGGT CGGCCTTCTC CTGCCTGGTA TCGTCATCCT GTCCTGCTAC 
TGCATTATCA TCTCCAAGCT GTCCCACTCC AAAGGCTATC AGAAGCGCAA GGCCCTCAAG 
ACCACAGTTA TCCTCATCCT GACTTTCTTC GCCTGCTGGC TGCCCTACTA CATTGGGATC 
AGCATTGACT CCTTCATCCT TCTGGAAATC ATCCAGCAAG GGTGTGAGTT TGAGAGCACT 
GTGCACAAGT GGATTTCCAT CACCGAGGCC CTAGCTTTTT TTCACTGCTG CCTGAATCCC 
ATCCTCTATG CCTTCCTTGG GGCCAAATTT AAAACCTCTG CCCAGCATGC ACTCACCTCT 
GTGAGCAGAG GGTCCAGCCT GAAGATCCTC TCCAAGGGCA AGCGAGGTGG ACATTCTTCT 
GTCTCAACCG AGTCTGAATC TTCAAGTTTT CACTCCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776726.1
CDS	89..1150
Translation	MEGIRIFTSDNYTEDDLGSGDYDSMKEPCFREENAHFNRIFLPTVYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVDAVANWYFGKFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQKPRKLLAEKVVYVGVWLPAVLLTIPDLIFADIKEVDERYICDRFYPSDLWLVVFQFQHIVVGLLLPGIVILSCYCIIISKLSHSKGYQKRKALKTTVILILTFFACWLPYYIGISIDSFILLEIIQQGCEFESTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS

Target ORF information:

RefSeq Version	NM_174301.3
Organism	Bos taurus(cattle)
Definition	Bos taurus C-X-C motif chemokine receptor 4 (CXCR4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174301.3

ORF Insert Sequence:

ATGGAAGGGA TCCGTATATT CACTTCCGAT AATTACACCG AGGATGACTT GGGCTCGGGT 
GACTATGATT CCATGAAGGA ACCCTGCTTC CGGGAAGAAA ATGCCCATTT CAACCGGATC 
TTCCTGCCCA CTGTCTACTC CATCATCTTC CTGACTGGCA TAGTGGGCAA CGGATTGGTC 
ATTCTGGTCA TGGGTTACCA GAAGAAACTA AGAAGCATGA CGGACAAGTA CAGACTGCAC 
CTGTCTGTGG CGGACCTCCT GTTTGTCCTC ACGCTTCCCT TCTGGGCAGT CGATGCTGTG 
GCAAACTGGT ACTTTGGGAA GTTCCTCTGC AAGGCAGTCC ATGTCATCTA CACAGTCAAC 
CTCTACAGCA GTGTCCTCAT CCTGGCCTTT ATCAGTCTGG ACCGGTACCT GGCTATCGTC 
CATGCTACCA ACAGTCAGAA GCCAAGGAAG CTGCTGGCTG AAAAGGTGGT CTATGTTGGT 
GTCTGGCTAC CTGCTGTCCT GTTGACTATT CCTGATCTCA TCTTTGCTGA CATCAAGGAG 
GTGGATGAGA GGTACATCTG TGATCGCTTC TATCCCAGCG ACCTGTGGCT AGTGGTGTTT 
CAGTTTCAGC ACATCGTGGT CGGCCTTCTC CTGCCTGGTA TCGTCATCCT GTCCTGCTAC 
TGCATTATCA TCTCCAAGCT GTCCCACTCC AAAGGCTATC AGAAGCGCAA GGCCCTCAAG 
ACCACAGTTA TCCTCATCCT GACTTTCTTC GCCTGCTGGC TGCCCTACTA CATTGGGATC 
AGCATTGACT CCTTCATCCT TCTGGAAATC ATCCAGCAAG GGTGTGAGTT TGAGAGCACT 
GTGCACAAGT GGATTTCCAT CACCGAGGCC CTAGCTTTTT TTCACTGCTG CCTGAATCCC 
ATCCTCTATG CCTTCCTTGG GGCCAAATTT AAAACCTCTG CCCAGCATGC ACTCACCTCT 
GTGAGCAGAG GGTCCAGCCT GAAGATCCTC TCCAAGGGCA AGCGAGGTGG ACATTCTTCT 
GTCTCAACCG AGTCTGAATC TTCAAGTTTT CACTCCAGCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of specific alleles for the bovine chemokine (C-X-C) receptor type 4 (CXCR4) gene in West African cattle questions its role as a candidate for trypanotolerance.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases4230-3(2016 08)
?lvarez I,P?rez-Pardal L,Traor? A,Fern?ndez I,Goyache F

Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.
Molecular and cellular endocrinology391(1-2)10-21(2014 Jun)
Sayasith K,Sirois J

C-X-C chemokine receptor type 4 and cytokine expressions in cows of a dairy herd with high prevalence of calves persistently infected with bovine viral diarrhea virus.
The Japanese journal of veterinary research61(3)109-16(2013 Aug)
Helal MA,Hoshino Y,Takagi S,Tajima M

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Sequence and expression of a neuropeptide Y receptor cDNA.
Molecular pharmacology40(6)869-75(1991 Dec)
Rimland J,Xin W,Sweetnam P,Saijoh K,Nestler EJ,Duman RS

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CXCR4 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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