CRHR1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRHR1
Entrez Gene ID	281716
Full Name	corticotropin releasing hormone receptor 1
Synonyms	CRFR1
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174287.1	NP_776712.1	corticotropin-releasing factor receptor 1 precursor

Pathways from BioSystems

Homologies

	CRHR1	NP_001027975.1
Mus musculus (house mouse)	Crhr1	NP_031788.1
Rattus norvegicus (Norway rat)	Crhr1	NP_112261.1
Xenopus tropicalis (tropical clawed frog)	LOC100498637	XP_002938039.2
Pan troglodytes (chimpanzee)	CRHR1	XP_003953028.1
Gallus gallus (chicken)	CRHR1	NP_989652.1
Danio rerio (zebrafish)	crhr1	XP_696346.3
Anopheles gambiae (African malaria mosquito)	GPRDIH1	XP_315466.4
Bos taurus (cattle)	CRHR1	NP_776712.1
Caenorhabditis elegans (roundworm)	C18B12.2	NP_510496.1
Drosophila melanogaster (fruit fly)	Dh44-R2	NP_725175.3
Homo sapiens (human)	CRHR1	NP_001138618.1
Canis lupus familiaris (dog)	CRHR1	XP_005624253.1

Gene Ontology
Bibliography

Related articles in PubMed

Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages.
Li Q, Hegge R, Bridges PJ, Matthews JC
PloS one12(9)e0184612(2017)

Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland.
Squillacioti C, De Luca A, Al? S, Ciarcia R, Germano G, Vittoria A, Mirabella N
Anatomia, histologia, embryologia43(6)429-34(2014 Dec)

Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland.
Squillacioti C, De Luca A, Liguori G, Paino S, Mirabella N
General and comparative endocrinology172(3)416-22(2011 Jul)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Bacterial lipopolysaccharide-induced coordinate downregulation of arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 messenger ribonucleic acids in the anterior pituitary of endotoxemic steers.
Qahwash IM, Cassar CA, Radcliff RP, Smith GW
Endocrine18(1)13-20(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
Title: Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland.

CRHR1 and CRHR2 are expressed in the bovine adrenal gland.
Title: Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland.

results indicate that arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3]
Title: Bacterial lipopolysaccharide-induced coordinate downregulation of arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 messenger ribonucleic acids in the anterior pituitary of endotoxemic steers.

The following CRHR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRHR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa39022	NM_174287.1 Latest version!	Bos taurus corticotropin releasing hormone receptor 1 (CRHR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRHR1 ( NM_174287.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776712.1 Bos taurus corticotropin releasing hormone receptor 1 (CRHR1), mRNA.

Price & Availability↑

CloneID	OBa39022
Clone ID Related Accession (Same CDS sequence)	NM_174287.1
Accession Version	NM_174287.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Bos taurus(cattle)
Product	corticotropin-releasing factor receptor 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB055434.1. ##Evidence-Data-START## Transcript exon combination :: AB055434.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145431, SAMN03145437 [ECO:0000348] ##Evidence-Data-END##

ATGGGACGGC GCCCGCAGCT CCGGCTTGTC AAGGCCCTTC TCCTCCTGGG GCTGAACTCC 
ATCTCTGCCT CCCTCCAGGA CCAGCATTGC GAGAGCTTGT CCGTGGCCAG CAACGTCTCT 
GGACTGCAGT GCAATGCTTC CGTGGACCTT ATTGGTACCT GCTGGCCCCA GAGTCCTGCA 
GGGCAGTTGG TGGTTCGACC CTGCCTCGTA TTTTTCTATG GTGTCCGCTA CAATACCACA 
AACAACGGCT ACCGGGAGTG CCTGGCCAAT GGCACGTGGG CCGCCCGCGT GAACTACTCC 
GAGTGCCAAG AGATCCTCAG CGAGGAGAAG AAGAGCAAGG TGCACTACCA CATCGCTGTC 
ATCATCAACT ACCTAGGCCA CTGCATCTCC CTGGCGGCCC TCCTGGTGGC CTTTGTCCTC 
TTTCTGCGGC TCAGGAGCAT CCGGTGCCTG AGAAACATCA TCCACTGGAA CCTCATCTCA 
GCCTTCATCC TGCGCAATGC CACGTGGTTC GTGGTCCAGC TCACCATGAG CCCCGAAGTC 
CATCAGAGCA ACGTGGGCTG GTGCAGGCTG GTGACAGCCG CCTACAACTA CTTCCACGTG 
ACCAACTTCT TCTGGATGTT CGGTGAGGGC TGCTACCTGC ACACGGCCAT CGTGCTCACG 
TACTCCACAG ACCGGCTGCG AAAGTGGATG TTTATCTGCA TCGGCTGGGG TGTGCCTTTC 
CCCATCATTG TGGCCTGGGC CATTGGGAAG CTGTACTACG ACAATGAGAA GTGCTGGTTT 
GGCAAAAGGC CTGGGGTGTA CACTGACTAC ATCTACCAGG GCCCGATGAT CTTGGTCCTG 
CTGATCAATT TCATCTTCCT TTTCAACATC GTCCGCATCC TCATGACCAA ACTCCGGGCA 
TCCACCACCT CTGAGACCAT TCAGTACAGG AAGGCTGTGA AGGCCACTCT GGTGCTGCTC 
CCCCTCCTGG GCATCACGTA CATGCTGTTC TTCGTGAACC CTGGGGAGGA CGAGGTCTCC 
AGGGTCGTCT TCATCTACTT CAACTCCTTC CTGGAATCTT TCCAGGGCTT CTTCGTGTCT 
GTGTTCTACT GCTTCCTCAA CAGCGAGGTC CGCTCTGCCA TCCGGAAGAG GTGGCACCGC 
TGGCAGGACA AGCACTCAAT CCGTGCCCGC GTGGCTCGCG CCATGTCCAT CCCCACCTCC 
CCCACCCGTG TCAGCTTTCA CAGCATCAAG CAGTCCACAG CAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776712.1
CDS	1..1248
Translation	MGRRPQLRLVKALLLLGLNSISASLQDQHCESLSVASNVSGLQCNASVDLIGTCWPQSPAGQLVVRPCLVFFYGVRYNTTNNGYRECLANGTWAARVNYSECQEILSEEKKSKVHYHIAVIINYLGHCISLAALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV

Target ORF information:

RefSeq Version	NM_174287.1
Organism	Bos taurus(cattle)
Definition	Bos taurus corticotropin releasing hormone receptor 1 (CRHR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174287.1

ORF Insert Sequence:

ATGGGACGGC GCCCGCAGCT CCGGCTTGTC AAGGCCCTTC TCCTCCTGGG GCTGAACTCC 
ATCTCTGCCT CCCTCCAGGA CCAGCATTGC GAGAGCTTGT CCGTGGCCAG CAACGTCTCT 
GGACTGCAGT GCAATGCTTC CGTGGACCTT ATTGGTACCT GCTGGCCCCA GAGTCCTGCA 
GGGCAGTTGG TGGTTCGACC CTGCCTCGTA TTTTTCTATG GTGTCCGCTA CAATACCACA 
AACAACGGCT ACCGGGAGTG CCTGGCCAAT GGCACGTGGG CCGCCCGCGT GAACTACTCC 
GAGTGCCAAG AGATCCTCAG CGAGGAGAAG AAGAGCAAGG TGCACTACCA CATCGCTGTC 
ATCATCAACT ACCTAGGCCA CTGCATCTCC CTGGCGGCCC TCCTGGTGGC CTTTGTCCTC 
TTTCTGCGGC TCAGGAGCAT CCGGTGCCTG AGAAACATCA TCCACTGGAA CCTCATCTCA 
GCCTTCATCC TGCGCAATGC CACGTGGTTC GTGGTCCAGC TCACCATGAG CCCCGAAGTC 
CATCAGAGCA ACGTGGGCTG GTGCAGGCTG GTGACAGCCG CCTACAACTA CTTCCACGTG 
ACCAACTTCT TCTGGATGTT CGGTGAGGGC TGCTACCTGC ACACGGCCAT CGTGCTCACG 
TACTCCACAG ACCGGCTGCG AAAGTGGATG TTTATCTGCA TCGGCTGGGG TGTGCCTTTC 
CCCATCATTG TGGCCTGGGC CATTGGGAAG CTGTACTACG ACAATGAGAA GTGCTGGTTT 
GGCAAAAGGC CTGGGGTGTA CACTGACTAC ATCTACCAGG GCCCGATGAT CTTGGTCCTG 
CTGATCAATT TCATCTTCCT TTTCAACATC GTCCGCATCC TCATGACCAA ACTCCGGGCA 
TCCACCACCT CTGAGACCAT TCAGTACAGG AAGGCTGTGA AGGCCACTCT GGTGCTGCTC 
CCCCTCCTGG GCATCACGTA CATGCTGTTC TTCGTGAACC CTGGGGAGGA CGAGGTCTCC 
AGGGTCGTCT TCATCTACTT CAACTCCTTC CTGGAATCTT TCCAGGGCTT CTTCGTGTCT 
GTGTTCTACT GCTTCCTCAA CAGCGAGGTC CGCTCTGCCA TCCGGAAGAG GTGGCACCGC 
TGGCAGGACA AGCACTCAAT CCGTGCCCGC GTGGCTCGCG CCATGTCCAT CCCCACCTCC 
CCCACCCGTG TCAGCTTTCA CAGCATCAAG CAGTCCACAG CAGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pituitary genomic expression profiles of steers are altered by grazing of high vs. low endophyte-infected tall fescue forages.
PloS one12(9)e0184612(2017)
Li Q,Hegge R,Bridges PJ,Matthews JC

Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland.
Anatomia, histologia, embryologia43(6)429-34(2014 Dec)
Squillacioti C,De Luca A,Al? S,Ciarcia R,Germano G,Vittoria A,Mirabella N

Expression of urocortin and corticotropin-releasing hormone receptors in the bovine adrenal gland.
General and comparative endocrinology172(3)416-22(2011 Jul)
Squillacioti C,De Luca A,Liguori G,Paino S,Mirabella N

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Bacterial lipopolysaccharide-induced coordinate downregulation of arginine vasopressin receptor V3 and corticotropin-releasing factor receptor 1 messenger ribonucleic acids in the anterior pituitary of endotoxemic steers.
Endocrine18(1)13-20(2002 Jun)
Qahwash IM,Cassar CA,Radcliff RP,Smith GW

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CRHR1 cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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