OXTR cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	OXTR
Entrez Gene ID	281371
Full Name	oxytocin receptor
General protein information	Preferred Names oxytocin receptor Names oxytocin receptor OT-R
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174134.2	NP_776559.1	oxytocin receptor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	OXTR	XP_001144020.1
	OXTR	NP_001038197.1
Mus musculus (house mouse)	Oxtr	NP_001074616.1
Danio rerio (zebrafish)	oxtrl	NP_001186298.1
Danio rerio (zebrafish)	oxtr	NP_001186299.1
Xenopus tropicalis (tropical clawed frog)	LOC100493876	XP_002936297.1
Canis lupus familiaris (dog)	OXTR	NP_001185588.1
Bos taurus (cattle)	OXTR	NP_776559.1
Rattus norvegicus (Norway rat)	Oxtr	NP_037003.2
Gallus gallus (chicken)	OXTR	NP_001026740.1
Homo sapiens (human)	OXTR	NP_000907.2

Gene Ontology
Bibliography

Related articles in PubMed

Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow.
Rekawiecki R, Nowocin A, Kotwica J
Prostaglandins & other lipid mediators92(1-4)13-8(2010 Jun)

Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.
Krishnaswamy N, Danyod G, Chapdelaine P, Fortier MA
Endocrinology150(2)897-905(2009 Feb)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Expression and regulation of functional oxytocin receptors in bovine T lymphocytes.
Ndiaye K, Poole DH, Pate JL
Biology of reproduction78(4)786-93(2008 Apr)

Prolonged progesterone treatment of endometrial epithelial cells modifies the effect of estradiol on their sensitivity to oxytocin.
Komb? A, Sirois J, Goff AK
Steroids68(7-8)651-8(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
Title: Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow.

Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.
Title: Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.

study demonstrated that bovine lymphocytes express oxytocin receptors and that this expression can be regulated in a steroid-dependent manner
Title: Expression and regulation of functional oxytocin receptors in bovine T lymphocytes.

the presence of oxytocin receptors (OTR) in oviductal tissues is evident in the follicular phase cow
Title: The concentrations of catecholamines and oxytocin receptors in the oviduct and its contractile activity in cows during the estrous cycle.

These data show that E2 can stimulate PGF2 alpha secretion by increasing OXTR expression in bovine endometrial cells in vitro, but only after exposure to P4.
Title: Prolonged progesterone treatment of endometrial epithelial cells modifies the effect of estradiol on their sensitivity to oxytocin.

The following OXTR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OXTR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa43489	NM_174134.2 Latest version!	Bos taurus oxytocin receptor (OXTR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OXTR ( NM_174134.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776559.1 Bos taurus oxytocin receptor (OXTR), mRNA.

Price & Availability↑

CloneID	OBa43489
Clone ID Related Accession (Same CDS sequence)	NM_174134.2
Accession Version	NM_174134.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1176bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Bos taurus(cattle)
Product	oxytocin receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF101724.1. On Jun 3, 2003 this sequence version replaced NM_174134.1. ##Evidence-Data-START## Transcript exon combination :: AF101724.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145416 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGGTG CGTTTGCGGC TAACTGGAGC GCTGAGGCGG TCAACGGGAG CGCGGCGCCG 
CCGGGAACCG AGGGCAATCG CACTGCCGGG CCGCCACAGC GCAACGAGGC CCTGGCGCGG 
GTGGAGGTGG CCGTGCTGTG CCTCATCCTG TTCCTGGCGC TGAGCGGCAA CGCGTGCGTG 
CTGCTAGCGC TGCGCACCAC GCGCCACAAG CACTCGCGCC TCTTCTTCTT CATGAAGCAC 
CTGAGCATAG CCGACCTGGT AGTGGCGGTG TTCCAGGTGC TGCCGCAGCT TCTGTGGGAC 
ATCACGTTCC GCTTCTACGG GCCCGACCTG CTGTGCCGCC TCGTCAAGTA CCTGCAGGTT 
GTGGGCATGT TCGCGTCCAC CTACCTGCTG CTGCTCATGT CGCTCGACCG CTGCCTGGCC 
ATCTGCCAGC CGCTGCGCTC GCTGAGCCGC CGCACCGACC GCCTGGCGGT ACTCGTCACA 
TGGCTCGGCT GCCTGGTGGC CAGCGCGCCG CAGGTGCACA TCTTCTCGCT GCGCGAGGTG 
GCCGACGGTG TCTTCGACTG CTGGGCCGTT TTCATTCAAC CCTGGGGGCC CAAGGCCTAC 
ATCACGTGGA TCACGCTCGC CGTCTACATT GTGCCCGTCA TCGTCCTTGC CACCTGCTAT 
GGCCTTATCA GCTTCAAGAT CTGGCAGAAT TTACGGCTCA AGACGGCGGC GGCGGCGGCA 
GAGGCTGCCG CGGGGGCTGA GGGCGAGGCG GCAGACTGGG CGGGGCGCGC GATTCTGGCC 
CGCGTCAGCA ACGTCAAGCT CATCTCTAAG GCCAAGATCC GCACGGTCAA GATGACCTTC 
ATCGTCGTGC TGGCCTTCAT CGTGTGCTGG ACGCCATTCT TTTTCGTGCA GATGTGGAGT 
GTCTGGGATG CCGATGCGCC CAAGGAAGCC TCACCTTTCA TCATCGCCAT GCTCCTGGCC 
AGCCTCAACA GCTGCTGCAA CCCCTGGATC TACATGCTCT TCACGGGCCA CCTCTTCCAA 
GAACTTGTGC AGCGCTTCCT CTGCTGCTCA TTCCGCCGCC TGAAAGGCAG CCGGCCTGGG 
GAGACAAGCG TCAGCAAAAA GAGCAACTCG TCTACCTTTG TCCTGAGCCA GTACAGCTCC 
AGCCAGAGAA GATGCTCGCA GCCATCCACG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776559.1
CDS	154..1329
Translation	MEGAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLSRRTDRLAVLVTWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLATCYGLISFKIWQNLRLKTAAAAAEAAAGAEGEAADWAGRAILARVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFVQMWSVWDADAPKEASPFIIAMLLASLNSCCNPWIYMLFTGHLFQELVQRFLCCSFRRLKGSRPGETSVSKKSNSSTFVLSQYSSSQRRCSQPSTL

Target ORF information:

RefSeq Version	NM_174134.2
Organism	Bos taurus(cattle)
Definition	Bos taurus oxytocin receptor (OXTR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174134.2

ORF Insert Sequence:

ATGGAGGGTG CGTTTGCGGC TAACTGGAGC GCTGAGGCGG TCAACGGGAG CGCGGCGCCG 
CCGGGAACCG AGGGCAATCG CACTGCCGGG CCGCCACAGC GCAACGAGGC CCTGGCGCGG 
GTGGAGGTGG CCGTGCTGTG CCTCATCCTG TTCCTGGCGC TGAGCGGCAA CGCGTGCGTG 
CTGCTAGCGC TGCGCACCAC GCGCCACAAG CACTCGCGCC TCTTCTTCTT CATGAAGCAC 
CTGAGCATAG CCGACCTGGT AGTGGCGGTG TTCCAGGTGC TGCCGCAGCT TCTGTGGGAC 
ATCACGTTCC GCTTCTACGG GCCCGACCTG CTGTGCCGCC TCGTCAAGTA CCTGCAGGTT 
GTGGGCATGT TCGCGTCCAC CTACCTGCTG CTGCTCATGT CGCTCGACCG CTGCCTGGCC 
ATCTGCCAGC CGCTGCGCTC GCTGAGCCGC CGCACCGACC GCCTGGCGGT ACTCGTCACA 
TGGCTCGGCT GCCTGGTGGC CAGCGCGCCG CAGGTGCACA TCTTCTCGCT GCGCGAGGTG 
GCCGACGGTG TCTTCGACTG CTGGGCCGTT TTCATTCAAC CCTGGGGGCC CAAGGCCTAC 
ATCACGTGGA TCACGCTCGC CGTCTACATT GTGCCCGTCA TCGTCCTTGC CACCTGCTAT 
GGCCTTATCA GCTTCAAGAT CTGGCAGAAT TTACGGCTCA AGACGGCGGC GGCGGCGGCA 
GAGGCTGCCG CGGGGGCTGA GGGCGAGGCG GCAGACTGGG CGGGGCGCGC GATTCTGGCC 
CGCGTCAGCA ACGTCAAGCT CATCTCTAAG GCCAAGATCC GCACGGTCAA GATGACCTTC 
ATCGTCGTGC TGGCCTTCAT CGTGTGCTGG ACGCCATTCT TTTTCGTGCA GATGTGGAGT 
GTCTGGGATG CCGATGCGCC CAAGGAAGCC TCACCTTTCA TCATCGCCAT GCTCCTGGCC 
AGCCTCAACA GCTGCTGCAA CCCCTGGATC TACATGCTCT TCACGGGCCA CCTCTTCCAA 
GAACTTGTGC AGCGCTTCCT CTGCTGCTCA TTCCGCCGCC TGAAAGGCAG CCGGCCTGGG 
GAGACAAGCG TCAGCAAAAA GAGCAACTCG TCTACCTTTG TCCTGAGCCA GTACAGCTCC 
AGCCAGAGAA GATGCTCGCA GCCATCCACG CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Relationship between concentrations of progesterone, oxytocin, noradrenaline, gene expression and protein level for their receptors in corpus luteum during estrous cycle in the cow.
Prostaglandins & other lipid mediators92(1-4)13-8(2010 Jun)
Rekawiecki R,Nowocin A,Kotwica J

Oxytocin receptor down-regulation is not necessary for reducing oxytocin-induced prostaglandin F(2alpha) accumulation by interferon-tau in a bovine endometrial epithelial cell line.
Endocrinology150(2)897-905(2009 Feb)
Krishnaswamy N,Danyod G,Chapdelaine P,Fortier MA

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Expression and regulation of functional oxytocin receptors in bovine T lymphocytes.
Biology of reproduction78(4)786-93(2008 Apr)
Ndiaye K,Poole DH,Pate JL

Prolonged progesterone treatment of endometrial epithelial cells modifies the effect of estradiol on their sensitivity to oxytocin.
Steroids68(7-8)651-8(2003 Sep)
Komb? A,Sirois J,Goff AK

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OXTR cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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