MC4R cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MC4R
Entrez Gene ID	281300
Full Name	melanocortin 4 receptor
General protein information	Preferred Names melanocortin 4 receptor Names melanocortin receptor 4 MC4-R
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174110.1	NP_776535.1	melanocortin receptor 4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MC4R	NP_776535.1
Mus musculus (house mouse)	Mc4r	NP_058673.2
Xenopus tropicalis (tropical clawed frog)	mc4r	XP_004915370.1
Homo sapiens (human)	MC4R	NP_005903.2
Canis lupus familiaris (dog)	MC4R	NP_001074193.1
	MC4R	XP_001088600.1
Pan troglodytes (chimpanzee)	MC4R	NP_001153207.1
Rattus norvegicus (Norway rat)	Mc4r	NP_037231.1
Gallus gallus (chicken)	MC4R	NP_001026685.1
Danio rerio (zebrafish)	mc4r	NP_775385.1

Gene Ontology
Bibliography

Related articles in PubMed

Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes.
Deng TX, Pang CY, Liu MQ, Zhang C, Liang XW
Genetics and molecular research : GMR15(2)(2016 Jul)

Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo).
Seong J, Suh DS, Park KD, Lee HK, Kong HS
Molecular biology reports39(4)3597-601(2012 Apr)

Polymorphisms in MC4R gene and correlations with economic traits in cattle.
Huang M, Gao X, Li JY, Ren HY, Chen JB, Xu SZ
Molecular biology reports37(8)3941-4(2010 Dec)

Mutations of MC4R gene and its association with economic traits in Qinchuan cattle.
Liu H, Tian W, Zan L, Wang H, Cui H
Molecular biology reports37(1)535-40(2010 Jan)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Based on the SNP data, seven haplotypes were constructed. Three SNPs H1 (AGT), H2 (GAT), and H3 (GAC) accounted for 93.0% of the total individuals. Statistical analysis indicated that the SNP g.1104C>T was significantly associated with milk yield, protein, and fat percentage.
Title: Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes.

The MC4R gene may thus be a candidate gene for carcass traits with MC4R single nucleotide polymorphisms being potentially valuable as genetic markers for economic traits in Hanwoo.
Title: Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo).

The aim was to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits.
Title: Polymorphisms in MC4R gene and correlations with economic traits in cattle.

The results suggested that -129A>G and 1,069C>G single nucleotide polymorphism of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.
Title: Mutations of MC4R gene and its association with economic traits in Qinchuan cattle.

Single nucleotide polymorphisms in 5'-untranslated region of MC4R gene, were detected.
Title: Association between variants in the 5'-untranslated region of the bovine MC4R gene and two growth traits in Nanyang cattle.

The following MC4R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MC4R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41467	NM_174110.1 Latest version!	Bos taurus melanocortin 4 receptor (MC4R), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MC4R ( NM_174110.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776535.1 Bos taurus melanocortin 4 receptor (MC4R), mRNA.

Price & Availability↑

CloneID	OBa41467
Clone ID Related Accession (Same CDS sequence)	NM_174110.1
Accession Version	NM_174110.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Bos taurus(cattle)
Product	melanocortin receptor 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF265221.1. ##Evidence-Data-START## Transcript exon combination :: AF265221.1 [ECO:0000332] ##Evidence-Data-END##

ATGAACTCTA CCCAGCCCCT TGGGATGCAC ACCTCTCTCC ACTCCTGGAA CCGCAGCGCC 
CACGGAATGC CCACCAATGT CAGTGAGTCC CTGGCAAAAG GCTACTCGGA CGGGGGGTGC 
TATGAGCAGC TCTTTGTCTC TCCCGAGGTG TTTGTGACTC TGGGGGTCAT CAGCTTGTTG 
GAGAATATTC TGGTGATCGT GGCCATAGCC AAGAACAAGA ATCTGCACTC ACCCATGTAC 
TTTTTCATCT GCAGCCTGGC TGTGGCTGAC ATGTTGGTGA GCGTTTCCAA CGGGTCGGAA 
ACCATTGTCA TCACCCTGCT GAACAGCACG GACACGGACG CGCAGAGCTT CACGGTGGAT 
ATTGACAATG TCATTGACTC GGTGATCTGT AGCTCCTTGC TTGCCTCCAT CTGCAGCTTG 
CTGTCGATCG CGGTGGACAG GTACTTCACT ATCTTCTATG CGCTCCAGTA CCATAACATC 
ATGACGGTGA AGCGGGTGGC GATCACCATC AGCGCCATCT GGGCAGCCTG CACGGTGTCG 
GGCGTCTTGT TCATCATTTA CTCAGACAGC AGTGCTGTTA TCATCTGCCT CATCACCGTG 
TTCTTCACCA TGCTGGCTCT CATGGCGTCT CTCTATGTCC ACATGTTCCT CATGGCCAGA 
CTCCACATTA AGAGGATCGC GGTCCTGCCA GGTAGCGGCA CCATCCGCCA GGGCGCCAAC 
ATGAAGGGGG CGATTACCCT GACCATACTG ATCGGGGTCT TTGTTGTCTG CTGGGCCCCC 
TTCTTCCTGC ACCTGATATT CTACATCTCT TGTCCCCAGA ACCCATACTG TGTGTGTTTC 
ATGTCTCACT TTAACCTGTA CCTCATCCTC ATCATGTGCA ATTCCATCAT TGACCCTCTG 
ATTTATGCCC TGCGGAGCCA AGAACTGAGG AAAACCTTCA AAGAGATCAT TTGTTGCTCT 
CCTCTAGGTG GCCTCTGTGA TTTGTCTAGC AGATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776535.1
CDS	214..1212
Translation	MNSTQPLGMHTSLHSWNRSAHGMPTNVSESLAKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVDIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVAITISAIWAACTVSGVLFIIYSDSSAVIICLITVFFTMLALMASLYVHMFLMARLHIKRIAVLPGSGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCSPLGGLCDLSSRY

Target ORF information:

RefSeq Version	NM_174110.1
Organism	Bos taurus(cattle)
Definition	Bos taurus melanocortin 4 receptor (MC4R), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174110.1

ORF Insert Sequence:

ATGAACTCTA CCCAGCCCCT TGGGATGCAC ACCTCTCTCC ACTCCTGGAA CCGCAGCGCC 
CACGGAATGC CCACCAATGT CAGTGAGTCC CTGGCAAAAG GCTACTCGGA CGGGGGGTGC 
TATGAGCAGC TCTTTGTCTC TCCCGAGGTG TTTGTGACTC TGGGGGTCAT CAGCTTGTTG 
GAGAATATTC TGGTGATCGT GGCCATAGCC AAGAACAAGA ATCTGCACTC ACCCATGTAC 
TTTTTCATCT GCAGCCTGGC TGTGGCTGAC ATGTTGGTGA GCGTTTCCAA CGGGTCGGAA 
ACCATTGTCA TCACCCTGCT GAACAGCACG GACACGGACG CGCAGAGCTT CACGGTGGAT 
ATTGACAATG TCATTGACTC GGTGATCTGT AGCTCCTTGC TTGCCTCCAT CTGCAGCTTG 
CTGTCGATCG CGGTGGACAG GTACTTCACT ATCTTCTATG CGCTCCAGTA CCATAACATC 
ATGACGGTGA AGCGGGTGGC GATCACCATC AGCGCCATCT GGGCAGCCTG CACGGTGTCG 
GGCGTCTTGT TCATCATTTA CTCAGACAGC AGTGCTGTTA TCATCTGCCT CATCACCGTG 
TTCTTCACCA TGCTGGCTCT CATGGCGTCT CTCTATGTCC ACATGTTCCT CATGGCCAGA 
CTCCACATTA AGAGGATCGC GGTCCTGCCA GGTAGCGGCA CCATCCGCCA GGGCGCCAAC 
ATGAAGGGGG CGATTACCCT GACCATACTG ATCGGGGTCT TTGTTGTCTG CTGGGCCCCC 
TTCTTCCTGC ACCTGATATT CTACATCTCT TGTCCCCAGA ACCCATACTG TGTGTGTTTC 
ATGTCTCACT TTAACCTGTA CCTCATCCTC ATCATGTGCA ATTCCATCAT TGACCCTCTG 
ATTTATGCCC TGCGGAGCCA AGAACTGAGG AAAACCTTCA AAGAGATCAT TTGTTGCTCT 
CCTCTAGGTG GCCTCTGTGA TTTGTCTAGC AGATATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes.
Genetics and molecular research : GMR15(2)(2016 Jul)
Deng TX,Pang CY,Liu MQ,Zhang C,Liang XW

Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo).
Molecular biology reports39(4)3597-601(2012 Apr)
Seong J,Suh DS,Park KD,Lee HK,Kong HS

Polymorphisms in MC4R gene and correlations with economic traits in cattle.
Molecular biology reports37(8)3941-4(2010 Dec)
Huang M,Gao X,Li JY,Ren HY,Chen JB,Xu SZ

Mutations of MC4R gene and its association with economic traits in Qinchuan cattle.
Molecular biology reports37(1)535-40(2010 Jan)
Liu H,Tian W,Zan L,Wang H,Cui H

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

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MC4R cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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